Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness

Journal of Applied Physiology

Volumn 101, Issue 6, 2006, Pages 1751-1759

  Soucy, Kevin G ^a   Ryoo, Sungwoo ^a   Benjo, Alexandre ^a   Hyun, Kyo Lim ^a,b   Gupta, Gaurav ^a   Sohi, Jayson S ^a   Elser, Jeremy ^a   Aon, Miguel A ^a   Nyhan, Daniel ^a   Shoukas, Artin A ^a   Berkowitz, Dan E ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b Yonsei University Wonju   (South Korea)

Author keywords

Aging; Endothelial dysfunction; Mechanotransduction; Nitric oxide synthase; Serine threonine kinase Akt

Indexed keywords

4 AMINO 5 METHYLAMINO 2',7' DIFLUOROFLUORESCEIN DIACETATE; ACETYLCHOLINE; DYE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) METHYLARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PROTEIN KINASE B; SPHINGOSINE 1 PHOSPHATE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; AORTA FLOW; ARTICLE; BLOOD VESSEL; CONTROLLED STUDY; ENDOTHELIUM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PULSE WAVE; RAT; RIGIDITY; SHEAR FLOW; SHEAR STRESS; SIGNAL TRANSDUCTION; STEADY STATE; VASODILATATION; WILD TYPE;

AGE FACTORS; AGING; ANIMALS; AORTA; ELASTICITY; MALE; MICE; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; RATS; RATS, WISTAR; SHEAR STRENGTH; VASCULAR RESISTANCE;

EID: 33845400838     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00138.2006     Document Type: Article

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