Mitochondria, oxygen free radicals, disease and ageing

Trends in Biochemical Sciences

Volumn 25, Issue 10, 2000, Pages 502-508

  Raha, Sandeep ^a,b   Robinson, Brian H ^a,b  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL; GLUTATHIONE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; OXYGEN RADICAL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UBIQUINOL CYTOCHROME C REDUCTASE;

AGING; CARDIOMYOPATHY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DROSOPHILA; ELECTRON TRANSPORT; ENZYME DEFICIENCY; GENE SEQUENCE; HUMAN; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESPIRATORY CHAIN; REVIEW; TELOMERE;

AGING; DISEASE; HUMAN; METABOLISM, INBORN ERRORS; MITOCHONDRIA; NADH, NADPH OXIDOREDUCTASES; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; SUPEROXIDES; SUPPORT, NON-U.S. GOV'T; UBIQUINOL-CYTOCHROME-C REDUCTASE;

EID: 0034306267     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(00)01674-1     Document Type: Review

References (55)

1. Superoxide radical and superoxide dismutases
2. The inactivation of Fe-S cluster containing hydrolyases by superoxide
3. Oxy-radicals and related species: their formation, lifetimes and reactions
4. The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidatioin of protein, DNA and membrane phospholipids
5. Elevated 'hydroxyl radical' generation in vivo in an animal model of amyotrophic lateral sclerosis
6. Evidence against the generation of free hydroxyl radicals from the interaction of copper, zinc superoxide dismutase and hydrogen peroxide
7. Mitochondrial production of superoxide radical and hydrogen peroxide
8. An analysis of the role of coenzyme Q in free radical generation and as an anti-oxidant
9. Generation of superoxide anion by mitochondria and impairment of their functions during anoxia and reoxygenation in vitro
10. The Gpx1 gene encodes mitochondrial glutathione peroxidase in the mouse liver
11. NADH and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation
12. Oxidative phosphorylation diseases
13. 3H] dihydrorotenone
14. NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone
15. The 49-kDa subunit of NADH-ubiquinone oxidoreductase (complex I) is involved in the binding of piericidin and rotenone, two quinone related inhibitors
16. Iron-sulfur clusters/semiquinones in Complex I
17. Proton translocation by membrane-bound NADH:ubiquinone-oxidoreductase (complex I) through redox-gated ligand conduction
18. The proton-translocating NADH-quinone oxidoreductase (NDH-1) of thermophilic bacterium Thermus thermophilus HB-8. Complete DNA sequence of the gene cluster and thermostable properties of the expressed NQO subunit
19. Familial cardiomyopathy with cataracts and lactic acidosis: A defect in complex I (NADH-dehydrogenase) of the mitochondrial respiratory chain
20. Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase
21. The protonmotive Q cycle. Energy transduction by coupling of proton translocation to electron transfer by the cytochrome bc1 complex
22. Detection of mitochondria-derived reactive oxygen species production by chemilumigenic probes lucigenin and luminol
23. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
24. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice
25. Extension of Drosophila life span by over expression of human SOD1 in motor neurons
26. Human complex I deficiency: clinical spectrum and involvement of oxygen free radicals in the pathogenicity of the defect
27. Excessive formation of hydroxyl radicals and aldehydic lipid peroxidation products in cultured skin fibroblasts from patients with complex I deficiency
28. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
29. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals
30. The aging process
31. Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species
32. The physiological significance of mitochondrial proton leak in animal cells and tissues
33. The biochemical, pathophysiological, and medical aspects of ubiquinone function
34. Comparisons of Coenzyme Q bound to mitochondrial membrane proteins among different mammalian species
35. The effect of dietary restriction on mitochondrial function in aging
36. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
37. Bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis
38. Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioural timing
39. Clk-1 controls respiration, behaviour and aging in the nematode Caenorhabditis elegans
40. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
41. Down's syndrome: morphological remodelling and increased complexity in the neuromuscular junction of transgenic CuZn-superoxide dismutase mice
42. Transgenic mice with elevated level of CuZnSOD are highly susceptible to malaria infection
43. Reversible impairment of long-term potentiation in transgenic Cu/Zn-SOD mice
44. Inhibition of cell growth in NIH/3T3 fibroblasts by overexpression of manganese superoxide dismutase: mechanistic studies
45. Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells
46. The protective role of manganese superoxide dismutase against adriamycin induced acute cardiotoxicity in transgenic mice
47. Mild hyperoxia shortens telomeres and inhibits proliferation of human fibroblasts: a model for senescence?
48. Low oxygen concentration extends the lifespan of cultured human diploid cells
49. Telomeres shorten during aging of human fibroblasts
50. DNA damage and repair in telomeres: relation to aging
51. Extension of lifespan by inroduction of telomerase into normal human cells
52. Preferential accumulation of single-stranded regions in telomeres of human fibroblasts
53. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
54. Altered levels of primary antioxidant enzymes in progeria skin fibroblasts