5-Methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: Effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling

Circulation

Volumn 114, Issue 11, 2006, Pages 1193-1201

  Antoniades, Charalambos ^a   Shirodaria, Cheerag ^a   Warrick, Nicholas ^a   Cai, Shijie ^a   De Bono, Joseph ^a   Lee, Justin ^a   Leeson, Paul ^a   Neubauer, Stefan ^a   Ratnatunga, Chandi ^a   Pillai, Ravi ^a   Refsum, Helga ^b   Channon, Keith M ^a,c  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Acetylcholine; Antioxidants; Coronary disease; Endothelium; Free radicals; Nitric oxide; Nitric oxide synthase

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; ACETYLCHOLINE; ACETYLSALICYLIC ACID; BIOPTERIN; BRADYKININ; HOMOCYSTEINE; PEROXYNITRITE; SUPEROXIDE;

ADULT; AGED; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; ENZYME SYNTHESIS; EX VIVO STUDY; FEMALE; HUMAN; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SAPHENOUS VEIN; VASOMOTOR REFLEX;

ACETYLCHOLINE; ANTIOXIDANTS; ATHEROSCLEROSIS; BIOLOGICAL AVAILABILITY; BIOPTERIN; BRADYKININ; CORONARY ARTERIOSCLEROSIS; CORONARY ARTERY BYPASS; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; HOMOCYSTEINE; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PEROXYNITROUS ACID; PROTEIN BINDING; SUPEROXIDES; TETRAHYDROFOLATES;

EID: 33748645122     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.106.612325     Document Type: Article

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