Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats

Circulation Research

Volumn 83, Issue 3, 1998, Pages 279-286

  Cernadas, María R ^a   De Miguel, Lourdes Sánchez ^a   García Durán, Margarita ^a   González Fernández, Fernando ^a   Millás, Inmaculada ^a   Montón, Mercedes ^a   Rodrigo, José ^b   Rico, Luis ^a   Fernández, Patricia ^b   De Frutos, Trinidad ^a   Rodríguez Feo, Juan A ^a   Guerra, José ^a   Caramelo, Carlos ^a   Casado, Santos ^a   López Farré, Antonio ^a  

^a Hospital U   (Spain)

^b INSTITUTO CAJAL   (Spain)

Author keywords

Acetylcholine; Aging; Arteries; Endothelium derived relaxing factor

Indexed keywords

ACETYLCHOLINE; ANGIOTENSIN; ARGININE; BRADYKININ; CALCIUM; CITRULLINE; CYCLIC GMP; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE; NITRITE; NITROPRUSSIDE SODIUM;

ADOLESCENT; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; AORTA; ARTICLE; BLOOD VESSEL WALL; CONTROLLED STUDY; ENZYME INDUCTION; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM;

EID: 0032504749     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.83.3.279     Document Type: Article

References (36)

1. Moncada S, Palmer RMJ, Higgs A. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev. 1991;43:109-141.
2. Radomski MW, Moncada S. Regulation of vascular homeostasis by nitric oxide. Thromb Haemost. 1993;70:36-41.
3. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993;329:2002-2012.
4. López-Farré A, Caramelo C, Esteban A, Alberola ML, Millás I, Montón M, Casado S. Effects of aspirin on platelet-neutrophil interactions: role of nitric oxide and endothelin-1. Circulation. 1995;91:2080-2088.
5. Radomski MW, Palmer RMJ, Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet. 1987; 2:1057-1058.
6. May GR, Crook P, Moore PK, Page CP. The role of nitric oxide as an endogenous regulator of platelet and neutrophil activation within the pulmonary circulation of the rabbit. Br J Pharmacol. 1991;102:759-763.
7. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A. 1991;88:587-590.
8. Trachtman H, Futterweit S, Singhal P. Nitric oxide modulates the synthesis of extracellular matrix proteins in cultured rat mesangial cells. Biochem Biophys Res Commun. 1995;207:120-125.
9. Sessa WC. The nitric oxide synthase family of proteins. J Vasc Res. 1994;31:131-143.
10. Katsuki S, Arnold W, Mittal C, Murad F. Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerine and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. J Cyclic Nucleotide Res. 1977;3:23-35.
11. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992;6:3051-3064.
12. Chinellato A, Pandolfo L, Ragazzi E, Zambonin MR, Froldi G, De Biasik M, Caparrotta L, Fassina G. Effect of age on rabbit aortic responses to relaxant endothelium-dependent and endothelium-independent agents. Bloodvessels. 1991;28:358-365.
13. Gerhard M, Roddy MA, Creager SJ, Creager MA. Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension. 1996;27:849-853.
14. 2-purinergic receptors on vascular smooth muscle and endothelium. Hypertension. 1992;19:286-289.
15. Moritoki H, Yoshikawa T, Hisayama T, Takeuchi S. Possible mechanisms of age-associated reduction of vascular relaxation caused by atrial natriuretic peptide. Eur J Pharmacol. 1992;210:61-68.
16. Alonso J, Sánchez de Miguel L, Montón M, Casado S, López-Farré A. Endothelial-cytosolic proteins bind to the 3′ untranslated region of endothelial nitric oxide synthase mRNA: regulation by tumor necrosis factor alpha. Mol Cell Biol. 1997;17:5719-5726.
17. Belmin J, Bernard C, Corman B, Merval R, Esposito B, Tedgui A. Increased production of tumor necrosis factor-alpha and interleukin-6 by arterial wall of aged rats. Am J Physiol. 1995;268:H2288-H2293.
18. Lopez Farré A, Gómez-Garré D, Bernabeu F, López-Novoa JM. A role for endothelin in the maintenance of postischemic renal failure in rats. J Physiol (Lond). 1991;444:513-522.
19. Gallego MJ, López Farré A, Riesco A, Montón M, Grandes S, Casado S, Caramelo C. Blockade of endothelium-dependent responses in conscious rats by cyclosporin A: effect of L-arginine. Am J Physiol. 1993;264: H708-H714.
20. 2+. Circ Res. 1994;74:477-484.
21. Laemmli NK. Change of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
22. López-Farré A, Mosquera JR, Sánchez de Miguel L, Millás I, de Frutos T, Montón M, Sierra MP, Riesco A, Casado S. Endothelial cells inhibit nitric oxide generation by vascular smooth muscle cells: role of transforming growth factor-β. Arterioscler Thromb Vasc Biol. 1996;16: 1263-1268.
23. López-Farré A, Sánchez de Miguel L, Caramelo C, Gómez-Macías J, García R, Mosquera JR, de Frutos T, Millás I, Rivas F, Echezarreta G, Casado S. Role of nitric oxide in autocrine control of growth and apoptosis of endothelial cells. Am J Physiol. 1997;41:H760-H768.
24. Riesco A, Caramelo C, Blum G, Montón M, Gallego MJ, Casado S, López-Farré A. Nitric oxide-generating system as an autocrine mechanism in human polymorphonuclear leukocytes. Biochem J. 1993; 292:791-796.
25. Lakatta EG, Mitchell JH, Pomerance A, Rowe GG. Human aging: changes in structure and function. J Am Coll Cardiol. 1987;10(suppl A):42A-47A.
26. Cliff W. Aging and arterial structure. In: Schwartz CJ, ed. Structure and Function of the Circulation. New York, NY: Plenum Publishing Corp; 1981:635-665.
27. Sessa WC, Pritchard K, Seyedi N, Wang J, Hintze TH. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res. 1994;74: 349-353.
28. Ranjan V, Xiao Z, Diamond SL. Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear-stress. Am J Physiol. 1995; 269:H550-H555.
29. Nishida K, Harrison DG, Navas JP, Fisher A, Dockery SP, Uematsu M, Neren RM, Alexandre RW, Murphy TJ. Molecular cloning and characterization of constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest. 1992;90:2092-2096.
30. Walter R, Schaffner A, Schoedon G. Differential regulation of constitutive and inducible nitric oxide production by inflammatory stimuli in murine endothelial cells. Biochem Biophys Res Commun. 1994;202: 450-455.
31. Myers PR, Zhong Q, Jones JJ, Tanner MA, Adams HR, Parker JL. Release of EDRF and NO in ex vivo perfused aorta: inhibition by in vivo E. coli endotoxemia. Am J Physiol. 1995;268:H955-H961.
32. Minor RL, Myers PR, Guerra R, Bates JN, Harrison DG. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest. 1990;86:2109-2116.
33. Le Cras TD, Xue C, Rengasawy A, Johns RA. Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am J Physiol. 1996;270:L164-L170.
34. Buga GM, Griscavage JM, Rogers ME, lgnarro LJ. Negative feedback regulation of endothelial cell function by nitric oxide. Circ Res. 1993;73: 808-812.
35. Griscovage JM, Hoblas AJ, Ignarro LJ. Negative modulation of nitric oxide synthase by nitric oxide and nitroso components. Adv Pharmacol. 1993;34:215-234.
36. Cohen GA, Chaudhuri G, Zinner MJ, Ignarro LJ. Nitric oxide regulates endothelium-dependent vasodilator responses in the rabbit hindquarter vascular cells in vivo. Am J Physiol. 1996;271:H133-H139.