-
1
-
-
0025854527
-
Coronary thrombolysis for the elderly?
-
Gurwitz JH, Goldberg RJ, Gore JM. Coronary thrombolysis for the elderly? JAMA. 1991;265:1720-1723.
-
(1991)
JAMA
, vol.265
, pp. 1720-1723
-
-
Gurwitz, J.H.1
Goldberg, R.J.2
Gore, J.M.3
-
2
-
-
77956938607
-
Mechanisms of vascular aging: New perspectives
-
Ungvari Z, Kaley G, de Cabo R, Sonntag WE, Csiszar A. Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci. 2010;65:1028-1041.
-
(2010)
J Gerontol A Biol Sci Med Sci.
, vol.65
, pp. 1028-1041
-
-
Ungvari, Z.1
Kaley, G.2
De Cabo, R.3
Sonntag, W.E.4
Csiszar, A.5
-
3
-
-
70350439125
-
Overexpression of Mn superoxide dismutase does not increase life span in mice
-
Jang YC, Perez VI, Song W, et al. Overexpression of Mn superoxide dismutase does not increase life span in mice. J Gerontol A Biol Sci Med Sci. 2009;64(11):1114-1125.
-
(2009)
J Gerontol A Biol Sci Med Sci.
, vol.64
, Issue.11
, pp. 1114-1125
-
-
Jang, Y.C.1
Perez, V.I.2
Song, W.3
-
4
-
-
75149126964
-
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity
-
Zhang Y, Ikeno Y, Qi W, et al. Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. J Gerontol A Biol Sci Med Sci. 2009;64:1212-1220.
-
(2009)
J Gerontol A Biol Sci Med Sci.
, vol.64
, pp. 1212-1220
-
-
Zhang, Y.1
Ikeno, Y.2
Qi, W.3
-
5
-
-
34948853679
-
Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis
-
Ran Q, Liang H, Ikeno Y, et al. Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. J Gerontol A Biol Sci Med Sci. 2007;62:932-942. (Pubitemid 47531208)
-
(2007)
Journals of Gerontology - Series A Biological Sciences and Medical Sciences
, vol.62
, Issue.9
, pp. 932-942
-
-
Ran, Q.1
Liang, H.2
Ikeno, Y.3
Qi, W.4
Prolla, T.A.5
Roberts II, L.J.6
Wolf, N.7
Vanremmen, H.8
Richardson, A.9
-
6
-
-
55449136486
-
Inflammation and endothelial dysfunction during aging: Role of NF-{kappa}B
-
Csiszar A, Wang M, Lakatta EG, Ungvari ZI. Inflammation and endothelial dysfunction during aging: role of NF-{kappa}B. J Appl Physiol. 2008;105:1333-1341.
-
(2008)
J Appl Physiol.
, vol.105
, pp. 1333-1341
-
-
Csiszar, A.1
Wang, M.2
Lakatta, E.G.3
Ungvari, Z.I.4
-
7
-
-
54449084867
-
Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice
-
Yoh K, Hirayama A, Ishizaki K, et al. Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice. Genes Cells. 2008;13:1159-1170.
-
(2008)
Genes Cells.
, vol.13
, pp. 1159-1170
-
-
Yoh, K.1
Hirayama, A.2
Ishizaki, K.3
-
8
-
-
58149352893
-
Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease
-
Xue M, Qian Q, Antonysunil A, Rabbani N, Babaei-Jadidi R, Thornalley PJ. Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease. Diabetes. 2008;57(10):2809-2817.
-
(2008)
Diabetes.
, vol.57
, Issue.10
, pp. 2809-2817
-
-
Xue, M.1
Qian, Q.2
Antonysunil, A.3
Rabbani, N.4
Babaei-Jadidi, R.5
Thornalley, P.J.6
-
9
-
-
40949142846
-
Mechanisms underlying caloric restriction and lifespan regulation: Implications for vascular aging
-
Ungvari Z, Parrado-Fernandez C, Csiszar A, de Cabo R. Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. Circ Res. 2008;102:519-528.
-
(2008)
Circ Res.
, vol.102
, pp. 519-528
-
-
Ungvari, Z.1
Parrado-Fernandez, C.2
Csiszar, A.3
De Cabo, R.4
-
10
-
-
77953741269
-
Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
-
Ungvari Z, Bagi Z, Feher A, et al. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol. 2010;299:H18-H24.
-
(2010)
Am J Physiol Heart Circ Physiol.
, vol.299
-
-
Ungvari, Z.1
Bagi, Z.2
Feher, A.3
-
11
-
-
57249104720
-
Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes
-
He X, Kan H, Cai L, Ma Q. Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes. J Mol Cell Cardiol. 2009;46:47-58.
-
(2009)
J Mol Cell Cardiol.
, vol.46
, pp. 47-58
-
-
He, X.1
Kan, H.2
Cai, L.3
Ma, Q.4
-
12
-
-
79955068967
-
Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia
-
Ungvari Z, Bailey-Downs L, Gautam T, et al. Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia. Am J Physiol Heart Circ Physiol. 2011;300(4):H1133-H1140.
-
(2011)
Am J Physiol Heart Circ Physiol.
, vol.300
, Issue.4
-
-
Ungvari, Z.1
Bailey-Downs, L.2
Gautam, T.3
-
13
-
-
33845619005
-
Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: Role of reactive oxygen/nitrogen species
-
DOI 10.1016/j.freeradbiomed.2006.10.043, PII S0891584906006745
-
Warabi E, Takabe W, Minami T, et al. Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species. Free Radic Biol Med. 2007;42:260-269. (Pubitemid 44959746)
-
(2007)
Free Radical Biology and Medicine
, vol.42
, Issue.2
, pp. 260-269
-
-
Warabi, E.1
Takabe, W.2
Minami, T.3
Inoue, K.4
Itoh, K.5
Yamamoto, M.6
Ishii, T.7
Kodama, T.8
Noguchi, N.9
-
14
-
-
77951479702
-
Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: Novel point of convergence between electrophilic and unfolded protein stress pathways
-
Afonyushkin T, Oskolkova OV, Philippova M, et al. Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways. Arterioscler Thromb Vasc Biol. 2010;30:1007-1013.
-
(2010)
Arterioscler Thromb Vasc Biol.
, vol.30
, pp. 1007-1013
-
-
Afonyushkin, T.1
Oskolkova, O.V.2
Philippova, M.3
-
15
-
-
34547178903
-
2 production promotes endothelial NF-κB activation in aged rat arteries
-
DOI 10.1152/ajpheart.01346.2006
-
Ungvari Z, Orosz Z, Labinskyy N, et al. Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries. Am J Physiol Heart Circ Physiol. 2007;293:H37-H47. (Pubitemid 47108162)
-
(2007)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.293
, Issue.1
-
-
Ungvari, Z.1
Orosz, Z.2
Labinskyy, N.3
Rivera, A.4
Xiangmin, Z.5
Smith, K.6
Csiszar, A.7
-
16
-
-
0037076784
-
Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function
-
DOI 10.1161/01.RES.0000020401.61826.EA
-
Csiszar A, Ungvari Z, Edwards JG, et al. Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ Res. 2002;90:1159-1166. (Pubitemid 34786900)
-
(2002)
Circulation Research
, vol.90
, Issue.11
, pp. 1159-1166
-
-
Csiszar, A.1
Ungvari, Z.2
Edwards, J.G.3
Kaminski, P.4
Wolin, M.S.5
Koller, A.6
Kaley, G.7
-
17
-
-
48349144852
-
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
-
Pearson KJ, Baur JA, Lewis KN, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008;8:157-168.
-
(2008)
Cell Metab.
, vol.8
, pp. 157-168
-
-
Pearson, K.J.1
Baur, J.A.2
Lewis, K.N.3
-
18
-
-
33847032609
-
Vasculoprotective effects of anti-TNFalfa treatment in aging
-
Csiszar A, Labinskyy N, Smith K, Rivera A, Orosz Z, Ungvari Z. Vasculoprotective effects of anti-TNFalfa treatment in aging. Am J Pathol. 2007;170:388-698.
-
(2007)
Am J Pathol.
, vol.170
, pp. 388-698
-
-
Csiszar, A.1
Labinskyy, N.2
Smith, K.3
Rivera, A.4
Orosz, Z.5
Ungvari, Z.6
-
19
-
-
0034044004
-
Peripheral vascular endothelial dysfunction and apoptosis in old monkeys
-
Asai K, Kudej RK, Shen YT, et al. Peripheral vascular endothelial dysfunction and apoptosis in old monkeys. Arterioscler Thromb Vasc Biol. 2000;20:1493-1499. (Pubitemid 30353879)
-
(2000)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.20
, Issue.6
, pp. 1493-1499
-
-
Asai, K.1
Kudej, R.K.2
Shen, Y.-T.3
Yang, G.-P.4
Takagi, G.5
Kudej, A.B.6
Geng, Y.-J.7
Sato, N.8
Nazareno, J.B.9
Vatner, D.E.10
Natividad, F.11
Bishop, S.P.12
Vatner, S.F.13
-
20
-
-
3943060162
-
Passage-dependent changes in baboon endothelial cells - Relevance to in vitro aging
-
DOI 10.1089/1044549041562294
-
Shi Q, Aida K, Vandeberg JL, Wang XL. Passage-dependent changes in baboon endothelial cells-relevance to in vitro aging. DNA Cell Biol. 2004;23:502-509. (Pubitemid 39050556)
-
(2004)
DNA and Cell Biology
, vol.23
, Issue.8
, pp. 502-509
-
-
Shi, Q.1
Aida, K.2
Vandeberg, J.L.3
Xing, L.W.4
-
21
-
-
0035970120
-
A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys
-
DOI 10.1073/pnas.98.3.1171
-
Vaitkevicius PV, Lane M, Spurgeon H, et al. A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys. Proc Natl Acad Sci U S A. 2001;98:1171-1175. (Pubitemid 32121205)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.3
, pp. 1171-1175
-
-
Vaitkevicius, P.V.1
Lane, M.2
Spurgeon, H.3
Ingram, D.K.4
Roth, G.S.5
Egan, J.J.6
Vasan, S.7
Wagle, D.R.8
Ulrich, P.9
Brines, M.10
Wuerth, J.P.11
Cerami, A.12
Lakatta, E.G.13
-
22
-
-
34249683717
-
An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts
-
de Magalhaes JP, Costa J, Church GM. An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts. J Gerontol A Biol Sci Med Sci. 2007;62:149-160. (Pubitemid 47065738)
-
(2007)
Journals of Gerontology - Series A Biological Sciences and Medical Sciences
, vol.62
, Issue.2
, pp. 149-160
-
-
De Magalhaes, J.P.1
Costa, J.2
Church, G.M.3
-
23
-
-
58249098409
-
The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: Proteomic approach
-
Addabbo F, Ratliff B, Park HC, et al. The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach. Am J Pathol. 2009;174:34-43.
-
(2009)
Am J Pathol.
, vol.174
, pp. 34-43
-
-
Addabbo, F.1
Ratliff, B.2
Park, H.C.3
-
24
-
-
67650659852
-
Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1
-
Csiszar A, Labinskyy N, Jimenez R, et al. Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1. Mech Ageing Dev. 2009;130:518-527.
-
(2009)
Mech Ageing Dev.
, vol.130
, pp. 518-527
-
-
Csiszar, A.1
Labinskyy, N.2
Jimenez, R.3
-
25
-
-
77958061482
-
Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats
-
Ungvari Z, Gautam T, Koncz P, et al. Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats. J Gerontol A Biol Sci Med Sci. 2010;65:1145-1156.
-
(2010)
J Gerontol A Biol Sci Med Sci.
, vol.65
, pp. 1145-1156
-
-
Ungvari, Z.1
Gautam, T.2
Koncz, P.3
-
26
-
-
18544384985
-
2, and high intravascular pressure
-
DOI 10.1161/01.CIR.0000164201.40634.1D
-
Csiszar A, Smith KE, Koller A, Kaley G, Edwards JG, Ungvari Z. Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure. Circulation. 2005;111:2364-2372. (Pubitemid 40655331)
-
(2005)
Circulation
, vol.111
, Issue.18
, pp. 2364-2372
-
-
Csiszar, A.1
Smith, K.E.2
Koller, A.3
Kaley, G.4
Edwards, J.G.5
Ungvari, Z.6
-
27
-
-
44949220235
-
Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats
-
Ungvari ZI, Labinskyy N, Gupte SA, Chander PN, Edwards JG, Csiszar A. Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats. Am J Physiol Heart Circ Physiol. 2008;294:H2121- H2128.
-
(2008)
Am J Physiol Heart Circ Physiol.
, vol.294
-
-
Ungvari, Z.I.1
Labinskyy, N.2
Gupte, S.A.3
Chander, P.N.4
Edwards, J.G.5
Csiszar, A.6
-
28
-
-
33749365317
-
Resveratrol attenuates TNF-α-induced activation of coronary arterial endothelial cells: Role of NF-κB inhibition
-
DOI 10.1152/ajpheart.00340.2006
-
Csiszar A, Smith K, Labinskyy N, Orosz Z, Rivera A, Ungvari Z. Resveratrol attenuates TNF-{alpha}-induced activation of coronary arterial endothelial cells: role of NF-{kappa}B inhibition. Am J Physiol. 2006;291:H1694-H1699. (Pubitemid 44497674)
-
(2006)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.291
, Issue.4
-
-
Csiszar, A.1
Smith, K.2
Labinskyy, N.3
Orosz, Z.4
Rivera, A.5
Ungvari, Z.6
-
29
-
-
36249022195
-
Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity
-
DOI 10.1111/j.1474-9726.2007.00339.x
-
Csiszar A, Labinskyy N, Zhao X, et al. Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity. Aging Cell. 2007;6:783-797. (Pubitemid 350131047)
-
(2007)
Aging Cell
, vol.6
, Issue.6
, pp. 783-797
-
-
Csiszar, A.1
Labinskyy, N.2
Zhao, X.3
Hu, F.4
Serpillon, S.5
Huang, Z.6
Ballabh, P.7
Levy, R.J.8
Hintze, T.H.9
Wolin, M.S.10
Austad, S.N.11
Podlutsky, A.12
Ungvari, Z.13
-
30
-
-
77952958303
-
Elevated mineralocorticoid receptor activity in aged rat vascular smooth muscle cells promotes a proinflammatory phenotype via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase and epidermal growth factor receptor-dependent pathways
-
Krug AW, Allenhofer L, Monticone R, et al. Elevated mineralocorticoid receptor activity in aged rat vascular smooth muscle cells promotes a proinflammatory phenotype via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase and epidermal growth factor receptor-dependent pathways. Hypertension. 2010;55:1476-1483.
-
(2010)
Hypertension.
, vol.55
, pp. 1476-1483
-
-
Krug, A.W.1
Allenhofer, L.2
Monticone, R.3
-
31
-
-
49249100288
-
Vasoprotective effects of resveratrol and SIRT1: Attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
-
Csiszar A, Labinskyy N, Podlutsky A, et al. Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol. 2008;294:H2721-H2735.
-
(2008)
Am J Physiol Heart Circ Physiol.
, vol.294
-
-
Csiszar, A.1
Labinskyy, N.2
Podlutsky, A.3
-
32
-
-
57049132064
-
Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice
-
Csiszar A, Labinskyy N, Perez V, et al. Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice. Am J Physiol Heart Circ Physiol. 2008;295:H1882-H1894.
-
(2008)
Am J Physiol Heart Circ Physiol.
, vol.295
-
-
Csiszar, A.1
Labinskyy, N.2
Perez, V.3
-
33
-
-
0034643340
-
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
-
DOI 10.1038/35008121
-
Nishikawa T, Edelstein D, Du XL, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature. 2000;404:787-790. (Pubitemid 30212409)
-
(2000)
Nature
, vol.404
, Issue.6779
, pp. 787-790
-
-
Nishikawa, T.1
Edelstein, D.2
Du, X.L.3
Yamagishi, S.-I.4
Matsumura, T.5
Kaneda, Y.6
Yorek, M.A.7
Beebe, D.8
Oates, P.J.9
Hammes, H.-P.10
Glardino, I.11
Brownlee, M.12
-
34
-
-
4544354262
-
Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I)
-
DOI 10.1074/jbc.M406576200
-
Lambert AJ, Brand MD. Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I). J Biol Chem. 2004;279:39414-39420. (Pubitemid 39258206)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.38
, pp. 39414-39420
-
-
Lambert, A.J.1
Brand, M.D.2
-
35
-
-
33144469523
-
Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype
-
DOI 10.2353/ajpath.2006.050284
-
Csiszar A, Ahmad M, Smith KE, et al. Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype. Am J Pathol. 2006;168:629-638. (Pubitemid 43271160)
-
(2006)
American Journal of Pathology
, vol.168
, Issue.2
, pp. 629-638
-
-
Csiszar, A.1
Ahmad, M.2
Smith, K.E.3
Labinskyy, N.4
Gao, Q.5
Kaley, G.6
Edwards, J.G.7
Wolin, M.S.8
Ungvari, Z.9
-
36
-
-
1842509760
-
Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging
-
DOI 10.1152/physiolgenomics.00136.2003
-
Csiszar A, Ungvari Z, Koller A, Edwards JG, Kaley G. Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging. Physiol Genomics. 2004;17:21-30. (Pubitemid 38924147)
-
(2004)
Physiological Genomics
, vol.17
, pp. 21-30
-
-
Csiszar, A.1
Ungvari, Z.2
Koller, A.3
Edwards, J.G.4
Kaley, G.5
-
37
-
-
34547870564
-
Vascular aging in the longest-living rodent, the naked mole rat
-
DOI 10.1152/ajpheart.01287.2006
-
Csiszar A, Labinskyy N, Orosz Z, Xiangmin Z, Buffenstein R, Ungvari Z. Vascular aging in the longest-living rodent, the naked mole rat. Am J Physiol. 2007;293:H919-H927. (Pubitemid 47254187)
-
(2007)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.293
, Issue.2
-
-
Csiszar, A.1
Labinskyy, N.2
Orosz, Z.3
Xiangmin, Z.4
Buffenstein, R.5
Ungvari, Z.6
-
38
-
-
34250216014
-
Direct evidence of endothelial oxidative stress with aging in humans: Relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-κB
-
DOI 10.1161/01.RES.0000269183.13937.e8
-
Donato AJ, Eskurza I, Silver AE, et al. Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium- dependent dilation and upregulation of nuclear factor-kappaB. Circ Res. 2007;100:1659-1666. (Pubitemid 46897269)
-
(2007)
Circulation Research
, vol.100
, Issue.11
, pp. 1659-1666
-
-
Donato, A.J.1
Eskurza, I.2
Silver, A.E.3
Levy, A.S.4
Pierce, G.L.5
Gates, P.E.6
Seals, D.R.7
-
39
-
-
79957794634
-
Salicylate treatment improves age-associated vascular endothelial dysfunction: Potential role of nuclear factor {kappa}B and forkhead box O phosphorylation
-
Lesniewski LA, Durrant JR, Connell ML, Folian BJ, Donato AJ, Seals DR. Salicylate treatment improves age-associated vascular endothelial dysfunction: potential role of nuclear factor {kappa}B and forkhead box O phosphorylation. J Gerontol A Biol Sci Med Sci. 2011;66:409-418.
-
(2011)
J Gerontol A Biol Sci Med Sci.
, vol.66
, pp. 409-418
-
-
Lesniewski, L.A.1
Durrant, J.R.2
Connell, M.L.3
Folian, B.J.4
Donato, A.J.5
Seals, D.R.6
-
40
-
-
64249118922
-
B6D2F1 mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging
-
Lesniewski LA, Connell ML, Durrant JR, et al. B6D2F1 mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging. J Gerontol A Biol Sci Med Sci. 2009;64:9-20.
-
(2009)
J Gerontol A Biol Sci Med Sci.
, vol.64
, pp. 9-20
-
-
Lesniewski, L.A.1
Connell, M.L.2
Durrant, J.R.3
-
41
-
-
79955154110
-
Genetic deletion of nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts
-
Jodar L, Mercken EM, Ariza J, et al. Genetic deletion of nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts. J Gerontol A Biol Sci Med Sci. 2011;66:247-256.
-
(2011)
J Gerontol A Biol Sci Med Sci.
, vol.66
, pp. 247-256
-
-
Jodar, L.1
Mercken, E.M.2
Ariza, J.3
-
42
-
-
40649108843
-
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
-
DOI 10.1073/pnas.0712162105
-
Pearson KJ, Lewis KN, Price NL, et al. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A. 2008;105:2325-2330. (Pubitemid 351520512)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.7
, pp. 2325-2330
-
-
Pearson, K.J.1
Lewis, K.N.2
Price, N.L.3
Chang, J.W.4
Perez, E.5
Cascajo, M.V.6
Tamashiro, K.L.7
Poosala, S.8
Csiszar, A.9
Ungvari, Z.10
Kensler, T.W.11
Yamamoto, M.12
Egan, J.M.13
Longo, D.L.14
Ingram, D.K.15
Navas, P.16
De Cabo, R.17
-
43
-
-
77954018074
-
Dietary interventions to extend life span and health span based on calorie restriction
-
Minor RK, Allard JS, Younts CM, Ward TM, de Cabo R. Dietary interventions to extend life span and health span based on calorie restriction. J Gerontol A Biol Sci Med Sci. 2010;65:695-703.
-
(2010)
J Gerontol A Biol Sci Med Sci.
, vol.65
, pp. 695-703
-
-
Minor, R.K.1
Allard, J.S.2
Younts, C.M.3
Ward, T.M.4
De Cabo, R.5
-
44
-
-
79551646862
-
NRF2, cancer and calorie restriction
-
Martin-Montalvo A, Villalba JM, Navas P, de Cabo R. NRF2, cancer and calorie restriction. Oncogene. 2011;30:505-520.
-
(2011)
Oncogene.
, vol.30
, pp. 505-520
-
-
Martin-Montalvo, A.1
Villalba, J.M.2
Navas, P.3
De Cabo, R.4
-
45
-
-
40749104203
-
SKNy Worms and Long Life
-
DOI 10.1016/j.cell.2008.03.002, PII S0092867408003322
-
Jasper H. SKNy worms and long life. Cell. 2008;132:915-916. (Pubitemid 351381748)
-
(2008)
Cell
, vol.132
, Issue.6
, pp. 915-916
-
-
Jasper, H.1
-
46
-
-
0037428445
-
Laminar flow induction of antioxidant response element-mediated genes in endothelial cells: A novel anti-inflammatory mechanism
-
DOI 10.1074/jbc.M203161200
-
Chen XL, Varner SE, Rao AS, et al. Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism. J Biol Chem. 2003;278:703-711. (Pubitemid 36790739)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.2
, pp. 703-711
-
-
Chen, X.-L.1
Varner, S.E.2
Rao, A.S.3
Grey, J.Y.4
Thomas, S.5
Cook, C.K.6
Wasserman, M.A.7
Medford, R.M.8
Jaiswal, A.K.9
Kunsch, C.10
-
47
-
-
48049102141
-
Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo
-
Jyrkkanen HK, Kansanen E, Inkala M, et al. Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo. Circ Res. 2008;103:e1-e9.
-
(2008)
Circ Res.
, vol.103
-
-
Jyrkkanen, H.K.1
Kansanen, E.2
Inkala, M.3
-
48
-
-
73949142348
-
Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state
-
Zakkar M, Van der Heiden K, Luong LA, et al. Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arterioscler Thromb Vasc Biol. 2009;29(11):1851-1857.
-
(2009)
Arterioscler Thromb Vasc Biol.
, vol.29
, Issue.11
, pp. 1851-1857
-
-
Zakkar, M.1
Van Der Heiden, K.2
Luong, L.A.3
-
49
-
-
46249090088
-
KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells
-
Fledderus JO, Boon RA, Volger OL, et al. KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells. Arterioscler Thromb Vasc Biol. 2008;28:1339-1346.
-
(2008)
Arterioscler Thromb Vasc Biol.
, vol.28
, pp. 1339-1346
-
-
Fledderus, J.O.1
Boon, R.A.2
Volger, O.L.3
-
50
-
-
1542723493
-
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
-
DOI 10.1073/pnas.0400282101
-
Suh JH, Shenvi SV, Dixon BM, et al. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci U S A. 2004;101:3381-3386. (Pubitemid 38338203)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.10
, pp. 3381-3386
-
-
Suh, J.H.1
Shenvi, S.V.2
Dixon, B.M.3
Liu, H.4
Jaiswal, A.K.5
Liu, R.-M.6
Hagen, T.M.7
-
52
-
-
64249150743
-
Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes
-
Collins AR, Lyon CJ, Xia X, et al. Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes. Circ Res. 2009;104:e42-e54.
-
(2009)
Circ Res.
, vol.104
-
-
Collins, A.R.1
Lyon, C.J.2
Xia, X.3
-
54
-
-
77949495487
-
Procyanidins extracted from the lotus seedpod ameliorate age-related antioxidant deficit in aged rats
-
Xu J, Rong S, Xie B, et al. Procyanidins extracted from the lotus seedpod ameliorate age-related antioxidant deficit in aged rats. J Gerontol A Biol Sci Med Sci. 2010;65:236-241.
-
(2010)
J Gerontol A Biol Sci Med Sci.
, vol.65
, pp. 236-241
-
-
Xu, J.1
Rong, S.2
Xie, B.3
-
55
-
-
75649114237
-
Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress
-
Chen CN, Brown-Borg HM, Rakoczy SG, Ferrington DA, Thompson LV. Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress. J Gerontol A Biol Sci Med Sci. 2010;65:129-137.
-
(2010)
J Gerontol A Biol Sci Med Sci.
, vol.65
, pp. 129-137
-
-
Chen, C.N.1
Brown-Borg, H.M.2
Rakoczy, S.G.3
Ferrington, D.A.4
Thompson, L.V.5
-
57
-
-
70350464512
-
Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells
-
Ungvari Z, Labinskyy N, Mukhopadhyay P, et al. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol. 2009;297:H1876-H1881.
-
(2009)
Am J Physiol Heart Circ Physiol.
, vol.297
-
-
Ungvari, Z.1
Labinskyy, N.2
Mukhopadhyay, P.3
-
58
-
-
38349158077
-
Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy
-
DOI 10.1038/nprot.2007.327, PII NPROT.2007.327
-
Mukhopadhyay P, Rajesh M, Hasko G, Hawkins BJ, Madesh M, Pacher P. Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Nat Protoc. 2007;2:2295-2301. (Pubitemid 351565867)
-
(2007)
Nature Protocols
, vol.2
, Issue.9
, pp. 2295-2301
-
-
Mukhopadhyay, P.1
Rajesh, M.2
Hasko, G.3
Hawkins, B.J.4
Madesh, M.5
Pacher, P.6
-
59
-
-
54549121996
-
Predictors of cognitive decline in older individuals with diabetes
-
Bruce DG, Davis WA, Casey GP, et al. Predictors of cognitive decline in older individuals with diabetes. Diabetes Care. 2008;31:2103-2107.
-
(2008)
Diabetes Care.
, vol.31
, pp. 2103-2107
-
-
Bruce, D.G.1
Davis, W.A.2
Casey, G.P.3
-
60
-
-
33846863589
-
Nitric oxide and peroxynitrite in health and disease
-
DOI 10.1152/physrev.00029.2006
-
Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007;87:315-424. (Pubitemid 46217686)
-
(2007)
Physiological Reviews
, vol.87
, Issue.1
, pp. 315-424
-
-
Pacher, P.1
Beckman, J.S.2
Liaudet, L.3
-
61
-
-
0037137287
-
Poly(ADP-ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity
-
DOI 10.1161/01.CIR.0000038365.78031.9C
-
Szabo C, Zanchi A, Komjati K, et al. Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity. Circulation. 2002;106:2680-2686. (Pubitemid 35364922)
-
(2002)
Circulation
, vol.106
, Issue.21
, pp. 2680-2686
-
-
Szabo, C.1
Zanchi, A.2
Komjati, K.3
Pacher, P.4
Krolewski, A.S.5
Quist, W.C.6
LoGerfo, F.W.7
Horton, E.S.8
Veves, A.9
-
62
-
-
77954857743
-
Suppression of oxidative stress by resveratrol after isometric contractions in gastrocnemius muscles of aged mice
-
Ryan MJ, Jackson JR, Hao Y, et al. Suppression of oxidative stress by resveratrol after isometric contractions in gastrocnemius muscles of aged mice. J Gerontol A Biol Sci Med Sci. 2010;65:815-831.
-
(2010)
J Gerontol A Biol Sci Med Sci.
, vol.65
, pp. 815-831
-
-
Ryan, M.J.1
Jackson, J.R.2
Hao, Y.3
-
63
-
-
79955125211
-
Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome
-
Labbe A, Garand C, Cogger VC, et al. Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome. J Gerontol A Biol Sci Med Sci. 2011;66:264-278.
-
(2011)
J Gerontol A Biol Sci Med Sci.
, vol.66
, pp. 264-278
-
-
Labbe, A.1
Garand, C.2
Cogger, V.C.3
-
64
-
-
79951794971
-
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
-
Miller RA, Harrison DE, Astle CM, et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2011;66:191-201.
-
(2011)
J Gerontol A Biol Sci Med Sci.
, vol.66
, pp. 191-201
-
-
Miller, R.A.1
Harrison, D.E.2
Astle, C.M.3
-
65
-
-
79951618862
-
Protective effects of resveratrol against senescence-associated changes in cultured human fibroblasts
-
Giovannelli L, Pitozzi V, Jacomelli M, et al. Protective effects of resveratrol against senescence-associated changes in cultured human fibroblasts. J Gerontol A Biol Sci Med Sci. 2011;66:9-18.
-
(2011)
J Gerontol A Biol Sci Med Sci.
, vol.66
, pp. 9-18
-
-
Giovannelli, L.1
Pitozzi, V.2
Jacomelli, M.3
|