Novel mechanism for endothelial dysfunction: Dysregulation of dimethylarginine dimethylaminohydrolase

Circulation

Volumn 99, Issue 24, 1999, Pages 3092-3095

  Ito, Akira ^a   Tsao, Philip S ^a   Adimoolam, Shanthi ^a   Kimoto, Masumi ^b   Ogawa, Tadashi ^c   Cooke, John P ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OKAYAMA PREFECTURAL UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Amino acids; Asymmetric dimethylarginine; Endothelium; Lipoproteins; Nitric oxide

Indexed keywords

CITRULLINE; DIMETHYLARGININASE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE SYNTHASE; OXIDIZED LOW DENSITY LIPOPROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BIOACCUMULATION; CELL CULTURE; CONTROLLED STUDY; DEGRADATION; ENDOTHELIUM CELL; ENDOTHELIUM LESION; ENZYME ASSAY; ENZYME REGULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; UMBILICAL VEIN; WESTERN BLOTTING;

EID: 0033594888     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.99.24.3092     Document Type: Article

References (16)

1. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288: 373-376.
2. Cooke JP, Dzau VJ. Derangements of the nitric oxide synthase pathway, L-arginine, and cardiovascular diseases. Circulation. 1997; 96:379-382.
3. Vallance P, Leone AM, Calver A, Collier J, Moncada S. Endogenous dimethylarginine as an inhibitor of nitric oxide synthase. J Cardiovasc Pharmacol. 1992;20(suppl 12):560-562.
4. ∈-mono-, di-, and trimethyllysine, and glucosylgalactosyl-and galactosyl-δ-hydroxylysine from human urine. J Biol Chem. 1970;245:5751-5758.
5. G dimethylarginine by human endothelial cells. Endothelium. 1993;1:137-140.
6. G-dimethylarginine dimethylaminohydrolase in human tissues using a monoclonal antibody. J Biochem. 1995;117:237-238.
7. Li H, Oehrlein SA, Wallerath T, Ihrig-Biedevt I, Wohlfart P, Ulshofer T, Jessen T, Herget T, Forstermann U, Kleinen H. Activation of protein kinase C alpha and/or epsilon enhances transcription of the human endothelial nitric oxide synthase gene. Mol Pharmacol. 1998; 53:630-637.
8. Parthasarathy S, Barnett J, Fong LG. High density lipoprotein inhibits oxidative modification of low density lipoprotein. Biochem Biophys Acta. 1990;1044:275-283.
9. Boger RH, Bode-Boger SM, Szuba A, Tsao PS, Chan JR, Tangphao O, Blaschke TF, Cooke JP. Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation. 1998;98:1842-1847.
10. G-dimethylarginine dimethylaminohydrolase, from rat kidney. J Biol Chem. 1989;264:10205-10209.
11. Bode-Boger SM, Boger RH, Kienke S, Junker W, Frolich JC. Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits. Biochem Biophys Res Commun. 1996;219:598-603.
12. Boger RH, Bode-Boger SM, Thiele W, Junker W, Alexander K, Frolich JC. Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease. Circulation. 1997;95: 2068-2074.
13. Kurose I, Wolf R, Grisham MB, Granger DN. Effects of an endogenous inhibitor of nitric oxide synthesis on postcapillary venules. Am J Physiol. 1995;268:H2224-H2231.
14. Faraci FM, Brian JE, Heistad DD. Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase. Am J Physiol. 1995; 269:H1522-H1527.
15. MacAllister RJ, Parry H, Kimoto M, Ogawa T, Russel RJ, Hodson H, Whitley GSJ, Vallance P. Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase. Br J Pharmacol. 1996;119: 1533-1540.
16. Lerman A, Burnett JC Jr, Higano ST, McKinley LJ, Holmes DR Jr. Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation. 1998;97:2123-2128.