Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress

Aging Cell

Volumn 10, Issue 6, 2011, Pages 1032-1037

  Pierce, Gary L ^a,b   Donato, Anthony J ^a,c,d   Larocca, Thomas J ^a   Eskurza, Iratxe ^a   Silver, Annemarie E ^a   Seals, Douglas R ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Aging; Endothelial function; Nicotinamide adenine dinucleotide phosphate oxidase; Nitrotyrosine; Nuclear factor kappa B; Superoxide dismutase

Indexed keywords

3 NITROTYROSINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE DISMUTASE;

ADULT; AEROBIC EXERCISE; ARTERY BLOOD FLOW; ARTERY DILATATION; ARTICLE; BRACHIAL ARTERY; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; GROUPS BY AGE; HABIT; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OBESITY; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SEDENTARY LIFESTYLE; VASCULAR ENDOTHELIUM;

ADULT; AGING; BRACHIAL ARTERY; CARDIOVASCULAR DISEASES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; EXERCISE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; NADPH OXIDASE; OXIDATIVE STRESS; OXYGEN CONSUMPTION; RISK FACTORS; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA; TYROSINE; VASODILATION;

EID: 81155128684     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2011.00748.x     Document Type: Article

References (37)

1. Adams V, Linke A, Krankel N, Erbs S, Gielen S, Mobius-Winkler S, Gummert JF, Mohr FW, Schuler G, Hambrecht R (2005) Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease. Circulation 111, 555-562.
2. Blair SN, Kampert JB, Kohl 3rd HW, Barlow CE, Macera CA, Paffenbarger Jr RS, Gibbons LW (1996) Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA 276, 205-210.
3. Braith RW, Schofield RS, Hill JA, Casey DP, Pierce GL (2008) Exercise training attenuates progressive decline in brachial artery reactivity in heart transplant recipients. J. Heart Lung Transplant. 27, 52-59.
4. Cai H, Harrison D (2000) Endothelial dysfunction in cardiovascular disease: role of oxidant stress. Circulation 87, 840-844.
5. Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE (1994) Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J. Am. Coll. Cardiol. 24, 471-476.
6. Christou DD, Gentile CL, DeSouza CA, Seals DR, Gates PE (2005) Fatness is a better predictor of cardiovascular disease risk factor profile than aerobic fitness in healthy men. Circulation 111, 1904-1914.
7. Davidson SM, Duchen MR (2007) Endothelial mitochondria: contributing to vascular function and disease. Circ. Res. 100, 1128-1141.
8. Donald AE, Halcox JP, Charakida M, Storry C, Wallace SM, Cole TJ, Friberg P, Deanfield JE (2008) Methodological approaches to optimize reproducibility and power in clinical studies of flow-mediated dilation. J. Am. Coll. Cardiol. 51, 1959-1964.
9. Donato AJ, Eskurza I, Silver AE, Levy AS, Pierce GL, Gates PE, Seals DR (2007) Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. Circ. Res. 100, 1659-1666.
10. Donato AJ, Black AD, Jablonski KL, Gano LB, Seals DR (2008) Aging is associated with greater nuclear NFkappaB, reduced IkappaBalpha and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell 7, 805-812.
11. Durrant JR, Seals DR, Connell ML, Russell MJ, Lawson BR, Folian BJ, Donato AJ, Lesniewski LA (2009) Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase. J. Physiol. 587, 3271-3285.
12. Eskurza I, Monahan K, Robinson J, Seals D (2004) Effect of acute and chronic ascorbic acid augmentation on flow-mediated dilation with physically active and sedentary aging. J. Physiol. 556, 215-224.
13. Eskurza I, Myerburgh L, Khan Z, Seals D (2005) Tetrahydrobiopterin augments endothelial-dependent dilation in sedentary but not habitually exercising older adults. J. Physiol. 568, 3.
14. Eskurza I, Kahn Z, Seals D (2006) Xanthine oxidase does not contribute to impaired peripheral artery conduit artery endothelium-dependent dilatation with aging. J. Physiol. 571, 661-668.
15. Faraci FM, Didion SP (2004) Vascular protection: superoxide dismutase isoforms in the vessel wall. Arterioscler. Thromb. Vasc. Biol. 24, 1367-1373.
16. Franzoni F, Ghiadoni L, Galetta F, Plantinga Y, Lubrano V, Huang Y, Salvetti G, Regoli F, Taddei S, Santoro G, Salvetti A (2005) Physical activity, plasma antioxidant capacity, and endothelium-dependent vasodilation in young and older men. Am. J. Hypertens. 18, 510-516.
17. Fukai T, Folz R, Landmesser U, Harrison D (2002) Extracellular superoxide dismutase and cardiovascular diseases. Circ. Res. 55, 239-249.
18. Gokce N, Vita JA, Bader DS, Sherman DL, Hunter LM, Holbrook M, O'Malley C, Keaney Jr JF, Balady GJ (2002) Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease. Am. J. Cardiol. 90, 124-127.
19. Green DJ (2009) Exercise training as vascular medicine: direct impacts on the vasculature in humans. Exerc. Sport Sci. Rev. 37, 196-202.
20. Helenius M, Hanninen M, Lehtinen S, Salminen A (1996) Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle. J. Mol. Cell. Cardiol. 28, 487-498.
21. Lakatta E, Levy D (2003) Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease. Circulation 107, 139-146.
22. Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C, Harrison D, Hornig B, Drexler H (2002) Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure. Role of xanthine oxidase and extracellular superoxide dismutase. Circulation 106, 3073-3078.
23. Lassegue B, Griendling KK (2010) NADPH oxidases: functions and pathologies in the vasculature. Arterioscler. Thromb. Vasc. Biol. 30, 653-661.
24. Lesniewski LA, Connell ML, Durrant JR, Folian BJ, Anderson MC, Donato AJ, Seals DR (2009) B6D2F1 mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging. J. Gerontol. A Biol. Sci. Med. Sci. 64, 9-20.
25. Lesniewski LA, Durrant JR, Connell ML, Henson GD, Black AD, Donato AJ, Seals DR (2011) Aerobic exercise reverses arterial inflammation with aging in mice. Am. J. Physiol. Heart Circ. Physiol. 301, H1025-H1032.
26. Matthews JN, Altman DG, Campbell MJ, Royston P (1990) Analysis of serial measurements in medical research. BMJ 300, 230-235.
27. Moien-Afshari F, Ghosh S, Elmi S, Rahman MM, Sallam N, Khazaei M, Kieffer TJ, Brownsey RW, Laher I (2008) Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice. Diabetologia 51, 1327-1337.
28. Pierce GL, Lesniewski LA, Lawson BR, Beske SD, Seals DR (2009) Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans. Circulation 119, 1284-1292.
29. Pierce GL, Eskurza I, Walker AE, Fay TN, Seals DR (2011) Sex specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults. Clin. Sci. (Lond.) 120, 13-23.
30. Rinder MR, Spina RJ, Ehsani AA (2000) Enhanced endothelium-dependent vasodilation in older endurance-trained men. J. Appl. Physiol. 88, 761-766.
31. Silver AE, Beske SD, Christou DD, Donato AJ, Moreau KL, Eskurza I, Gates PE, Seals DR (2007) Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47(phox) expression and evidence of endothelial oxidative stress. Circulation 115, 627-637.
32. Sui X, LaMonte MJ, Laditka JN, Hardin JW, Chase N, Hooker SP, Blair SN (2007) Cardiorespiratory fitness and adiposity as mortality predictors in older adults. JAMA 298, 2507-2516.
33. Taddei S, Galetta F, Virdis A, Ghiadoni L, Salvetti G, Franzoni F, Giusti C, Salvetti A (2000) Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. Circulation 101, 2896-2901.
34. Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A, Salvetti A (2001) Age-related reduction of NO availability and oxidative stress in humans. Hypertension 38, 274-279.
35. Ungvari Z, Orosz Z, Labinskyy N, Rivera A, Xiangmin Z, Smith K, Csiszar A (2007) Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries. Am. J. Physiol. Heart Circ. Physiol. 293, H37-H47.
36. Yeboah J, Crouse JR, Hsu FC, Burke GL, Herrington DM (2007) Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation 115, 2390-2397.
37. Yeboah J, Folsom AR, Burke GL, Johnson C, Polak JF, Post W, Lima JA, Crouse JR, Herrington DM (2009) Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis. Circulation 120, 502-509.