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Volumn 110, Issue 9, 2012, Pages 1238-1251

FOXOs and sirtuins in vascular growth, maintenance, and aging

Author keywords

Aging; Angiogenesis; Forkhead box O; Hypoxia signaling; Metabolism; Sirtuin; Vascular biology

Indexed keywords

NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SIRTUIN; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SIRTUIN 4; SIRTUIN 5; SIRTUIN 6; SIRTUIN 7; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR FOXO4; UNCLASSIFIED DRUG;

EID: 84860743760     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.246488     Document Type: Review
Times cited : (128)

References (140)
  • 1
    • 34249689753 scopus 로고    scopus 로고
    • Molecular regulation of angiogenesis and lymphangiogenesis
    • Adams RH, Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol. 2007;8:464-478.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 464-478
    • Adams, R.H.1    Alitalo, K.2
  • 2
    • 80052015813 scopus 로고    scopus 로고
    • Molecular control of endothelial cell behaviour during blood vessel morphogenesis
    • Herbert SP, Stainier DY. Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol. 2011;12: 551-564.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 551-564
    • Herbert, S.P.1    Stainier, D.Y.2
  • 3
    • 80052933197 scopus 로고    scopus 로고
    • Basic and therapeutic aspects of angiogenesis
    • Potente M, Gerhardt H, Carmeliet P. Basic and therapeutic aspects of angiogenesis. Cell. 2011;146:873-887.
    • (2011) Cell , vol.146 , pp. 873-887
    • Potente, M.1    Gerhardt, H.2    Carmeliet, P.3
  • 4
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature. 2011;473:298-307.
    • (2011) Nature , vol.473 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 6
    • 54849382700 scopus 로고    scopus 로고
    • Vascular aging: Insights from studies on cellular senescence, stem cell aging, and progeroid syndromes
    • Minamino T, Komuro I. Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes. Nat Clin Pract Cardiovasc Med. 2008;5:637-648.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 637-648
    • Minamino, T.1    Komuro, I.2
  • 9
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon CJ. The genetics of ageing. Nature. 2010;464:504-512.
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 10
    • 77950265945 scopus 로고    scopus 로고
    • Linking functional decline of telomeres, mitochondria and stem cells during ageing
    • Sahin E, Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature. 2010;464:520-528.
    • (2010) Nature , vol.464 , pp. 520-528
    • Sahin, E.1    Depinho, R.A.2
  • 11
    • 40949149823 scopus 로고    scopus 로고
    • Signaling networks in aging
    • Greer EL, Brunet A. Signaling networks in aging. J Cell Sci. 2008;121: 407-412.
    • (2008) J Cell Sci , vol.121 , pp. 407-412
    • Greer, E.L.1    Brunet, A.2
  • 12
    • 67649356581 scopus 로고    scopus 로고
    • DSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster
    • Bauer JH, Morris SN, Chang C, Flatt T, Wood JG, Helfand SL. dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster. Aging (Albany NY). 2009;1:38-48.
    • (2009) Aging (Albany NY) , vol.1 , pp. 38-48
    • Bauer, J.H.1    Morris, S.N.2    Chang, C.3    Flatt, T.4    Wood, J.G.5    Helfand, S.L.6
  • 13
    • 80053460544 scopus 로고    scopus 로고
    • The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO
    • Rizki G, Iwata TN, Li J, Riedel CG, Picard CL, Jan M, Murphy CT, Lee SS. The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genet. 2011;7:e1002235.
    • (2011) PLoS Genet , vol.7
    • Rizki, G.1    Iwata, T.N.2    Li, J.3    Riedel, C.G.4    Picard, C.L.5    Jan, M.6    Murphy, C.T.7    Lee, S.S.8
  • 14
    • 80053168829 scopus 로고    scopus 로고
    • Absence of effects of Sir2 overexpression on lifespan in C. elegans and drosophila
    • Burnett C, Valentini S, Cabreiro F, et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and drosophila. Nature. 2011; 477:482-485.
    • (2011) Nature , vol.477 , pp. 482-485
    • Burnett, C.1    Valentini, S.2    Cabreiro, F.3
  • 15
    • 41549135942 scopus 로고    scopus 로고
    • FOXO transcription factors in the maintenance of cellular homeostasis during aging
    • Salih DA, Brunet A. FOXO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol. 2008;20: 126-136.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 126-136
    • Salih, D.A.1    Brunet, A.2
  • 16
    • 77949887506 scopus 로고    scopus 로고
    • Mammalian sirtuins: Biological insights and disease relevance
    • Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol. 2010;5:253-295.
    • (2010) Annu Rev Pathol , vol.5 , pp. 253-295
    • Haigis, M.C.1    Sinclair, D.A.2
  • 17
    • 67949102053 scopus 로고    scopus 로고
    • Recent progress in the biology and physiology of sirtuins
    • Finkel T, Deng CX, Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature. 2009;460:587-591.
    • (2009) Nature , vol.460 , pp. 587-591
    • Finkel, T.1    Deng, C.X.2    Mostoslavsky, R.3
  • 19
    • 35348972430 scopus 로고    scopus 로고
    • Genetic links between diet and lifespan: Shared mechanisms from yeast to humans
    • Bishop NA, Guarente L. Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat Rev Genet. 2007;8:835-844.
    • (2007) Nat Rev Genet , vol.8 , pp. 835-844
    • Bishop, N.A.1    Guarente, L.2
  • 20
    • 33744976074 scopus 로고    scopus 로고
    • C. elegans Sir-2.1 interacts with 14-3-3 proteins to activate Daf-16 and extend life span
    • Berdichevsky A, Viswanathan M, Horvitz HR, Guarente L. C. elegans Sir-2.1 interacts with 14-3-3 proteins to activate Daf-16 and extend life span. Cell. 2006;125:1165-1177.
    • (2006) Cell , vol.125 , pp. 1165-1177
    • Berdichevsky, A.1    Viswanathan, M.2    Horvitz, H.R.3    Guarente, L.4
  • 21
  • 24
    • 0038152845 scopus 로고    scopus 로고
    • Suppression of ovarian follicle activation in mice by the transcription factor FOXO3a
    • Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA. Suppression of ovarian follicle activation in mice by the transcription factor FOXO3a. Science. 2003;301:215-218.
    • (2003) Science , vol.301 , pp. 215-218
    • Castrillon, D.H.1    Miao, L.2    Kollipara, R.3    Horner, J.W.4    Depinho, R.A.5
  • 25
    • 41849128523 scopus 로고    scopus 로고
    • The FOXO code
    • Calnan DR, Brunet A. The FOXO code. Oncogene. 2008;27:2276-2288.
    • (2008) Oncogene , vol.27 , pp. 2276-2288
    • Calnan, D.R.1    Brunet, A.2
  • 30
    • 34447626095 scopus 로고    scopus 로고
    • SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
    • Wang F, Nguyen M, Qin FX, Tong Q. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell. 2007;6: 505-514.
    • (2007) Aging Cell , vol.6 , pp. 505-514
    • Wang, F.1    Nguyen, M.2    Qin, F.X.3    Tong, Q.4
  • 31
    • 70349208608 scopus 로고    scopus 로고
    • SIRT3 blocks the cardiac hypertrophic response by augmenting FOXO3a-dependent antioxidant defense mechanisms in mice
    • Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP. SIRT3 blocks the cardiac hypertrophic response by augmenting FOXO3a-dependent antioxidant defense mechanisms in mice. J Clin Invest. 2009;119:2758-2771.
    • (2009) J Clin Invest , vol.119 , pp. 2758-2771
    • Sundaresan, N.R.1    Gupta, M.2    Kim, G.3    Rajamohan, S.B.4    Isbatan, A.5    Gupta, M.P.6
  • 32
    • 79958206937 scopus 로고    scopus 로고
    • Franklin h. Epstein lecture: Sirtuins, aging, and medicine
    • Guarente L. Franklin h. Epstein lecture: sirtuins, aging, and medicine. N Engl J Med. 2011;364:2235-2244.
    • (2011) N Engl J Med , vol.364 , pp. 2235-2244
    • Guarente, L.1
  • 33
    • 80053134340 scopus 로고    scopus 로고
    • Regulation of Caenorhabditis elegans lifespan by SIR-2.1 transgenes
    • Viswanathan M, Guarente L. Regulation of Caenorhabditis elegans lifespan by SIR-2.1 transgenes. Nature. 2011;477:E1-E2.
    • (2011) Nature , vol.477
    • Viswanathan, M.1    Guarente, L.2
  • 34
    • 34347354447 scopus 로고    scopus 로고
    • Sir2 and calorie restriction in yeast: A skeptical perspective
    • Kaeberlein M, Powers RW III. Sir2 and calorie restriction in yeast: a skeptical perspective. Ageing Res Rev. 2007;6:128-140.
    • (2007) Ageing Res Rev , vol.6 , pp. 128-140
    • Kaeberlein, M.1    Powers Iii, R.W.2
  • 37
    • 34250365395 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of the NAD-dependent histone deacetylase SIRT1
    • Tanno M, Sakamoto J, Miura T, Shimamoto K, Horio Y. Nucleocytoplasmic shuttling of the NAD-dependent histone deacetylase SIRT1. J Biol Chem. 2007;282:6823-6832.
    • (2007) J Biol Chem , vol.282 , pp. 6823-6832
    • Tanno, M.1    Sakamoto, J.2    Miura, T.3    Shimamoto, K.4    Horio, Y.5
  • 38
    • 77954353059 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: Possible direct function in mitochondrial biogenesis
    • Aquilano K, Vigilanza P, Baldelli S, Pagliei B, Rotilio G, Ciriolo MR. Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. J Biol Chem. 2010;285: 21590-21599.
    • (2010) J Biol Chem , vol.285 , pp. 21590-21599
    • Aquilano, K.1    Vigilanza, P.2    Baldelli, S.3    Pagliei, B.4    Rotilio, G.5    Ciriolo, M.R.6
  • 39
    • 0037160097 scopus 로고    scopus 로고
    • Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1
    • Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1. J Biol Chem. 2002;277:45099-45107.
    • (2002) J Biol Chem , vol.277 , pp. 45099-45107
    • Bitterman, K.J.1    Anderson, R.M.2    Cohen, H.Y.3    Latorre-Esteves, M.4    Sinclair, D.A.5
  • 40
    • 79958041304 scopus 로고    scopus 로고
    • Fine tuning our cellular factories: Sirtuins in mitochondrial biology
    • Zhong L, Mostoslavsky R. Fine tuning our cellular factories: sirtuins in mitochondrial biology. Cell Metab. 2011;13:621-626.
    • (2011) Cell Metab , vol.13 , pp. 621-626
    • Zhong, L.1    Mostoslavsky, R.2
  • 41
    • 79952266729 scopus 로고    scopus 로고
    • Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy
    • Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, Sinclair DA. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY). 2010;2:914-923.
    • (2010) Aging (Albany NY) , vol.2 , pp. 914-923
    • Hafner, A.V.1    Dai, J.2    Gomes, A.P.3    Xiao, C.Y.4    Palmeira, C.M.5    Rosenzweig, A.6    Sinclair, D.A.7
  • 45
    • 70349983805 scopus 로고    scopus 로고
    • Different roles of FOXO1 and FOXO3 in the control of endothelial cell morphology
    • Matsukawa M, Sakamoto H, Kawasuji M, Furuyama T, Ogawa M. Different roles of FOXO1 and FOXO3 in the control of endothelial cell morphology. Genes Cells. 2009;14:1167-1181.
    • (2009) Genes Cells , vol.14 , pp. 1167-1181
    • Matsukawa, M.1    Sakamoto, H.2    Kawasuji, M.3    Furuyama, T.4    Ogawa, M.5
  • 46
    • 59649085554 scopus 로고    scopus 로고
    • Angiogenesis: A team effort coordinated by Notch
    • Phng LK, Gerhardt H. Angiogenesis: a team effort coordinated by Notch. Dev Cell. 2009;16:196-208.
    • (2009) Dev Cell , vol.16 , pp. 196-208
    • Phng, L.K.1    Gerhardt, H.2
  • 49
    • 79951828819 scopus 로고    scopus 로고
    • Identification of a mechanism underlying regulation of the antiangiogenic forkhead transcription factor FOXO1 in cultured endothelial cells and ischemic muscle
    • Milkiewicz M, Roudier E, Doyle JL, Trifonova A, Birot O, Haas TL. Identification of a mechanism underlying regulation of the antiangiogenic forkhead transcription factor FOXO1 in cultured endothelial cells and ischemic muscle. Am J Pathol. 2011;178:935-944.
    • (2011) Am J Pathol , vol.178 , pp. 935-944
    • Milkiewicz, M.1    Roudier, E.2    Doyle, J.L.3    Trifonova, A.4    Birot, O.5    Haas, T.L.6
  • 51
    • 33846005165 scopus 로고    scopus 로고
    • A novel class of vascular endothelial growth factorresponsive genes that require forkhead activity for expression
    • Abid MR, Shih SC, Otu HH, Spokes KC, Okada Y, Curiel DT, Minami T, Aird WC. A novel class of vascular endothelial growth factorresponsive genes that require forkhead activity for expression. J Biol Chem. 2006;281:35544-35553.
    • (2006) J Biol Chem , vol.281 , pp. 35544-35553
    • Abid, M.R.1    Shih, S.C.2    Otu, H.H.3    Spokes, K.C.4    Okada, Y.5    Curiel, D.T.6    Minami, T.7    Aird, W.C.8
  • 52
    • 77951239443 scopus 로고    scopus 로고
    • FOXO3 modulates endothelial gene expression and function by classical and alternative mechanisms
    • Czymai T, Viemann D, Sticht C, Molema G, Goebeler M, Schmidt M. FOXO3 modulates endothelial gene expression and function by classical and alternative mechanisms. J Biol Chem. 2010;285:10163-10178.
    • (2010) J Biol Chem , vol.285 , pp. 10163-10178
    • Czymai, T.1    Viemann, D.2    Sticht, C.3    Molema, G.4    Goebeler, M.5    Schmidt, M.6
  • 54
    • 78751506082 scopus 로고    scopus 로고
    • SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse
    • Ou X, Chae HD, Wang RH, Shelley WC, Cooper S, Taylor T, Kim YJ, Deng CX, Yoder MC, Broxmeyer HE. SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood. 2011;117:440-450.
    • (2011) Blood , vol.117 , pp. 440-450
    • Ou, X.1    Chae, H.D.2    Wang, R.H.3    Shelley, W.C.4    Cooper, S.5    Taylor, T.6    Kim, Y.J.7    Deng, C.X.8    Yoder, M.C.9    Broxmeyer, H.E.10
  • 55
    • 79955926985 scopus 로고    scopus 로고
    • Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
    • Guarani V, Deflorian G, Franco CA, et al. Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature. 2011;473:234-238.
    • (2011) Nature , vol.473 , pp. 234-238
    • Guarani, V.1    Deflorian, G.2    Franco, C.A.3
  • 57
    • 77955046461 scopus 로고    scopus 로고
    • SIRT1 suppresses betaamyloid production by activating the alpha-secretase gene Adam10
    • Donmez G, Wang D, Cohen DE, Guarente L. SIRT1 suppresses betaamyloid production by activating the alpha-secretase gene Adam10. Cell. 142:320-332.
    • Cell , vol.142 , pp. 320-332
    • Donmez, G.1    Wang, D.2    Cohen, D.E.3    Guarente, L.4
  • 58
    • 59649112848 scopus 로고    scopus 로고
    • Regulation of angiogenesis by oxygen and metabolism
    • Fraisl P, Mazzone M, Schmidt T, Carmeliet P. Regulation of angiogenesis by oxygen and metabolism. Dev Cell. 2009;16:167-179.
    • (2009) Dev Cell , vol.16 , pp. 167-179
    • Fraisl, P.1    Mazzone, M.2    Schmidt, T.3    Carmeliet, P.4
  • 60
    • 18044393806 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle
    • Ouchi N, Shibata R, Walsh K. AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle. Circ Res. 2005;96:838-846.
    • (2005) Circ Res , vol.96 , pp. 838-846
    • Ouchi, N.1    Shibata, R.2    Walsh, K.3
  • 62
    • 77954601017 scopus 로고    scopus 로고
    • LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis
    • Ohashi K, Ouchi N, Higuchi A, Shaw RJ, Walsh K. LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis. J Biol Chem. 2010;285:22291-22298.
    • (2010) J Biol Chem , vol.285 , pp. 22291-22298
    • Ohashi, K.1    Ouchi, N.2    Higuchi, A.3    Shaw, R.J.4    Walsh, K.5
  • 63
    • 79960949691 scopus 로고    scopus 로고
    • The logic linking protein acetylation and metabolism
    • Guarente L. The logic linking protein acetylation and metabolism. Cell Metab. 2011;14:151-153.
    • (2011) Cell Metab , vol.14 , pp. 151-153
    • Guarente, L.1
  • 64
    • 79951963618 scopus 로고    scopus 로고
    • Adhesion molecule signalling: Not always a sticky business
    • Cavallaro U, Dejana E. Adhesion molecule signalling: not always a sticky business. Nat Rev Mol Cell Biol. 2011;12:189-197.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 189-197
    • Cavallaro, U.1    Dejana, E.2
  • 67
    • 0041529844 scopus 로고    scopus 로고
    • 11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1
    • Potente M, Fisslthaler B, Busse R, Fleming I. 11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1. J Biol Chem. 2003;278:29619-29625.
    • (2003) J Biol Chem , vol.278 , pp. 29619-29625
    • Potente, M.1    Fisslthaler, B.2    Busse, R.3    Fleming, I.4
  • 68
    • 38849098449 scopus 로고    scopus 로고
    • Shear stress-induced activation of the AMP-activated protein kinase regulates FOXO1a and angiopoietin-2 in endothelial cells
    • Dixit M, Bess E, Fisslthaler B, Hartel FV, Noll T, Busse R, Fleming I. Shear stress-induced activation of the AMP-activated protein kinase regulates FOXO1a and angiopoietin-2 in endothelial cells. Cardiovasc Res. 2008;77:160-168.
    • (2008) Cardiovasc Res , vol.77 , pp. 160-168
    • Dixit, M.1    Bess, E.2    Fisslthaler, B.3    Hartel, F.V.4    Noll, T.5    Busse, R.6    Fleming, I.7
  • 72
    • 59649088602 scopus 로고    scopus 로고
    • Key transcriptional regulators of the vasoprotective effects of shear stress
    • Boon RA, Horrevoets AJ. Key transcriptional regulators of the vasoprotective effects of shear stress. Hamostaseologie. 2009;29:39-40.
    • (2009) Hamostaseologie , vol.29 , pp. 39-40
    • Boon, R.A.1    Horrevoets, A.J.2
  • 73
    • 74249099068 scopus 로고    scopus 로고
    • Activation of SIRT1 by resveratrol induces Klf2 expression conferring an endothelial vasoprotective phenotype
    • Gracia-Sancho J, Villarreal G Jr, Zhang Y, Garcia-Cardena G. Activation of SIRT1 by resveratrol induces Klf2 expression conferring an endothelial vasoprotective phenotype. Cardiovasc Res. 2010;85: 514-519.
    • (2010) Cardiovasc Res , vol.85 , pp. 514-519
    • Gracia-Sancho, J.1    Villarreal Jr., G.2    Zhang, Y.3    Garcia-Cardena, G.4
  • 75
    • 59649117924 scopus 로고    scopus 로고
    • Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    • Mazzone M, Dettori D, Leite de Oliveira R, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell. 2009;136:839-851.
    • (2009) Cell , vol.136 , pp. 839-851
    • Mazzone, M.1    Dettori, D.2    Leite De Oliveira, R.3
  • 76
    • 78649364332 scopus 로고    scopus 로고
    • Hypoxia-inducible factors and the response to hypoxic stress
    • Majmundar AJ, Wong WJ, Simon MC. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell. 2010;40:294-309.
    • (2010) Mol Cell , vol.40 , pp. 294-309
    • Majmundar, A.J.1    Wong, W.J.2    Simon, M.C.3
  • 77
    • 66749129781 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1
    • Dioum EM, Chen R, Alexander MS, Zhang Q, Hogg RT, Gerard RD, Garcia JA. Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science. 2009;324:1289-1293.
    • (2009) Science , vol.324 , pp. 1289-1293
    • Dioum, E.M.1    Chen, R.2    Alexander, M.S.3    Zhang, Q.4    Hogg, R.T.5    Gerard, R.D.6    Garcia, J.A.7
  • 78
    • 65249185780 scopus 로고    scopus 로고
    • Downregulation of miR-199a derepresses hypoxia-inducible factor-1 alpha and sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes
    • Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF, Abdellatif M. Downregulation of miR-199a derepresses hypoxia-inducible factor-1 alpha and sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res. 2009;104:879-886.
    • (2009) Circ Res , vol.104 , pp. 879-886
    • Rane, S.1    He, M.2    Sayed, D.3    Vashistha, H.4    Malhotra, A.5    Sadoshima, J.6    Vatner, D.E.7    Vatner, S.F.8    Abdellatif, M.9
  • 79
    • 79954609893 scopus 로고    scopus 로고
    • Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner
    • Chen R, Dioum EM, Hogg RT, Gerard RD, Garcia JA. Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner. J Biol Chem. 2011;286:13869-13878.
    • (2011) J Biol Chem , vol.286 , pp. 13869-13878
    • Chen, R.1    Dioum, E.M.2    Hogg, R.T.3    Gerard, R.D.4    Garcia, J.A.5
  • 80
    • 70350441907 scopus 로고    scopus 로고
    • The role of sirtuins in the control of metabolic homeostasis
    • Yu J, Auwerx J. The role of sirtuins in the control of metabolic homeostasis. Ann N Y Acad Sci. 2009;1173(Suppl 1):E10-E19.
    • (2009) Ann N y Acad Sci , vol.1173 , Issue.SUPPL. 1
    • Yu, J.1    Auwerx, J.2
  • 81
    • 77949916570 scopus 로고    scopus 로고
    • SIRT1-a metabolic sensor that controls blood vessel growth
    • Guarani V, Potente M. SIRT1-a metabolic sensor that controls blood vessel growth. Curr Opin Pharmacol. 2010;10:139-145.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 139-145
    • Guarani, V.1    Potente, M.2
  • 82
    • 74549142287 scopus 로고    scopus 로고
    • The histone deacetylase SIRT6 regulates glucose homeostasis via HIF1alpha
    • Zhong L, D'Urso A, Toiber D, et al. The histone deacetylase SIRT6 regulates glucose homeostasis via HIF1alpha. Cell. 2010;140:280-293.
    • (2010) Cell , vol.140 , pp. 280-293
    • Zhong, L.1    D'Urso, A.2    Toiber, D.3
  • 84
    • 77955499804 scopus 로고    scopus 로고
    • SIRT1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1 alpha
    • Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW. SIRT1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1 alpha. Mol Cell. 2010;38:864-878.
    • (2010) Mol Cell , vol.38 , pp. 864-878
    • Lim, J.H.1    Lee, Y.M.2    Chun, Y.S.3    Chen, J.4    Kim, J.E.5    Park, J.W.6
  • 85
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell. 2007;130:223-233.
    • (2007) Cell , vol.130 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 87
    • 34250897968 scopus 로고    scopus 로고
    • SIRT1 regulates the function of the Nijmegen breakage syndrome protein
    • Yuan Z, Zhang X, Sengupta N, Lane WS, Seto E. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell. 2007; 27:149-162.
    • (2007) Mol Cell , vol.27 , pp. 149-162
    • Yuan, Z.1    Zhang, X.2    Sengupta, N.3    Lane, W.S.4    Seto, E.5
  • 88
    • 43149118368 scopus 로고    scopus 로고
    • Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation
    • Li K, Casta A, Wang R, Lozada E, Fan W, Kane S, Ge Q, Gu W, Orren D, Luo J. Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. J Biol Chem. 2008;283:7590-7598.
    • (2008) J Biol Chem , vol.283 , pp. 7590-7598
    • Li, K.1    Casta, A.2    Wang, R.3    Lozada, E.4    Fan, W.5    Kane, S.6    Ge, Q.7    Gu, W.8    Orren, D.9    Luo, J.10
  • 89
    • 35349011597 scopus 로고    scopus 로고
    • SIRT1 modulates premature senescence-like phenotype in human endothelial cells
    • Ota H, Akishita M, Eto M, Iijima K, Kaneki M, Ouchi Y. SIRT1 modulates premature senescence-like phenotype in human endothelial cells. J Mol Cell Cardiol. 2007;43:571-579.
    • (2007) J Mol Cell Cardiol , vol.43 , pp. 571-579
    • Ota, H.1    Akishita, M.2    Eto, M.3    Iijima, K.4    Kaneki, M.5    Ouchi, Y.6
  • 90
    • 77952496696 scopus 로고    scopus 로고
    • SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells
    • Zu Y, Liu L, Lee MY, Xu C, Liang Y, Man RY, Vanhoutte PM, Wang Y. SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells. Circ Res. 2010;106:1384-1393.
    • (2010) Circ Res , vol.106 , pp. 1384-1393
    • Zu, Y.1    Liu, L.2    Lee, M.Y.3    Xu, C.4    Liang, Y.5    Man, R.Y.6    Vanhoutte, P.M.7    Wang, Y.8
  • 91
    • 43049121395 scopus 로고    scopus 로고
    • Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of NAMPT
    • Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of NAMPT. Dev Cell. 2008;14:661-673.
    • (2008) Dev Cell , vol.14 , pp. 661-673
    • Fulco, M.1    Cen, Y.2    Zhao, P.3    Hoffman, E.P.4    McBurney, M.W.5    Sauve, A.A.6    Sartorelli, V.7
  • 97
    • 67649819237 scopus 로고    scopus 로고
    • Mutual dependence of FOXO3a and PGC-1 alpha in the induction of oxidative stress genes
    • Olmos Y, Valle I, Borniquel S, Tierrez A, Soria E, Lamas S, Monsalve M. Mutual dependence of FOXO3a and PGC-1 alpha in the induction of oxidative stress genes. J Biol Chem. 2009;284:14476-14484.
    • (2009) J Biol Chem , vol.284 , pp. 14476-14484
    • Olmos, Y.1    Valle, I.2    Borniquel, S.3    Tierrez, A.4    Soria, E.5    Lamas, S.6    Monsalve, M.7
  • 101
    • 67651151249 scopus 로고    scopus 로고
    • Association of common genetic variation in the Insulin/IGF1 signaling pathway with human longevity
    • Pawlikowska L, Hu D, Huntsman S, et al. Association of common genetic variation in the Insulin/IGF1 signaling pathway with human longevity. Aging Cell. 2009;8:460-472.
    • (2009) Aging Cell , vol.8 , pp. 460-472
    • Pawlikowska, L.1    Hu, D.2    Huntsman, S.3
  • 103
    • 10844236451 scopus 로고    scopus 로고
    • Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
    • Nemoto S, Fergusson MM, Finkel T. Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science. 2004;306:2105-2108.
    • (2004) Science , vol.306 , pp. 2105-2108
    • Nemoto, S.1    Fergusson, M.M.2    Finkel, T.3
  • 104
    • 84954358441 scopus 로고    scopus 로고
    • Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53
    • Wang F, Marshall CB, Yamamoto K, Li GY, Plevin MJ, You H, Mak TW, Ikura M. Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53. J Mol Biol. 2008;384:590-603.
    • (2008) J Mol Biol , vol.384 , pp. 590-603
    • Wang, F.1    Marshall, C.B.2    Yamamoto, K.3    Li, G.Y.4    Plevin, M.J.5    You, H.6    Mak, T.W.7    Ikura, M.8
  • 105
    • 33745163907 scopus 로고    scopus 로고
    • Regulation of transactivationindependent proapoptotic activity of p53 by FOXO3a
    • You H, Yamamoto K, Mak TW. Regulation of transactivationindependent proapoptotic activity of p53 by FOXO3a. Proc Natl Acad Sci USA. 2006;103:9051-9056.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9051-9056
    • You, H.1    Yamamoto, K.2    Mak, T.W.3
  • 106
    • 68049111575 scopus 로고    scopus 로고
    • P53 negatively regulates the transcriptional activity of FOXO3a under oxidative stress
    • Miyaguchi Y, Tsuchiya K, Sakamoto K. p53 negatively regulates the transcriptional activity of FOXO3a under oxidative stress. Cell Biol Int. 2009;33:853-860.
    • (2009) Cell Biol Int , vol.33 , pp. 853-860
    • Miyaguchi, Y.1    Tsuchiya, K.2    Sakamoto, K.3
  • 108
    • 0035955754 scopus 로고    scopus 로고
    • ENOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization
    • Matsushita H, Chang E, Glassford AJ, Cooke JP, Chiu CP, Tsao PS. eNOS activity is reduced in senescent human endothelial cells: preservation by hTERT immortalization. Circ Res. 2001;89:793-798.
    • (2001) Circ Res , vol.89 , pp. 793-798
    • Matsushita, H.1    Chang, E.2    Glassford, A.J.3    Cooke, J.P.4    Chiu, C.P.5    Tsao, P.S.6
  • 114
    • 77955417245 scopus 로고    scopus 로고
    • MicroRNA-34a regulation of endothelial senescence
    • Ito T, Yagi S, Yamakuchi M. MicroRNA-34a regulation of endothelial senescence. Biochem Biophys Res Commun. 2010;398:735-740.
    • (2010) Biochem Biophys Res Commun , vol.398 , pp. 735-740
    • Ito, T.1    Yagi, S.2    Yamakuchi, M.3
  • 115
    • 79951887419 scopus 로고    scopus 로고
    • Forkhead box O as a sensor, mediator, and regulator of redox signaling
    • de Keizer PL, Burgering BM, Dansen TB. Forkhead box O as a sensor, mediator, and regulator of redox signaling. Antioxid Redox Signal. 2011;14:1093-1106.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 1093-1106
    • De Keizer, P.L.1    Burgering, B.M.2    Dansen, T.B.3
  • 117
    • 79956319051 scopus 로고    scopus 로고
    • Progress and challenges in translating the biology of atherosclerosis
    • Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011;473:317-325.
    • (2011) Nature , vol.473 , pp. 317-325
    • Libby, P.1    Ridker, P.M.2    Hansson, G.K.3
  • 118
    • 54149103338 scopus 로고    scopus 로고
    • Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
    • Zhang QJ, Wang Z, Chen HZ, Zhou S, Zheng W, Liu G, Wei YS, Cai H, Liu DP, Liang CC. Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res. 2008;80:191-199.
    • (2008) Cardiovasc Res , vol.80 , pp. 191-199
    • Zhang, Q.J.1    Wang, Z.2    Chen, H.Z.3    Zhou, S.4    Zheng, W.5    Liu, G.6    Wei, Y.S.7    Cai, H.8    Liu, D.P.9    Liang, C.C.10
  • 119
    • 47749085845 scopus 로고    scopus 로고
    • Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice
    • Do GM, Kwon EY, Kim HJ, Jeon SM, Ha TY, Park T, Choi MS. Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice. Biochem Biophys Res Commun. 2008;374:55-59.
    • (2008) Biochem Biophys Res Commun , vol.374 , pp. 55-59
    • Do, G.M.1    Kwon, E.Y.2    Kim, H.J.3    Jeon, S.M.4    Ha, T.Y.5    Park, T.6    Choi, M.S.7
  • 120
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-kappa B-dependent transcription and cell survival by the SIRT1 deacetylase
    • Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW. Modulation of NF-kappa B-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 2004;23:2369-2380.
    • (2004) EMBO J , vol.23 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3    Keller, M.D.4    Jones, D.R.5    Frye, R.A.6    Mayo, M.W.7
  • 121
    • 36749087548 scopus 로고    scopus 로고
    • Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
    • Milne JC, Lambert PD, Schenk S, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007;450:712-716.
    • (2007) Nature , vol.450 , pp. 712-716
    • Milne, J.C.1    Lambert, P.D.2    Schenk, S.3
  • 122
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444:337-342.
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3
  • 125
    • 34548857700 scopus 로고    scopus 로고
    • SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1b
    • Sun C, Zhang F, Ge X, Yan T, Chen X, Shi X, Zhai Q. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1b. Cell Metab. 2007;6:307-319.
    • (2007) Cell Metab , vol.6 , pp. 307-319
    • Sun, C.1    Zhang, F.2    Ge, X.3    Yan, T.4    Chen, X.5    Shi, X.6    Zhai, Q.7
  • 127
    • 34948883324 scopus 로고    scopus 로고
    • SIRT1 deacetylates and positively regulates the nuclear receptor LXR
    • Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell. 2007;28:91-106.
    • (2007) Mol Cell , vol.28 , pp. 91-106
    • Li, X.1    Zhang, S.2    Blander, G.3    Tse, J.G.4    Krieger, M.5    Guarente, L.6
  • 129
    • 82955169641 scopus 로고    scopus 로고
    • Proatherogenic abnormalities of lipid metabolism in SIRT1 transgenic mice are mediated through CREB deacetylation
    • Qiang L, Lin HV, Kim-Muller JY, Welch CL, Gu W, Accili D. Proatherogenic abnormalities of lipid metabolism in SIRT1 transgenic mice are mediated through CREB deacetylation. Cell Metab. 2011;14:758-767.
    • (2011) Cell Metab , vol.14 , pp. 758-767
    • Qiang, L.1    Lin, H.V.2    Kim-Muller, J.Y.3    Welch, C.L.4    Gu, W.5    Accili, D.6
  • 130
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span: From yeast to humans
    • Fontana L, Partridge L, Longo VD. Extending healthy life span: from yeast to humans. Science. 2010;328:321-326.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 133
    • 82455212901 scopus 로고    scopus 로고
    • SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
    • Hirschey MD, Shimazu T, Jing E, et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell. 2011.
    • (2011) Mol Cell
    • Hirschey, M.D.1    Shimazu, T.2    Jing, E.3
  • 136
    • 80054769188 scopus 로고    scopus 로고
    • SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
    • Kim HS, Vassilopoulos A, Wang RH, et al. SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell. 2011;20:487-499.
    • (2011) Cancer Cell , vol.20 , pp. 487-499
    • Kim, H.S.1    Vassilopoulos, A.2    Wang, R.H.3
  • 137
    • 37549002891 scopus 로고    scopus 로고
    • Mammalian SIR2 homolog SIRT3 regulates global mitochondrial lysine acetylation
    • Lombard DB, Alt FW, Cheng HL, et al. Mammalian SIR2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007;27:8807-8814.
    • (2007) Mol Cell Biol , vol.27 , pp. 8807-8814
    • Lombard, D.B.1    Alt, F.W.2    Cheng, H.L.3
  • 138
    • 65249087389 scopus 로고    scopus 로고
    • SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
    • Nakagawa T, Lomb DJ, Haigis MC, Guarente L. SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell. 2009;137:560-570.
    • (2009) Cell , vol.137 , pp. 560-570
    • Nakagawa, T.1    Lomb, D.J.2    Haigis, M.C.3    Guarente, L.4
  • 139
    • 31044445366 scopus 로고    scopus 로고
    • Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
    • Mostoslavsky R, Chua KF, Lombard DB, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 2006; 124:315-329.
    • (2006) Cell , vol.124 , pp. 315-329
    • Mostoslavsky, R.1    Chua, K.F.2    Lombard, D.B.3
  • 140
    • 41449083867 scopus 로고    scopus 로고
    • SIRT7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
    • Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, Braun T, Bober E. SIRT7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res. 2008;102:703-710.
    • (2008) Circ Res , vol.102 , pp. 703-710
    • Vakhrusheva, O.1    Smolka, C.2    Gajawada, P.3    Kostin, S.4    Boettger, T.5    Kubin, T.6    Braun, T.7    Bober, E.8


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