Caloric restriction improves endothelial dysfunction during vascular aging: Effects on nitric oxide synthase isoforms and oxidative stress in rat aorta

Experimental Gerontology

Volumn 45, Issue 11, 2010, Pages 848-855

  Zanetti, Michela ^a   Gortan Cappellari, Gianluca ^a   Burekovic, Ismet ^a   Barazzoni, Rocco ^a   Stebel, Marco ^a   Guarnieri, Gianfranco ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Aging; Caloric restriction; Endothelium; Nitric oxide; Superoxide

Indexed keywords

3 NITROTYROSINE; CALCIUM; COPPER ZINC SUPEROXIDE DISMUTASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MANGANESE SUPEROXIDE DISMUTASE; NITRITE; SIRTUIN 1; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

AGE DISTRIBUTION; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD LEVEL; CALORIC RESTRICTION; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VASODILATATION;

AGING; ANIMALS; AORTA; CALCIUM; CALORIC RESTRICTION; ENDOTHELIUM, VASCULAR; ISOENZYMES; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; RATS; RATS, INBRED F344; SIRTUIN 1; SUPEROXIDE DISMUTASE; UP-REGULATION; VASODILATION;

RATTUS;

EID: 77957820976     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2010.07.002     Document Type: Article

References (40)

1. Brown K.A., Didion S.P., Andresen J.J., Faraci F.M. Effect of aging, MnSOD deficiency, and genetic background on endothelial function: evidence for MnSOD haploinsufficiency. Arterioscler. Thromb. Vasc. Biol. 2007, 27:1941-1946.
2. Castello L., Froio T., Cavallini G., Biasi F., Sapino A., Leonarduzzi G., Bergamini E., Poli G., Chiarpotto E. Calorie restriction protects against age-related rat aorta sclerosis. FASEB J. 2005, 19:1863-1865.
3. Cernadas M.R., Sanchez de Miguel L., Garcia-Duran M., Gonzalez-Fernandez F., Millas I., Monton M., Rodrigo J., Rico L., Fernandez P., de Frutos T., Rodriguez-Feo J.A., Guerra J., Caramelo C., Asado S., Lopez-Farre A. Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats. Circ. Res. 1998, 83:279-286.
4. Chou T.C., Yen M.H., Li C.Y., Ding Y.A. Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension 1998, 31:643-648.
5. Csiszar A., Ungvari Z., Edwards J.G., Kaminski P., Wolin M.S., Koller A., Kaley G. Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ. Res. 2002, 90:159-166.
6. Csiszar A., Pacher P., Kaley G., Ungvari Z. Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging. Curr. Vasc. Pharmacol. 2005, 3:285-291.
7. Csiszar A., Labinskyy N., Jimenez R., Pinto J.T., Ballabh P., Losonczy G., Pearson K.J., de Cabo R., Ungvari Z. Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT 1. Mech. Age. Dev. 2009, 130:518-527.
8. Didion S.P., Kinzenbaw D.A., Schrader L.I., Faraci F.M. Heterozygous CuZn superoxide dismutase deficiency produces a vascular phenotype with aging. Hypertension 2006, 48:1072-1079.
9. Egashira K., Inou T., Hirooka Y., Kai H., Sugimachi M., Suzuki S., Kuga T., Urabe Y., Takeshita A. Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation 1993, 88:77-81.
10. Ferrer M., Sanchez M., Minoves N., Salaices M., Belfagon G. Aging increases neuronal nitric oxide release and superoxide anion generation in mesenteric arteries from spontaneously hypertensive rats. J. Vasc. Res. 2003, 40:509-519.
11. Ferrini M.G., Vernet D., Magee T.R., Shahed A., Qian A., Rajfer J., Gonzalez-Cadavid N.F. Antifibrotic role of inducible nitric oxide synthase. Nitric Oxide 2002, 6:283-294.
12. Ferrini M.G., Davila H.H., Valente E.G.A., Gonzalez-Cadavid N.F., Rajfer J. Aging-related induction of inducible nitric oxide synthase is vasculo-protective to the arterial media. Cardiovasc. Res. 2004, 61:796-805.
13. Fontana L., Meyer T.E., Klein S., Holloszy J.O. Long-term calorie restriction is highly effective in reducing the risk of atherosclerosis in humans. Proc. Natl Acad. Sci. USA 2004, 101:6659-6663.
14. Fujimoto M., Shimizu N., Kunii K., Jeevendra Martyn J.A., Ueki K., Kaneki M. A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice. Diabetes 2005, 54:1340-1348.
15. Goettsch W., Lattmann T., Amann K., Szibor M., Morawietz H., Munter K., Muller S.P., Shaw S., Barton M. Increased expression of endothelin-1 and inducible nitric oxide synthase isoform II in aging arteries in vivo: implications for atherosclerosis. Biochem. Biophys. Res. Commun. 2001, 280:908-913.
16. Guo Z.M., Yang H., Hamilton M.L., VanRemmen H., Richardson A. Effects of age and food restriction on oxidative DNA damage and antioxidant enzyme activities in the mouse aorta. Mech. Ageing Dev. 2001, 122:1771-1786.
17. Hamilton C.A., Brosnan M.J., McIntyre M., Graham D., Dominiczak A.F. Superoxide excess in hypertension and aging. Hypertension 2001, 37:529-534.
18. Hatake K., Kakishita E., Wakabayashi I., Sakiyama N., Hishida S. Effect of aging on endothelium-dependent vascular relaxation of isolated human basilar artery to thrombin and bradykinin. Stroke 1990, 21:1039-1043.
19. Mattagajasingh I., Kim C.S., Naqvi A., Yamamori T., Hoffman T.A., Jung S.B., DeRicco J., Kasuno K., Irani K. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc. Natl Acad. Sci. USA 2007, 104:14855-14860.
20. Nagareddy P.R., McNeill J.H., MacLeod K.M. Chronic inhibition of inducible nitric oxide synthase ameliorates cardiovascular abnormalities in streptozotocin diabetic rats. Eur. J. Pharmacol. 2009, 611:53-59.
21. Naseem K.M., Riba R., Troxler M. Evaluation of nitrotyrosine-containing proteins in blood platelets. Methods Mol. Biol. 2004, 273:301-312.
22. Patel R., Cardneau J.D., Colles S.M., Graham L.M. Synthetic smooth muscle cell phenotype is associated with increased nicotinamide adenine dinucleotide phosphate oxidase activity: effect on collagen secretion. J. Vasc. Surg. 2006, 43:364-371.
23. Payne J.A., Reckelhoff J.F., Khalil R.A. Role of oxidative stress in age-related reduction of NO-cGMP-mediated vascular reactivity in SHR. Am. J. Physiol. 2003, 285:R542-R551.
24. Pippenger C.E., Browne R.W., Armstrong D. Regulatory antioxidant enzymes. Methods Mol. Biol. 1998, 108:299-313.
25. Salter M., Knowles R.G. Assay of NOS activity by the measurement of conversion of oxyhemoglobin to methemoglobin by NO. Methods Mol. Biol. 1998, 100:61-65.
26. Singh N., Prasad S., Singer S.R., MacAllister R.J. Ageing is associated with impairment of nitric oxide and prostanoid dilator pathways in the human forearm. Clin. Sci. 2002, 102:595-600.
27. Smith A.R., Visioli F., Hagen T.M. Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age. Arch. Biochem. Biophys. 2006, 454:100-105.
28. Smith A.R., Visioli F., Hagen T.M. Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A. Aging Cell 2006, 5:391-400.
29. Ungvari Z., Parrado-Fernandez C., Csiszar A., de Cabo R. Mechanisms underlying caloric restriction and lifespan regulation. Circ. Res. 2008, 102:519-528.
30. van der Loo B., Labugger R., Skepper J.N., Bachschmid M., Kilo J., Powell J.M., Palacios-Callender M., Erusalimsky J.D., Quaschning T., Malinski T., Gygi D., Ullrich V., Lüscher T.F. Enhanced peroxynitrite formation is associated with vascular aging. J. Exp. Med. 2000, 192:1731-1744.
31. van der Loo B., Labugger R., Aebischer C.P., Skepper J.N., Bachschmid M., Spitzer V., Kilo J., Altwegg L., Ullrich V., Luscher T.F. Cardiovascular aging is associated with vitamin E increase. Circulation 2002, 105:1635-1638.
32. van der Loo B., Bachschmid M., Labugger R., Schildknecht S., Kilo J., Hahn R., Palacios-Callender M., Lüscher T.F. Expression and activity patterns of nitric oxide synthases and antioxidant enzymes reveal a substantial heterogeneity between cardiac and vascular aging in the rat. Biogerontology 2005, 6:325-334.
33. van der Loo B., Bachschmid M., Skepper J.N., Labugger R., Schildknecht S., Hahn R., Müssig E., Gygi D., Lüscher T.F. Age-associated cellular relocation of Sod 1 as a self-defense is a futile mechanism to prevent vascular aging. Biochem. Biophys. Res. Commun. 2006, 344:972-980.
34. Vernet D., Ferrini M.G., Valente E.G., Magee T.R., Bou-Gharios G., Rajfer J., Gonzalez-Cadavid N.F. Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model. Nitric Oxide 2002, 7:262-276.
35. Viner R.I., Ferrington D.A., Hühmer A.F., Bigelow D.J., Schöneich C. Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca-ATPase of rat skeletal muscle during aging: a peroxynitrite-mediated process?. FEBS Lett. 1996, 379:286-290.
36. Virdis A., Colucci R., Fornai M., Polini A., Daghini E., Duranti E., Ghisu N., Versari D., Dardano A., Blandizzi C., Taddei S., Del Tacca M., Monzani F. Inducible nitric oxide synthase is involved in endothelial dysfunction of mesenteric small arteries from hypothyroid rats. Endocrinology 2009, 150:1033-1042.
37. Weiss E.P., Racette S.B., Villareal D.T., Fontana L., Steger-May K., Schechtman K.B., Klein S., Holloszy J.O. Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am. J. Clin. Nutr. 2006, 84:1033-1042. and the Washington University School of Medicine CELERIE Group.
38. Wenzel P., Schuhmacher S., Kienhöfer J., Müller J., Hortmann M., Oelze M., Schulz E., Treiber N., Kawamoto T., Scharffetter-Kochanek K., Münzel T., Bürkle A., Bachschmid M.M., Daiber A. Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction. Cardiovasc. Res. 2008, 80:280-289.
39. Yagi K. Simple procedure for specific assay of lipid hydroperoxides in serum or plasma. Methods Mol. Biol. 1998, 108:107-110.
40. Zanetti M., Barazzoni R., Vadori M., Stebel M., Biolo G., Guarnieri G. Lack of direct effect of moderate hyperleptinemia to improve endothelial function in lean rat aorta: role of calorie restriction. Atherosclerosis 2004, 175:253-259.