Aging Is Associated with reduced prostacyclin-mediated dilation in the human forearm

Hypertension

Volumn 53, Issue 6, 2009, Pages 973-978

  Nicholson, Wayne T ^a,c   Vaa, Brianna ^a   Hesse, Christiane ^a,b   Eisenach, John H ^a   Joyner, Michael J ^a  

^a Mayo Clinic College of Medicine   (Germany)

^b BAYER PHARMA AG   (Germany)

^c MAYO CLINIC   (United States)

Author keywords

Aging; Blood flow; NO; Prostaglandins

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) METHYLARGININE; PROSTACYCLIN;

ADULT; AGED; AGING; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FOREARM BLOOD FLOW; HUMAN; MALE; PLETHYSMOGRAPHY; PRIORITY JOURNAL; VASCULAR SMOOTH MUSCLE; VASODILATATION; AGE; ANALYSIS OF VARIANCE; BLOOD FLOW; BRACHIAL ARTERY; COHORT ANALYSIS; COMPARATIVE STUDY; DRUG EFFECT; FOREARM; INTRAARTERIAL DRUG ADMINISTRATION; METHODOLOGY; MIDDLE AGED; PHYSIOLOGY; PROBABILITY; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; VASCULAR ENDOTHELIUM; VASCULARIZATION; VASOCONSTRICTION;

ADULT; AGE FACTORS; AGED; AGING; ANALYSIS OF VARIANCE; BRACHIAL ARTERY; COHORT STUDIES; ENDOTHELIUM, VASCULAR; EPOPROSTENOL; FEMALE; FOREARM; HUMANS; INFUSIONS, INTRA-ARTERIAL; MALE; MIDDLE AGED; PLETHYSMOGRAPHY; PROBABILITY; REGIONAL BLOOD FLOW; RISK FACTORS; SENSITIVITY AND SPECIFICITY; SEX FACTORS; VASOCONSTRICTION; VASODILATION; YOUNG ADULT;

EID: 67049134326     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.108.121483     Document Type: Article

References (20)

1. Tao J, Jin YF, Yang Z, Wang LC, Gao XR, Lui L, Ma H. Reduced arterial elasticity is associated with endothelial dysfunction in persons of advancing age: comparative study of noninvasive pulse wave analysis and laser Doppler blood flow measurement. Am J Hypertens. 2004;17: 654-659.
2. Matz RL, Andriantsitohaina R. Age-related endothelial dysfunction: potential implications for pharmacotherapy. Drugs Aging. 2003;20: 527-550.
3. Yildiz O. Vascular smooth muscle and endothelial functions in aging. Ann N Y Acad Sci. 2007;1100:353-360.
4. Singh N, Prasad S, Singer DR, MacAllister RJ. Ageing is associated with impairment of nitric oxide and prostanoid dilator pathways in the human forearm. Clin Sci (Land). 2002;102:595-600.
5. Narumiya S, FitzGerald GA. Genetic and pharmacological analysis of prostanoid receptor function. J Clin Invest. 2001;108:25-30.
6. Tang EH, Vanhoutte PM. Gene expression changes of prostanoid syn-thases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. Physiol Genomics. 2008; 32:409-418.
7. Fitzgerald GA. Coxibs and cardiovascular disease. N Engl J Med. 2004; 351:1709-1711.
8. Solomon DH, Schneeweiss S, Glynn RJ, Kiyota Y, Levin R, Mogun H, Avorn J. Relationship between selective cyclooxygenase-2 inhibitors and acute myocardial infarction in older adults. Circulation. 2004; 109: 2068-2073.
9. Solomon SD, Wittes J, Finn PV, Fowler R, Viner J, Bertagnolli MM, Arber N, Levin B, Meinert CL, Martin B, Pater JL, Goss PE, Lance P, Obara S, Chew EY, Kim J, Arndt G, Hawk E. Cardiovascular risk of celecoxib in 6 randomized placebo-controlled trials: the cross trial safety analysis. Circulation. 2008;117:2104-2113.
10. Torgrimson BN, Meendering JR, Kaplan PF, Minson CT. Endothelial function across an oral contraceptive cycle in women using levonorgestrel and ethinyl estradiol. Am J Physiol Heart Circ Physiol. 2007;292: H2874-H2880.
11. Dietz NM, Rivera JM, Eggener SE, Fix RT, Warner DO, Joyner MJ. Nitric oxide contributes to the rise in forearm blood flow during mental stress in humans. J Physiol. 1994;480(pt 2):361-368.
12. Joyner MJ, Dietz NM, Shepherd JT. From Belfast to Mayo and beyond: the use and future of plethysmography to study blood flow in human limbs. J Appl Physiol. 2001;91:2431-2441.
13. Eisenach JH, Clark ES, Charkoudian N, Dinenno FA, Atkinson JL, Fealey RD, Dietz NM, Joyner MJ. Effects of chronic sympathectomy on vascular function in the human forearm. J Appl Physiol. 2002;92: 2019-2025.
14. Schrage WG, Dietz NM, Eisenach JH, Joyner MJ. Agonist-dependent variablity of contributions of nitric oxide and prostaglandins in human skeletal muscle. J Appl Physiol. 2005;98:1251-1257.
15. Engelke KA, Halliwill JR, Proctor DN, Dietz NM, Joyner MJ. Contribution of nitric oxide and prostaglandins to reactive hyperemia in human forearm. J Appl Physiol. 1996:81:1807-1814.
16. Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol. 1994;24:471-476.
17. Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A, Salvetti A. Age-related reduction of NO availability and oxidative stress in humans. Hypertension. 2001;38:274-279.
18. DeSouza CA, Clevenger CM, Greiner JJ, Smith DT, Hoetzer GL, Shapiro LF, Stauffer BL. Evidence for agonist-specific endothelial vasodilator dysfunction with ageing in healthy humans. J Physiol. 2002;542: 255-262.
19. Kamper AM, Paul LC, Blauw GJ. Prostaglandins are involved in acetylcholine- and 5-hydroxytryptamine-induced, nitric oxide-mediated vasodilatation in human forearm. J Cardiovasc Pharmacol. 2002;40: 922-929.
20. Schrage WG, Eisenach JH, Joyner MJ. Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans. J Physiol. 2007;579:227-236.