STAT1 mediates cellular senescence induced by angiotensin II and H 2O 2 in human glomerular mesangial cells

Molecular and Cellular Biochemistry

Volumn 365, Issue 1-2, 2012, Pages 9-17

  Jiao, Sumin ^a   Meng, Fanji ^a   Zhang, Jin ^a   Yang, Xue ^a   Zheng, Xiaoyu ^a   Wang, Lining ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Cellular senescence; Human glomerular mesangial cells; p53 p21 Cip1 pathway; STAT1 signaling; STAT3 signaling

Indexed keywords

ANGIOTENSIN II; BETA GALACTOSIDASE; HYDROGEN PEROXIDE; PROTEIN P21; PROTEIN P53; STAT1 PROTEIN; STAT3 PROTEIN;

ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL VIABILITY; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MESANGIUM CELL; PROTEIN EXPRESSION; SENESCENCE; SIGNAL TRANSDUCTION;

ANGIOTENSIN II; BETA-GALACTOSIDASE; CELL AGING; CELL SHAPE; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYDROGEN PEROXIDE; MESANGIAL CELLS; PHOSPHORYLATION; RNA INTERFERENCE; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84860246804     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-1197-3     Document Type: Article

References (53)

1. MJ Sampson DA Hughes 2006 Chromosomal telomere attrition as a mechanism for the increased risk of epithelial cancers and senescent phenotypes in type 2 diabetes Diabetologia 49 1726 1731 16791617 10.1007/s00125-006-0322-4 1:STN:280:DC%2BD28vgslygsQ%3D%3D
2. MJ Sampson MS Winterbone JC Hughes N Dozio DA Hughes 2006 Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes Diabetes Care 29 283 289 16443874 10.2337/diacare.29.02.06.dc05-1715 1:CAS:528: DC%2BD28Xhs1Kiur4%3D
3. I Ben-Porath RA Weinberg 2004 When cells get stressed: an integrative view of cellular senescence J Clin Invest 113 8 13 14702100 1:CAS:528: DC%2BD2cXjsVGmsg%3D%3D
4. K Itahana J Campisi GP Dimri 2007 Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay Methods Mol Biol 371 21 31 17634571 10.1007/978-1-59745-361-5-3 1:CAS:528: DC%2BD2sXls1Knu7s%3D
5. A Melk V Ramassar LM Helms R Moore D Rayner K Solez PF Halloran 2000 Telomere shortening in kidneys with age J Am Soc Nephrol (JASN) 11 444 453 1:CAS:528:DC%2BD3cXhslWmsLo%3D
6. DL Vaux A Strasser 1996 The molecular biology of apoptosis Proc Natl Acad Sci USA 93 2239 2244 8637856 10.1073/pnas.93.6.2239 1:CAS:528: DyaK28XhvVSksLc%3D
7. Y Mukai H Shimokawa M Higashi K Morikawa T Matoba J Hiroki I Kunihiro HM Talukder A Takeshita 2002 Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging in rats Arterioscler Thromb Vasc Biol 22 1445 1450 12231564 10.1161/01.ATV.0000029121.63691.CE 1:CAS:528:DC%2BD38XntVKktbg%3D
8. Y Kansui K Fujii K Goto I Abe M Iida 2002 Angiotensin II receptor antagonist improves age-related endothelial dysfunction J Hypertens 20 439 446 11875311 10.1097/00004872-200203000-00019 1:CAS:528:DC%2BD38XmvFCntL4%3D
9. T Imanishi K Kobayashi A Kuroi H Ikejima T Akasaka 2008 Pioglitazone inhibits angiotensin II-induced senescence of endothelial progenitor cell Hypertens Res 31 757 765 18633188 10.1291/hypres.31.757 1:CAS:528: DC%2BD1cXos12ju7s%3D
10. H Shan X Bai X Chen 2008 Angiotensin II induces endothelial cell senescence via the activation of mitogen-activated protein kinases Cell Biochem Funct 26 459 466 18383564 10.1002/cbf.1467 1:CAS:528:DC%2BD1cXnvVSqsL0%3D
11. KE Herbert Y Mistry R Hastings T Poolman L Niklason B Williams 2008 Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways Circ Res 102 201 208 17991883 10.1161/CIRCRESAHA.107.158626 1:CAS:528:DC%2BD1cXhtVGktLY%3D
12. T Imanishi T Hano I Nishio 2005 Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress J Hypertens 23 97 104 15643130 10.1097/00004872-200501000-00018 1:CAS:528: DC%2BD2MXitVCitQ%3D%3D
13. C Schindler DE Levy T Decker 2007 JAK-STAT signaling: from interferons to cytokines J Biol Chem 282 20059 20063 17502367 10.1074/jbc.R700016200 1:CAS:528:DC%2BD2sXnsFWntr8%3D
14. DE Levy JE Darnell Jr 2002 Stats: transcriptional control and biological impact Nat Rev Mol Cell Biol 3 651 662 12209125 10.1038/nrm909 1:CAS:528:DC%2BD38Xmslansrw%3D
15. YE Chin M Kitagawa WC Su ZH You Y Iwamoto XY Fu 1996 Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1 Science 272 719 722 8614832 10.1126/science.272.5262.719 1:CAS:528:DyaK28Xislamtrs%3D
16. A Dimberg I Karlberg K Nilsson F Oberg 2003 Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells Blood 102 254 261 12637327 10.1182/blood-2002-10-3149 1:CAS:528:DC%2BD3sXltFemu7o%3D
17. S Xiao D Li HQ Zhu MG Song XR Pan PM Jia LL Peng AX Dou GQ Chen SJ Chen Z Chen JH Tong 2006 RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins Proc Natl Acad Sci USA 103 16448 16453 17050680 10.1073/pnas.0607830103 1:CAS:528:DC%2BD28Xht1WmsLjL
18. P Bernabei EM Coccia L Rigamonti M Bosticardo G Forni S Pestka CD Krause A Battistini F Novelli 2001 Interferon-gamma receptor 2 expression as the deciding factor in human T, B, and myeloid cell proliferation or death J Leukoc Biol 70 950 960 11739558 1:CAS:528:DC%2BD3MXpt1SjtLY%3D
19. S Hubackova Z Novakova K Krejcikova M Kosar J Dobrovolna P Duskova H Hanzlikova M Vancurova P Barath J Bartek Z Hodny 2010 Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling Cell cycle 9 3085 3099 20699642 10.4161/cc.9.15. 12521 1:CAS:528:DC%2BC3cXhsFOisbbJ
20. TL Wang YH Yang H Chang CR Hung 2004 Angiotensin II signals mechanical stretch-induced cardiac matrix metalloproteinase expression via JAK-STAT pathway J Mol Cell Cardiol 37 785 794 15350851 10.1016/j.yjmcc.2004.06.016 1:CAS:528:DC%2BD2cXntlart74%3D
21. AK Banes-Berceli S Shaw G Ma M Brands DC Eaton DM Stern D Fulton RW Caldwell MB Marrero 2006 Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells Am J Physiol 291 F116 F121 10.1152/ajprenal.00502.2005 1:CAS:528:DC%2BD28XntFGgs70%3D
22. XD Wang XM Chen JZ Wang Q Hong Z Feng B Fu F Zhou FY Wang DM Fan 2006 Signal transducers and activators of transcription 3 mediates up-regulation of angiotensin II-induced tissue inhibitor of metalloproteinase-1 expression in cultured human senescent fibroblasts Chin Med J 119 1094 1102 16834928 1:CAS:528:DC%2BD28XnvF2nsr4%3D
23. F Amiri S Shaw X Wang J Tang JL Waller DC Eaton MB Marrero 2002 Angiotensin II activation of the JAK/STAT pathway in mesangial cells is altered by high glucose Kidney Int 61 1605 1616 11967010 10.1046/j.1523-1755.2002.00311. x 1:CAS:528:DC%2BD38XjvFWiu7w%3D
24. NR Madamanchi S Li C Patterson MS Runge 2001 Reactive oxygen species regulate heat-shock protein 70 via the JAK/STAT pathway Arterioscler Thromb Vasc Biol 21 321 326 11231909 10.1161/01.ATV.21.3.321 1:CAS:528:DC%2BD3MXhvVyrsrw%3D
25. R Gorina C Sanfeliu A Galito A Messeguer AM Planas 2007 Exposure of glia to pro-oxidant agents revealed selective Stat1 activation by H2O2 and Jak2-independent antioxidant features of the Jak2 inhibitor AG490 Glia 55 1313 1324 17607690 10.1002/glia.20542
26. H Zhou B Huang J Du L Wang 2010 Role of the JAK2/STAT pathway and losartan in human glomerular mesangial cell senescence Mol Med Rep 3 393 398 1:CAS:528:DC%2BC3cXlslShsbs%3D
27. GP Dimri X Lee G Basile M Acosta G Scott C Roskelley EE Medrano M Linskens I Rubelj O Pereira-Smith, et al. 1995 A biomarker that identifies senescent human cells in culture and in aging skin in vivo Proc Natl Acad Sci USA 92 9363 9367 7568133 10.1073/pnas.92.20.9363 1:CAS:528:DyaK2MXosVWlur0%3D
28. X Zhang X Chen D Wu W Liu J Wang Z Feng G Cai B Fu Q Hong J Du 2006 Downregulation of connexin 43 expression by high glucose induces senescence in glomerular mesangial cells J Am Soc Nephrol 17 1532 1542 16675599 10.1681/ASN.2005070776 1:CAS:528:DC%2BD28XlvVemtbc%3D
29. QM Chen JC Bartholomew J Campisi M Acosta JD Reagan BN Ames 1998 Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication Biochem J 332 Pt 1 43 50 9576849 1:CAS:528:DyaK1cXjslSgt74%3D
30. AW Lin M Barradas JC Stone L van Aelst M Serrano SW Lowe 1998 Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling Genes Dev 12 3008 3019 9765203 10.1101/gad.12.19. 3008 1:CAS:528:DyaK1cXmslehs7Y%3D
31. AJ Hale CA Smith LC Sutherland VE Stoneman VL Longthorne AC Culhane GT Williams 1996 Apoptosis: molecular regulation of cell death Eur J Biochem 236 1 26 8617251 10.1111/j.1432-1033.1996.00001.x 1:CAS:528:DyaK28Xhtlansrg%3D
32. M Muller 2009 Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations Antioxid Redox Signal 11 59 98 18976161 10.1089/ars.2008.2104 1:CAS:528:DC%2BD1cXhtlWrsL3M
33. QM Chen J Liu JB Merrett 2000 Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts Biochem J 347 543 551 10749685 10.1042/0264-6021:3470543 1:CAS:528:DC%2BD3cXjt1GgtbY%3D
34. T Hunter 1993 Braking the cycle Cell 75 839 841 8252620 10.1016/0092-8674(93)90528-X 1:CAS:528:DyaK2cXisl2lsQ%3D%3D
35. CJ Sherr JM Roberts 1995 Inhibitors of mammalian G1 cyclin-dependent kinases Genes Dev 9 1149 1163 7758941 10.1101/gad.9.10.1149 1:CAS:528: DyaK2MXlvFShs7Y%3D
36. Y Luo J Hurwitz J Massague 1995 Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1 Nature 375 159 161 7753174 10.1038/375159a0 1:CAS:528:DyaK2MXls1WisrY%3D
37. BD Chang Y Xuan EV Broude H Zhu B Schott J Fang IB Roninson 1999 Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs Oncogene 18 4808 4818 10490814 10.1038/sj.onc.1203078 1:CAS:528:DyaK1MXlvFygurw%3D
38. M David E Petricoin 3rd C Benjamin R Pine MJ Weber AC Larner 1995 Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins Science 269 1721 1723 7569900 10.1126/science.7569900 1:CAS:528:DyaK2MXot1aitbY%3D
39. P Kovarik M Mangold K Ramsauer H Heidari R Steinborn A Zotter DE Levy M Muller T Decker 2001 Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression EMBO J 20 91 100 11226159 10.1093/emboj/20.1.91 1:CAS:528:DC%2BD3MXhvVCmtL0%3D
40. HS Kim MS Lee 2007 STAT1 as a key modulator of cell death Cell Signal 19 454 465 17085014 10.1016/j.cellsig.2006.09.003 1:CAS:528:DC%2BD2sXntlCmsQ%3D%3D
41. S Agrawal ML Agarwal M Chatterjee-Kishore GR Stark GM Chisolm 2002 Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis Mol Cell Biol 22 1981 1992 11884587 10.1128/MCB.22.7.1981-1992.2002 1:CAS:528:DC%2BD38Xit1KisLk%3D
42. X Xu XY Fu J Plate AS Chong 1998 IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression Cancer Res 58 2832 2837 9661898 1:CAS:528: DyaK1cXksFCqt7k%3D
43. PA Townsend TM Scarabelli SM Davidson RA Knight DS Latchman A Stephanou 2004 STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis J Biol Chem 279 5811 5820 14602726 10.1074/jbc.M302637200 1:CAS:528: DC%2BD2cXhtFCjs74%3D
44. G Dimco RA Knight DS Latchman A Stephanou 2010 STAT1 interacts directly with cyclin D1/Cdk4 and mediates cell cycle arrest Cell cycle 9 4638 4649 21084836 10.4161/cc.9.23.13955 1:CAS:528:DC%2BC3MXit1Krsb4%3D
45. AP Costa-Pereira S Tininini B Strobl T Alonzi JF Schlaak H Is'harc I Gesualdo SJ Newman IM Kerr V Poli 2002 Mutational switch of an IL-6 response to an interferon-gamma-like response Proc Natl Acad Sci USA 99 8043 8047 12060750 10.1073/pnas.122236099 1:CAS:528:DC%2BD38XkvVGjtLk%3D
46. Y Qing GR Stark 2004 Alternative activation of STAT1 and STAT3 in response to interferon-gamma J Biol Chem 279 41679 41685 15284232 10.1074/jbc.M406413200 1:CAS:528:DC%2BD2cXnvFWgtro%3D
47. Y Shen G Devgan JE Darnell Jr JF Bromberg 2001 Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1 Proc Natl Acad Sci USA 98 1543 1548 11171987 10.1073/pnas.041588198 1:CAS:528:DC%2BD3MXhsVWjtbw%3D
48. J Bromberg 2002 Stat proteins and oncogenesis J Clin Invest 109 1139 1142 11994401 1:CAS:528:DC%2BD38XjsFalsL8%3D
49. B Barre S Avril O Coqueret 2003 Opposite regulation of myc and p21waf1 transcription by STAT3 proteins J Biol Chem 278 2990 2996 12438313 10.1074/jbc.M210422200 1:CAS:528:DC%2BD3sXmt1Glsw%3D%3D
50. S Giraud F Bienvenu S Avril H Gascan DM Heery O Coqueret 2002 Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a J Biol Chem 277 8004 8011 11773079 10.1074/jbc.M111486200 1:CAS:528: DC%2BD38XitFyms7k%3D
51. G Tsirpanlis S Chatzipanagiotou F Boufidou V Kordinas M Zoga F Alevyzaki K Stamatelou E Frangou L Savva C Nicolaou 2006 Serum oxidized low-density lipoprotein is inversely correlated to telomerase activity in peripheral blood mononuclear cells of haemodialysis patients Nephrology 11 506 509 17199788 10.1111/j.1440-1797.2006.00697.x 1:CAS:528:DC%2BD2sXhvVamsro%3D
52. SR Lai AP Cunningham VQ Huynh LG Andrews TO Tollefsbol 2007 Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop Exp Cell Res 313 322 330 17134697 10.1016/j.yexcr.2006.10.014 1:CAS:528:DC%2BD2sXls1GlsQ%3D%3D
53. SD Perrault PJ Hornsby DH Betts 2005 Global gene expression response to telomerase in bovine adrenocortical cells Biochem Biophys Res Commun 335 925 936 16105662 10.1016/j.bbrc.2005.07.156 1:CAS:528:DC%2BD2MXpsVCnsrg%3D