메뉴 건너뛰기




Volumn 15, Issue 6, 2011, Pages 1749-1761

Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; HYPOXIA INDUCIBLE FACTOR; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SMAD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 79960027346     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2010.3652     Document Type: Review
Times cited : (53)

References (167)
  • 1
    • 71549144988 scopus 로고    scopus 로고
    • Lipid oxidation and peroxidation in CNS health and disease: From molecular mechanisms to therapeutic opportunities
    • Adibhatla RM and Hatcher JF. Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 12: 125-169, 2010.
    • (2010) Antioxid Redox Signal , vol.12 , pp. 125-169
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 3
    • 0033992481 scopus 로고    scopus 로고
    • The Yin-Yang of TCF=beta-catenin signaling
    • Barker N, Morin PJ, and Clevers H. The Yin-Yang of TCF=beta-catenin signaling. Adv Cancer Res 77: 1-24, 2000.
    • (2000) Adv Cancer Res , vol.77 , pp. 1-24
    • Barker, N.1    Morin, P.J.2    Clevers, H.3
  • 4
    • 34250745912 scopus 로고    scopus 로고
    • o site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production
    • DOI 10.1083/jcb.200609074
    • Bell EL, Klimova TA, Eisenbart J, Moraes CT, Murphy MP, Budinger GR, and Chandel NS. The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol 177: 1029-1036, 2007. (Pubitemid 46955707)
    • (2007) Journal of Cell Biology , vol.177 , Issue.6 , pp. 1029-1036
    • Bell, E.L.1    Klimova, T.A.2    Eisenbart, J.3    Moraes, C.T.4    Murphy, M.P.5    Budinger, G.R.S.6    Chandel, N.S.7
  • 6
    • 34249681337 scopus 로고    scopus 로고
    • p53: New roles in metabolism
    • DOI 10.1016/j.tcb.2007.04.004, PII S0962892407000955
    • Bensaad K and Vousden KH. p53: new roles in metabolism. Trends Cell Biol 17: 286-291, 2007. (Pubitemid 46829848)
    • (2007) Trends in Cell Biology , vol.17 , Issue.6 , pp. 286-291
    • Bensaad, K.1    Vousden, K.H.2
  • 9
    • 0034980863 scopus 로고    scopus 로고
    • Inhibition of HIF-1- and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions
    • Blagosklonny MV, Giannakakou P, Romanova LY, Ryan KM, Vousden KH, and Fojo T. Inhibition of HIF-1-and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions. Carcinogenesis 22: 861-867, 2001. (Pubitemid 32514949)
    • (2001) Carcinogenesis , vol.22 , Issue.6 , pp. 861-867
    • Blagosklonny, M.V.1    Giannakakou, P.2    Romanova, L.Y.3    Ryan, K.M.4    Vousden, K.H.5    Fojo, T.6
  • 10
    • 34547098814 scopus 로고    scopus 로고
    • Apoptosis by cisplatin requires p53 mediated p38α MAPK activation through ROS generation
    • DOI 10.1007/s10495-007-0082-8
    • Bragado P, Armesilla A, Silva A, and Porras A. Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation. Apoptosis 12: 1733-1742, 2007. (Pubitemid 47106882)
    • (2007) Apoptosis , vol.12 , Issue.9 , pp. 1733-1742
    • Bragado, P.1    Armesilla, A.2    Silva, A.3    Porras, A.4
  • 11
    • 0030719486 scopus 로고    scopus 로고
    • Aerobic glycolysis by proliferating cells: Protection against oxidative stress at the expense of energy yield
    • DOI 10.1023/A:1022498714522
    • Brand K. Aerobic glycolysis by proliferating cells: protection against oxidative stress at the expense of energy yield. J Bioenerg Biomembr 29: 355-364, 1997. (Pubitemid 27498415)
    • (1997) Journal of Bioenergetics and Biomembranes , vol.29 , Issue.4 , pp. 355-364
    • Brand, K.1
  • 12
  • 13
    • 48449101433 scopus 로고    scopus 로고
    • P53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
    • Budanov AV and Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134: 451-460, 2008.
    • (2008) Cell , vol.134 , pp. 451-460
    • Budanov, A.V.1    Karin, M.2
  • 14
    • 2142815107 scopus 로고    scopus 로고
    • Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD
    • DOI 10.1126/science.1095569
    • Budanov AV, Sablina AA, Feinstein E, Koonin EV, and Chumakov PM. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304: 596-600, 2004. (Pubitemid 38541920)
    • (2004) Science , vol.304 , Issue.5670 , pp. 596-600
    • Budanov, A.V.1    Sablina, A.A.2    Feinstein, E.3    Koonin, E.V.4    Chumakov, P.M.5
  • 15
    • 0033485261 scopus 로고    scopus 로고
    • Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
    • Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Anderson CW, Appella E, and Fornace AJ, Jr. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 18: 6845-6854, 1999.
    • (1999) EMBO J , vol.18 , pp. 6845-6854
    • Bulavin, D.V.1    Saito, S.2    Hollander, M.C.3    Sakaguchi, K.4    Anderson, C.W.5    Appella, E.6    Fornace Jr., A.J.7
  • 16
    • 0028918334 scopus 로고
    • Superoxide and hydrogen peroxide in relation to mammalian cell proliferation
    • Burdon RH. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic Biol Med 18: 775-794, 1995.
    • (1995) Free Radic Biol Med , vol.18 , pp. 775-794
    • Burdon, R.H.1
  • 18
    • 0034595644 scopus 로고    scopus 로고
    • 2-induced cell death
    • DOI 10.1074/jbc.M910045199
    • Buschmann T, Yin Z, Bhoumik A, and Ronai Z. Aminoterminal-derived JNK fragment alters expression and activity of c-Jun, ATF2, and p53 and increases H2O2-induced cell death. J Biol Chem 275: 16590-16596, 2000. (Pubitemid 30398884)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.22 , pp. 16590-16596
    • Buschmann, T.1    Yin, Z.2    Bhoumik, A.3    Ronai, Z.4
  • 19
    • 33644967242 scopus 로고    scopus 로고
    • Wnt signaling: Complexity at the surface
    • Cadigan KM and Liu YI. Wnt signaling: complexity at the surface. J Cell Sci 119: 395-402, 2006.
    • (2006) J Cell Sci , vol.119 , pp. 395-402
    • Cadigan, K.M.1    Liu, Y.I.2
  • 20
    • 33644620740 scopus 로고    scopus 로고
    • NO restores HIF-1alpha hydroxylation during hypoxia: Role of reactive oxygen species
    • Callapina M, Zhou J, Schmid T, Kohl R, and Brune B. NO restores HIF-1alpha hydroxylation during hypoxia: role of reactive oxygen species. Free Radic BiolMed 39: 925-936, 2005.
    • (2005) Free Radic BiolMed , vol.39 , pp. 925-936
    • Callapina, M.1    Zhou, J.2    Schmid, T.3    Kohl, R.4    Brune, B.5
  • 22
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • DOI 10.1126/science.296.5573.1655
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science 296: 1655-1657, 2002. (Pubitemid 34579158)
    • (2002) Science , vol.296 , Issue.5573 , pp. 1655-1657
    • Cantley, L.C.1
  • 23
    • 55549098874 scopus 로고    scopus 로고
    • Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity
    • Carmona-Cuenca I, Roncero C, Sancho P, Caja L, Fausto N, Fernandez M, and Fabregat I. Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity. J Hepatol 49: 965-976, 2008.
    • (2008) J Hepatol , vol.49 , pp. 965-976
    • Carmona-Cuenca, I.1    Roncero, C.2    Sancho, P.3    Caja, L.4    Fausto, N.5    Fernandez, M.6    Fabregat, I.7
  • 25
    • 0038799736 scopus 로고    scopus 로고
    • Oxidative DNA damage: Mechanisms, mutation, and disease
    • DOI 10.1096/fj.02-0752rev
    • Cooke MS, Evans MD, Dizdaroglu M, and Lunec J. Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 17: 1195-1214, 2003. (Pubitemid 36775767)
    • (2003) FASEB Journal , vol.17 , Issue.10 , pp. 1195-1214
    • Cooke, M.S.1    Evans, M.D.2    Dizdaroglu, M.3    Lunec, J.4
  • 26
    • 0038274163 scopus 로고    scopus 로고
    • Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads
    • DOI 10.1016/S0092-8674(03)00308-8
    • Cordenonsi M, Dupont S, Maretto S, Insinga A, Imbriano C, and Piccolo S. Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads. Cell 113: 301-314, 2003. (Pubitemid 36556113)
    • (2003) Cell , vol.113 , Issue.3 , pp. 301-314
    • Cordenonsi, M.1    Dupont, S.2    Maretto, S.3    Insinga, A.4    Imbriano, C.5    Piccolo, S.6
  • 27
    • 73849144014 scopus 로고    scopus 로고
    • Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling
    • Cox AG, Winterbourn CC, and Hampton MB. Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling. Biochem J 425: 313-325, 2009.
    • (2009) Biochem J , vol.425 , pp. 313-325
    • Cox, A.G.1    Winterbourn, C.C.2    Hampton, M.B.3
  • 28
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • DOI 10.1038/35065000
    • Chang L and Karin M. Mammalian MAP kinase signalling cascades. Nature 410: 37-40, 2001. (Pubitemid 32225829)
    • (2001) Nature , vol.410 , Issue.6824 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 29
    • 0038529602 scopus 로고    scopus 로고
    • Direct interactions between HIF-1α and Mdm2 modulate p53 function
    • DOI 10.1074/jbc.C200694200
    • Chen D, Li M, Luo J, and Gu W. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem 278: 13595-13598, 2003. (Pubitemid 36799889)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.16 , pp. 13595-13598
    • Chen, D.1    Li, M.2    Luo, J.3    Gu, W.4
  • 30
    • 0037444791 scopus 로고    scopus 로고
    • Low levels of glutathione peroxidase 1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15 in pro-oxidant-induced aponecrosis
    • DOI 10.1042/BJ20021870
    • Cheng WH, Zheng X, Quimby FR, Roneker CA, and Lei XG. Low levels of glutathione peroxidase 1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15 in prooxidant-induced aponecrosis. Biochem J 370: 927-934, 2003. (Pubitemid 36399085)
    • (2003) Biochemical Journal , vol.370 , Issue.3 , pp. 927-934
    • Cheng, W.-H.1    Zheng, X.2    Quimby, F.R.3    Roneker, C.A.4    Lei, X.G.5
  • 32
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • DOI 10.1016/0092-8674(94)90380-8
    • Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, and Davis RJ. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76: 1025-1037, 1994. (Pubitemid 24106383)
    • (1994) Cell , vol.76 , Issue.6 , pp. 1025-1037
    • Derijard, B.1    Hibi, M.2    Wu, I.-H.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.J.8
  • 34
    • 33746819118 scopus 로고    scopus 로고
    • Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression
    • DOI 10.1074/jbc.M601083200
    • Dhar SK, Xu Y, Chen Y, and St. Clair DK. Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression. J Biol Chem 281: 21698-21709, 2006. (Pubitemid 44181873)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.31 , pp. 21698-21709
    • Dhar, S.K.1    Xu, Y.2    Chen, Y.3    St. Clair, D.K.4
  • 35
    • 33846811520 scopus 로고    scopus 로고
    • p38α MAP Kinase as a Sensor of Reactive Oxygen Species in Tumorigenesis
    • DOI 10.1016/j.ccr.2006.12.013, PII S1535610806003801
    • Dolado I, Swat A, Ajenjo N, De Vita G, Cuadrado A, and Nebreda AR. p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis. Cancer Cell 11: 191-205, 2007. (Pubitemid 46209847)
    • (2007) Cancer Cell , vol.11 , Issue.2 , pp. 191-205
    • Dolado, I.1    Swat, A.2    Ajenjo, N.3    De Vita, G.4    Cuadrado, A.5    Nebreda, A.R.6
  • 36
    • 1342321750 scopus 로고    scopus 로고
    • PI 3-kinase, Akt and cell survival
    • DOI 10.1016/j.semcdb.2004.01.002
    • Downward J. PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 15: 177-182, 2004. (Pubitemid 38251646)
    • (2004) Seminars in Cell and Developmental Biology , vol.15 , Issue.2 , pp. 177-182
    • Downward, J.1
  • 37
    • 0035945676 scopus 로고    scopus 로고
    • Reciprocal down-regulation of p53 and SOD2 gene expression-implication in p53 mediated apoptosis
    • DOI 10.1038/sj.onc.1204101
    • Drane P, Bravard A, Bouvard V, and May E. Reciprocal down-regulation of p53 and SOD2 gene expressionimplication in p53 mediated apoptosis. Oncogene 20: 430-439, 2001. (Pubitemid 32158223)
    • (2001) Oncogene , vol.20 , Issue.4 , pp. 430-439
    • Drane, P.1    Bravard, A.2    Bouvard, V.3    May, E.4
  • 39
    • 34248194200 scopus 로고    scopus 로고
    • The regulation of AMPK β1, TSC2, and PTEN expression by p53: Stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
    • DOI 10.1158/0008-5472.CAN-06-4149
    • Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, and Levine AJ. The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res 67: 3043-3053, 2007. (Pubitemid 46724841)
    • (2007) Cancer Research , vol.67 , Issue.7 , pp. 3043-3053
    • Feng, Z.1    Hu, W.2    De Stanchina, E.3    Teresky, A.K.4    Jin, S.5    Lowe, S.6    Levine, A.J.7
  • 41
    • 0041703021 scopus 로고    scopus 로고
    • TGFbeta1-induced suppression of glutathione antioxidant defenses in hepatocytes: Caspasedependent post-translational and caspase-independent transcriptional regulatory mechanisms
    • Franklin CC, Rosenfeld-Franklin ME, White C, Kavanagh TJ, and Fausto N. TGFbeta1-induced suppression of glutathione antioxidant defenses in hepatocytes: caspasedependent post-translational and caspase-independent transcriptional regulatory mechanisms. FASEB J 17: 1535-1537, 2003.
    • (2003) FASEB J , vol.17 , pp. 1535-1537
    • Franklin, C.C.1    Rosenfeld-Franklin, M.E.2    White, C.3    Kavanagh, T.J.4    Fausto, N.5
  • 46
    • 0042734428 scopus 로고    scopus 로고
    • Oxidative stress and aging: Beyond correlation
    • Golden TR, Hinerfeld DA, and Melov S. Oxidative stress and aging: beyond correlation. Aging Cell 1: 117-123, 2002.
    • (2002) Aging Cell , vol.1 , pp. 117-123
    • Golden, T.R.1    Hinerfeld, D.A.2    Melov, S.3
  • 48
    • 85047699328 scopus 로고    scopus 로고
    • Cross-talk between Akt, p53 and Mdm2: Possible implications for the regulation of apoptosis
    • DOI 10.1038/sj/onc/1205181
    • Gottlieb TM, Leal JF, Seger R, Taya Y, and Oren M. Crosstalk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene 21: 1299-1303, 2002. (Pubitemid 34185247)
    • (2002) Oncogene , vol.21 , Issue.8 , pp. 1299-1303
    • Gottlieb, T.M.1    Martinez Leal, J.F.2    Seger, R.3    Taya, Y.4    Oren, M.5
  • 49
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • DOI 10.1038/379088a0
    • Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, and Giaccia AJ. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379: 88-91, 1996. (Pubitemid 26008141)
    • (1996) Nature , vol.379 , Issue.6560 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6    Giaccia, A.J.7
  • 50
    • 0028110809 scopus 로고
    • Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by lowoxygen conditions is independent of p53 status
    • Graeber TG, Peterson JF, Tsai M, Monica K, Fornace AJ, Jr., and Giaccia AJ. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by lowoxygen conditions is independent of p53 status. Mol Cell Biol 14: 6264-6277, 1994.
    • (1994) Mol Cell Biol , vol.14 , pp. 6264-6277
    • Graeber, T.G.1    Peterson, J.F.2    Tsai, M.3    Monica, K.4    Fornace Jr., A.J.5    Giaccia, A.J.6
  • 51
    • 34347220473 scopus 로고    scopus 로고
    • Defining the Role of mTOR in Cancer
    • DOI 10.1016/j.ccr.2007.05.008, PII S1535610807001511
    • Guertin DA and Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 12: 9-22, 2007. (Pubitemid 47001784)
    • (2007) Cancer Cell , vol.12 , Issue.1 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 53
    • 0036224633 scopus 로고    scopus 로고
    • Signal transduction in development: Holding the key
    • DOI 10.1016/S1534-5807(02)00156-9
    • Harwood AJ. Signal transduction in development: holding the key. Dev Cell 2: 384-385, 2002. (Pubitemid 34436567)
    • (2002) Developmental Cell , vol.2 , Issue.4 , pp. 384-385
    • Harwood, A.J.1
  • 54
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • DOI 10.1038/387296a0
    • Haupt Y, Maya R, Kazaz A, and Oren M. Mdm2 promotes the rapid degradation of p53. Nature 387: 296-299, 1997. (Pubitemid 27220766)
    • (1997) Nature , vol.387 , Issue.6630 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 55
    • 0037082103 scopus 로고    scopus 로고
    • Reactive oxygen species and protein oxidation in aging: A look back, a look ahead
    • DOI 10.1006/abbi.2001.2630
    • Hensley K and Floyd RA. Reactive oxygen species and protein oxidation in aging: a look back, a look ahead. Arch Biochem Biophys 397: 377-383, 2002. (Pubitemid 34852306)
    • (2002) Archives of Biochemistry and Biophysics , vol.397 , Issue.2 , pp. 377-383
    • Hensley, K.1    Floyd, R.A.2
  • 56
    • 0028171968 scopus 로고
    • Mediation of c-Myc-induced apoptosis by p53
    • Hermeking H and Eick D. Mediation of c-Myc-induced apoptosis by p53. Science 265: 2091-2093, 1994.
    • (1994) Science , vol.265 , pp. 2091-2093
    • Hermeking, H.1    Eick, D.2
  • 57
    • 0035078341 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor β in fetal hepatocytes
    • DOI 10.1096/fj.00-0267com
    • Herrera B, Alvarez AM, Sanchez A, Fernandez M, Roncero C, Benito M, and Fabregat I. Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes. FASEB J 15: 741-751, 2001. (Pubitemid 32245992)
    • (2001) FASEB Journal , vol.15 , Issue.3 , pp. 741-751
    • Herrera, B.1    Alvarez, A.M.2    Sanchez, A.3    Fernandez, M.4    Roncero, C.5    Benito, M.6    Fabregat, I.7
  • 58
    • 0034874036 scopus 로고    scopus 로고
    • L down-regulation, and early cytochrome c release in apoptosis induced by transforming growth factor β in rat fetal hepatocytes
    • DOI 10.1053/jhep.2001.27447
    • Herrera B, Fernandez M, Alvarez AM, Roncero C, Benito M, Gil J, and Fabregat I. Activation of caspases occurs downstream from radical oxygen species production, BclxL down-regulation, and early cytochrome C release in apoptosis induced by transforming growth factor beta in rat fetal hepatocytes. Hepatology 34: 548-556, 2001. (Pubitemid 32786646)
    • (2001) Hepatology , vol.34 , Issue.3 , pp. 548-556
    • Herrera, B.1    Fernandez, M.2    Alvarez, A.M.3    Roncero, C.4    Benito, M.5    Gil, J.6    Fabregat, I.7
  • 59
    • 0347318117 scopus 로고    scopus 로고
    • Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-β in fetal rat hepatocytes
    • DOI 10.1016/j.freeradbiomed.2003.09.020
    • Herrera B, Murillo MM, Alvarez-Barrientos A, Beltran J, Fernandez M, and Fabregat I. Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-beta in fetal rat hepatocytes. Free Radic Biol Med 36: 16-26, 2004. (Pubitemid 38068288)
    • (2004) Free Radical Biology and Medicine , vol.36 , Issue.1 , pp. 16-26
    • Herrera, B.1    Murillo, M.M.2    Alvarez-Barrientos, A.3    Beltran, J.4    Fernandez, M.5    Fabregat, I.6
  • 60
    • 0027423418 scopus 로고
    • Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
    • Hibi M, Lin A, Smeal T, Minden A, and Karin M. Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 7: 2135-2148, 1993. (Pubitemid 23336140)
    • (1993) Genes and Development , vol.7 , Issue.11 , pp. 2135-2148
    • Hibi, M.1    Lin, A.2    Smeal, T.3    Minden, A.4    Karin, M.5
  • 61
    • 70349172032 scopus 로고    scopus 로고
    • Should i stay or should i go: Beta-catenin decides under stress
    • Hoogeboom D and Burgering BM. Should I stay or should I go: beta-catenin decides under stress. Biochim Biophys Acta 1796: 63-74, 2009.
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 63-74
    • Hoogeboom, D.1    Burgering, B.M.2
  • 63
    • 70349492724 scopus 로고    scopus 로고
    • Pharmacologic p53 activation blocks cell cycle progression but fails to induce senescence in epithelial cancer cells
    • Huang B, Deo D, Xia M, and Vassilev LT. Pharmacologic p53 activation blocks cell cycle progression but fails to induce senescence in epithelial cancer cells. Mol Cancer Res 7: 1497-1509, 2009.
    • (2009) Mol Cancer Res , vol.7 , pp. 1497-1509
    • Huang, B.1    Deo, D.2    Xia, M.3    Vassilev, L.T.4
  • 64
    • 0033617288 scopus 로고    scopus 로고
    • P38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389
    • Huang C, Ma WY, Maxiner A, Sun Y, and Dong Z. p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389. J Biol Chem 274: 12229-12235, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 12229-12235
    • Huang, C.1    Ma, W.Y.2    Maxiner, A.3    Sun, Y.4    Dong, Z.5
  • 65
    • 74949087380 scopus 로고    scopus 로고
    • BBR induces apoptosis in HepG2 cell through an Akt-ASK1-ROSp38MAPKs- linked cascade
    • Hyun MS, Hur JM, Mun YJ, Kim D, and Woo WH. BBR induces apoptosis in HepG2 cell through an Akt-ASK1-ROSp38MAPKs-linked cascade. J Cell Biochem 109: 329-338, 2010.
    • (2010) J Cell Biochem , vol.109 , pp. 329-338
    • Hyun, M.S.1    Hur, J.M.2    Mun, Y.J.3    Kim, D.4    Woo, W.H.5
  • 67
  • 70
    • 33947217823 scopus 로고    scopus 로고
    • Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia
    • DOI 10.1038/ncb1534, PII NCB1534
    • Kaidi A, Williams AC, and Paraskeva C. Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nat Cell Biol 9: 210-217, 2007. (Pubitemid 46420864)
    • (2007) Nature Cell Biology , vol.9 , Issue.2 , pp. 210-217
    • Kaidi, A.1    Williams, A.C.2    Paraskeva, C.3
  • 71
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote TNFα-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    • DOI 10.1016/j.cell.2004.12.041
    • Kamata H, Honda S, Maeda S, Chang L, Hirata H, and Karin M. Reactive oxygen species promote TNFalphainduced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120: 649-661, 2005. (Pubitemid 40343077)
    • (2005) Cell , vol.120 , Issue.5 , pp. 649-661
    • Kamata, H.1    Honda, S.-I.2    Maeda, S.3    Chang, L.4    Hirata, H.5    Karin, M.6
  • 73
    • 0346655211 scopus 로고    scopus 로고
    • BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha
    • Kim JY, Ahn HJ, Ryu JH, Suk K, and Park JH. BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha. J Exp Med 199: 113-124, 2004.
    • (2004) J Exp Med , vol.199 , pp. 113-124
    • Kim, J.Y.1    Ahn, H.J.2    Ryu, J.H.3    Suk, K.4    Park, J.H.5
  • 74
    • 0037031848 scopus 로고    scopus 로고
    • p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NF κB-dependent transcription and stabilization by serine 15 phosphorylation
    • DOI 10.1074/jbc.M202862200
    • Kim SJ, Hwang SG, Shin DY, Kang SS, and Chun JS. p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 viaNFkappa B-dependent transcription and stabilization by serine 15 phosphorylation. J Biol Chem 277: 33501-33508, 2002. (Pubitemid 34984874)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.36 , pp. 33501-33508
    • Kim, S.-J.1    Hwang, S.-G.2    Shin, D.Y.3    Kang, S.-S.4    Chun, J.-S.5
  • 75
    • 0037059796 scopus 로고    scopus 로고
    • ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status
    • DOI 10.1074/jbc.M107231200
    • Kim SJ, Ju JW, Oh CD, Yoon YM, Song WK, Kim JH, Yoo YJ, Bang OS, Kang SS, and Chun JS. ERK-1=2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status. J Biol Chem 277: 1332-1339, 2002. (Pubitemid 34968887)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.2 , pp. 1332-1339
    • Kim, S.-J.1    Ju, N.-W.2    Oh, C.-D.3    Yoon, Y.-M.4    Song, W.K.5    Kim, J.-H.6    Yoo, Y.J.7    Bang, O.-S.8    Kang, S.-S.9    Chun, J.-S.10
  • 76
    • 33845351956 scopus 로고    scopus 로고
    • β-Catenin destruction complex: Insights and questions from a structural perspective
    • DOI 10.1038/sj.onc.1210055, PII 1210055
    • Kimelman D and Xu W. beta-catenin destruction complex: insights and questions from a structural perspective. Oncogene 25: 7482-7491, 2006. (Pubitemid 44885747)
    • (2006) Oncogene , vol.25 , Issue.57 , pp. 7482-7491
    • Kimelman, D.1    Xu, W.2
  • 77
    • 0035914446 scopus 로고    scopus 로고
    • Osmotic shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20
    • Kishi H, Nakagawa K, Matsumoto M, Suga M, Ando M, Taya Y, and Yamaizumi M. Osmotic shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20. J Biol Chem 276: 39115-39122, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 39115-39122
    • Kishi, H.1    Nakagawa, K.2    Matsumoto, M.3    Suga, M.4    Ando, M.5    Taya, Y.6    Yamaizumi, M.7
  • 78
    • 0029790979 scopus 로고    scopus 로고
    • Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents
    • Knebel A, Rahmsdorf HJ, Ullrich A, and Herrlich P. Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. EMBO J 15: 5314-5325, 1996. (Pubitemid 26336214)
    • (1996) EMBO Journal , vol.15 , Issue.19 , pp. 5314-5325
    • Knebel, A.1    Rahmsdorf, H.J.2    Ullrich, A.3    Herrlich, P.4
  • 82
    • 11144234525 scopus 로고    scopus 로고
    • Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species
    • DOI 10.1074/jbc.M406879200
    • Kurz EU, Douglas P, and Lees-Miller SP. Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species. J Biol Chem 279: 53272-53281, 2004. (Pubitemid 40051831)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.51 , pp. 53272-53281
    • Kurz, E.U.1    Douglas, P.2    Lees-Miller, S.P.3
  • 85
    • 77949593677 scopus 로고    scopus 로고
    • Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases
    • Leto TL, Morand S, Hurt D, and Ueyama T. Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases. Antioxid Redox Signal 11: 2607-2619, 2009.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2607-2619
    • Leto, T.L.1    Morand, S.2    Hurt, D.3    Ueyama, T.4
  • 87
    • 59349107940 scopus 로고    scopus 로고
    • The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: P53
    • Levine AJ. The common mechanisms of transformation by the small DNA tumor viruses: the inactivation of tumor suppressor gene products: p53. Virology 384: 285-293, 2009.
    • (2009) Virology , vol.384 , pp. 285-293
    • Levine, A.J.1
  • 88
    • 33646807832 scopus 로고    scopus 로고
    • The P53 pathway: What questions remain to be explored?
    • Levine AJ, Hu W, and Feng Z. The P53 pathway: what questions remain to be explored? Cell Death Differ 13: 1027-1036, 2006.
    • (2006) Cell Death Differ , vol.13 , pp. 1027-1036
    • Levine, A.J.1    Hu, W.2    Feng, Z.3
  • 89
    • 30344473639 scopus 로고    scopus 로고
    • Systematic intervention of transcription for identifying network response to disease and cellular phenotypes
    • DOI 10.1093/bioinformatics/bti752
    • Li H and Zhan M. Systematic intervention of transcription for identifying network response to disease and cellular phenotypes. Bioinformatics 22: 96-102, 2006. (Pubitemid 43057013)
    • (2006) Bioinformatics , vol.22 , Issue.1 , pp. 96-102
    • Li, H.1    Zhan, M.2
  • 90
    • 0142039878 scopus 로고    scopus 로고
    • The Phosphatase MKP1 Is a Transcriptional Target of p53 Involved in Cell Cycle Regulation
    • DOI 10.1074/jbc.M307149200
    • Li M, Zhou JY, Ge Y, Matherly LH, and Wu GS. The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation. J Biol Chem 278: 41059-41068, 2003. (Pubitemid 37280929)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.42 , pp. 41059-41068
    • Li, M.1    Zhou, J.-Y.2    Ge, Y.3    Matherly, L.H.4    Wu, G.S.5
  • 92
    • 0037126392 scopus 로고    scopus 로고
    • The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis
    • DOI 10.1038/sj.onc.1205862
    • Liu G and Chen X. The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis. Oncogene 21: 7195-7204, 2002. (Pubitemid 35305606)
    • (2002) Oncogene , vol.21 , Issue.47 , pp. 7195-7204
    • Liu, G.1    Chen, X.2
  • 93
    • 0035947083 scopus 로고    scopus 로고
    • Siah-1 mediates a novel β-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein
    • DOI 10.1016/S1097-2765(01)00241-6
    • Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL, White RL, and Matsunami N. Siah-1 mediates a novel betacatenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell 7: 927-936, 2001. (Pubitemid 32525740)
    • (2001) Molecular Cell , vol.7 , Issue.5 , pp. 927-936
    • Liu, J.1    Stevens, J.2    Rote, C.A.3    Yost H.Joseph4    Hu, Y.5    Neufeld, K.L.6    White, R.L.7    Matsunami, N.8
  • 94
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • DOI 10.1038/362847a0
    • Lowe SW, Schmitt EM, Smith SW, Osborne BA, and Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847-849, 1993. (Pubitemid 23132161)
    • (1993) Nature , vol.362 , Issue.6423 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 95
    • 0242552555 scopus 로고    scopus 로고
    • Influence of Induced Reactive Oxygen Species in p53-Mediated Cell Fate Decisions
    • DOI 10.1128/MCB.23.23.8576-8585.2003
    • Macip S, Igarashi M, Berggren P, Yu J, Lee SW, and Aaronson SA. Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol 23: 8576-8585, 2003. (Pubitemid 37433363)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.23 , pp. 8576-8585
    • Macip, S.1    Igarashi, M.2    Berggren, P.3    Yu, J.4    Lee, S.W.5    Aaronson, S.A.6
  • 97
    • 0035947080 scopus 로고    scopus 로고
    • Siah-1, SIP, and Ebi collaborate in a novel pathway for β-catenin degradation linked to p53 responses
    • DOI 10.1016/S1097-2765(01)00242-8
    • Matsuzawa SI and Reed JC. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. Mol Cell 7: 915-926, 2001. (Pubitemid 32525739)
    • (2001) Molecular Cell , vol.7 , Issue.5 , pp. 915-926
    • Matsuzawa, S.-I.1    Reed, J.C.2
  • 98
    • 70349438994 scopus 로고    scopus 로고
    • Tumour suppression by p53: A role for the DNA damage response?
    • Meek DW. Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer 9: 714-723, 2009.
    • (2009) Nat Rev Cancer , vol.9 , pp. 714-723
    • Meek, D.W.1
  • 99
    • 34147104339 scopus 로고    scopus 로고
    • Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1/2 signaling
    • PII CBB4711
    • Mehdi MZ, Azar ZM, and Srivastava AK. Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1=2 signaling. Cell Biochem Biophys 47: 1-10, 2007. (Pubitemid 46570693)
    • (2007) Cell Biochemistry and Biophysics , vol.47 , Issue.1 , pp. 1-10
    • Mehdi, M.Z.1    Azar, Z.M.2    Srivastava, A.K.3
  • 100
    • 34547669249 scopus 로고    scopus 로고
    • The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain
    • Mellert H, Sykes SM, Murphy ME, and McMahon SB. The ARF=oncogene pathway activates p53 acetylation within the DNA binding domain. Cell Cycle 6: 1304-1306, 2007. (Pubitemid 47327961)
    • (2007) Cell Cycle , vol.6 , Issue.11 , pp. 1304-1306
    • Mellert, H.1    Sykes, S.M.2    Murphy, M.E.3    McMahon, S.B.4
  • 101
    • 0028966941 scopus 로고
    • P53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1
    • Milne DM, Campbell LE, Campbell DG, and Meek DW. p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1. J Biol Chem 270: 5511-5518, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 5511-5518
    • Milne, D.M.1    Campbell, L.E.2    Campbell, D.G.3    Meek, D.W.4
  • 102
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T and Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299, 1995.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 103
    • 33745363911 scopus 로고    scopus 로고
    • DNA damage signaling and p53-dependent senescence after prolonged β-interferon stimulation
    • DOI 10.1091/mbc.E05-09-0858
    • Moiseeva O, Mallette FA, Mukhopadhyay UK, Moores A, and Ferbeyre G. DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. Mol Biol Cell 17: 1583-1592, 2006. (Pubitemid 44011578)
    • (2006) Molecular Biology of the Cell , vol.17 , Issue.4 , pp. 1583-1592
    • Moiseeva, O.1    Mallette, F.A.2    Mukhopadhyay, U.K.3    Moores, A.4    Ferbeyre, G.5
  • 104
    • 0028299842 scopus 로고
    • RADICALES LIBRES DE OXIGENO Y SUPEROXIDO DISMUTASAS. ASPECTOS BIOLOGICOS Y MEDICOS
    • Monte M and Sacerdote de Lustig E. [Free radicals of oxygen and superoxide dismutase. Biological and medical aspects]. Medicina (B Aires) 54: 61-68, 1994. (Pubitemid 24117269)
    • (1994) Medicina , vol.54 , Issue.1 , pp. 61-68
    • Monte, M.1    Sacerdote De Lustig, E.2
  • 106
    • 0037205007 scopus 로고    scopus 로고
    • The promise and perils of Wnt signaling through β-catenin
    • DOI 10.1126/science.1071549
    • Moon RT, Bowerman B, Boutros M, and Perrimon N. The promise and perils of Wnt signaling through beta-catenin. Science 296: 1644-1646, 2002. (Pubitemid 34579151)
    • (2002) Science , vol.296 , Issue.5573 , pp. 1644-1646
    • Moon, R.T.1    Bowerman, B.2    Boutros, M.3    Perrimon, N.4
  • 107
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • DOI 10.1016/S1097-2765(01)00214-3
    • Nakano K and Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7: 683-694, 2001. (Pubitemid 32706359)
    • (2001) Molecular Cell , vol.7 , Issue.3 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 108
    • 0037192473 scopus 로고    scopus 로고
    • Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
    • DOI 10.1126/science.1069004
    • Nemoto S and Finkel T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 295: 2450-2452, 2002. (Pubitemid 34270258)
    • (2002) Science , vol.295 , Issue.5564 , pp. 2450-2452
    • Nemoto, S.1    Finkel, T.2
  • 109
    • 56849118516 scopus 로고    scopus 로고
    • Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
    • Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I, Unterman T, and Hay N. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 14: 458-470, 2008.
    • (2008) Cancer Cell , vol.14 , pp. 458-470
    • Nogueira, V.1    Park, Y.2    Chen, C.C.3    Xu, P.Z.4    Chen, M.L.5    Tonic, I.6    Unterman, T.7    Hay, N.8
  • 110
    • 69949160564 scopus 로고    scopus 로고
    • Redox mechanisms in hepatic chronic wound healing and fibrogenesis
    • Novo E and Parola M. Redox mechanisms in hepatic chronic wound healing and fibrogenesis. Fibrogenesis Tissue Repair 1: 1-5, 2008.
    • (2008) Fibrogenesis Tissue Repair , vol.1 , pp. 1-5
    • Novo, E.1    Parola, M.2
  • 111
    • 0034640281 scopus 로고    scopus 로고
    • Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
    • DOI 10.1126/science.288.5468.1053
    • Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, and Tanaka N. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288: 1053-1058, 2000. (Pubitemid 30324238)
    • (2000) Science , vol.288 , Issue.5468 , pp. 1053-1058
    • Oda, E.1    Ohki, R.2    Murasawa, H.3    Nemoto, J.4    Shibue, T.5    Yamashita, T.6    Tokino, T.7    Taniguchi, T.8    Tanaka, N.9
  • 115
    • 34248379012 scopus 로고    scopus 로고
    • Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: Lessons from recent developments in the IARC TP53 database
    • DOI 10.1002/humu.20495
    • Petitjean A, Mathe E, Kato S, Ishioka C, Tavtigian SV, Hainaut P, and Olivier M. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum Mutat 28: 622-629, 2007. (Pubitemid 46744292)
    • (2007) Human Mutation , vol.28 , Issue.6 , pp. 622-629
    • Petitjean, A.1    Mathe, E.2    Kato, S.3    Ishioka, C.4    Tavtigian, S.V.5    Hainaut, P.6    Olivier, M.7
  • 116
    • 11144280578 scopus 로고    scopus 로고
    • Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data
    • DOI 10.1593/neo.04277
    • Pilarsky C, Wenzig M, Specht T, Saeger HD, and Grutzmann R. Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data. Neoplasia 6: 744-750, 2004. (Pubitemid 40041492)
    • (2004) Neoplasia , vol.6 , Issue.6 , pp. 744-750
    • Pilarsky, C.1    Wenzig, M.2    Specht, T.3    Saeger, H.D.4    Grutzmann, R.5
  • 117
    • 27844526600 scopus 로고    scopus 로고
    • Akt-dependent transformation: There is more to growth than just surviving
    • DOI 10.1038/sj.onc.1209097, PII 1209097
    • Plas DR and Thompson CB. Akt-dependent transformation: there is more to growth than just surviving. Oncogene 24: 7435-7442, 2005. (Pubitemid 41637983)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7435-7442
    • Plas, D.R.1    Thompson, C.B.2
  • 118
    • 0030930366 scopus 로고    scopus 로고
    • A model for p53-induced apoptosis
    • DOI 10.1038/38525
    • Polyak K, Xia Y, Zweier JL, Kinzler KW, and Vogelstein B. A model for p53-induced apoptosis. Nature 389: 300-305, 1997. (Pubitemid 27406646)
    • (1997) Nature , vol.389 , Issue.6648 , pp. 300-305
    • Polyak, K.1    Xia, Y.2    Zweier, J.L.3    Kinzler, K.W.4    Vogelstein, B.5
  • 120
    • 23844477888 scopus 로고    scopus 로고
    • The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway
    • DOI 10.1074/jbc.M504852200
    • Rivera A and Maxwell SA. The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurindependent pathway. J Biol Chem 280: 29346-29354, 2005. (Pubitemid 41161390)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.32 , pp. 29346-29354
    • Rivera, A.1    Maxwell, S.A.2
  • 121
    • 68049105076 scopus 로고    scopus 로고
    • Role of hypoxia in the hallmarks of human cancer
    • Ruan K, Song G, and Ouyang G. Role of hypoxia in the hallmarks of human cancer. J Cell Biochem 107: 1053-1062, 2009.
    • (2009) J Cell Biochem , vol.107 , pp. 1053-1062
    • Ruan, K.1    Song, G.2    Ouyang, G.3
  • 122
  • 124
    • 0026006294 scopus 로고
    • Senescence as a mode of tumor suppression
    • Sager R. Senescence as a mode of tumor suppression. Environ Health Perspect 93: 59-62, 1991.
    • (1991) Environ Health Perspect , vol.93 , pp. 59-62
    • Sager, R.1
  • 125
    • 0034193343 scopus 로고    scopus 로고
    • A role for the p38 mitogen-activated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents
    • Sanchez-Prieto R, Rojas JM, Taya Y, and Gutkind JS. A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents. Cancer Res 60: 2464-2472, 2000. (Pubitemid 30262438)
    • (2000) Cancer Research , vol.60 , Issue.9 , pp. 2464-2472
    • Sanchez-Prieto, R.1    Rojas, J.M.2    Taya, Y.3    Gutkind, J.S.4
  • 126
    • 85047696046 scopus 로고    scopus 로고
    • Regulation of p73 by c-Abl through the p38 MAP kinase pathway
    • DOI 10.1038/sj/onc/1205134
    • Sanchez-Prieto R, Sanchez-Arevalo VJ, Servitja JM, and Gutkind JS. Regulation of p73 by c-Abl through the p38 MAP kinase pathway. Oncogene 21: 974-979, 2002. (Pubitemid 34146311)
    • (2002) Oncogene , vol.21 , Issue.6 , pp. 974-979
    • Sanchez-Prieto, R.1    Sanchez-Arevalo, V.J.2    Servitja, J.-M.3    Gutkind, J.S.4
  • 127
    • 0032981837 scopus 로고    scopus 로고
    • Acceleration of c-myc-induced hepatocarcinogenesis by co-expression of transforming growth factor (TGF)-α in transgenic mice is associated with TGF-β1 signaling disruption
    • Santoni-Rugiu E, Jensen MR, Factor VM, and Thorgeirsson SS. Acceleration of c-myc-induced hepatocarcinogenesis by co-expression of transforming growth factor (TGF)-alpha in transgenic mice is associated with TGF-beta1 signaling disruption. Am J Pathol 154: 1693-1700, 1999. (Pubitemid 29262851)
    • (1999) American Journal of Pathology , vol.154 , Issue.6 , pp. 1693-1700
    • Santoni-Rugiu, E.1    Jensen, M.R.2    Factor, V.M.3    Thorgeirsson, S.S.4
  • 128
    • 28244469041 scopus 로고    scopus 로고
    • Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
    • DOI 10.1074/jbc.M506096200
    • Sarbassov DD and Sabatini DM. Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex. J Biol Chem 280: 39505-39509, 2005. (Pubitemid 41713908)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.47 , pp. 39505-39509
    • Sarbassov, D.D.1    Sabatini, D.M.2
  • 129
    • 2642574174 scopus 로고    scopus 로고
    • p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1)
    • DOI 10.1042/BJ20031299
    • Schmid T, Zhou J, Kohl R, and Brune B. p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1). Biochem J 380: 289-295, 2004. (Pubitemid 38725754)
    • (2004) Biochemical Journal , vol.380 , Issue.1 , pp. 289-295
    • Schmid, T.1    Zhou, J.2    Kohl, R.3    Brune, B.4
  • 130
    • 38349127605 scopus 로고    scopus 로고
    • Differential gene expression involved in oxidative stress response caused by triethylene glycol dimethacrylate
    • Schweikl H, Hiller KA, Eckhardt A, Bolay C, Spagnuolo G, Stempfl T, and Schmalz G. Differential gene expression involved in oxidative stress response caused by triethylene glycol dimethacrylate. Biomaterials 29: 1377-1387, 2008.
    • (2008) Biomaterials , vol.29 , pp. 1377-1387
    • Schweikl, H.1    Hiller, K.A.2    Eckhardt, A.3    Bolay, C.4    Spagnuolo, G.5    Stempfl, T.6    Schmalz, G.7
  • 131
    • 69449089766 scopus 로고    scopus 로고
    • TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditions
    • Seifert A, Taubert H, Hombach-Klonisch S, Fischer B, and Navarrete Santos A. TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditions. Int J Oncol 35: 417-424, 2009.
    • (2009) Int J Oncol , vol.35 , pp. 417-424
    • Seifert, A.1    Taubert, H.2    Hombach-Klonisch, S.3    Fischer, B.4    Navarrete Santos, A.5
  • 132
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a)
    • DOI 10.1016/S0092-8674(00)81902-9
    • Serrano M, Lin AW, McCurrach ME, Beach D, and Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88: 593-602, 1997. (Pubitemid 27152402)
    • (1997) Cell , vol.88 , Issue.5 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 133
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • DOI 10.1016/S0092-8674(03)00432-X
    • Shi Y and Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113: 685-700, 2003. (Pubitemid 36724933)
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 134
    • 0038011249 scopus 로고    scopus 로고
    • 2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis
    • Shimada K, Nakamura M, Ishida E, Kishi M, and Konishi N. Roles of p38-and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis 24: 1067-1075, 2003. (Pubitemid 36827258)
    • (2003) Carcinogenesis , vol.24 , Issue.6 , pp. 1067-1075
    • Shimada, K.1    Nakamura, M.2    Ishida, E.3    Kishi, M.4    Konishi, N.5
  • 135
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • Siegel PM and Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 3: 807-821, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 807-821
    • Siegel, P.M.1    Massague, J.2
  • 136
    • 0034468736 scopus 로고    scopus 로고
    • Role of reactive oxygen species (ROS) in apoptosis induction
    • DOI 10.1023/A:1009616228304
    • Simon HU, Haj-Yehia A, and Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5: 415-418, 2000. (Pubitemid 32162623)
    • (2000) Apoptosis , vol.5 , Issue.5 , pp. 415-418
    • Simon, H.-U.1    Haj-Yehia, A.2    Levi-Schaffer, F.3
  • 139
    • 0033597221 scopus 로고    scopus 로고
    • Transcriptional activation of the human glutathione peroxidase promoter by p53
    • Tan M, Li S, Swaroop M, Guan K, Oberley LW, and Sun Y. Transcriptional activation of the human glutathione peroxidase promoter by p53. J Biol Chem 274: 12061-12066, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 12061-12066
    • Tan, M.1    Li, S.2    Swaroop, M.3    Guan, K.4    Oberley, L.W.5    Sun, Y.6
  • 140
    • 33748466565 scopus 로고    scopus 로고
    • Specificity in reactive oxidant signaling: Think globally, act locally
    • Terada LS. Specificity in reactive oxidant signaling: think globally, act locally. J Cell Biol 174: 615-623, 2006.
    • (2006) J Cell Biol , vol.174 , pp. 615-623
    • Terada, L.S.1
  • 141
    • 0032500838 scopus 로고    scopus 로고
    • Induction of p53 and Bax during TGF-β1 initiated apoptosis in rat liver epithelial cells
    • DOI 10.1006/bbrc.1998.9411
    • Teramoto T, Kiss A, and Thorgeirsson SS. Induction of p53 and Bax during TGF-beta 1 initiated apoptosis in rat liver epithelial cells. Biochem Biophys Res Commun 251: 56-60, 1998. (Pubitemid 28498062)
    • (1998) Biochemical and Biophysical Research Communications , vol.251 , Issue.1 , pp. 56-60
    • Teramoto, T.1    Kiss, A.2    Thorgeirsson, S.S.3
  • 144
    • 4644227579 scopus 로고    scopus 로고
    • p73 isoforms can induce T-cell factor-dependent transcription in gastrointestinal cells
    • DOI 10.1158/0008-5472.CAN-04-2176
    • Tomkova K, Belkhiri A, El-Rifai W, and Zaika AI. p73 isoforms can induce T-cell factor-dependent transcription in gastrointestinal cells. Cancer Res 64: 6390-6393, 2004. (Pubitemid 39297891)
    • (2004) Cancer Research , vol.64 , Issue.18 , pp. 6390-6393
    • Tomkova, K.1    Belkhiri, A.2    El-Rifai, W.3    Zaika, A.I.4
  • 145
    • 77953931313 scopus 로고    scopus 로고
    • Inter-connection between mitochondria and HIFs
    • Tormos KV and Chandel NS. Inter-connection between mitochondria and HIFs. J Cell Mol Med 14: 795-804, 2010.
    • (2010) J Cell Mol Med , vol.14 , pp. 795-804
    • Tormos, K.V.1    Chandel, N.S.2
  • 148
    • 33745316089 scopus 로고    scopus 로고
    • Identification of a tumour suppressor network opposing nuclear Akt function
    • DOI 10.1038/nature04809, PII NATURE04809
    • Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, and Pandolfi PP. Identification of a tumour suppressor network opposing nuclear Akt function. Nature 441: 523-527, 2006. (Pubitemid 44050155)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 523-527
    • Trotman, L.C.1    Alimonti, A.2    Scaglioni, P.P.3    Koutcher, J.A.4    Cordon-Cardo, C.5    Pandolfi, P.P.6
  • 149
    • 0142150051 scopus 로고    scopus 로고
    • Mitochondrial formation of reactive oxygen species
    • DOI 10.1113/jphysiol.2003.049478
    • Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol 552: 335-344, 2003. (Pubitemid 37321833)
    • (2003) Journal of Physiology , vol.552 , Issue.2 , pp. 335-344
    • Turrens, J.F.1
  • 150
    • 0041836252 scopus 로고    scopus 로고
    • Dual-specificity phospha tase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53
    • DOI 10.1038/sj.onc.1206845
    • Ueda K, Arakawa H, and Nakamura Y. Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53. Oncogene 22: 5586-5591, 2003. (Pubitemid 37102694)
    • (2003) Oncogene , vol.22 , Issue.36 , pp. 5586-5591
    • Ueda, K.1    Arakawa, H.2    Nakamura, Y.3
  • 153
    • 70849093542 scopus 로고    scopus 로고
    • Reactive oxygen speciesdependent signaling regulates cancer
    • Weinberg F and Chandel NS. Reactive oxygen speciesdependent signaling regulates cancer. Cell Mol Life Sci 66: 3663-3673, 2009.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 3663-3673
    • Weinberg, F.1    Chandel, N.S.2
  • 154
    • 36248990364 scopus 로고    scopus 로고
    • FOXM1, a typical proliferation-associated transcription factor
    • DOI 10.1515/BC.2007.159
    • Wierstra I and Alves J. FOXM1, a typical proliferationassociated transcription factor. Biol Chem 388: 1257-1274, 2007. (Pubitemid 350135573)
    • (2007) Biological Chemistry , vol.388 , Issue.12 , pp. 1257-1274
    • Wierstra, I.1    Alves, J.2
  • 155
    • 4444240191 scopus 로고    scopus 로고
    • The functional interactions between the p53 and MAPK signaling pathways
    • Wu GS. The functional interactions between the p53 and MAPK signaling pathways. Cancer Biol Ther 3: 156-161, 2004.
    • (2004) Cancer Biol Ther , vol.3 , pp. 156-161
    • Wu, G.S.1
  • 156
    • 34948820665 scopus 로고    scopus 로고
    • PAC1 is a direct transcription target of E2F-1 in apoptotic signaling
    • DOI 10.1038/sj.onc.1210484, PII 1210484
    • Wu J, Jin YJ, Calaf GM, Huang WL, and Yin Y. PAC1 is a direct transcription target of E2F-1 in apoptotic signaling. Oncogene 26: 6526-6535, 2007. (Pubitemid 47530605)
    • (2007) Oncogene , vol.26 , Issue.45 , pp. 6526-6535
    • Wu, J.1    Jin, Y.J.2    Calaf, G.M.3    Huang, W.-L.4    Yin, Y.5
  • 157
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
    • Wullschleger S, Loewith R, and Hall MN. TOR signaling in growth and metabolism. Cell 124: 471-484, 2006. (Pubitemid 43199434)
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 158
    • 0033935979 scopus 로고    scopus 로고
    • Creatine and creatinine metabolism
    • Wyss M and Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev 80: 1107-1213, 2000. (Pubitemid 30452013)
    • (2000) Physiological Reviews , vol.80 , Issue.3 , pp. 1107-1213
    • Wyss, M.1    Kaddurah-Daouk, R.2
  • 159
    • 46749154578 scopus 로고    scopus 로고
    • Role of TAp73alpha in induction of apoptosis by transforming growth factor-beta in gastric cancer cells
    • Yamamura Y, Lee WL, Goh MX, and Ito Y. Role of TAp73alpha in induction of apoptosis by transforming growth factor-beta in gastric cancer cells. FEBS Lett 582: 2663-2667, 2008.
    • (2008) FEBS Lett , vol.582 , pp. 2663-2667
    • Yamamura, Y.1    Lee, W.L.2    Goh, M.X.3    Ito, Y.4
  • 161
    • 64649086259 scopus 로고    scopus 로고
    • Small-molecule activation of p53 blocks hypoxiainducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia
    • Yang J, Ahmed A, Poon E, Perusinghe N, de Haven Brandon A, Box G, Valenti M, Eccles S, Rouschop K, Wouters B, and Ashcroft M.Small-molecule activation of p53 blocks hypoxiainducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia. Mol Cell Biol 29: 2243-2253, 2009.
    • (2009) Mol Cell Biol , vol.29 , pp. 2243-2253
    • Yang, J.1    Ahmed, A.2    Poon, E.3    Perusinghe, N.4    De Haven Brandon, A.5    Box, G.6    Valenti, M.7    Eccles, S.8    Rouschop, K.9    Wouters, B.10    Ashcroft, M.11
  • 162
    • 0037417281 scopus 로고    scopus 로고
    • PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression
    • DOI 10.1038/nature01519
    • Yin Y, Liu YX, Jin YJ, Hall EJ, and Barrett JC. PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. Nature 422: 527-531, 2003. (Pubitemid 36433648)
    • (2003) Nature , vol.422 , Issue.6931 , pp. 527-531
    • Yin, Y.1    Llu, Y.-X.2    Jin, Y.J.3    Hall, E.J.4    Barrett, J.C.5
  • 163
    • 1942520427 scopus 로고    scopus 로고
    • Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses
    • DOI 10.1007/s10038-003-0122-3
    • Yoon KA, Nakamura Y, and Arakawa H. Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses. J Hum Genet 49: 134-140, 2004. (Pubitemid 38506727)
    • (2004) Journal of Human Genetics , vol.49 , Issue.3 , pp. 134-140
    • Yoon, K.-A.1    Nakamura, Y.2    Arakawa, H.3
  • 164
    • 33646229039 scopus 로고    scopus 로고
    • 46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage
    • DOI 10.1074/jbc.M512074200
    • Yoshida K, Liu H, and Miki Y. Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage. J Biol Chem 281: 5734-5740, 2006. (Pubitemid 43847672)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.9 , pp. 5734-5740
    • Yoshida, K.1    Liu, H.2    Miki, Y.3
  • 165
    • 44849137874 scopus 로고    scopus 로고
    • Sugar and fat-that's where it's at: Metabolic changes in tumors
    • Young CD and Anderson SM. Sugar and fat-that's where it's at: metabolic changes in tumors. Breast Cancer Res 10: 202, 2008.
    • (2008) Breast Cancer Res , vol.10 , pp. 202
    • Young, C.D.1    Anderson, S.M.2
  • 166
    • 18144382261 scopus 로고    scopus 로고
    • p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase
    • DOI 10.1158/0008-5472.CAN-04-3835
    • Zhao Y, Chaiswinga L, Velez JM, Batinic-Haberle I, Colburn NH, Oberley TD, and St. Clair DK. p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. Cancer Res 65: 3745-3750, 2005. (Pubitemid 40616352)
    • (2005) Cancer Research , vol.65 , Issue.9 , pp. 3745-3750
    • Zhao, Y.1    Chaiswing, L.2    Velez, J.M.3    Batinic-Haberle, I.4    Colburn, N.H.5    Oberley, T.D.6    St. Clair, D.K.7
  • 167
    • 0037151032 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons
    • DOI 10.1074/jbc.M200042200
    • Zhu Y, Mao XO, Sun Y, Xia Z, and Greenberg DA. p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons. J Biol Chem 277: 22909-22914, 2002. (Pubitemid 34967274)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.25 , pp. 22909-22914
    • Zhu, Y.1    Mao, X.O.2    Sun, Y.3    Xia, Z.4    Greenberg, D.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.