Deletion of p66shc gene protects against age-related endothelial dysfunction

Circulation

Volumn 110, Issue 18, 2004, Pages 2889-2895

  Francia, Pietro ^a,b,c,d   Delli Gatti, Chiara ^a,b   Bachschmid, Markus ^e   Martin Padura, Ines ^f   Savoia, Carmine ^c,d   Migliaccio, Enrica ^f   Pelicci, Pier Giuseppe ^f   Schiavoni, Marzia ^a,b   Lüscher, Thomas Felix ^a,b   Volpe, Massimo ^c,d   Cosentino, Francesco ^a,b,c,d,g  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d IRCCS NEUROMED   (Italy)

^e UNIVERSITY OF KONSTANZ   (Germany)

^f EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^g UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Aging; Endothelium; Free radicals; Genes; Nitric oxide

Indexed keywords

3 NITROTYROSINE; ACETYLCHOLINE; CHEMICAL AGENT; COELENTERAZINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MANGANESE SUPEROXIDE DISMUTASE; NITRIC OXIDE; PROTEIN; PROTEIN P66; PROTEIN SHC; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; 3-NITROTYROSINE; DRUG DERIVATIVE; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, MOUSE; NOS3 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SRC HOMOLOGY 2 DOMAIN CONTAINING, TRANSFORMING PROTEIN 1; SRC HOMOLOGY 2 DOMAIN-CONTAINING, TRANSFORMING PROTEIN 1; TYROSINE;

AGING; ANIMAL TISSUE; ARTICLE; CHEMOLUMINESCENCE; GENE DELETION; GENE INACTIVATION; IMMUNOHISTOCHEMISTRY; LIFESPAN; MALE; MOUSE; MUSCLE TONE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSOR; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASCULAR RING; WESTERN BLOTTING; WILD TYPE; ANIMAL; AORTA; CHEMISTRY; COMPARATIVE STUDY; GENETICS; LONGEVITY; METABOLISM; MOUSE MUTANT; MUSCLE ISOMETRIC CONTRACTION; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION; VASOCONSTRICTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGING; ANIMALS; AORTA; ENDOTHELIUM, VASCULAR; ISOMETRIC CONTRACTION; LONGEVITY; MALE; MICE; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PROTEINS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; TYROSINE; VASOCONSTRICTION;

EID: 8144229685     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000147731.24444.4D     Document Type: Article

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