Anti-inflammatory effects of resveratrol: Possible role in prevention of age-related cardiovascular disease

Annals of the New York Academy of Sciences

Volumn 1215, Issue 1, 2011, Pages 117-122

  Csiszar, Anna ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Aging; Resveratrol; Vascular dysfunction

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE PEROXIDASE; HEME OXYGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RESVERATROL; SIRTUIN 1; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA;

AGING; ANGIOGENESIS; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROGENESIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; CORONARY ARTERY DISEASE; DRUG EFFECT; HEART PROTECTION; HUMAN; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; KNOCKOUT MOUSE; NONHUMAN; OXIDATIVE STRESS; SACCHAROMYCES CEREVISIAE; STROKE;

EID: 78851468985     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2010.05848.x     Document Type: Article

References (65)

1. Keys, A., A. Menotti, M.J. Karvonen, et al 1986. The diet and 15-year death rate in the seven countries study. Am. J. Epidemiol. 124: 903-915.
2. de Lorgeril, M., P. Salen, J.L. Martin, et al 1999. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 99: 779-785.
3. Wood, J.G., B. Rogina, S. Lavu, et al 2004. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430: 686-689.
4. Howitz, K.T., K.J. Bitterman, H.Y. Cohen, et al 2003. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191-196.
5. Baur, J.A., K.J. Pearson, N.L. Price, et al 2006. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-342.
6. Kim, D., M.D. Nguyen, M.M. Dobbin, et al 2007. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 26: 3169-3179.
7. Pearson, K.J., J.A. Baur, K.N. Lewis, et al 2008. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life Span. Cell Metab. 8: 157-168.
8. Lagouge, M., C. Argmann, Z. Gerhart-Hines, et al 2006. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127: 1109-1122.
9. Csiszar, A., M. Wang, E.G. Lakatta & Z. I. Ungvari 2008. Inflammation and endothelial dysfunction during aging: role of NF-{kappa}B. J. Appl. Physiol. 105: 1333-1341.
10. Csiszar, A., Z. Ungvari, J.G. Edwards, et al 2002. Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ. Res. 90: 1159-1166.
11. Van Der Loo, B., R. Labugger, J.N. Skepper, et al 2000. Enhanced peroxynitrite formation is associated with vascular aging. J. Exp. Med. 192: 1731-1744.
12. Adler, A., E. Messina, B. Sherman, et al 2003. NAD(P)H oxidase-generated superoxide anion accounts for reduced control of myocardial O2 consumption by NO in old Fischer 344 rats. Am. J. Physiol. Heart Circ. Physiol. 285: H1015-H1022.
13. Donato, A.J., I. Eskurza, A.E. Silver, et al 2007. Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. Circ. Res. 100: 1659-1666.
14. Jacobson, A., C. Yan, Q. Gao, et al 2007. Aging enhances pressure-induced arterial superoxide formation. Am. J. Physiol. Heart Circ. Physiol. 293: H1344-H1350.
15. Ungvari, Z., R. Buffenstein, S.N. Austad, et al 2008. Oxidative stress in vascular senescence: lessons from successfully aging species. Front Biosci. 13: 5056-5070.
16. Hoffmann, J., J. Haendeler, A. Aicher, et al 2001. Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide. Circ. Res. 89: 709-715.
17. Csiszar, A., Z. Ungvari, A. Koller, et al 2004. Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging. Physiol. Genomics 17: 21-30.
18. Ungvari, Z.I., N. Labinskyy, S.A. Gupte, et al 2008. Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats. Am. J. Physiol. Heart Circ. Physiol. 294: H2121-H2128.
19. Addabbo, F., B. Ratliff, H.C. Park, et al 2009. The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach. Am. J. Pathol. 174: 34-43.
20. Csiszar, A., N. Labinskyy, J.T. Pinto, et al 2009. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 297: H13-H20.
21. Li, W., S. Mital, C. Ojaimi, et al 2004. Premature death and age-related cardiac dysfunction in male eNOS-knockout mice. J. Mol. Cell Cardiol. 37: 671-680.
22. Ungvari, Z.I., Z. Orosz, N. Labinskyy, et al 2007. Increased mitochondrial H2O2 production promotes endothelial NF-kB activation in aged rat arteries. Am. J. Physiol. Heart Circ. Physiol. 293: H37-H47.
23. Cernadas, M.R., L. Sanchez de Miguel, M. Garcia-Duran, et al 1998. Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats. Circ. Res. 83: 279-286.
24. Csiszar, A., N. Labinskyy, K. Smith, et al 2007. Vasculoprotective effects of anti-TNFalfa treatment in aging. Am. J. Pathol. 170: 388-698.
25. Hattori, R., H. Otani, N. Maulik & D.K. Das 2002. Pharmacological preconditioning with resveratrol: role of nitric oxide. Am. J. Physiol. Heart Circ. Physiol. 282: H1988-H1995.
26. Juric, D., P. Wojciechowski, D.K. Das & T. Netticadan 2007. Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol. Am. J. Physiol. 292: H2138-H2143.
27. Gurusamy, N., D. Ray, I. Lekli & D.K. Das 2010. Red wine antioxidant resveratrol-modified cardiac stem cells regenerate infarcted myocardium. J Cell Mol. Med. 14: 2235-9.
28. Csiszar, A., N. Labinskyy, S. Olson, et al 2009. Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats. Hypertension 54: 668-675.
29. Zhang, H., J. Zhang, Z. Ungvari & C. Zhang 2009. Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress. Arterioscler Thromb. Vasc. Biol. 29: 1164-1171.
30. Ungvari, Z., N. Labinskyy, P. Mukhopadhyay, et al 2009. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 297: H1876-H1881.
31. Zhang, H., B. Morgan, B.J. Potter, et al 2010. Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress. Am. J. Physiol. Heart Circ. Physiol 299: H985-94.
32. Bradamante, S., L. Barenghi, F. Piccinini, et al 2003. Resveratrol provides late-phase cardioprotection by means of a nitric oxide- and adenosine-mediated mechanism. Eur. J. Pharmacol. 465: 115-123.
33. Taubert, D. & R. Berkels 2003. Upregulation and activation of eNOS by resveratrol. Circulation 107: e78-e79; author reply e78-e79.
34. Ungvari, Z., Z. Orosz, A. Rivera, et al 2007. Resveratrol increases vascular oxidative stress resistance. Am. J. Physiol. 292: H2417-H2424.
35. Thirunavukkarasu, M., S.V. Penumathsa, S. Koneru, et al 2007. Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of nitric oxide, thioredoxin, and heme oxygenase. Free Radic. Biol. Med. 43: 720-729.
36. Das, S., C.G. Fraga & D.K. Das 2006. Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFkappaB. Free Radic. Res. 40: 1066-1075.
37. Ungvari, Z., Z. Bagi, A. Feher, et al 2010. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am. J. Physiol. Heart Circ. Physiol. 299: H18-H24.
38. Chow, S.E., Y.C. Hshu, J.S. Wang & J.K. Chen 2007. Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages. J. Appl. Physiol. 102: 1520-1527.
39. Wung, B.S., M.C. Hsu, C.C. Wu & C.W. Hsieh 2005. Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: effects on the inhibition of STAT3 phosphorylation. Life Sci. 78: 389-397.
40. Shigematsu, S., S. Ishida, M. Hara, et al 2003. Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants. Free Radic. Biol. Med. 34: 810-817.
41. Csiszar, A., K. Smith, N. Labinskyy, et al 2006. Resveratrol attenuates TNF-{alpha}-induced activation of coronary arterial endothelial cells: role of NF-{kappa}B inhibition. Am. J. Physiol. 291: H1694-H1699.
42. Ungvari, Z., Z. Orosz, N. Labinskyy, et al 2007. Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries. Am. J. Physiol. Heart Circ. Physiol. 293: H37-H47.
43. Csiszar, A., N. Labinskyy, A. Podlutsky, et al 2008. Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am. J. Physiol. Heart Circ. Physiol. 294: H2721-H2735.
44. Tsai, S.H., S.Y. Lin-Shiau & J.K. Lin 1999. Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol. Br. J. Pharmacol. 126: 673-680.
45. Manna, S.K., A. Mukhopadhyay & B.B. Aggarwal 2000. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J. Immunol. 164: 6509-6519.
46. Ferrero, M.E., A.E. Bertelli, A. Fulgenzi, et al 1998. Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium. Am. J. Clin. Nutr. 68: 1208-1214.
47. Moon, S.O., W. Kim, M.J. Sung, et al 2006. Resveratrol suppresses tumor necrosis factor-alpha-induced fractalkine expression in endothelial cells. Mol. Pharmacol. 70: 112-119.
48. Gehm, B.D., J.M. McAndrews, P.Y. Chien & J.L. Jameson 1997. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc. Natl. Acad. Sci. USA 94:14138-14143.
49. Klinge, C.M., N.S. Wickramasinghe, M.M. Ivanova & S.M. Dougherty 2008. Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells. FASEB J. 22: 2185-2197.
50. Danz, E.D., J. Skramsted, N. Henry, et al 2009. Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway. Free Radic. Biol. Med. 46: 1589-1597.
51. Miyazaki, R., T. Ichiki, T. Hashimoto, et al 2008. SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 28: 1263-1269.
52. Gracia-Sancho, J., G. Villarreal Jr., Y. Zhang & G. Garcia-Cardena 2009. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype. Cardiovasc. Res. 85: 514-519.
53. Baur, J.A. & D.A. Sinclair 2006. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 5: 493-506.
54. Milne, J.C., P.D. Lambert, S. Schenk, et al 2007. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450: 712-716.
55. Dasgupta, B. & J. Milbrandt 2007. Resveratrol stimulates AMP kinase activity in neurons. Proc. Natl. Acad. Sci. USA 104: 7217-7222.
56. Pacholec, M., B.A. Chrunyk, D. Cunningham, et al 2010. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J. Biol. Chem. 285: 8340-8351.
57. Csiszar, A., N. Labinskyy, R. Jimenez, et al 2009. Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1. Mech. Ageing Dev. 130: 518-527.
58. Yeung, F., J.E. Hoberg, C.S. Ramsey, et al 2004. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. Embo J. 23: 2369-2380.
59. Hsieh, T.C., Z. Wang, C.V. Hamby & J.M. Wu 2005. Inhibition of melanoma cell proliferation by resveratrol is correlated with upregulation of quinone reductase 2 and p53. Biochem. Biophys. Res. Commun. 334: 223-230.
60. Wang, Z., T.C. Hsieh, Z. Zhang, et al 2004. Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography. Biochem. Biophys. Res. Commun. 323: 743-749.
61. Chen, C.Y., J.H. Jang, M.H. Li & Y.J. Surh 2005. Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells. Biochem. Biophys. Res. Commun. 331: 993-1000.
62. Kode, A., S. Rajendrasozhan, S. Caito, et al 2008. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am. J. Physiol. Lung Cell Mol. Physiol. 294: L478-L488.
63. Abraham, J. & R.W. Johnson 2009. Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice. Rejuvenation Res. 12: 445-453.
64. Ranney, A. & M.S. Petro 2009. Resveratrol protects spatial learning in middle-aged C57BL/6 mice from effects of ethanol. Behav. Pharmacol. 20: 330-336.
65. Oomen, C.A., E. Farkas, V. Roman, et al 2009. Resveratrol preserves cerebrovascular density and cognitive function in aging mice. Front Aging Neurosci. 1: 4.