Ageing affects nitric oxide synthase, cyclooxygenase and oxidative stress enzymes expression differently in mesenteric resistance arteries

Autonomic and Autacoid Pharmacology

Volumn 25, Issue 4, 2005, Pages 155-162

  Briones, A M ^a,b   Montoya, N ^a   Giraldo, J ^a   Vila, E ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Ageing; Cyclooxygenase; Nitric oxide synthase; Oxidative stress; Resistance arteries

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ARACHIDONIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANYLATE CYCLASE; INDOMETACIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PHENYLEPHRINE; PROSTAGLANDIN SYNTHASE; PROTEIN P22; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE DISMUTASE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CONTROLLED STUDY; ENZYME SUBUNIT; MALE; MESENTERIC ARTERY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; UPREGULATION; WESTERN BLOTTING;

ACETYLCHOLINE; AGING; ANIMALS; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; INDOMETHACIN; MALE; MESENTERIC ARTERIES; NADPH OXIDASE; NG-NITROARGININE METHYL ESTER; NITROBENZENES; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; SULFONAMIDES; UP-REGULATION; VASCULAR RESISTANCE; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 26044445766     PISSN: 14748665     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1474-8673.2005.00344.x     Document Type: Article

References (38)

1. ARMSTRONG, S.J., ZHANG, Y., STEWART, K.G. & DAVIDGE, S.T. (2002). Estrogen replacement reduces PGHS-2-dependent vasoconstriction in the aged rat. Am. J. Physiol. Heart Circ. Physiol., 283, H893-H898.
2. BABIOR, B.M. (1999). Nadph oxidase: and update. Blood, 93, 1464-1476.
3. BISHOP-BAILEY, D., HLA, T. & MITCHELL, J.A. (1999). Cyclooxygenase-2 in vascular smooth muscle. Int. J. Mol. Med., 3, 41-48.
4. BRANDES, R.P. & KREUZER, J. (2005). Vascular NADPH oxidases: molecular mechanisms of activation. Cardiovasc. Res., 65, 16-27.
5. BRIONES, A.M., ALONSO, M.J., HERNANZ, R., TOVAR, S., VILA, E. & SALAICES, M. (2002). Hypertension alters the participation of contractile prostanoids and superoxide anions in lipopolysaccharide effects on small mesenteric arteries. Life Sci., 71, 1997-2014.
6. CERNADAS, M.R., SÁNCHEZ DE MIGUEL, L., GARCÍA-DURAN, M., GONZÁLEZ FERNÁNDEZ, F., MILLAS, I., MONTÓN, M., RODRIGO, J., RICO, L., FERNÁNDEZ, P., DE FRUTOS, T., RODRÍGUEZ-FEO, J.A., GUERRA, J., CARAMELO, C., CASADO, s. & LÓPEZ-FARRE, A. (1998). Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats. Circ. Res., 83, 279-286.
7. CHEN, L., DAUM, G., FISCHER, J.W., HAWKINS, S., BOCHATON-PIALLAT, M.L., GABBIANI, G. & CLOWES, A.W. (2000). Loss of Expression of the ß Subunit of Soluble Guanylyl Cyclase Prevents Nitric Oxide-Mediated Inhibition of DNA Synthesis in Smooth Muscle Cells of Old Rats. Circ. Res., 86, 520-526.
8. CHOU, T.C., YEN, M.H., LI, C.Y. & DING, Y.A. (1998). Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension, 31, 643-648.
9. 2, inducible and constitutive cyclooxygenase, and inducible nitric oxide synthase. Biochem. Pharmacol., 55, 105-111.
10. CSISZAR, A., UNGVARI, Z., EDWARDS, J.G., KAMINSKI, P., WOLIN, M.S., KOLLER, A. & KALEY, G. (2002). Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ. Res., 90, 1159-1166.
11. DAVIDGE, S.T., HUBEL, C.A. & MCLAUGHLIN, M.K. (1996). Impairment of vascular function is associated with an age-related increase of lipid peroxidation in rats. Am. J. Physiol., 271, R1625-R1631.
12. FURCHGOTT, R.F. & VANHOUTTE, P.M. (1989). Endothelium-derived relaxing and contracting factors. FASEB J., 3, 2007-2017.
13. GARCIA-COHEN, B.C., MARIN, J., DIEZ-PICAZO, L.D., BAENA, A.B., SALAICES, M. & RODRÍGUEZ-MARTÍNEZ, M.A. (2000). Oxidative stress induced by tert-butyl hydroperoxide causes vasoconstriction in the aorta from hypertensive and aged rats: role of cyclooxygenase-2 isoform. J. Pharmacol. Exp. Ther., 293, 75-81.
14. GRYGLEWSKI, R.J., PALMER, R.M.J. & MONCADA, S. (1986). Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature, 320, 454-456.
15. HAMILTON, C.A., BROSNAN, M.J., MCINTYRE, M., GRAHAM, D. & DOMINICZAK, A.F. (2001). Superoxide excess in hypertension and aging. A common cause of endothelial dysfunction. Hypertension, 37, 529-534.
16. HEYMES, C., HABIB, A., YANG, D., MATHIEU, E., MAROTTE, F., SAMUEL, J. & BOULANGER, C.M. (2000). Cyclo-oxygenase-1 and -2 contribution to endothelial dysfunction in ageing. Br. J. Pharmacol., 131, 804-810.
17. HWA, J.J., GHIBAUDI, L., WILLIAMS, P. CHATTERJEE, M. (1994). Comparison of acetylcholine-dependent relaxation in large and small arteries of rat mesenteric vascular bed. Am. J. Physiol., 266, H952-H958.
18. KOGA, T., TAKATA, Y., KOBAYASHI, K., TAKISHITA, S., YAMASHITA, Y. & FUJISHIMA, M. (1989). Age and hypertension promote endothelium-dependent contractions to acetylcholine in the aorta of the rat. Hypertension, 14, 542-548.
19. MARÍN, J. & RODRÍGUEZ-MARTÍNEZ, M.A. (1999). Age-related changes in vascular responses. Exp. Gerontol., 34, 503-512.
20. MATZ, R.L., ALVAREZ DE SOTOMAYOR, M., SCHOTT, C. & ANDRIANTSITOHAINA, R. (2003). Preservation of vascular contraction during ageing: dual effect on calcium handling and sensitization. Br. J. Pharmacol., 138, 745-750.
21. MATZ, R.L., ALVAREZ DE SOTOMAYOR, M., SCHOTT, C., STOCLET, J.C. & ANDRIANTSITOHAINA, R. (2000). Vascular bed heterogeneity in age-related endothelial dysfunction with respect to NO and eicosanoids. Br. J. Pharmacol., 131, 303-311.
22. MAZARIO, J., GAITAN, G. & HERRERO, J.F. (2001). Cyclooxygenase-1 vs cyclooxygenase-2 inhibitors in the induction of antinociception in rodent withdrawal reflexes. Neuropharmacology, 40, 937-946.
23. MIRALPEIX, M., CAMACHO, M., LÓPEZ-BELMONTE, J., CANALÍAS, F., BELETA, J., PALACIOS, J.M. & VILA, L. (1997). Selective induction of cyclo-oxygenase-2 activity in the permanent human endotelial cell line HUV-EC-C: biochemical and pharmacological characterization. Br. J. Pharmacol., 121, 171-180.
24. MITCHELL, J.A., AKARASEREENONT, P., THIEMERMANN, C., FLOWER, R.J. & VANE, J.R., 1994. Selectivity of nonsteroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA 90, 1693-1697.
25. MOMBOULI, J.V. & VANHOUTTE, P.M. (1999). Endothelial dysfunction: from physiology to therapy. J. Mol. Cell. Cardiol., 31, 61-74.
26. MONCADA, S., PALMER, R.M.J. & HIGGS, E.A. (1991). Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-142.
27. MULVANY, M.J. & HALPERN, W. (1977). Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res., 41, 19-26.
28. RODRÍGUEZ-MARTÍNEZ, M.A., ALONSO, M.J., REDONDO, J., SALAICES, M. & MARÍN, J. (1998). Role of lipid peroxidation and the glutathione-dependent antioxidant system in the impairment of endothelium-dependent relaxations with age. Br. J. Pharmacol., 123, 113-121.
29. RUBANYI, G.M. & VANHOUTTE, P.M. (1986). Superoxide anions and hyperoxia inactive endothelium-derived relaxing factor. Am. J. Physiol., 250, H822-H827.
30. SCHUTZER, W.E. & MADER, S.L. (2003). Age-related changes in vascular adrenergic signalling: clinical and mechanistic implications. Aging Res., 2, 169-190.
31. STEWART, K.G., ZHANG, Y. & DAVIDGE, S.T. (2000). Aging increases COX-2-dependent vasoconstriction in rat mesenteric arteries. Hypertension, 35, 1242-1247.
32. SULLIVAN, J.C. & DAVIDSON, C.A. (2001). Gender differences in the effect of age on electrical field stimulation (EFS)-induced adrenergic vasoconstriction in rat mesenteric arteries. J. Pharmacol. Exp. Ther., 296, 782-788.
33. SUN, D., HUANG, A., YAN, E.H., WU, Z., YAN, C., KAMINSKI, P.M., OURY, T.D., WOLIN, M.S. & KALEY, G. (2004). Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats. Am. J. Physiol. Heart Circ. Physiol., 286, 0H2249-H2256.
34. TABERNERO, A., NADAUD, S., CORMAN, B., ATKINSON, J. & CAPDEVILLE-ATKINSON, C. (2000). Effects of chronic and acute aminoguanidine treatment on tail artery vasomotion in ageing rats. Br. J. Pharmacol., 131, 1227-1235.
35. VAN DER LOO, B., LABUGGER, R., SKEPPER, J.N. et al. (2000). Enhanced peroxynitrite formation is associated with vascular aging. J. Exp. Med., 192, 1731-1744.
36. WILCOX, C.S. (2003). Redox regulation of the afferent arteriole and tubuloglomerular feedback. Acta Physiol. Scand., 179, 217-223.
37. YU, B.P. & CHUNG, H.Y. (2001). Oxidative stress and vascular ageing. Diabetes Res. Clin. Pract., 54, S73-S80.
38. ZALBA, G., SAN JOSÉ, G.D., FORTUÑO, M.N., FORTUÑO, A., BEAUMONT, F.J. & DÍEZ, J. (2001). Oxidative stress in arterial hypertension: role of NADP/NADPH oxidase. Hypertension, 38, 1395-1399.