Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 297, Issue 1, 2009, Pages

  Ndubuizu, Obinna I ^a   Chavez, Juan C ^b   LaManna, Joseph C ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

Author keywords

Aging; Hypoxia; Hypoxia inducible factor 1; Hypoxia inducible factor 2

Indexed keywords

CARBONATE DEHYDRATASE IX; CYCLOOXYGENASE 2; EARLY GROWTH RESPONSE FACTOR 1; ERYTHROPOIETIN; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MESSENGER RNA; NUCLEAR PROTEIN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; VASCULOTROPIN;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; CORRELATION ANALYSIS; FISCHER 344 RAT; GENE EXPRESSION REGULATION; HYPOXIA; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; RAT; REAL TIME POLYMERASE CHAIN REACTION; TISSUE OXYGENATION; WESTERN BLOTTING;

AGE FACTORS; AGING; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARBONIC ANHYDRASES; CEREBRAL CORTEX; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE TRANSPORTER TYPE 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMEDIATE-EARLY PROTEINS; MALE; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, INBRED F344; RNA, MESSENGER; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 67650065272     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90829.2008     Document Type: Article

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