The ubiquitin-proteasome system at the crossroads of stress-response and ageing pathways: A handle for skin care?

Ageing Research Reviews

Volumn 5, Issue 1, 2006, Pages 60-90

  Brégégère, François ^a,b   Milner, Yoram ^b   Friguet, Bertrand ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Ageing; Chaperone; E3 ligase; Heat shock; Keratinocyte; Oxidative stress; Photoageing; Proteasome; Proteolysis; Senescence; Signal transduction; Skin; Ubiquitin

Indexed keywords

ACETYLSALICYLIC ACID; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CHAPERONE; CHYMOTRYPSIN INHIBITOR; EVODIAMINE; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PLANT MEDICINAL PRODUCT; PR 39; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN RAD1; RETINOIC ACID; SALAZOSULFAPYRIDINE; SALICYLIC ACID; UBIQUITIN;

AGING; ASTHMA; CELL AGING; CELL CYCLE REGULATION; CELL SURVIVAL; CUTANEOUS PARAMETERS; DNA REPAIR; DNA TRANSCRIPTION; DRUG ANTAGONISM; DRUG INHIBITION; HORMONE RESPONSE; HUMAN; ISCHEMIA; MULTIPLE SCLEROSIS; NONHUMAN; PHOTOAGING; PROTEIN DEGRADATION; PROTEIN METABOLISM; PSORIASIS; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SKIN CARE; STRESS; UBIQUITINATION; ULTRAVIOLET RADIATION;

EID: 31344434396     PISSN: 15681637     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arr.2005.09.002     Document Type: Short Survey

References (233)

1. C. Acquaviva, G. Bossis, P. Ferrera, F. Brockly, I. Jariel-Encontre, and M. Piechaczyk Multiple degradation pathways for Fos family proteins Ann. N. Y. Acad. Sci. 973 2002 426 434
2. B.B. Aggarwal Signalling pathways of the TNF superfamily: a double-edged sword Nat. Rev. Immunol. 3 2003 745 756
3. B.B. Aggarwal, and S. Shishodia Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning Ann. N. Y. Acad. Sci. 1030 2004 434 441
4. V.B. Andela, and R. Rosier The proteasome inhibitor MG132 attenuates retinoic acid receptor trans-activation and enhances trans-repression of nuclear factor κB. Potential relevance to chemo-preventive interventions with retinoids Mol. Cancer 2004 3
5. Y. Aragane, D. Kulms, D. Metze, G. Wilkes, B. Pöppelmann, T.A. Luger, and T. Schwarz Ultraviolet light induces apoptosis via direct activation of CD95, Fas/APO-1, independently of its ligand CD95L J. Cell. Biol. 140 1998 171 182
6. J. Arnold, and T. Grune PARP-mediated proteasome activation: a co-ordination of DNA repair and protein degradation? BioEssays 24 2002 1060 1065
7. J.F. Bazan Structural design and molecular evolution of a cytokine receptor superfamily Proc. Natl. Acad. Sci. U.S.A. 87 1990 6934 6938
8. A.A. Beg, W.C. Sha, R.T. Bronson, S. Ghosh, and D. Baltimore Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB Nature 376 1995 167 170
9. A.A. Beg, and D. Baltimore An essential role for NF-κB in preventing TNF-α-induced cell death Science 274 1996 782 784
10. K. Bender, C. Blattner, A. Knebel, M. Iordanov, P. Herrlich, and H.J. Rahmsdorf UV-induced signal transduction J. Photochem. Photobiol. B 37 1997 1 17
11. WAF1 to promote DNA repair Cell 114 2003 599 610
12. E.S. Berleth, E.M. Kasperek, S.P. Grill, J.A. Braunscheidel, L.A. Graziani, and C.M. Pickart Inhibition of ubiquitin-protein ligase, E3, by mono- and bifunctional phenylarsenoxides J. Biol. Chem. 267 1992 16403 16411
13. D. Bernard, K. Gosselin, D. Monte, C. Vercamer, F. Bouali, A. Pourtier, B. Vandenbunder, and C. Abbadie Involvement of Rel/nuclear factor-κB transcription factors in keratinocyte senescence Cancer Res. 64 2004 472 481
14. M. Berneburg, S. Grether-Beck, V. Kurten, T. Ruzicka, K. Briviba, H. Sies, and J. Krutmann Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion J. Biol. Chem. 274 1999 15345 15349
15. S. Bonni, H.R. Wang, C.G. Causing, P. Kavsak, S.L. Stroschein, K. Luo, and J.L. Wrana TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation Nat. Cell Biol. 3 2001 587 595
16. F. Boraldi, L. Bini, S. Liberatori, A. Armini, V. Pallini, R. Tiozzo, I. Pasquali-Ronchetti, and D. Quaglino Proteome analysis of dermal fibroblasts cultured in vitro from human healthy subjects of different ages Proteomics 3 2003 917 929
17. M. Boudjelal, Z. Wang, J.J. Voorhees, and G.J. Fisher Ubiquitin/proteasome pathway regulates levels of retinoic acid receptor γ and retinoid X receptor α in human keratinocytes Cancer Res. 60 2000 2247 2252
18. M. Boudjelal, J.J. Voorhees, and G.J. Fisher Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells Exp. Cell Res. 274 2002 130 137
19. M.C. Branchet, S. Boisnic, C. Frances, and A.M. Robert Skin thickness changes in normal aging skin Gerontology 36 1990 28 35
20. D.M. Brantley, C.L. Chen, R.S. Muraoka, P.B. Bushdid, J.L. Bradberry, F. Kittrell, D. Medina, L.M. Matrisian, L.D. Kerr, and F.E. Yull Nuclear factor-kappaB regulates proliferation and branching in mouse mammary epithelium Mol. Biol. Cell 12 2001 1445 1455
21. F. Brégégère, Y. Soroka, J. Bismuth, B. Friguet, and Y. Milner Cellular senescence in human keratinocytes: unchanged proteolytic capacity and increased protein load Exp. Gerontol. 38 2003 619 629
22. M. Brennan, H. Bhatti, K.C. Nerusu, N. Bhagavathula, S. Kang, G.J. Fisher, J. Varani, and J.J. Voorhees Matrix metalloproteinase-1 is the major collagenolytic enzyme responsible for collagen damage in UV-irradiated human skin Photochem. Photobiol. 78 2003 43 48
23. M. Broemer, D. Krappmann, and C. Scheiderheit Requirement of Hsp90 activity for IκB kinase, IKK, biosynthesis and for constitutive and inducible IKK and NFκB activation Oncogene 23 2004 5378 5386
24. C.S. Brower, S. Sato, C. Tomomori-Sato, T. Kamura, A. Pause, R. Stearman, R.D. Klausner, S. Malik, W.S. Lane, I. Sorokina, R.G. Roeder, J.W. Conaway, and R.C. Conaway Mammalian mediator subunit mMED8 is an elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase Proc. Natl. Acad. Sci. U.S.A. 99 2002 10353 10358
25. A.L. Bulteau, I. Petropoulos, and B. Friguet Age-related alterations of proteasome structure and function in aging epidermis Exp. Gerontol. 35 2000 767 777
26. A.L. Bulteau, M. Moreau, C. Nizard, and B. Friguet Impairment of proteasome function upon UVA- and UVB-irradiation of human keratinocytes Free Radic. Biol. Med. 32 2002 1157 1170
27. A.M. Burger, and A.K. Seth The ubiquitin-mediated degradation in cancer: therapeutic implications Eur. J. Cancer 40 2004 2217 2229
28. J. Campisi From cells to organisms: what can we learn about aging from cells in cultures? Exp. Gerontol. 36 2001 607 618
29. J. Campisi Cellular senescence as a tumor-suppressor mechanism Trends Cell Biol. 11 2001 S27 S31
30. G. Carrard, A.L. Bulteau, I. Petropoulos, and B. Friguet Impairment of proteasome structure and function in aging Int. J. Biochem. Cell Biol. 34 2002 1461 1474
31. G. Carrard, M. Dieu, M. Raes, O. Toussaint, and B. Friguet Impact of ageing on proteasome structure and function in human lymphocytes Int. J. Biochem. Cell Biol. 35 2003 728 739
32. L. Chen, U. Shinde, T.G. Ortolan, and K. Madura Ubiquitin-associated, UBA, domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly EMBO Rep. 2 2001 933 938
33. L. Chen, and K. Madura Rad23 promotes the targeting of proteolytic substrates to the proteasome Mol. Cell. Biol. 22 2002 4902 4913
34. N. Chondrogianni, I. Petropoulos, C. Franceschi, B. Friguet, and E.S. Gonos Fibroblast cultures from healthy centenarians have an active proteasome Exp. Gerontol. 35 2000 721 728
35. J.H. Chung, S. Kang, J. Varani, J. Lin, G.J. Fisher, and J.J. Voorhees Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin in vivo J. Invest. Dermatol. 115 2000 177 182
36. C.M. Chuong, B.J. Nickoloff, P.M. Elias, L.A. Goldsmith, E. Macher, P.A. Maderson, J.P. Sundberg, H. Tagami, P.M. Plonka, K. Thestrup-Pedersen, B.A. Bernard, J.M. Schröder, P. Dotto, C.H. Chang, M.L. Williams, K.R. Feingold, L.E. King, A.M. Kligman, J.L. Rees, and E. Christophers What is the 'true' function of skin? Exp. Dermatol. 11 2002 159 187
37. M. Conconi, I. Petropoulos, I. Emod, E. Turlin, F. Biville, and B. Friguet Protection from oxidative inactivation of the 20S proteasome by heat-shock protein 90 Biochem. J. 333 1998 407 415
38. O. Coux, K. Tanaka, and A.L. Goldberg Structure and functions of the 20S and 26S proteasomes Annu. Rev. Biochem. 65 1996 801 847
39. A. Dace, L. Zhao, K.S. Park, T. Furuno, N. Takamura, M. Nakanishi, B.L. West, J.A. Hanover, and S.Y. Cheng Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors Proc. Natl. Acad. Sci. U.S.A. 97 2000 8985 8990
40. X. Dai, K. Yamasaki, Y. Shirakata, K. Sayama, and K. Hashimoto All-trans-retinoic acid induces interleukin-8 via the nuclear factor-κB and p38 mitogen-activated protein kinase pathways in normal human keratinocytes J. Invest. Dermatol. 123 2004 1078 1085
41. D. Darr, and I. Fridovich Free radicals in cutaneous biology J. Invest. Dermatol. 102 1994 671 675
42. Q. Deng, R. Liao, B.L. Wu, and P. Sun High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts J. Biol. Chem. 279 2004 1050 1059
43. R. Derynck, R.J. Akhurst, and A. Balmain TGF-β signaling in tumor suppression and cancer progression Nat. Genet. 29 2001 117 129
44. Y. Devary, C. Rosette, J.A. DiDonato, and M. Karin NF-κB activation by ultraviolet light not dependent on nuclear signal Science 261 1996 1442 1445
45. G.P. Dimri, X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E.E. Medrano, M. Linskens, I. Rubelj, O. Pereira-Smith, M. Peacocke, and J. Campisi A novel biomarker identifies senescent human cells in culture and ageing skin in vivo Proc. Natl. Acad. Sci. U.S.A. 92 1995 9363 9367
46. L.A. Donehower Does p53 affect organismal ageing? J. Cell. Physiol. 192 2002 23 33
47. D. Dutaud, L. Aubry, L. Henry, D. Levieux, K.B. Hendil, L. Kuehn, J.P. Bureau, and A. Ouali Development and evaluation of a sandwich ELISA for quantification of the 20S proteasome in human plasma J. Immunol. Methods 260 2002 183 193
48. P.J. Elliot, T.M. Zollner, and W.H. Boehncke Prtoeasome inhibition: a new anti-inflammatory strategy J. Mol. Med. 81 2003 235 245
49. D. Engelberg, C. Klein, H. Martinetto, K. Struhl, and M. Karin The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals Cell 77 1994 381 390
50. C. Esser, S. Alberti, and J. Höhfeld Cooperation of molecular chaperones with the ubiquitin/proteasome system Biochim. Biophys. Acta 1695 2004 171 188
51. S. Fang, J.P. Jensen, R.L. Ludwig, K.H. Vousden, and A.M. Weissman Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 J. Biol. Chem. 275 2000 8945 8951
52. S. Fang, and A.M. Weissman A field guide to ubiquitylation Cell. Mol. Life Sci. 61 2004 1546 1561
53. 3 and retinoid X receptor function Am. J. Physiol. Endocrinol. Metab. 279 2000 E213 E220
54. G. Ferbeyre, E. de Stanchina, A.W. Lin, E. Querido, M.E. Mc Currach, G.J. Hannon, and S.W. Lowe Oncogenic ras and p53 cooperate to induce cellular senescence Mol. Cell. Biol. 22 2002 3497 3508
55. A. Ferdous, F. Gonzalez, L. Sun, T. Kodadek, and S.A. Johnston The 19S regulatory particle of the proteasome is required for efficient transcription elongation by RNA polynerase II Mol. Cells 7 2001 981 991
56. G.J. Fisher, and J.J. Voorhees Molecular mechanisms of photoaging and its prevention by retinoic acid: ultraviolet irradiation induces MAP kinase signal transduction cascades that induce Ap-1-regulated matrix metalloproteinases that degrade human skin in vivo J. Invest. Dermatol. Symp. Proc. 3 1998 61 68
57. G.J. Fisher, H.S. Talwar, J. Lin, P. Lin, F. McPhillips, Z.Q. Wang, X. Li, Y. Wan, S. Kang, and J.J. Voorhees Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo J. Clin. Invest. 101 1998 1432 1440
58. G.J. Fisher, M.D. Kang, J. Varani, Z. Bata-Csorgo, Y. Wan, S. Datta, and J.J. Voorhees Mechanisms of photoaging and chronological skin aging Arch. Dermatol. 138 2002 1462 1470
59. C.C. Franklin, and A.S. Kraft Conditional expression of the mitogen-activated protein kinase, MAPK, phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells J. Biol. Chem. 271 1997 3604 3607
60. B. Friguet, A.L. Bulteau, N. Chondrogianni, M. Conconi, and I. Petropoulos Protein degradation by the proteasome and its implications in aging Ann. N. Y. Acad. Sci. 908 2000 143 154
61. 2-induced senescence-like phenotype in human diploid fibroblasts Free Radic. Biol. Med. 33 2002 1334 1346
62. M. Gaczynska, K.L. Rock, T. Spies, and A.L. Goldberg Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7 Proc. Natl. Acad. Sci. USA 91 1994 9213 9217
63. Y. Gao, S. Lecker, M.J. Post, A.J. Hietaranta, J. Li, R. Volk, M. Li, K. Sato, A.K. Saluja, M.L. Steer, A.L. Goldberg, and M. Simons Inhibition of ubiquitin-proteasome pathway-mediated IκBα degradation by a naturally occurring antibacterial peptide J. Clin. Invest. 106 2000 439 448
64. M. Gao, T. Labuda, Y. Xia, E. Gallagher, D. Fang, Y.C. Liu, and M. Karin Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch Science 306 2004 271 275
65. M. Gianni, A. Bauer, E. Garattini, P. Chambon, and C. Rochette-Egly Phosphorylation by p38 MAPK and recruitment of SUG-1 are required for RA-induced RARγ degradation and transactivation EMBO J. 21 2002 3760 3769
66. C. Giardina, and A. Hubbard Growing old with nuclear factor-κB Cell Stress Chaperones 7 2002 207 212
67. B.A. Gilchrest In vitro assessment of keratinocyte ageing J. Invest. Dermatol. 81 1983 184s 189s
68. T.G. Gillette, F. Gonzalez, A. Delahodde, S.A. Johnston, and T. Kodadek Physical and functional association of RNA polymerase II and the proteasome Proc. Natl. Acad. Sci. U.S.A. 101 2004 5904 5909
69. S. Glockzin, F.X. Ogi, A. Hengstermann, M. Scheffner, and C. Blattner Involvement of the DNA repair protein hHR23 in p53 degradation Mol. Cell. Biol. 23 2003 8960 8969
70. A.L. Goldberg Protein degradation and protection against misfolded or damaged proteins Nature 426 2003 895 899
71. F. Gonzalez, A. Delahodde, T. Kodadek, and S.A. Johnston Recruitment of a 19S proteasome subcomplex to an activated promoter Science 296 2002 548 550
72. K. Gosselin, and C. Abbadie Involvement of a Rel/NF-κB transcription factors in senescence Exp. Gerontol. 38 2003 1271 1283
73. D. Goukassian, F. Gad, M. Yaar, M.S. Eller, U.S. Nehal, and B.A. Gilchrest Mechanisms and implications of the age-associated decrease in DNA repair capacity FASEB J. 14 2000 1325 1334
74. M.S. Greenblatt, W.P. Bennett, M. Hollstein, and C.C. Harris Mutations in the p53 tumor suppressor gene - clues to cancer etiology and molecular pathogenesis Cancer Res. 54 1994 4855 4878
75. G.L. Grove Age-related differences in the healing of superficial skin wounds in humans Arch. Dermatol. Res. 272 1982 381 385
76. T. Grune, T. Reinheckel, and K.J. Davies Degradation of oxidized proteins in mammalian cells FASEB J. 11 1997 526 534
77. Gutsmann-Conrad, A.R. Heydari, S. You, and A. Richardson The expression of heat shock protein 70 decreases with cellular senescence in vitro and in cells derived from young and old human subjects Exp. Cell Res. 241 1998 404 413
78. R. Haq, J.D. Brenton, M. Takahashi, D. Finan, A. Finkielsztein, S. Damaraju, R. Rottapel, and B. Zanke Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence Cancer Res. 62 2002 5076 5082
79. S. Hatakeyama, M. Matsumoto, M. Yada, and K.I. Nakayama Interaction of U-box-type ubiquitin-protein ligases (E3's) with molecular chaperones Genes Cells 9 2004 533 548
80. S. Hatakeyama, M. Watanabe, Y. Fujii, and K.I. Nakayama Targeted destruction of c-Myc by an engineered ubiquitin ligase suppresses cell transformation and tumor formation Cancer Res. 65 2005 7874 7879
81. S. Haupt, M. Berger, Z. Goldberg, and Y. Haupt Apoptosis - the p53 network J. Cell Sci. 116 2003 4077 4085
82. S. Hauser, G. Adelmant, P. Sarraf, H.M. Wright, E. Mueller, and B.M. Spiegelman Degradation of the peroxisome proliferator-activated receptor γ is linked to ligand-dependent activation J. Biol. Chem. 275 2000 18527 18533
83. R.T. Hay, L. Vuillard, J.M.P. Desterro, and M.S. Rodriguez Control of NF-κB transcriptional activation by signal induced proteolysis of IκBα Philos. Trans. R. Soc. Lond. B 354 1999 1601 1609
84. M. Helenius, M. Hanninen, S.K. Lehtinen, and A. Salminen Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB Biochem. J. 318 1996 603 608
85. A.R. Heydari, S. You, R. Takahashi, A. Gutsmann-Conrad, K.D. Sarge, and A. Richardson Age-related alterations in the activation of heat shock transcription factor 1 in rat hepatocytes Exp. Cell Res. 256 2000 83 93
86. C.C. Hsieh, and J. Papaconstantinou The effect of ageing on p38 signaling pathway activity in the mouse liver and the response to ROS generated by 3-nitropropionic acid Mech. Ageing Dev. 123 2002 1423 1435
87. C.C. Hsieh, J.I. Rosenblatt, and J. Papaconstantinou Age-associated changes in SAPK/JNK and p38 MAPK signaling in response to the generation of ROS by 3-nitropropionic acid Mech. Ageing Dev. 124 2003 733 746
88. J.M. Huibregtse, J.C. Yang, and S.L. Beaudenon The large subunit of RNA-polymerase II is a substrate of the Rsp 5 ubiquitin-protein ligase Proc. Natl. Acad. Sci. USA 94 1997 3656 3661
89. E. Hutter, H. Unterluggauer, F. Uberall, H. Schramek, and P. Jansen-Durr Replicative senescence of human fibroblasts: the role of Ras-dependent signaling and 0xidative stress Exp. Gerontol. 37 2002 1165 1174
90. H. Ichikawa, Y. Takada, A. Murukami, and B.B. Aggarwal Identification of a novel blocker of I{kappa}B{alpha} kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-{kappa}B-regulated gene products J. Immunol. 174 2005 7383 7392
91. J. Imai, M. Mruya, H. Yashiroda, I. Yahara, and K. Tanaka The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome EMBO J. 22 2003 3557 3567
92. M.O. Imhof, and D.P. McDonnell Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors Mol. Cell. Biol. 16 1996 2594 2605
93. A. Israël The IKK complex: an integrator of all signals that activate NF-κB? Trends Cell Biol. 10 2000 129 133
94. H. Iwasa, J. Han, and F. Ishikawa Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway Genes Cells 8 2003 131 144
95. P.K. Jackson, A.G. Eldridge, E. Freed, L. Furstenthal, J.Y. Hsu, B.K. Kaiser, and J.D.R. Reimann The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases Trends Cell Biol. 10 2000 429 439
96. C. Jantschitsch, and F. Trautinger Heat shock and UV-induced DNA damage and mutagenesis in skin Photochem. Photobiol. Sci. 2 2003 899 903
97. H. Kamata, S. Honda, S. Maeda, L. Chang, H. Hirata, and M. Karin Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases Cell 120 2005 649 661
98. Z. Kang, A. Pirskanen, O.A. Jänne, and J.J. Plvimo Involvement of proteasome in the dynamic assembly of the androgen receptor transcription complex J. Biol. Chem. 277 2002 48366 48371
99. J. Kanitakis Anatomy, histology and immunochemistry of normal human skin Eur. J. Dermatol. 12 2002 390 401
100. M. Karin Mitogen-activated protein kinase cascades as regulators of stress responses Ann. N. Y. Acad. Sci. 851 1998 139 146
101. M. Karin, and Y. Ben-Neriah Phosphorylation meets ubiquitination: the control of NF-κB activity Annu. Rev. Immunol. 18 2000 621 663
102. M. Karin, Y. Yumamoto, and Q.M. Wang The IKK NF-κB system: a treasure trove for drug development Nat. Rev. Drug Discov. 3 2004 17 26
103. P. Kavsak, R.K. Rasmussen, C.G. Causing, S. Bonni, H. Zhu, G.H. Thomsen, and J.L. Wrana Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF β receptor for degradation Mol. Cells 6 2000 1365 1375
104. S.M. Keyse Protein phosphatases and the regulation of mitogen-activated protein kinase signalling Curr. Opin. Cell. Biol. 12 2000 186 192
105. B.T. Kile, B.A. Schulman, W.S. Alexander, N.A. Nicola, H.M.E. Martin, and D.J. Hilton The SOCS box: a tale of destruction and degradation T. I. B. S. 27 2002 235 241
106. T. Kim, and T. Maniatis Regulation of interferon-γ-activated STAT1 by the ubiquitin-proteasome pathway Science 272 1996 1717 1719
107. S.Y. Kim, A. Herbst, K.A. Tworkowski, S.E. Salghetti, and W.P. Tansey Skp2 regulates Myc protein stability and activity Mol. Cells 11 2003 1177 1188
108. T. Kondo, M. Kobayashi, M. Tanaka, A. Yokoyama, S. Suzuki, N. Kato, M. Onozawa, K. Chiba, S. Hashimo, M. Imamura, Y. Minami, N. Minamino, and M. Asaka Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex J. Biol. Chem. 279 2004 27315 27319
109. F. Köntgen, R.J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlinton, and S. Gerondakis Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression Genes Dev. 9 1995 1965 1977
110. M.P. Kracklauer, and C. Schmidt At the crossroads of SUMO and NF-κB Mol. Cancer 2 2003 39
111. M. Kroll, F. Arenzana-Seisdedod, F. Bachelerie, D. Thomas, B. Friguet, and M. Conconi The secondary fungal metabolite gliotoxin targets proteolytic activities of the proteasome Chem. Biol. 6 1999 689 698
112. D. Kulms, and T. Schwarz 20 years after - milestones in molecular photobiology J. Invest. Dermatol. Symp. Proc. 7 2002 46 50
113. A. Kumar, Y. Takada, A.M. Boriek, and B.B. Aggarwal Nuclear factor-κB: its role in health and disease J. Mol. Med. 82 2004 434 448
114. J.D. Laney, and M. Hochstrasser Substrate targeting in the ubiquitin system Cell 97 1999 427 430
115. C.A. Lange, T. Shen, and K.B. Horwitz Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome Proc. Natl. Acad. Sci. U.S.A. 97 2000 1032 1037
116. C.K. Lee, R.G. Klopp, R. Weindruch, and T.A. Prolla Gene expression profile of ageing and its retardation by caloric restriction Science 285 1999 1390 1393
117. S. Legrand-Poels, S. Schoonbroodt, J.Y. Matroule, and J. Piette NF-κB: an important transcription factor in photobiology J. Photochem. Photobiol. 45 1998 1 8
118. R.L. Levine, and E.R. Stadtman Oxidative modification of proteins during aging Exp. Gerontol. 36 2001 1495 1502
119. D.E. Levy, and J.E. Darnell Jr. Stats: transcriptional control and biological impact Nat. Rev. Mol. Cell. Biol. 3 2002 651 662
120. N. Li, and M. Karin Is NF-κB the sensor of oxidative stress? FASEB J. 13 1999 1137 1143
121. I.K. Lim, H. Won Hong, I.H. Kwak, G. Yoon, and S.C. Park Cytoplasmic retention of p-Erk 1/2 and nuclear accumulation of actin proteins during cellular senescence in human diploid fibroblasts Mech. Ageing Dev. 119 2000 113 130
122. A.W. Lin, and S.W. Lowe Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation Proc. Natl. Acad. Sci. U.S.A. 98 2001 5025 5030
123. Y. Liu, K.Z. Guyton, M. Gorospe, Q. Xu, G.C. Kokkonen, Y.D. Mock, G.S. Roth, and N.J. Holbrook Age-related decline in mitogen-activated protein kinase activity in epidermal growth factor-stimulated rat hepatocytes J. Biol. Chem. 271 1996 3604 3607
124. R.S. Lo, and J. Massagué Ubiquitin-dependent degradation of TGF-β-activated Smad2 Nat. Cell Biol. 1 1999 472 478
125. D.B. Lombard, K.F. Chua, R. Mostoslavsky, S. Franco, M. Gostissa, and F.W. Alt DNA repair, genome stability, and aging Cell 120 2005 497 512
126. L. Lommel, L. Chen, K. Madura, and K. Sweder The 26S proteasome negatively regulates the level of overall genomic nucleotide excision repair Nucleic Acids Res. 28 2000 4839 4845
127. L. Lommel, T. Ortolan, L. Chen, K. Madura, and K.S. Sweder Proteolysis of a nucleotide excision repair protein by the the 26S proteasome Curr. Genet. 42 2002 9 20
128. D.M. Lonard, Z. Nawaz, C.L. Smith, and B.W. O'Malley The 26S proteasome is required for estrogen receptor-α and coactivator turnover and for efficient estrogen receptor-α transactivation Mol. Cells 5 2000 939 948
129. Z. Lu, X. Shuichan, C. Joazeiro, M.H. Cobb, and T. Hunter The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2 Mol. Cells 9 2002 945 956
130. D.H. Ly, D.J. Lockhart, R.A. Lerner, and P. Schultz Mitotic misregulation and human ageing Science 287 2000 2486 2492
131. R.T. Lum, S.S. Kerwar, S.M. Meyer, M.G. Nelson, S.R. Schow, D. Shiffman, M.M. Wick, and A. Joly A new structural class of proteasome inhibitors that prevent NF-κB activation Biochem. Pharmacol. 55 1998 1391 1397
132. Z. Luo, J. Zheng, Y. Lu, and D.B. Bregman Ultraviolet radiation alters the phosphorylation of RNA polymerase II large subunit and accelerates its proteasome-dependent degradation Mutat. Res. 486 2001 259 274
133. K. Madison Barrier function of the skin: "la raison d'être" of the epidermis J. Invest. Dermatol. 121 2003 231 241
134. M. Magnani, R. Crinelli, M. Bianchi, and A. Antonelli The ubiquitin-dependent proteolytic system and other potential targets for the modulation of nuclear factor-κB, NF-κB Curr. Drug Targets 1 2000 387 399
135. J. Massagué How cells read TGF-β signals Nat. Rev. Mol. Cell. Biol. 1 2000 169 178
136. J. Massagué, S.W. Blain, and R.S. Lo TGF-β signaling in growth control, cancer, and herritable disorders Cell 103 2000 295 309
137. K. Masuda, H. Shima, M. Watanabe, and K. Kikuchi MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein J. Biol. Chem. 276 2001 39002 39011
138. H. Masuyama, and P.N. MacDonald Proteasome-mediated degradation of the vitamin D receptor, VDR, and a putative role for SUG1 interaction with the AF-2 domain of VDR J. Cell. Biochem. 71 1998 429 440
139. H. McDonough, and C. Patterson CHIP: a link between the chaperone and proteasome systems Cell Stress Chaperones 8 2003 303 308
140. P. Mieczkowski, W. Dajewski, A. Podlaska, A. Skoneczna, Z. Ciesla, and E. Sledziewska-Gojska Expression of UMP1 is inducible by DNA damage and required for resistance os S. cerevisiae to UV light Curr. Genet. 38 2000 53 59
141. A.J. Millis, M. Hoyle, H.M. McCue, and H. Martini Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts Exp. Cell. Res. 201 1992 373 379
142. A. Moustakas, S. Souchelnytskyi, and C.H. Heldin Smad regulation in TGF-β signal transduction J. Cell Sci. 114 2001 4359 4369
143. S. Müller, A. Ledl, and D. Schmidt SUMO: a regulator of gene expression and genome integrity Oncogene 23 2004 1998 2008
144. T. Muramatsu, M. Hatoko, H. Tada, T. Shirai, and T. Ohnishi Age-related decrease in the inductability of heat-shock protein 72 in normal human skin Br. J. Dermatol. 134 1996 1035 1038
145. A.M. Musti, M. Treier, and D. Bohmann Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases Science 275 1997 400 402
146. G. Nardai, P. Csermely, and C. Söti Chaperone function and chaperone overload in the aged. A preliminary analysis Exp. Gerontol. 37 2002 1257 1262
147. A.S. Nateri, L. Riera-Sans, C. Da Costa, and A. Behrens The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling Science 303 2004 1374 1378
148. Z. Nawaz, D.M. Lonard, A.P. Dennis, C.L. Smith, and B.W. O'Malley Proteasome-dependent degradation of the human estrogen receptor Proc. Natl. Acad. Sci. U.S.A. 96 1999 1858 1862
149. Z. Nawaz, and B.W. O'Malley Urban renewal in the nucleus: is protein turnover by proteasomes absolutely required for nuclear receptor-regulated transcription Mol. Endocrinol. 18 2004 493 499
150. B.J. Nickoloff, J.-Z. Qin, V. Chaturvedi, P. Bacon, J. Panella, and M.F. Denning Life and death signaling pathways contributing to skin cancer J. Invest. Dermatol. Symp. Proc. 7 2002 27 35
151. K. Okazaki, and N. Sagata The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells EMBO J. 14 1995 5048 5059
152. T.G. Ortolan, L. Chen, P. Tangaonkar, and K. Madura Rad23 stabilizes Rad4 from degradation by the Ub/proteasome pathway Nucleic Acids Res. 32 2004 6490 6500
153. H.L. Pahl, B. Krauss, K. Schulze-Osthoff, T. Decker, E.B.-M. Traenckner, M. Vogt, C. Myers, T. Parks, P. Warring, Mühlbacher, A.-P. Czernilovsky, and P.A. Baeuerle The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-κB J. Exp. Med. 183 1996 1829 1840
154. D.A. Parsell, and S. Lindquist The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins Annu. Rev. Genet. 27 1993 437 496
155. I. Petropoulos, M. Conconi, X. Wang, B. Hoenel, F. Brégé gère, Y. Milner, and B. Friguet Increase of oxidatively modified protein is associated with a decrease of proteasome activity and content in ageing epidermal cells J. Gerontol. A Biol. Sci. Med. Sci. 55 2000 B220 B227
156. B.K. Pilcher, M. Wang, X.J. Qin, W.C. Parks, R.M. Senior, and H.G. Welgus Role of matrix metalloproteinases and their inhibition in cutaneous wound healing and allergic contact hypersensitivity Ann. N. Y. Acad. Sci. 878 1999 12 24
157. + T lymphocyte subsets during ageing Exp. Gerontol. 37 2002 359 367
158. S. Ponnappan, G. Uken-Trebilcock, M. Lindquist, and U. Ponnappan Tyrosine phosphorylation-dependent activation of NFkappaB is compromised in T cells from the elderly Exp. Gerontol. 39 2004 559 566
159. B. Pöppelmann, K. Klimmek, E. Strozyk, R. Voss, T. Schwarz, and D. Kulms NFκB-dependent down-regulation of tumor necrosis factor receptor-associated proteins contributes to interleukin-1-mediated enhancement of ultraviolet B-induced apoptosis J. Biol. Chem. 280 2005 15635 15643
160. T.R. Pray, F. Parlati, J. Huang, B.R. Wong, D.G. Payan, M.K. Bennett, S.D. Issakani, S. Molineaux, and S. Demo Cell cycle regulatory E3 ubiquitin ligases as anticancer targets Drug Resist. Updat. 5 2002 249 258
161. J.Z. Qin, V. Chaturvedi, M.F. Denning, D. Choubey, M.O. Diaz, and B.J. Nickoloff Role of NFκB in the apoptotic-resistant phenotype of keratinocytes J. Biol. Chem. 274 1999 37957 37964
162. C. Rachez, and L.P. Freedman Mediator complexes and transcription Curr. Opin. Cell Biol. 13 2001 274 280
163. R. Ravi, and A. Bedi NF-κB in cancer - a friend turned foe Drug Resist. Updat. 7 2004 53 67
164. K. Riabowol, J. Schiff, and M.Z. Gilman Transcription factor AP-1 activity is required for initiation of DNA synthesis and lost during cellular ageing Proc. Natl. Acad. Sci. U.S.A. 89 1992 157 161
165. L. Rittié, and G.J. Fisher UV-light-induced signal cascades and skin aging Ageing Res. Rev. 1 2002 705 720
166. D.M. Rubin, O. Coux, I. Wefes, C. Hengartner, R.A. Young, A.L. Goldberg, and D. Finley Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome Nature 379 1996 655 657
167. S.J. Russell, S.H. Reed, W. Huang, E.C. Friedberg, and S.A. Johnston The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair Mol. Cells 3 1999 687 695
168. K.M. Sakamoto, K.B. Kim, A. Kumagai, F. Mercurio, C.M. Crews, and R.J. Deshaies Protacs: chimeric molecules that target proteins to the Skp1-cullin-F box complex for ubiquitination and degradation Proc. Natl. Acad. Sci. U.S.A. 98 2001 8554 8559
169. K.M. Sakamoto, K.B. Kim, R. Vermas, A. Ransick, B. Stein, C.M. Crew, and R.J. Deshaies Development of protacs to target cancer-promoting proteins for ubiquitination and degradation Mol. Cell. Proteomics 2 2003 1350 1358
170. S.E. Salghetti, M. Muratani, H. Wijnen, B. Futcher, and W.P. Tansey Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis Proc. Natl. Acad. Sci. U.S.A. 97 2000 3118 3123
171. S.E. Salghetti, A.A. Caudy, J.G. Chenoweth, and W.P. Tansey Regulation of transcritional activation domain function by ubiquitin Science 293 2001 1651 1653
172. S.E. Salghetti, S.Y. Kim, and W.P. Tansey Destruction of ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc EMBO J. 18 2003 717 726
173. C. Schauber, L. Chen, P. Tongaonkar, I. Vega, D. Lambertson, W. Potts, and K. Madura Rad23 links DNA repair to the ubiquitin/proteasome pathway Nature 391 1998 715 718
174. M. Schmidt-Supprian, W. Bloch, G. Courtois, K. Addicks, A. Israel, K. Rajewsky, and M. Pasparakis NEMO/IKK γ-deficient mice model incontinentia pigmenti Mol. Cells 5 2000 981 992
175. J.S. Schneekloth Jr., F.N. Fonseca, M. Koldobskiy, A. Mandal, R. Deshaies, K. Sakamoto, and C.M. Crews Chemical genetic control of protein
176. S. Schoonbroodt, V. Ferreira, M. Best-Belpomme, J.R. Boelaert, S. Legrand-Poels, M. Korner, and J. Piette Crucial role of amino-terminal tyrosine residue 42 and carboxyl-terminal PEST domain of IκBα in NFκB activation by an oxidative stress J. Immunol. 164 2000 4292 4300
177. C.S. Seitz, Q. Lin, H. Deng, and P.A. Khavari Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB Proc. Natl. Acad. Sci. U.S.A. 95 1998 2307 2312
178. E. Shaulian, and M. Karin AP-1 as a regulator of cell life and death Nat. Cell Biol. 4 2002 E131 E136
179. T. Shibatani, M. Nazir, and W.F. Ward Alterations of rat liver 20S proteasome activities by age and food restriction J. Gerontol. Biol. Sci. 51 1996 316 322
180. M.M. Simon, Y. Aragane, A. Schwarz, T.A. Luger, and T. Schwarz UVB light induces nuclear factor kappa B (NF kappa B) activity independently from chromosomal DNA damage in cell-free cytosolic extracts J. Invest. Dermatol. 102 1994 422 427
181. N. Sitte, M. Huber, T. Grune, A. Ladhoff, W.D. Doecke, T. Von Zglinicki, and K.J. Davies Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts FASEB J. 14 2000 1490 1498
182. N. Sitte, K. Merker, T. Von Zglinicki, T. Grune, and K.J. Davies Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I - effects of proliferative senescence FASEB J. 14 2000 2495 2502
183. C. Söti, and P. Csermely Aging and molecular chaperones Exp. Gerontol. 38 2003 1037 1040
184. A.S. Sreedhar, C. Söti, and P. Csermely Inhibition of Hsp90: a new strategy for inhibiting protein kinases Biochem. Biophys. Acta 1697 2004 233 242
185. A. Stolzing, and T. Grune The proteasome and its function in the ageing process Clin. Exp. Dermatol. 26 2001 566 572
186. S.L. Stroschein, J.L. Bonni, J.L. Wrana, and K. Luo Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN Genes Dev. 15 2001 2822 2836
187. G.J. Strous, and P. van Kerkhof Ubiquitin system-dependent regulation of growth hormone receptor signal transduction Curr. Top. Microbiol. Immunol. 286 2004 81 118
188. Y. Suh Cell signaling in aging and apoptosis Mech. Ageing Dev. 123 2002 881 890
189. C. Sunderkotter, H. Kalden, and T.A. Luger Aging and the skin immune system Arch. Dermatol. 133 1997 1256 1262
190. K. Sweder, and K. Madura Regulation of repair by the 26S proteasome J. Biomed. Biotech. 2 2002 94 105
191. D.C. Swinney, Y.-Z. Xu, L.E. Scarafia, I. Lee, A.Y. Mak, Q.-F. Gan, C.S. Ramesha, M.A. Mulkins, J. Dunn, O.-Y. So, T. Biegel, M. Dinh, P. Volkel, J. Barnett, S.A. Dalrymple, S. Lee, and M. Huber A small molecule ubiquitination inhibitor blocks NF-κB-dependent cytokine expression in cells and rats J. Biol. Chem. 277 2002 23573 23581
192. P.A. Szweda, M. Camouse, K.C. Lundberg, T.D. Oberley, and L.I. Szweda Aging, lipofuscin formation, and free radical-mediated inhibition of cellular proteolytic systems Ageing Res. Rev. 2 2003 383 405
193. Y. Takada, Y. Kobayashi, and B.B. Aggarwal Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IKappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion J. Biol. Chem. 280 2005 17203 17212
194. K. Tanaka, T. Kawakami, K. Tateishi, H. Yashiroda, and T. Chiba Control of IκB-α proteolysis by the ubiquitin-proteasome pathway Biochimie 83 2001 351 356
195. P. Ten Dijke, M.J. Goumans, F. Itoh, and S. Itoh Regulation of cell proliferation by Smad proteins J. Cell. Physiol. 191 2002 1 16
196. C. Torres, M.K. Francis, A. Lorenzini, M. Tresini, and V.J. Cristofalo Metabolic stabilization of MAP kinase phosphatase-2 in senescence of human fibroblasts Exp. Cell Res. 290 2003 195 206
197. F. Trautinger Mechanisms of photodamage of the skin and its functional consequences for skin ageing Clin. Exp. Dermatol. 26 2001 573 577
198. Ha Oncogene 19 2000 1698 1709
199. N. Van der Lehr, S. Johansson, and L.G. Larsson Implication of the ubiquitin/proteasome system in Myc-regulated transcription Cell Cycle 2 2003 403 407
200. T. Van Laar, A.J. Van der Eb, and C. Terleth A role for Rad23 proteins in 26S proteasome-dependent protein degradation? Mutat. Res. 499 2002 53 61
201. J. Varani, G.J. Fisher, S. Kang, and J.J. Voorhees Molecular mechanisms of intrinsic skin aging and retinoid-induced repair and reversal J. Invest. Dermatol. Symp. Proc. 3 1998 57 60
202. L.T. Vassilev, B.T. Vu, B. Graves, D. Carvajal, F. Podlaski, Z. Filipovic, N. Kong, U. Kammlott, C. Lukacs, C. Klein, N. Fotouhi, and E. Liu In vivo activation of the p53 pathway by small molecule antagonists of MDM2 Science 303 2004 844 848
203. D. Voges, P. Zwickl, and W. Baumeister The 26S proteasome: a molecular machine designed for controlled proteolysis Annu. Rev. Biochem. 68 1999 1015 1068
204. J. Yun, and W.H. Lee Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd 45 upon DNA damage Mol. Cell. Biol. 23 2003 7305 7414
205. B.J. Wagner, and J.W. Margolis Age-dependent association of isolated bovine lens multicatalytic proteinase complex, proteasome, with heat-shock protein 90, an endogenous inhibitor Arch. Biochem. Biophys. 323 1995 455 462
206. C. Wahl, S. Liptay, G. Adler, and R.M. Schmid Sulfasalazine: a potent and specific inhibitor of Nclear Factor Kappa B J. Clin. Invest. 101 1998 1163 1174
207. A.D. Wallace, and J.A. Cidlowski Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids J. Biol. Chem. 276 2001 42714 42721
208. Y. Wan, M.W. Liu, and M.W. Kirschner The anaphase-promoting complex mediates TGF-β signaling by targeting SnoN for destruction Mol. Cells 8 2001 1027 1039
209. G. Weeda, M. Rossignol, R.A. Fraser, G.S. Winkler, W. Vermeulen, L.J. van't Veer, L. Ma, J.H.J. Hoeijmakers, and J.M. Egly The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor Nucleic Acids Res. 25 1997 2274 2283
210. J.B. Weitzman, L. Fiette, K. Matsuo, and M. Yaniv JunD protects cells from p53-dependent senescence and apoptosis Mol. Cells 6 2000 1109 1119
211. M.D. West The cellular and molecular biology of skin aging Arch. Dermatol. 130 1994 87 95
212. S. Wickner, M.R. Maurizi, and S. Gottesman Posttranslational quality control: folding, refolding, and degrading proteins Science 286 1999 1888 1893
213. C. Wójcik Proteasomes in apoptosis: villains or guardians? Cell. Mol. Life Sci. 56 1999 908 917
214. S. Wormald, and D.J. Hilton Inhibitors of cytokine signal transduction J. Biol. Chem. 279 2004 821 824
215. A. Mehra, and J.L. Wrana TGF-beta and the Smad signal transduction pathway Biochem. Cell. Biol. 80 2002 605 622
216. J. Wu On the role of proteasomes in cell biology and proteasome inhibition as a novel frontier in the development of immunosuppressants Am. J. Transplant. 2 2002 904 912
217. G.S. Wu The functional interactions between the p53 and MAPK signaling pathways Cancer Biol. Ther. 3 2004 156 161
218. A.B. Wysocki Skin anatomy, physiology, pathophysiology Nurs. Clin. North Am. 34 1999 777 797
219. M. Yaar, and B.A. Gilchrest Ageing and photoageing of keratinocytes and melanocytes Clin. Exp. Dermatol. 26 2001 583 591
220. Y. Yamamoto, and R.B. Gaynor Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer J. Clin. Invest. 107 2001 135 142
221. Y. Yamamoto, and R.B. Gaynor IκB kinases: key regulators of the NF-κB pathway Trends Biochem. Sci. 29 2004 72 79
222. S.H. Yang, E. Jaffray, B. Senthinathan, R.T. Hay, and A.D. Sharrocks SUMO and transcriptional repression - dynamic interactions between the MAP kinase and SUMO pathways Cell Cycle 2 2003 528 530
223. Y. Yang, C.C. Li, and A.M. Weissman Regulating the p53 system through ubiquitination Oncogene 23 2004 2096 2106
224. A. Yaron, H. Gonen, I. Alkalay, A. Hatzubai, S. Jung, S. Beyth, F. Mercurio, A.M. Manning, A. Ciechanover, and Y. Ben-Neriah Inhibition of NF-κB cellular function via specific targeting of the IκB-ubiquitin ligase EMBO J. 16 1997 6486 6494
225. A. Yaron, A. Hatzubai, M. Davis, I. Lavon, S. Amit, A.M. Manning, J.S. Andersen, M. Mann, F. Mercurio, and Y. Ben-Neriah Identifiaction of the receptor component of the IκB-ubiquitin ligase Nature 396 1998 590 594
226. M.J. Yin, Y. Yamamoto, and R.B. Gaynor The anti-inflammatory agents aspirin and salicylate inhibit the activity of I, kappa, B kinase-beta Nature 396 1998 77 80
227. J.C. Young, I. Moarefi, and F.U. Hartl Hsp90: a specialized but essential protein-folding tool J. Cell Biol. 154 2001 267 273
228. Y. Zhang, C. Chang, D.J. Gehling, A. Hemmati-Brivaniou, and R. Derynck Regulation of Smad degradation and activity by Smurf2, an ubiquitin ligase Proc. Natl. Acad. Sci. U.S.A. 98 2001 974 979
229. H. Zhang, and F. Burrows Targeting multiple signal transduction pathways through inhibition of Hsp90 J. Mol. Med. 82 2004 488 499
230. D. Zhang, S.H. Baek, A. Ho, H. Lee, Y.S. Jeong, and K. Kim Targeted degradation of proteins by small molecules: a novel tool for functional proteomics Comb. Chem. High Throughput Screen 7 2004 689 697
231. J. Zhu, M. Gianni, E. Kopf, N. Honoré, M. Chelbi-Alix, M. Koken, F. Quignon, C. Rochette-Egly, and H. de Thé Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor α, RARα, and oncogenic RARα fusion proteins Proc. Natl. Acad. Sci. U.S.A. 96 1999 14807 14812
232. H. Zhu, P. Kavsak, S. Abdollah, J. Wrana, and G.H. Thomsen A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation Nature 400 1999 687 693
233. T.M. Zollner, M. Podda, C. Pien, P.J. Elliot, R. Kaufman, and W.-H. Boehncke Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model J. Clin. Invest. 109 2002 671 679