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Volumn 4, Issue 8, 2012, Pages 525-534

Caloric restriction: Is mammalian life extension linked to p53?

Author keywords

Aging; Apoptosis; Caloric restriction; Cell cycle; Cell death; P53; Senescence

Indexed keywords


EID: 84868023147     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100481     Document Type: Review
Times cited : (58)

References (180)
  • 1
    • 0034033586 scopus 로고    scopus 로고
    • Caloric restriction and aging: an update
    • Masoro EJ. Caloric restriction and aging: an update. Exp. Gerontol. 2009; 35:299-305.
    • (2009) Exp. Gerontol. , vol.35 , pp. 299-305
    • Masoro, E.J.1
  • 2
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 1996; 273:59-63.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 3
    • 66749126389 scopus 로고    scopus 로고
    • Antioxidant defense and aging in C. elegans
    • Gems D, Doonan R. Antioxidant defense and aging in C. elegans. Cell Cycle. 2009; 8:1681-1687.
    • (2009) Cell Cycle , vol.8 , pp. 1681-1687
    • Gems, D.1    Doonan, R.2
  • 4
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition
    • Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle 2006; 5:2087-2102.
    • (2006) Cell Cycle , vol.5 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 6
    • 67549084381 scopus 로고    scopus 로고
    • Superoxide is the major reactive oxygen species regulating autophagy
    • Chen Y, Azad MB, Gibson SB. Superoxide is the major reactive oxygen species regulating autophagy. Cell Death Differ. 2009; 16:1040-1052.
    • (2009) Cell Death Differ , vol.16 , pp. 1040-1052
    • Chen, Y.1    Azad, M.B.2    Gibson, S.B.3
  • 7
    • 57749095081 scopus 로고    scopus 로고
    • Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
    • Doonan R, McElwee JJ, Matthijssens F, Walker GA, Houthoofd K, Back P, et al. Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Genes Dev. 2008; 22:3236-3241.
    • (2008) Genes Dev , vol.22 , pp. 3236-3241
    • Doonan, R.1    McElwee, J.J.2    Matthijssens, F.3    Walker, G.A.4    Houthoofd, K.5    Back, P.6
  • 8
    • 50649099122 scopus 로고    scopus 로고
    • Aging and survival: the genetics of life span extension by dietary restriction
    • Mair W, Dillin A. Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem. 2008; 77:727-754.
    • (2008) Annu Rev Biochem , vol.77 , pp. 727-754
    • Mair, W.1    Dillin, A.2
  • 9
    • 77955899773 scopus 로고    scopus 로고
    • Comparative transcriptional profiling identifies takeout as a gene that regulates life span
    • Bauer J et al. Comparative transcriptional profiling identifies takeout as a gene that regulates life span. Aging. 2010; 2:298-310.
    • (2010) Aging , vol.2 , pp. 298-310
    • Bauer, J.1
  • 12
    • 79958729836 scopus 로고    scopus 로고
    • Glucocorticoids induce long-lasting effects in neural stem cells resulting in senescence-related alterations
    • Bose R, Moors M, Tofighi R, Cascante A, Hermanson O, Ceccatelli S. Glucocorticoids induce long-lasting effects in neural stem cells resulting in senescence-related alterations. Cell Death Dis. 2010; 1:e92.
    • (2010) Cell Death Dis , vol.1
    • Bose, R.1    Moors, M.2    Tofighi, R.3    Cascante, A.4    Hermanson, O.5    Ceccatelli, S.6
  • 13
    • 77955463146 scopus 로고    scopus 로고
    • Nutrient regulation of mTORC1 and cell growth
    • Yan L, Mieulet V, Lamb RF. Nutrient regulation of mTORC1 and cell growth. Cell Cycle. 2010; 9:13, 2473-2474.
    • (2010) Cell Cycle , vol.9 , Issue.13 , pp. 2473-2474
    • Yan, L.1    Mieulet, V.2    Lamb, R.F.3
  • 14
    • 80055015834 scopus 로고    scopus 로고
    • βA3/A1-Crystallin controls anoikis-mediated cell death in astrocytes by modulating PI3K/AKT/mTOR and ERK survival pathways through the PKD/Bit1-signaling axis
    • Ma B, Sen T, Asnaghi L, Valapala M, Yang F, Hose S, McLeod DS, Lu Y, Eberhart C, Zigler JS Jr, Sinha D. βA3/A1-Crystallin controls anoikis-mediated cell death in astrocytes by modulating PI3K/AKT/mTOR and ERK survival pathways through the PKD/Bit1-signaling axis. Cell Death Dis 2011; 2:e217.
    • (2011) Cell Death Dis , vol.2
    • Ma, B.1    Sen, T.2    Asnaghi, L.3    Valapala, M.4    Yang, F.5    Hose, S.6    McLeod, D.S.7    Lu, Y.8    Eberhart, C.9    Zigler Jr, J.S.10    Sinha, D.11
  • 15
    • 79952662483 scopus 로고    scopus 로고
    • The integral role of mTOR in lipid metabolism
    • Soliman GA. The integral role of mTOR in lipid metabolism. Cell Cycle 2011; 10:861-862
    • (2011) Cell Cycle , vol.10 , pp. 861-862
    • Soliman, G.A.1
  • 16
    • 79953650247 scopus 로고    scopus 로고
    • mTOR upregulation of glycolytic enzymes promotes tumor development
    • Zha X, Sun Q, Zhang H. mTOR upregulation of glycolytic enzymes promotes tumor development. Cell Cycle 2011; 10:1015-1016.
    • (2011) Cell Cycle , vol.10 , pp. 1015-1016
    • Zha, X.1    Sun, Q.2    Zhang, H.3
  • 17
    • 79957904163 scopus 로고    scopus 로고
    • Nutrient amino acids signal to mTOR via inositol polyphosphate multikinase
    • Kim S, Snyder SH. Nutrient amino acids signal to mTOR via inositol polyphosphate multikinase. Cell Cycle 2011; 10:1708-10.
    • (2011) Cell Cycle , vol.10 , pp. 1708-1710
    • Kim, S.1    Snyder, S.H.2
  • 18
    • 79959191028 scopus 로고    scopus 로고
    • mTOR signaling in protein homeostasis: Less is more?
    • Conn CS, Qian SB. mTOR signaling in protein homeostasis: Less is more? Cell Cycle 2011; 10:1940-1947.
    • (2011) Cell Cycle , vol.10 , pp. 1940-1947
    • Conn, C.S.1    Qian, S.B.2
  • 19
    • 79960470913 scopus 로고    scopus 로고
    • mTOR complex 2 signaling and functions
    • Won Jun Oh, Jacinto E. mTOR complex 2 signaling and functions. Cell Cycle 2011; 10:2305-2316.
    • (2011) Cell Cycle , vol.10 , pp. 2305-2316
    • Won Jun Oh1    Jacinto, E.2
  • 20
    • 79961099905 scopus 로고    scopus 로고
    • From growing to secreting: New roles for mTOR in aging cells
    • Pani G. From growing to secreting: New roles for mTOR in aging cells. Cell Cycle 2011; 10:2450-2453.
    • (2011) Cell Cycle , vol.10 , pp. 2450-2453
    • Pani, G.1
  • 24
    • 79958276489 scopus 로고    scopus 로고
    • GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy
    • Heidari N, Hicks MA, Harada H. GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy. Cell Death Dis. 2010; 1:e76.
    • (2010) Cell Death Dis , vol.1
    • Heidari, N.1    Hicks, M.A.2    Harada, H.3
  • 27
    • 79959964606 scopus 로고    scopus 로고
    • Apigenin-induced apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of heat-shock protein-27
    • Gonzalez-Mejia ME, Voss OH, Murnan EJ, Doseff AI. Apigenin-induced apoptosis of leukemia cells is mediated by a bimodal and differentially regulated residue-specific phosphorylation of heat-shock protein-27. Cell Death Dis. 2010; 1:e64.
    • (2010) Cell Death Dis , vol.1
    • Gonzalez-Mejia, M.E.1    Voss, O.H.2    Murnan, E.J.3    Doseff, A.I.4
  • 28
    • 79958753992 scopus 로고    scopus 로고
    • Phosphorylation of Puma modulates its apoptotic function by regulating protein stability
    • Fricker M, O'Prey J, Tolkovsky AM, Ryan KM. Phosphorylation of Puma modulates its apoptotic function by regulating protein stability. Cell Death Dis. 2010; 1:e59.
    • (2010) Cell Death Dis , vol.1
    • Fricker, M.1    O'Prey, J.2    Tolkovsky, A.M.3    Ryan, K.M.4
  • 29
    • 79953719297 scopus 로고    scopus 로고
    • A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy
    • Placzek WJ, Wei J, Kitada S, Zhai D, Reed JC, Pellecchia M. A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy. Cell Death Dis. 2010; 1:e40.
    • (2010) Cell Death Dis , vol.1
    • Placzek, W.J.1    Wei, J.2    Kitada, S.3    Zhai, D.4    Reed, J.C.5    Pellecchia, M.6
  • 31
    • 79960024550 scopus 로고    scopus 로고
    • Distinct roles for the cellular inhibitors of apoptosis proteins 1 and 2
    • Graber TE, Holcik M. Distinct roles for the cellular inhibitors of apoptosis proteins 1 and 2. Cell Death Dis 2011; 2:e135.
    • (2011) Cell Death Dis , vol.2
    • Graber, T.E.1    Holcik, M.2
  • 35
    • 80052337651 scopus 로고    scopus 로고
    • TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms
    • Rauert H, Stühmer T, Bargou R, Wajant H, Siegmund D. TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms. Cell Death Dis 2011; 2: e194.
    • (2011) Cell Death Dis , vol.2
    • Rauert, H.1    Stühmer, T.2    Bargou, R.3    Wajant, H.4    Siegmund, D.5
  • 37
    • 80053410025 scopus 로고    scopus 로고
    • Cell death in disease: from 2010 onwards
    • Knight RA, Melino G. Cell death in disease: from 2010 onwards. Cell Death Dis 2011; 2: e202.
    • (2011) Cell Death Dis , vol.2
    • Knight, R.A.1    Melino, G.2
  • 38
    • 80053418778 scopus 로고    scopus 로고
    • Essential requirement of cytochrome c release for caspase activation by procaspase-activating compound defined by cellular models
    • Seervi M, Joseph J, Sobhan PK, Bhavya B, Santhoshkumar TR. Essential requirement of cytochrome c release for caspase activation by procaspase-activating compound defined by cellular models. Cell Death Dis 2011; 2: e207.
    • (2011) Cell Death Dis , vol.2
    • Seervi, M.1    Joseph, J.2    Sobhan, P.K.3    Bhavya, B.4    Santhoshkumar, T.R.5
  • 43
    • 78650175369 scopus 로고    scopus 로고
    • zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC-MAPKs-AP-1 pathway
    • Wu Y, Tan H, Huang Q, Sun X, Zhu X, Shen H. zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC-MAPKs-AP-1 pathway. Cell Death Differ 2010; 18:26-37.
    • (2010) Cell Death Differ , vol.18 , pp. 26-37
    • Wu, Y.1    Tan, H.2    Huang, Q.3    Sun, X.4    Zhu, X.5    Shen, H.6
  • 44
    • 78650169392 scopus 로고    scopus 로고
    • Bcl-2 proteins regulate ER membrane permeability to luminal proteins during ER stressinduced apoptosis
    • Wang X, Olberding K, White C, Li C. Bcl-2 proteins regulate ER membrane permeability to luminal proteins during ER stressinduced apoptosis. Cell Death Differ 2010; 18: 38-47.
    • (2010) Cell Death Differ , vol.18 , pp. 38-47
    • Wang, X.1    Olberding, K.2    White, C.3    Li, C.4
  • 45
    • 78650170269 scopus 로고    scopus 로고
    • A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum
    • Lian J, Wu X, He F, Karnak D, Tang W, Meng Y, Xiang D, Ji M, Lawrence T, Xu L. A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. Cell Death Differ 2010; 18: 60-71.
    • (2010) Cell Death Differ , vol.18 , pp. 60-71
    • Lian, J.1    Wu, X.2    He, F.3    Karnak, D.4    Tang, W.5    Meng, Y.6    Xiang, D.7    Ji, M.8    Lawrence, T.9    Xu, L.10
  • 46
    • 79951681506 scopus 로고    scopus 로고
    • Peroxiredoxin 6 interferes with TRAIL-induced death-inducing signaling complex formation by binding to death effector domain caspase
    • Choi H, Chang J, Jung Y. Peroxiredoxin 6 interferes with TRAIL-induced death-inducing signaling complex formation by binding to death effector domain caspase. Cell Death Differ 2010; 18: 405-414.
    • (2010) Cell Death Differ , vol.18 , pp. 405-414
    • Choi, H.1    Chang, J.2    Jung, Y.3
  • 47
    • 79951670106 scopus 로고    scopus 로고
    • INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis
    • Niture S, Jaiswal A. INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis. Cell Death Differ 2010; 18: 439-451.
    • (2010) Cell Death Differ , vol.18 , pp. 439-451
    • Niture, S.1    Jaiswal, A.2
  • 52
    • 79954418914 scopus 로고    scopus 로고
    • Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways
    • Zhang L, Lopez H, George N, Liu X, Pang X, Luo X. Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways. Cell Death Differ 2010; 18: 864-873.
    • (2010) Cell Death Differ , vol.18 , pp. 864-873
    • Zhang, L.1    Lopez, H.2    George, N.3    Liu, X.4    Pang, X.5    Luo, X.6
  • 53
    • 79958797383 scopus 로고    scopus 로고
    • F-box protein 10, an NF-κB-dependent anti-apoptotic protein, regulates TRAILinduced apoptosis through modulating c-Fos/c-FLIP pathway
    • Ge R, Wang Z, Zeng Q, Xu X, Olumi AF. F-box protein 10, an NF-κB-dependent anti-apoptotic protein, regulates TRAILinduced apoptosis through modulating c-Fos/c-FLIP pathway. Cell Death Differ 2011; 18: 1184-1195.
    • (2011) Cell Death Differ , vol.18 , pp. 1184-1195
    • Ge, R.1    Wang, Z.2    Zeng, Q.3    Xu, X.4    Olumi, A.F.5
  • 54
    • 80053985362 scopus 로고    scopus 로고
    • Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death
    • Hui K, Kanungo A, Elia A, Henderson JT. Caspase-3 deficiency reveals a physiologic role for Smac/DIABLO in regulating programmed cell death. Cell Death Differ 2011; 18: 1780-1790.
    • (2011) Cell Death Differ , vol.18 , pp. 1780-1790
    • Hui, K.1    Kanungo, A.2    Elia, A.3    Henderson, J.T.4
  • 57
    • 79958710326 scopus 로고    scopus 로고
    • Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus
    • Engel T, Tanaka K, Jimenez-Mateos EM, Caballero-Caballero A, Prehn JH, Henshall DC. Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus. Cell Death Dis. 2010; 1:e79.
    • (2010) Cell Death Dis , vol.1
    • Engel, T.1    Tanaka, K.2    Jimenez-Mateos, E.M.3    Caballero-Caballero, A.4    Prehn, J.H.5    Henshall, D.C.6
  • 59
    • 79953066263 scopus 로고    scopus 로고
    • BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus
    • Bunk EC, König HG, Bernas T, Engel T, Henshall DC, Kirby BP, Prehn JH. BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus. Cell Death Dis. 2010; 1:e15.
    • (2010) Cell Death Dis , vol.1
    • Bunk, E.C.1    König, H.G.2    Bernas, T.3    Engel, T.4    Henshall, D.C.5    Kirby, B.P.6    Prehn, J.H.7
  • 60
    • 0028860580 scopus 로고
    • Death of cultured human neuroblastoma-cells induced by hiv-1 gp120 is prevented by nmda receptor antagonists and inhibitors of nitric-oxide and cyclooxygenase
    • Corasaniti MT, Melino G, Navarra M, et al. Death of cultured human neuroblastoma-cells induced by hiv-1 gp120 is prevented by nmda receptor antagonists and inhibitors of nitric-oxide and cyclooxygenase. Neurodegenaration. 1995; 3:315-321.
    • (1995) Neurodegenaration , vol.3 , pp. 315-321
    • Corasaniti, M.T.1    Melino, G.2    Navarra, M.3
  • 61
    • 0027716421 scopus 로고    scopus 로고
    • Lithium and tacrine increase the expression of nitric-oxide synthase messenger-RNA in the hippocampus of rat
    • Bagetta G, Corasaniti MT, Melino G, et al. Lithium and tacrine increase the expression of nitric-oxide synthase messenger-RNA in the hippocampus of rat. Biochem. and Biophys. Res. Comm. 1997; 3:1132-1139.
    • (1997) Biochem. and Biophys. Res. Comm. , vol.3 , pp. 1132-1139
    • Bagetta, G.1    Corasaniti, M.T.2    Melino, G.3
  • 63
    • 79959988740 scopus 로고    scopus 로고
    • Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis
    • Lim MP, Devi LA, Rozenfeld R. Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis. Cell Death Dis 2011; 2: e170.
    • (2011) Cell Death Dis , vol.2
    • Lim, M.P.1    Devi, L.A.2    Rozenfeld, R.3
  • 64
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature. 2001; 411:355-365.
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 69
    • 79959985637 scopus 로고    scopus 로고
    • Differential effects of the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, on Akt activation and apoptosis
    • Chu KM, Minogue S, Hsuan JJ, Waugh MG. Differential effects of the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, on Akt activation and apoptosis. Cell Death Dis. 2010; 1:e106.
    • (2010) Cell Death Dis , vol.1
    • Chu, K.M.1    Minogue, S.2    Hsuan, J.J.3    Waugh, M.G.4
  • 70
    • 77956176703 scopus 로고    scopus 로고
    • IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter
    • Mitchell G, Fillinger J, Sittadjody S, Avila J, Burd R, Limesand K. IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter. Cell Death Dis. 2010; 1:e50.
    • (2010) Cell Death Dis , vol.1
    • Mitchell, G.1    Fillinger, J.2    Sittadjody, S.3    Avila, J.4    Burd, R.5    Limesand, K.6
  • 71
    • 79958736832 scopus 로고    scopus 로고
    • Functional phosphoproteomic analysis reveals coldshock domain protein A to be a Bcr-Abl effector-regulating proliferation and transformation in chronic myeloid leukemia
    • Sears D, Luong P, Yuan M, Nteliopoulos G, Man YK, Melo JV, Basu S. Functional phosphoproteomic analysis reveals coldshock domain protein A to be a Bcr-Abl effector-regulating proliferation and transformation in chronic myeloid leukemia. Cell Death Dis. 2010; 1:e93.
    • (2010) Cell Death Dis , vol.1
    • Sears, D.1    Luong, P.2    Yuan, M.3    Nteliopoulos, G.4    Man, Y.K.5    Melo, J.V.6    Basu, S.7
  • 72
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 1997; 91:231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 73
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
    • Del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science. 1997; 278:687-689.
    • (1997) Science , vol.278 , pp. 687-689
    • Del Peso, L.1    Gonzalez-Garcia, M.2    Page, C.3    Herrera, R.4    Nunez, G.5
  • 74
    • 0035736487 scopus 로고    scopus 로고
    • HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
    • Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat. Cell Biol. 2001; 3:973-982.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 973-982
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Zou, Y.4    Spohn, B.5    Hung, M.C.6
  • 75
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 2002; 4:648-657.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 76
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter CJ, Pedraza LG, Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 2002; 4:658-665.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 78
    • 78650174233 scopus 로고    scopus 로고
    • The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis
    • Kang Y, Lu M, Guan K. The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis. Cell Death Differ 2010; 18: 133-144.
    • (2010) Cell Death Differ , vol.18 , pp. 133-144
    • Kang, Y.1    Lu, M.2    Guan, K.3
  • 79
    • 0034982971 scopus 로고    scopus 로고
    • TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
    • Gao X, Pan D. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes & Dev. 2001; 15:1383-1392.
    • (2001) Genes & Dev , vol.15 , pp. 1383-1392
    • Gao, X.1    Pan, D.2
  • 80
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki K, Li Y, Xu T, Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes & Dev. 2003; 17:1829-1834.
    • (2003) Genes & Dev , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 81
    • 0038141979 scopus 로고    scopus 로고
    • Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
    • Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat. Cell Biol. 2003; 5:578-581.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 578-581
    • Zhang, Y.1    Gao, X.2    Saucedo, L.J.3    Ru, B.4    Edgar, B.A.5    Pan, D.6
  • 82
    • 67349086051 scopus 로고    scopus 로고
    • A hierarchical cascade activated by non-canonical Notch signaling and the mTOR-Rictor complex regulates neglect-induced death in mammalian cells
    • Perumalsamy LR, Nagala M, Banerjee P, Sarin A. A hierarchical cascade activated by non-canonical Notch signaling and the mTOR-Rictor complex regulates neglect-induced death in mammalian cells. Cell Death Differ. 2009; 6:879-889.
    • (2009) Cell Death Differ , vol.6 , pp. 879-889
    • Perumalsamy, L.R.1    Nagala, M.2    Banerjee, P.3    Sarin, A.4
  • 83
    • 57649203344 scopus 로고    scopus 로고
    • Autophagy in aging, disease and death: the true identity of a cell death impostor
    • Levine B, Kroemer G. Autophagy in aging, disease and death: the true identity of a cell death impostor. Cell Death Differ. 2009; 16:1-2.
    • (2009) Cell Death Differ , vol.16 , pp. 1-2
    • Levine, B.1    Kroemer, G.2
  • 84
    • 58249098507 scopus 로고    scopus 로고
    • A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress
    • Huang Q, Wu YT, Tan HL, Ong CN, Shen HM. A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress. Cell Death Differ. 2009; 16: 264-277.
    • (2009) Cell Death Differ , vol.16 , pp. 264-277
    • Huang, Q.1    Wu, Y.T.2    Tan, H.L.3    Ong, C.N.4    Shen, H.M.5
  • 85
    • 57649227693 scopus 로고    scopus 로고
    • Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinpathies
    • Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinpathies. Cell Death Differ. 2009; 16:46-56.
    • (2009) Cell Death Differ , vol.16 , pp. 46-56
    • Sarkar, S.1    Ravikumar, B.2    Floto, R.A.3    Rubinsztein, D.C.4
  • 86
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003; 115: 577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 87
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N. Sonenberg N. Upstream and downstream of mTOR. Genes & Dev. 2004; 18:1926-1945.
    • (2004) Genes & Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 88
    • 78149475031 scopus 로고    scopus 로고
    • Activation of mTOR coincides with autophagy during ligation-induced atrophy in the rat submandibular gland
    • Silver N, Proctor GB, Arno M. Carpenter GH. Activation of mTOR coincides with autophagy during ligation-induced atrophy in the rat submandibular gland. Cell Death Dis. 2010; 1:e14.
    • (2010) Cell Death Dis , vol.1
    • Silver, N.1    Proctor, G.B.2    Arno, M.3    Carpenter, G.H.4
  • 89
    • 57649234905 scopus 로고    scopus 로고
    • Autophagy genes and ageing
    • Vellai T. Autophagy genes and ageing. Cell Death Differ. 2009; 16:94-102.
    • (2009) Cell Death Differ , vol.16 , pp. 94-102
    • Vellai, T.1
  • 90
    • 57649203344 scopus 로고    scopus 로고
    • Autophagy in aging, disease and death: the true identity of a cell death impostor
    • Levine B. Kroemer G. Autophagy in aging, disease and death: the true identity of a cell death impostor. Cell Death Differ. 2009; 16:1-2.
    • (2009) Cell Death Differ , vol.16 , pp. 1-2
    • Levine, B.1    Kroemer, G.2
  • 91
    • 67549142261 scopus 로고    scopus 로고
    • Life and death partners: apoptosis, autophagy and the cross-talk between them
    • Eisenberg-Lerner A, Bialik S, Simon HU. Kimchi A. Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ. 2009; 16:966-975.
    • (2009) Cell Death Differ , vol.16 , pp. 966-975
    • Eisenberg-Lerner, A.1    Bialik, S.2    Simon, H.U.3    Kimchi, A.4
  • 93
    • 67549132527 scopus 로고    scopus 로고
    • The late stages of autophagy: how does the end begin?
    • Noda T, Fujita N, Yoshimori T. The late stages of autophagy: how does the end begin? Cell Death Differ. 2009; 16:984-990.
    • (2009) Cell Death Differ , vol.16 , pp. 984-990
    • Noda, T.1    Fujita, N.2    Yoshimori, T.3
  • 94
    • 67549136248 scopus 로고    scopus 로고
    • Toward the understanding of autophagy regulation and its interplay with cell death pathways
    • Fimia GM, Piacentini M. Toward the understanding of autophagy regulation and its interplay with cell death pathways. Cell Death Differ. 2009; 16:933-934.
    • (2009) Cell Death Differ , vol.16 , pp. 933-934
    • Fimia, G.M.1    Piacentini, M.2
  • 95
    • 79960013681 scopus 로고    scopus 로고
    • The role of reactive oxygen species and autophagy in safingol-induced cell death
    • Ling L, Tan K, Lin H, Chiu G. The role of reactive oxygen species and autophagy in safingol-induced cell death. Cell Death Dis 2011; 2: e129.
    • (2011) Cell Death Dis , vol.2
    • Ling, L.1    Tan, K.2    Lin, H.3    Chiu, G.4
  • 100
    • 79952628267 scopus 로고    scopus 로고
    • The Beclin 1 network regulates autophagy and apoptosis
    • Kang R, Zeh HJ, Lotze MT, Tang D. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 2011; 18: 571-580.
    • (2011) Cell Death Differ , vol.18 , pp. 571-580
    • Kang, R.1    Zeh, H.J.2    Lotze, M.T.3    Tang, D.4
  • 101
    • 79955854666 scopus 로고    scopus 로고
    • Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis
    • Barth JMI, Szabad J, Hafen E, Köhler K. Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis. Cell Death Differ 2010; 18: 915-924.
    • (2010) Cell Death Differ , vol.18 , pp. 915-924
    • Barth, J.M.I.1    Szabad, J.2    Hafen, E.3    Köhler, K.4
  • 102
    • 79958809001 scopus 로고    scopus 로고
    • Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
    • Vara D, Salazar M, Olea-Herrero N, Guzmán M, Velasco G, Díaz-Laviada I. Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy. Cell Death Differ 2011; 18: 1099-1111.
    • (2011) Cell Death Differ , vol.18 , pp. 1099-1111
    • Vara, D.1    Salazar, M.2    Olea-Herrero, N.3    Guzmán, M.4    Velasco, G.5    Díaz-Laviada, I.6
  • 104
    • 80051752834 scopus 로고    scopus 로고
    • Essential amino acids and glutamine regulate induction of mitochondrial elongation during autophagy
    • Gomes LC, Di Benedetto G, Scorrano L. Essential amino acids and glutamine regulate induction of mitochondrial elongation during autophagy. Cell Cycle 2011; 10: 2635-2639.
    • (2011) Cell Cycle , vol.10 , pp. 2635-2639
    • Gomes, L.C.1    Di Benedetto, G.2    Scorrano, L.3
  • 105
    • 80052415530 scopus 로고    scopus 로고
    • Coordinated epigenetic regulation of autophagy and apoptosis
    • Boehrer S, Lainey E, Kroemer G. Coordinated epigenetic regulation of autophagy and apoptosis. Cell Cycle 2011; 10: 2832-3.
    • (2011) Cell Cycle , vol.10 , pp. 2832-2833
    • Boehrer, S.1    Lainey, E.2    Kroemer, G.3
  • 108
    • 79959968916 scopus 로고    scopus 로고
    • The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress
    • Deng L, Feng J, Broaddus RR. The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress. Cell Death Dis. 2010; e32.
    • (2010) Cell Death Dis
    • Deng, L.1    Feng, J.2    Broaddus, R.R.3
  • 109
    • 79958266013 scopus 로고    scopus 로고
    • Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells
    • Bennett HL, Fleming JT, O'Prey J, Ryan KM, Leung HY. Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells. Cell Death Dis. 2010; 1:e72.
    • (2010) Cell Death Dis , vol.1
    • Bennett, H.L.1    Fleming, J.T.2    O'Prey, J.3    Ryan, K.M.4    Leung, H.Y.5
  • 111
    • 79958276489 scopus 로고    scopus 로고
    • GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy
    • Heidari N, Hicks MA, Harada H. GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy. Cell Death Dis. 2010; 1:e76.
    • (2010) Cell Death Dis , vol.1
    • Heidari, N.1    Hicks, M.A.2    Harada, H.3
  • 116
    • 78349308821 scopus 로고    scopus 로고
    • Negative regulation of autophagy
    • Liang C. Negative regulation of autophagy. Cell Death Differ. 2010; 12:1807-1815.
    • (2010) Cell Death Differ , vol.12 , pp. 1807-1815
    • Liang, C.1
  • 117
    • 65949113601 scopus 로고    scopus 로고
    • Targeting mTOR with rapamycin
    • Foster DA, Toschi A. Targeting mTOR with rapamycin. Cell Cycle. 2009; 8:1026-1029.
    • (2009) Cell Cycle , vol.8 , pp. 1026-1029
    • Foster, D.A.1    Toschi, A.2
  • 118
    • 57649227693 scopus 로고    scopus 로고
    • Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamineexpanded huntingtin and related proteinopathies
    • Sarkar1 S, Ravikumar B, Floto RA, Rubinsztein DC. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamineexpanded huntingtin and related proteinopathies. Cell Death Differ. 2009; 16:46-56.
    • (2009) Cell Death Differ , vol.16 , pp. 46-56
    • Sarkar1, S.1    Ravikumar, B.2    Floto, R.A.3    Rubinsztein, D.C.4
  • 119
    • 74849115774 scopus 로고    scopus 로고
    • TOR-driven aging
    • Blagosklonny MV. TOR-driven aging. Cell Cycle. 2009; 8:4055-4059.
    • (2009) Cell Cycle , vol.8 , pp. 4055-4059
    • Blagosklonny, M.V.1
  • 120
    • 77953645579 scopus 로고    scopus 로고
    • Rapamycin and quasi-programmed aging
    • Blagosklonny MV. Rapamycin and quasi-programmed aging. Cell Cycle. 2010; 9:1859-1862.
    • (2010) Cell Cycle , vol.9 , pp. 1859-1862
    • Blagosklonny, M.V.1
  • 121
    • 78650352864 scopus 로고    scopus 로고
    • Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal
    • Blagosklonny MV. Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal. Cell Cycle. 2010; 9:4788-4794.
    • (2010) Cell Cycle , vol.9 , pp. 4788-4794
    • Blagosklonny, M.V.1
  • 122
    • 77955722198 scopus 로고    scopus 로고
    • Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program
    • Blagosklonny MV. Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program. Cell Cycle. 2010; 9:3151-3156.
    • (2010) Cell Cycle , vol.9 , pp. 3151-3156
    • Blagosklonny, M.V.1
  • 123
    • 79955637336 scopus 로고    scopus 로고
    • Regulation of the autophagy initiating kinase ULK1 by nutrients: Roles of mTORC1 and AMPK
    • Kim J, Guan KL. Regulation of the autophagy initiating kinase ULK1 by nutrients: Roles of mTORC1 and AMPK. Cell Cycle 2011; 10:1337-1338.
    • (2011) Cell Cycle , vol.10 , pp. 1337-1338
    • Kim, J.1    Guan, K.L.2
  • 124
    • 81855225861 scopus 로고    scopus 로고
    • TORC1 activation and autophagy inhibition: Opposing forces in Rheb-driven tumorigenesis
    • Yu J, Henske EP. TORC1 activation and autophagy inhibition: Opposing forces in Rheb-driven tumorigenesis. Cell Cycle 2011; 10:3803-38004.
    • (2011) Cell Cycle , vol.10 , pp. 3803-38004
    • Yu, J.1    Henske, E.P.2
  • 125
    • 3142740860 scopus 로고    scopus 로고
    • Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
    • Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 2004; 305:390-392.
    • (2004) Science , vol.305 , pp. 390-392
    • Cohen, H.Y.1    Miller, C.2    Bitterman, K.J.3    Wall, N.R.4    Hekking, B.5    Kessler, B.6
  • 126
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 2004; 430:686-689.
    • (2004) Nature , vol.430 , pp. 686-689
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3    Howitz, K.4    Helfand, S.L.5    Tatar, M.6
  • 127
    • 77953635101 scopus 로고    scopus 로고
    • At the crossroad of lifespan, calorie restriction, chromatin and disease
    • Mostoslavsky R, Manel Esteller and Alejandro Vaquero. At the crossroad of lifespan, calorie restriction, chromatin and disease. Cell Cycle. 2010; 9:1907-1912.
    • (2010) Cell Cycle , vol.9 , pp. 1907-1912
    • Mostoslavsky, R.1    Esteller, M.2    Vaquero, A.3
  • 128
    • 0033214237 scopus 로고    scopus 로고
    • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    • Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Develop. 1999; 13:2570-2580.
    • (1999) Genes Develop , vol.13 , pp. 2570-2580
    • Kaeberlein, M.1    McVey, M.2    Guarente, L.3
  • 129
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature. 2001; 410:227-230.
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 131
    • 77953624320 scopus 로고    scopus 로고
    • Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR
    • Blagosklonny MV. Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR. Cell Death Dis. 2010; 1:e12.
    • (2010) Cell Death Dis , vol.1
    • Blagosklonny, M.V.1
  • 133
    • 79951881254 scopus 로고    scopus 로고
    • Protective roles of SIRT1 in atherosclerosis
    • Stein S, Matter CM. Protective roles of SIRT1 in atherosclerosis. Cell Cycle 2011; 10: 640-47.
    • (2011) Cell Cycle , vol.10 , pp. 640-647
    • Stein, S.1    Matter, C.M.2
  • 134
    • 79952642191 scopus 로고    scopus 로고
    • Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila
    • Antosh M, Whitaker R, Kroll A, Hosier S, Chang C, Bauer J, Cooper L, Neretti N, Helfand SL. Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila. Cell Cycle 2011; 10: 904-11.
    • (2011) Cell Cycle , vol.10 , pp. 904-911
    • Antosh, M.1    Whitaker, R.2    Kroll, A.3    Hosier, S.4    Chang, C.5    Bauer, J.6    Cooper, L.7    Neretti, N.8    Helfand, S.L.9
  • 135
    • 80052897214 scopus 로고    scopus 로고
    • SIRT1, p53 and mitotic chromosomes
    • Milner J, Allison SJ. SIRT1, p53 and mitotic chromosomes. Cell Cycle 2011; 10: 3049.
    • (2011) Cell Cycle , vol.10 , pp. 3049
    • Milner, J.1    Allison, S.J.2
  • 136
    • 35648995939 scopus 로고    scopus 로고
    • MSN2 and MSN4 link calorie restriction and TOR to Sirtuin-mediated lifespan extension in Saccharomyces cerevisiae
    • Medvedik O, Lamming DW, Kim KD, Sinclair DA. MSN2 and MSN4 link calorie restriction and TOR to Sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol. 2007; 5:e261.
    • (2007) PLoS Biol , vol.5
    • Medvedik, O.1    Lamming, D.W.2    Kim, K.D.3    Sinclair, D.A.4
  • 137
    • 67649369072 scopus 로고    scopus 로고
    • At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence
    • Demidenko ZN, Blagosklonny MV. At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence. Cell Cycle. 2009; 8:1901-1904.
    • (2009) Cell Cycle , vol.8 , pp. 1901-1904
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 138
    • 0018760324 scopus 로고
    • Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
    • Linzer DIH, Levine AJ. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell. 1979; 17:43-52.
    • (1979) Cell , vol.17 , pp. 43-52
    • Linzer, D.I.H.1    Levine, A.J.2
  • 139
    • 0018348655 scopus 로고
    • T-antigen is bound to a host protein in SV40-transformed cells
    • Lane D, Crawford LV. T-antigen is bound to a host protein in SV40-transformed cells. Nature. 1979; 278:261-263.
    • (1979) Nature , vol.278 , pp. 261-263
    • Lane, D.1    Crawford, L.V.2
  • 140
    • 0018743916 scopus 로고
    • Detection of a transformed-related antigen in chemically induced sarcomas and other transformed cells of the mouse
    • Deleo AB. et al. Detection of a transformed-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc. Natl Acad. Sci. USA. 1979; 76:2420-2424.
    • (1979) Proc. Natl Acad. Sci. USA. , vol.76 , pp. 2420-2424
    • Deleo, A.B.1
  • 142
    • 0024382760 scopus 로고
    • The p53 proto-oncogene can act as a suppressor of transformation
    • Finlay CA, Hinds PW, Levine AJ. The p53 proto-oncogene can act as a suppressor of transformation. Cell. 1989; 57:1083-1093.
    • (1989) Cell , vol.57 , pp. 1083-1093
    • Finlay, C.A.1    Hinds, P.W.2    Levine, A.J.3
  • 143
    • 0025611503 scopus 로고
    • Genetic mechanisms of tumor suppression by the human p53 gene
    • Chen PL, Chen YL, Bookstein R, Lee WH. Genetic mechanisms of tumor suppression by the human p53 gene. Science. 1990; 250:1576-1580.
    • (1990) Science , vol.250 , pp. 1576-1580
    • Chen, P.L.1    Chen, Y.L.2    Bookstein, R.3    Lee, W.H.4
  • 145
    • 79958710326 scopus 로고    scopus 로고
    • Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus
    • Engel T, Tanaka K, Jimenez-Mateos EM, Caballero-Caballero A, Prehn JH, Henshall DC. Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus. Cell Death Dis. 2010; 1:e79.
    • (2010) Cell Death Dis , vol.1
    • Engel, T.1    Tanaka, K.2    Jimenez-Mateos, E.M.3    Caballero-Caballero, A.4    Prehn, J.H.5    Henshall, D.C.6
  • 146
    • 79958753992 scopus 로고    scopus 로고
    • Phosphorylation of Puma modulates its apoptotic function by regulating protein stability
    • Fricker M, O'Prey J, Tolkovsky AM, Ryan KM. Phosphorylation of Puma modulates its apoptotic function by regulating protein stability. Cell Death Dis. 2010; 1:e59.
    • (2010) Cell Death Dis , vol.1
    • Fricker, M.1    O'Prey, J.2    Tolkovsky, A.M.3    Ryan, K.M.4
  • 147
    • 79959937596 scopus 로고    scopus 로고
    • p53-mediated delayed NF-κB activity enhances etoposideinduced cell death in medulloblastoma
    • Meley D, Spiller DG, White MR, McDowell H, Pizer B, Sée V. p53-mediated delayed NF-κB activity enhances etoposideinduced cell death in medulloblastoma. Cell Death Dis. 2010; 1:e41.
    • (2010) Cell Death Dis , vol.1
    • Meley, D.1    Spiller, D.G.2    White, M.R.3    McDowell, H.4    Pizer, B.5    Sée, V.6
  • 152
    • 0035874482 scopus 로고    scopus 로고
    • Induction of gene expression via activator protein-1 in the ascorbate protection against UV-induced damage
    • Catani MV, Rossi A, Costanzo A, et al. Induction of gene expression via activator protein-1 in the ascorbate protection against UV-induced damage. Biochemical Journal. 2001; 356:77-85.
    • (2001) Biochemical Journal , vol.356 , pp. 77-85
    • Catani, M.V.1    Rossi, A.2    Costanzo, A.3
  • 153
    • 80051789515 scopus 로고    scopus 로고
    • p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53
    • Melino G. p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ. 2011; 18:1487-1499.
    • (2011) Cell Death Differ , vol.18 , pp. 1487-1499
    • Melino, G.1
  • 154
    • 77952238224 scopus 로고    scopus 로고
    • p53-family proteins and their regulators: hubs and spokes in tumor suppression
    • Collavin L, Lunardi A, Del Sal G. p53-family proteins and their regulators: hubs and spokes in tumor suppression. Cell Death Differ. 2010; 17901-17911.
    • (2010) Cell Death Differ , pp. 17901-17911
    • Collavin, L.1    Lunardi, A.2    Del Sal, G.3
  • 156
    • 77955709042 scopus 로고    scopus 로고
    • Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53
    • Cheok CF, Kua N, Kaldis P, Lane DP. Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53. Cell Death Differ. 2010; 17:1486-1500.
    • (2010) Cell Death Differ , vol.17 , pp. 1486-1500
    • Cheok, C.F.1    Kua, N.2    Kaldis, P.3    Lane, D.P.4
  • 157
    • 74249099090 scopus 로고    scopus 로고
    • p53 stabilization: the importance of nuclear import
    • Marine JC. p53 stabilization: the importance of nuclear import. Cell Death Differ. 2010; 17:191-192.
    • (2010) Cell Death Differ , vol.17 , pp. 191-192
    • Marine, J.C.1
  • 160
    • 74249123570 scopus 로고    scopus 로고
    • The miR-34 family in cancer and apoptosis
    • Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ. 2010; 17:193-199.
    • (2010) Cell Death Differ , vol.17 , pp. 193-199
    • Hermeking, H.1
  • 161
    • 79959939374 scopus 로고    scopus 로고
    • PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells
    • Davies L, Spiller D, White MRH, Grierson I, Paraoan L. PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells. Cell Death Dis 2011; 2: e136.
    • (2011) Cell Death Dis , vol.2
    • Davies, L.1    Spiller, D.2    White, M.R.H.3    Grierson, I.4    Paraoan, L.5
  • 162
    • 79960014883 scopus 로고    scopus 로고
    • Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway
    • Koster R, Timmer-Bosscha H, Bischoff R, Gietema JA, de Jong S. Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway. Cell Death Dis 2011; 2: e148.
    • (2011) Cell Death Dis , vol.2
    • Koster, R.1    Timmer-Bosscha, H.2    Bischoff, R.3    Gietema, J.A.4    de Jong, S.5
  • 163
    • 79960024581 scopus 로고    scopus 로고
    • Reciprocal influence of the p53 and the hypoxic pathways
    • Sermeus A, Michiels C. Reciprocal influence of the p53 and the hypoxic pathways. Cell Death Dis 2011; 2: e164.
    • (2011) Cell Death Dis , vol.2
    • Sermeus, A.1    Michiels, C.2
  • 164
    • 79959979650 scopus 로고    scopus 로고
    • Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors
    • Vaseva AV, Yallowitz AR, Marchenko ND, Xu S, Moll UM. Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors. Cell Death Dis 2011; 2: e156.
    • (2011) Cell Death Dis , vol.2
    • Vaseva, A.V.1    Yallowitz, A.R.2    Marchenko, N.D.3    Xu, S.4    Moll, U.M.5
  • 166
    • 80052719816 scopus 로고    scopus 로고
    • Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death
    • Gao W, Shen Z, Shang L, Wang X. Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death. Cell Death Differ 2011; 18: 1598-1607.
    • (2011) Cell Death Differ , vol.18 , pp. 1598-1607
    • Gao, W.1    Shen, Z.2    Shang, L.3    Wang, X.4
  • 170
    • 36749081541 scopus 로고    scopus 로고
    • p53 regulates maternal reproduction through LIF
    • Hu W, Feng Z, Teresky AK, Levine AJ. p53 regulates maternal reproduction through LIF. Nature. 2007; 450:721-724.
    • (2007) Nature , vol.450 , pp. 721-724
    • Hu, W.1    Feng, Z.2    Teresky, A.K.3    Levine, A.J.4
  • 172
    • 12344273381 scopus 로고    scopus 로고
    • Variation in the human TP53 gene affects old age survival and cancer mortality
    • Van Heemst D, Mooijaart SP, Beekman M, et al. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp Gerontol. 2005; 40:11-5.
    • (2005) Exp Gerontol , vol.40 , pp. 11-15
    • Van Heemst, D.1    Mooijaart, S.P.2    Beekman, M.3
  • 173
    • 34250355147 scopus 로고    scopus 로고
    • Tumor suppressor p53 Arg-72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population
    • Orsted DD, Bojesen SE, Tybjaerg-Hansen A, Nordestgaard BG. Tumor suppressor p53 Arg-72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population. J Exp Med. 2007; 204:1295-1301.
    • (2007) J Exp Med , vol.204 , pp. 1295-1301
    • Orsted, D.D.1    Bojesen, S.E.2    Tybjaerg-Hansen, A.3    Nordestgaard, B.G.4
  • 175
    • 66849138420 scopus 로고    scopus 로고
    • Role of p53 in the antiproliferative effects of Sirt1 inhibition in prostate cancer cells
    • Jung-Hynes B, Ahmad N. Role of p53 in the antiproliferative effects of Sirt1 inhibition in prostate cancer cells. Cell Cycle. 2009; 8:1478-1483.
    • (2009) Cell Cycle , vol.8 , pp. 1478-1483
    • Jung-Hynes, B.1    Ahmad, N.2
  • 176
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng Z, Zhang H, Levine AJ, Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc. Natl. Acad. Sci. 2005; 102:8204-8209.
    • (2005) Proc. Natl. Acad. Sci. , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 177
    • 80055115885 scopus 로고    scopus 로고
    • Insulin resistance due to nutrient excess: Is it a consequence of AMPK downregulation?
    • Saha AK, Xu X, Balon TW, Brandon A, Kraegen EW, Ruderman NB. Insulin resistance due to nutrient excess: Is it a consequence of AMPK downregulation?. Cell Cycle 2011; 10: 3447-3451.
    • (2011) Cell Cycle , vol.10 , pp. 3447-3451
    • Saha, A.K.1    Xu, X.2    Balon, T.W.3    Brandon, A.4    Kraegen, E.W.5    Ruderman, N.B.6
  • 179
    • 74849113290 scopus 로고    scopus 로고
    • The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions
    • Matthew EM, Lori S. Hart, Aristotelis Astrinidis, Arunasalam Navaraj, Nathan G. Dolloff, David T. Dicker, Elizabeth P. Henske, and Wafik S. El-Deiry. The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions. Cell Cycle. 2009; 8:4168-4175.
    • (2009) Cell Cycle , vol.8 , pp. 4168-4175
    • Matthew, E.M.1    Hart, L.S.2    Astrinidis, A.3    Navaraj, A.4    Dolloff, N.G.5    Dicker, D.T.6    Henske, E.P.7    El-Deiry, W.S.8
  • 180
    • 85047699328 scopus 로고    scopus 로고
    • Cross-talk between Akt, p53 and Mdm2: Possible implications for the regulation of apoptosis
    • Gottlieb TM, Leal JF, Seger R, Taya Y, Oren M. Cross-talk between Akt, p53 and Mdm2: Possible implications for the regulation of apoptosis. Oncogene. 2002; 21:1299-1303.
    • (2002) Oncogene , vol.21 , pp. 1299-1303
    • Gottlieb, T.M.1    Leal, J.F.2    Seger, R.3    Taya, Y.4    Oren, M.5


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