Two isoforms of cyclooxygenase contribute to augmented endothelium- dependent contractions in femoral arteries of 1-year-old rats

Acta Pharmacologica Sinica

Volumn 29, Issue 2, 2008, Pages 185-192

  Shi, Yi ^a   Man, Ricky Y K ^a   Vanhoutte, Paul M ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Aging; Cyclooxygenase; Endothelium; Endothelium dependent contraction; Endothelium derived contracting factor; Oxidative stress; Reactive oxygen species; Thromboxane prostanoid receptors

Indexed keywords

CALCIMYCIN; CATALASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DICHLORODIHYDROFLUORESCEIN DIACETATE; FREE RADICAL; HYDROGEN PEROXIDE; INDOMETACIN; ISOENZYME; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; OXYGEN; PROSTAGLANDIN SYNTHASE; SALICYLIC ACID DERIVATIVE; TERUTROBAN; THROMBOXANE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; VALERYL SALICYLATE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; AUGMENTATION INDEX; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; ENZYME ACTIVITY; FEMORAL ARTERY; FLUORESCENCE; ISOMETRICS; NONHUMAN; OXIDATIVE STRESS; RAT; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE; UPREGULATION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ANIMALS; CATALASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FEMORAL ARTERY; GLUTATHIONE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 38749089857     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2008.00749.x     Document Type: Article

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