Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice

Free Radical Biology and Medicine

Volumn 51, Issue 1, 2011, Pages 38-52

  Ryan, Michael J ^a   Jackson, Janna R ^a   Hao, Yanlei ^a   Leonard, Stephen S ^b   Alway, Stephen E ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Aging; Apoptosis; Electrically evoked isometric contractions; Free radicals; Muscle atrophy; Oxidative stress; Sarcopenia

Indexed keywords

ALLOPURINOL; CASPASE 3; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE; HYDROGEN PEROXIDE; XANTHINE OXIDASE;

AGED; AGING; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; ENZYME ACTIVITY; ENZYME INHIBITION; EVOKED RESPONSE; EXERCISE; GASTROCNEMIUS MUSCLE; LIPID PEROXIDATION; MOUSE; MUSCLE FUNCTION; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AGE FACTORS; AGING; ALLOPURINOL; ANIMALS; APOPTOSIS; CASPASE 3; CATALASE; ELECTRIC STIMULATION; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; ISOMETRIC CONTRACTION; LIPID PEROXIDATION; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MUSCLE, SKELETAL; MUSCULOSKELETAL PHYSIOLOGICAL PHENOMENA; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; XANTHINE; XANTHINE OXIDASE;

MUS;

EID: 79957969884     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.04.002     Document Type: Article

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