메뉴 건너뛰기




Volumn 6, Issue 4, 2013, Pages 440-468

Design of siRNA therapeutics from the molecular scale

Author keywords

Delivery vehicle design; Liver cancer; RNAi; siRNA design; siRNA therapeutic

Indexed keywords

DRUG CARRIER; MESSENGER RNA; PLACEBO; SMALL INTERFERING RNA; SORAFENIB; VASCULOTROPIN RECEPTOR;

EID: 84875908270     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph6040440     Document Type: Review
Times cited : (38)

References (249)
  • 2
    • 0003964363 scopus 로고    scopus 로고
    • Americancancersociety, accessd on 26 November 2012
    • Americancancersociety. Cancer facts& figures 2012. Available online: http://www.cancer.org/research/cancerfactsfigures/cancerfactsfigures/cancer-facts-figures-2012/ (accessd on 26 November 2012).
    • (2012) Cancer Facts& Figures
  • 4
    • 79955580873 scopus 로고    scopus 로고
    • Hcc and angiogenesis: Possible targets and future directions
    • Zhu, A.X.; Duda, D.G.; Sahani, D.V.; Jain, R.K. Hcc and angiogenesis: Possible targets and future directions. Nat. Rev. Clin. Oncol. 2011, 8, 292-301.
    • (2011) Nat. Rev. Clin. Oncol , vol.8 , pp. 292-301
    • Zhu, A.X.1    Duda, D.G.2    Sahani, D.V.3    Jain, R.K.4
  • 5
    • 79955433548 scopus 로고    scopus 로고
    • Targeted therapies for hepatocellular carcinoma
    • Villanueva, A.; Llovet, J.M. Targeted therapies for hepatocellular carcinoma. Gastroenterology 2011, 140, 1410-1426.
    • (2011) Gastroenterology , vol.140 , pp. 1410-1426
    • Villanueva, A.1    Llovet, J.M.2
  • 6
    • 80052627990 scopus 로고    scopus 로고
    • Current progress of sirna/shrna therapeutics in clinical trials
    • Burnett, J.C.; Rossi, J.J.; Tiemann, K. Current progress of sirna/shrna therapeutics in clinical trials. Biotechnol. J. 2011, 6, 1130-1146.
    • (2011) Biotechnol. J , vol.6 , pp. 1130-1146
    • Burnett, J.C.1    Rossi, J.J.2    Tiemann, K.3
  • 7
    • 84867652280 scopus 로고    scopus 로고
    • The business of rnai therapeutics in 2012
    • Haussecker, D. The business of rnai therapeutics in 2012. Mol. Ther. Nucleic Acids 2012, 1, e8.
    • (2012) Mol. Ther. Nucleic Acids , Issue.1
    • Haussecker, D.1
  • 8
    • 79956311068 scopus 로고    scopus 로고
    • Rna-induced silencing complex-bound small interfering rna is a determinant of rna interference-mediated gene silencing in mice
    • Wei, J.; Jones, J.; Kang, J.; Card, A.; Krimm, M.; Hancock, P.; Pei, Y.; Ason, B.; Payson, E.; Dubinina, N, et al. Rna-induced silencing complex-bound small interfering rna is a determinant of rna interference-mediated gene silencing in mice. Mol. Pharmacol. 2011, 79, 953-963.
    • (2011) Mol. Pharmacol , vol.79 , pp. 953-963
    • Wei, J.1    Jones, J.2    Kang, J.3    Card, A.4    Krimm, M.5    Hancock, P.6    Pei, Y.7    Ason, B.8    Payson, E.9    Dubinina, N.10
  • 9
    • 31544456413 scopus 로고    scopus 로고
    • Insights into the kinetics of sirna-mediated gene silencing from live-cell and live-animal bioluminescent imaging
    • Bartlett, D.W. Insights into the kinetics of sirna-mediated gene silencing from live-cell and live-animal bioluminescent imaging. Nucleic Acids Res. 2006, 34, 322-333.
    • (2006) Nucleic Acids Res , vol.34 , pp. 322-333
    • Bartlett, D.W.1
  • 11
    • 78650635840 scopus 로고    scopus 로고
    • Mrna turnover rate limits sirna and microrna efficacy
    • Larsson, E.; Sander, C.; Marks, D. Mrna turnover rate limits sirna and microrna efficacy. Mol. Syst. Biol. 2010, 6, 1-9.
    • (2010) Mol. Syst. Biol , vol.6 , pp. 1-9
    • Larsson, E.1    Sander, C.2    Marks, D.3
  • 12
    • 1342346710 scopus 로고    scopus 로고
    • A conserved sirna-degrading rnase negatively regulates rna interference in c
    • Kennedy, S.; Wang, D.; Ruvkun, G. A conserved sirna-degrading rnase negatively regulates rna interference in c. Elegans. Nature 2004, 427, 645-649.
    • (2004) Elegans. Nature , vol.427 , pp. 645-649
    • Kennedy, S.1    Wang, D.2    Ruvkun, G.3
  • 13
    • 80054791942 scopus 로고    scopus 로고
    • High-dose sirnas upregulate mouse eri-1 at both transcription and posttranscription levels
    • Bian, Y.; Zhou, W.; Zhao, Y.; Li, X.; Geng, W.; Hao, R.; Yang, Q.; Huang, W. High-dose sirnas upregulate mouse eri-1 at both transcription and posttranscription levels. PLoS ONE 2011, 6, e26466.
    • (2011) PLoS ONE , vol.6
    • Bian, Y.1    Zhou, W.2    Zhao, Y.3    Li, X.4    Geng, W.5    Hao, R.6    Yang, Q.7    Huang, W.8
  • 15
    • 4644224489 scopus 로고    scopus 로고
    • Ve-cadherin increases the half-life of vegf receptor 2
    • Calera, M.R.; Venkatakrishnan, A.; Kazlauskas, A. Ve-cadherin increases the half-life of vegf receptor 2. Exp. Cell Res. 2004, 300, 248-256.
    • (2004) Exp. Cell Res , vol.300 , pp. 248-256
    • Calera, M.R.1    Venkatakrishnan, A.2    Kazlauskas, A.3
  • 16
    • 0024276817 scopus 로고
    • The epidermal growth factor receptor as a multifunctional allosteric protein
    • Schlessinger, J. The epidermal growth factor receptor as a multifunctional allosteric protein. Biochemistry 1988, 27, 3119-3123.
    • (1988) Biochemistry , vol.27 , pp. 3119-3123
    • Schlessinger, J.1
  • 17
    • 0025038410 scopus 로고
    • Bcr-abl and bcr proteins: Biochemical characterization and localization
    • Dhut, S.; Chaplin, T.; Young, B.D. Bcr-abl and bcr proteins: Biochemical characterization and localization. Leukemia 1990, 4, 745-750.
    • (1990) Leukemia , vol.4 , pp. 745-750
    • Dhut, S.1    Chaplin, T.2    Young, B.D.3
  • 18
    • 77951473777 scopus 로고    scopus 로고
    • Post-transcriptional regulation of mek-1 by polyamines through the rna-binding protein hur modulating intestinal epithelial apoptosis
    • Wang, P.Y.; Rao, J.N.; Zou, T.; Liu, L.; Xiao, L.; Yu, T.X.; Turner, D.J.; Gorospe, M.; Wang, J.Y. Post-transcriptional regulation of mek-1 by polyamines through the rna-binding protein hur modulating intestinal epithelial apoptosis. Biochem. J. 2010, 426, 293-306.
    • (2010) Biochem. J , vol.426 , pp. 293-306
    • Wang, P.Y.1    Rao, J.N.2    Zou, T.3    Liu, L.4    Xiao, L.5    Yu, T.X.6    Turner, D.J.7    Gorospe, M.8    Wang, J.Y.9
  • 19
    • 0023644925 scopus 로고
    • Processing of the platelet-derived growth factor receptor. Biosynthetic and degradation studies using anti-receptor antibodies
    • Keating, M.T.; Williams, L.T. Processing of the platelet-derived growth factor receptor. Biosynthetic and degradation studies using anti-receptor antibodies. J. Biol. Chem. 1987, 262, 7932-7937.
    • (1987) J. Biol. Chem , vol.262 , pp. 7932-7937
    • Keating, M.T.1    Williams, L.T.2
  • 21
    • 54449083925 scopus 로고    scopus 로고
    • Molecular targeted therapies in hepatocellular carcinoma
    • Llovet, J.M.; Bruix, J. Molecular targeted therapies in hepatocellular carcinoma. Hepatology 2008, 48, 1312-1327.
    • (2008) Hepatology , vol.48 , pp. 1312-1327
    • Llovet, J.M.1    Bruix, J.2
  • 24
    • 84875890034 scopus 로고    scopus 로고
    • Sirna design software for a target gene-specific rna interference
    • Naito, Y.; Ui-Tei, K. Sirna design software for a target gene-specific rna interference. Front. Genet. 2012, 3, 102.
    • (2012) Front. Genet , vol.3 , pp. 102
    • Naito, Y.1    Ui-Tei, K.2
  • 25
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of rna interference
    • Bernstein, E.; Caudy, A.A.; Hammond, S.M.; Hannon, G.J. Role for a bidentate ribonuclease in the initiation step of rna interference. Nature 2001, 409, 363-366.
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 26
    • 0034737298 scopus 로고    scopus 로고
    • Rnai: Double-stranded rna directs the atp-dependent cleavage of mrna at 21 to 23 nucleotide intervals
    • Zamore, P.D.; Tuschl, T.; Sharp, P.A.; Bartel, D.P. Rnai: Double-stranded rna directs the atp-dependent cleavage of mrna at 21 to 23 nucleotide intervals. Cell 2000, 101, 25-33.
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 27
    • 0035798415 scopus 로고    scopus 로고
    • Atp requirements and small interfering rna structure in the rna interference pathway
    • Nykänen, A.; Haley, B.; Zamore, P.D. Atp requirements and small interfering rna structure in the rna interference pathway. Cell 2001, 107, 309-321.
    • (2001) Cell , vol.107 , pp. 309-321
    • Nykänen, A.1    Haley, B.2    Zamore, P.D.3
  • 28
    • 0035803583 scopus 로고    scopus 로고
    • Functional anatomy of sirnas for mediating efficient rnai in drosophila melanogaster embryo lysate
    • Elbashir, S.M.; Martinez, J.; Patkaniowska, A.; Lendeckel, W.; Tuschl, T. Functional anatomy of sirnas for mediating efficient rnai in drosophila melanogaster embryo lysate. EMBO J. 2001, 20, 6877-6888.
    • (2001) EMBO J , vol.20 , pp. 6877-6888
    • Elbashir, S.M.1    Martinez, J.2    Patkaniowska, A.3    Lendeckel, W.4    Tuschl, T.5
  • 29
    • 59049105558 scopus 로고    scopus 로고
    • Human dicer binds short single-strand and double-strand rna with high affinity and interacts with different regions of the nucleic acids
    • Lima, W.F.; Murray, H.; Nichols, J.G.; Wu, H.; Sun, H.; Prakash, T.P.; Berdeja, A.R.; Gaus, H.J.; Crooke, S.T. Human dicer binds short single-strand and double-strand rna with high affinity and interacts with different regions of the nucleic acids. J. Biol. Chem. 2009, 284, 2535-2548.
    • (2009) J. Biol. Chem , vol.284 , pp. 2535-2548
    • Lima, W.F.1    Murray, H.2    Nichols, J.G.3    Wu, H.4    Sun, H.5    Prakash, T.P.6    Berdeja, A.R.7    Gaus, H.J.8    Crooke, S.T.9
  • 31
    • 0141868916 scopus 로고    scopus 로고
    • R2d2, a bridge between the initiation and effector steps of the drosophila rnai pathway
    • Liu, Q.H.; Rand, T.A.; Kalidas, S.; Du, F.H.; Kim, H.E.; Smith, D.P.; Wang, X.D. R2d2, a bridge between the initiation and effector steps of the drosophila rnai pathway. Science 2003, 301, 1921-1925.
    • (2003) Science , vol.301 , pp. 1921-1925
    • Liu, Q.H.1    Rand, T.A.2    Kalidas, S.3    Du, F.H.4    Kim, H.E.5    Smith, D.P.6    Wang, X.D.7
  • 35
    • 0034673638 scopus 로고    scopus 로고
    • An rna-directed nuclease mediates post-transcriptional gene silencing in drosophila cells
    • Hammond, S.M.; Bernstein, E.; Beach, D.; Hannon, G.J. An rna-directed nuclease mediates post-transcriptional gene silencing in drosophila cells. Nature 2000, 404, 293-296.
    • (2000) Nature , vol.404 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 37
    • 77950673634 scopus 로고    scopus 로고
    • Recognition of sirna asymmetry by tar rna binding protein
    • Gredell, J.A.; Dittmer, M.J.; Wu, M.; Chan, C.; Walton, S.P. Recognition of sirna asymmetry by tar rna binding protein. Biochemistry 2010, 49, 3148-3155.
    • (2010) Biochemistry , vol.49 , pp. 3148-3155
    • Gredell, J.A.1    Dittmer, M.J.2    Wu, M.3    Chan, C.4    Walton, S.P.5
  • 38
    • 79959872313 scopus 로고    scopus 로고
    • Sirna repositioning for guide strand selection by human dicer complexes
    • Noland, C.L.; Ma, E.; Doudna, J.A. Sirna repositioning for guide strand selection by human dicer complexes. Mol. Cell 2011, 43, 110-121.
    • (2011) Mol. Cell , vol.43 , pp. 110-121
    • Noland, C.L.1    Ma, E.2    Doudna, J.A.3
  • 39
    • 0142165224 scopus 로고    scopus 로고
    • Functional sirnas and mirnas exhibit strand bias
    • Khvorova, A.; Reynolds, A.; Jayasena, S.D. Functional sirnas and mirnas exhibit strand bias. Cell 2003, 115, 209-216.
    • (2003) Cell , vol.115 , pp. 209-216
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 40
    • 10744225153 scopus 로고    scopus 로고
    • Asymmetry in the assembly of the rnai enzyme complex
    • Schwarz, D.; Hutvagner, G.; Du, T.; Xu, Z.; Aronin, N.; Zamore, P. Asymmetry in the assembly of the rnai enzyme complex. Cell 2003, 115, 199-208.
    • (2003) Cell , vol.115 , pp. 199-208
    • Schwarz, D.1    Hutvagner, G.2    Du, T.3    Xu, Z.4    Aronin, N.5    Zamore, P.6
  • 41
    • 0033615491 scopus 로고    scopus 로고
    • A species of small antisense rna in posttranscriptional gene silencing in plants
    • Hamilton, A.; Baulcombe, D. A species of small antisense rna in posttranscriptional gene silencing in plants. Science 1999, 286, 950-952.
    • (1999) Science , vol.286 , pp. 950-952
    • Hamilton, A.1    Baulcombe, D.2
  • 42
    • 0035863097 scopus 로고    scopus 로고
    • Rna interference is mediated by 21-and 22-nucleotide rnas
    • Elbashir, S.M.; Lendeckel, W.; Tuschl, T. Rna interference is mediated by 21-and 22-nucleotide rnas. Genes Dev. 2001, 15, 188-200.
    • (2001) Genes Dev , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 43
    • 27744506761 scopus 로고    scopus 로고
    • Argonaute2 cleaves the anti-guide strand of sirna during risc activation
    • Rand, T.A.; Petersen, S.; Du, F.; Wang, X. Argonaute2 cleaves the anti-guide strand of sirna during risc activation. Cell 2005, 123, 621-629.
    • (2005) Cell , vol.123 , pp. 621-629
    • Rand, T.A.1    Petersen, S.2    Du, F.3    Wang, X.4
  • 44
    • 33645763485 scopus 로고    scopus 로고
    • Cleavage of the sirna passenger strand during risc assembly in human cells
    • Leuschner, P.J.F.; Ameres, S.L.; Kueng, S.; Martinez, J. Cleavage of the sirna passenger strand during risc assembly in human cells. EMBO Rep. 2006, 7, 314-320.
    • (2006) EMBO Rep , vol.7 , pp. 314-320
    • Leuschner, P.J.F.1    Ameres, S.L.2    Kueng, S.3    Martinez, J.4
  • 45
    • 27744590896 scopus 로고    scopus 로고
    • Passenger-strand cleavage facilitates assembly of sirna into ago2-containing rnai enzyme complexes
    • Matranga, C.; Tomari, Y.; Shin, C.; Bartel, D.; Zamore, P. Passenger-strand cleavage facilitates assembly of sirna into ago2-containing rnai enzyme complexes. Cell 2005, 123, 607-620.
    • (2005) Cell , vol.123 , pp. 607-620
    • Matranga, C.1    Tomari, Y.2    Shin, C.3    Bartel, D.4    Zamore, P.5
  • 48
    • 3042602447 scopus 로고    scopus 로고
    • Kinetic analysis of the rnai enzyme complex
    • Haley, B.; Zamore, P.D. Kinetic analysis of the rnai enzyme complex. Nat. Struct. Mol. Biol. 2004, 11, 599-606.
    • (2004) Nat. Struct. Mol. Biol , vol.11 , pp. 599-606
    • Haley, B.1    Zamore, P.D.2
  • 50
    • 84857777210 scopus 로고    scopus 로고
    • Biogenesis and function of endogenous and exogenous sirnas
    • Snead, N.M.; Rossi, J.J. Biogenesis and function of endogenous and exogenous sirnas. Wiley Interdiscip. Rev. RNA 2010, 1, 117-131.
    • (2010) Wiley Interdiscip. Rev. RNA , vol.1 , pp. 117-131
    • Snead, N.M.1    Rossi, J.J.2
  • 51
    • 60149088848 scopus 로고    scopus 로고
    • Origins and mechanisms of mirnas and sirnas
    • Carthew, R.W.; Sontheimer, E.J. Origins and mechanisms of mirnas and sirnas. Cell 2009, 136, 642-655.
    • (2009) Cell , vol.136 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 53
    • 77953479619 scopus 로고    scopus 로고
    • Structural basis for 5'-nucleotide base-specific recognition of guide rna by human ago2
    • Frank, F.; Sonenberg, N.; Nagar, B. Structural basis for 5'-nucleotide base-specific recognition of guide rna by human ago2. Nature 2010, 465, 818-822.
    • (2010) Nature , vol.465 , pp. 818-822
    • Frank, F.1    Sonenberg, N.2    Nagar, B.3
  • 54
    • 78449296513 scopus 로고    scopus 로고
    • Designing highly active sirnas for therapeutic applications
    • Walton, S.P.; Wu, M.; Gredell, J.A.; Chan, C. Designing highly active sirnas for therapeutic applications. FEBS J. 2010, 277, 4806-4813.
    • (2010) FEBS J , vol.277 , pp. 4806-4813
    • Walton, S.P.1    Wu, M.2    Gredell, J.A.3    Chan, C.4
  • 55
    • 84055222215 scopus 로고    scopus 로고
    • Dicer is dispensable for asymmetric risc loading in mammals
    • Betancur, J.G.; Tomari, Y. Dicer is dispensable for asymmetric risc loading in mammals. RNA 2012, 18, 24-30.
    • (2012) RNA , vol.18 , pp. 24-30
    • Betancur, J.G.1    Tomari, Y.2
  • 56
    • 26944431852 scopus 로고    scopus 로고
    • Small rna asymmetry in rnai: Function in risc assembly and gene regulation
    • Hutvagner, G. Small rna asymmetry in rnai: Function in risc assembly and gene regulation. FEBS Lett. 2005, 579, 5850-5857.
    • (2005) FEBS Lett , vol.579 , pp. 5850-5857
    • Hutvagner, G.1
  • 57
    • 39149106448 scopus 로고    scopus 로고
    • Efficient sirna selection using hybridization thermodynamics
    • Lu, Z.J.; Mathews, D.H. Efficient sirna selection using hybridization thermodynamics. Nucleic Acids Res. 2008, 36, 640-647.
    • (2008) Nucleic Acids Res , vol.36 , pp. 640-647
    • Lu, Z.J.1    Mathews, D.H.2
  • 61
    • 33846906687 scopus 로고    scopus 로고
    • More complete gene silencing by fewer sirnas: Transparent optimized design and biophysical signature
    • Ladunga, I. More complete gene silencing by fewer sirnas: Transparent optimized design and biophysical signature. Nucleic Acids Res. 2006, 35, 433-440.
    • (2006) Nucleic Acids Res , vol.35 , pp. 433-440
    • Ladunga, I.1
  • 62
    • 33748701701 scopus 로고    scopus 로고
    • Computational models with thermodynamic and composition features improve sirna design
    • Shabalina, S.A.; Spiridonov, A.N.; Ogurtsov, A.Y. Computational models with thermodynamic and composition features improve sirna design. BMC Bioinformatics 2006, 7.
    • (2006) BMC Bioinformatics , pp. 7
    • Shabalina, S.A.1    Spiridonov, A.N.2    Ogurtsov, A.Y.3
  • 63
    • 1642273831 scopus 로고    scopus 로고
    • An algorithm for selection of functional sirna sequences
    • Amarzguioui, M.; Prydz, H. An algorithm for selection of functional sirna sequences. Biochem. Biophys. Res. Commun. 2004, 316, 1050-1058.
    • (2004) Biochem. Biophys. Res. Commun , vol.316 , pp. 1050-1058
    • Amarzguioui, M.1    Prydz, H.2
  • 64
    • 33845631509 scopus 로고    scopus 로고
    • Integrated sirna design based on surveying of features associated with high rnai effectiveness
    • Gong, W.; Ren, Y.; Xu, Q.; Wang, Y.; Lin, D.; Zhou, H.; Li, T. Integrated sirna design based on surveying of features associated with high rnai effectiveness. BMC Bioinformatics 2006, 7, 516.
    • (2006) BMC Bioinformatics , vol.7 , pp. 516
    • Gong, W.1    Ren, Y.2    Xu, Q.3    Wang, Y.4    Lin, D.5    Zhou, H.6    Li, T.7
  • 65
    • 3542992506 scopus 로고    scopus 로고
    • An effective method for selecting sirna target sequences in mammalian cells
    • Takasaki, S.; Kotani, S.; Konagaya, A. An effective method for selecting sirna target sequences in mammalian cells. Cell Cycle 2004, 3, 788-793.
    • (2004) Cell Cycle , vol.3 , pp. 788-793
    • Takasaki, S.1    Kotani, S.2    Konagaya, A.3
  • 66
    • 33748209616 scopus 로고    scopus 로고
    • Efficient prediction of sirnas with sirnarules 1.0: An open-source java approach to sirna algorithms
    • Holen, T. Efficient prediction of sirnas with sirnarules 1.0: An open-source java approach to sirna algorithms. RNA 2006, 12, 1620-1625.
    • (2006) RNA , vol.12 , pp. 1620-1625
    • Holen, T.1
  • 67
    • 70349203686 scopus 로고    scopus 로고
    • Selecting effective sirna target sequences by using bayes' theorem
    • Takasaki, S. Selecting effective sirna target sequences by using bayes' theorem. Comput. Biol. Chem. 2009, 33, 368-372.
    • (2009) Comput. Biol. Chem , vol.33 , pp. 368-372
    • Takasaki, S.1
  • 68
    • 34047177954 scopus 로고    scopus 로고
    • Specific residues at every third position of sirna shape its efficient rnai activity
    • Katoh, T.; Suzuki, T. Specific residues at every third position of sirna shape its efficient rnai activity. Nucleic Acids Res. 2007, 35, e27.
    • (2007) Nucleic Acids Res , vol.35
    • Katoh, T.1    Suzuki, T.2
  • 69
    • 84856542174 scopus 로고    scopus 로고
    • A 5'-uridine amplifies mirna/mirna* asymmetry in drosophila by promoting rna-induced silencing complex formation
    • Seitz, H.; Tushir, J.S.; Zamore, P.D. A 5'-uridine amplifies mirna/mirna* asymmetry in drosophila by promoting rna-induced silencing complex formation. Silence 2011, 2, 4.
    • (2011) Silence , vol.2 , pp. 4
    • Seitz, H.1    Tushir, J.S.2    Zamore, P.D.3
  • 70
    • 20444455464 scopus 로고    scopus 로고
    • Target accessibility dictates the potency of human risc
    • Brown, K.M.; Chu, C.Y.; Rana, T.M. Target accessibility dictates the potency of human risc. Nat. Struct. Mol. Biol. 2005, 12, 469-470.
    • (2005) Nat. Struct. Mol. Biol , vol.12 , pp. 469-470
    • Brown, K.M.1    Chu, C.Y.2    Rana, T.M.3
  • 71
    • 34447102459 scopus 로고    scopus 로고
    • Molecular basis for target rna recognition and cleavage by human risc
    • Ameres, S.L.; Martinez, J.; Schroeder, R. Molecular basis for target rna recognition and cleavage by human risc. Cell 2007, 130, 101-112.
    • (2007) Cell , vol.130 , pp. 101-112
    • Ameres, S.L.1    Martinez, J.2    Schroeder, R.3
  • 72
    • 0033591465 scopus 로고    scopus 로고
    • Expanded sequence dependence of thermodynamic parameters improves prediction of rna secondary structure
    • Mathews, D.; Sabina, J.; Zuker, M.; Turner, D. Expanded sequence dependence of thermodynamic parameters improves prediction of rna secondary structure. J. Mol. Biol. 1999, 288, 911-940.
    • (1999) J. Mol. Biol , vol.288 , pp. 911-940
    • Mathews, D.1    Sabina, J.2    Zuker, M.3    Turner, D.4
  • 73
    • 3242877996 scopus 로고    scopus 로고
    • Sfold web server for statistical folding and rational design of nucleic acids
    • Ding, Y.; Chan, C.Y.; Lawrence, C.E. Sfold web server for statistical folding and rational design of nucleic acids. Nucleic Acids Res. 2004, 32, W135-W141.
    • (2004) Nucleic Acids Res , vol.32
    • Ding, Y.1    Chan, C.Y.2    Lawrence, C.E.3
  • 75
    • 43249105382 scopus 로고    scopus 로고
    • Impact of target mrna structure on sirna silencing efficiency: A large-scale study
    • Gredell, J.; Berger, A.; Walton, S. Impact of target mrna structure on sirna silencing efficiency: A large-scale study. Biotechnol. Bioeng. 2008, 100, 744-755.
    • (2008) Biotechnol. Bioeng , vol.100 , pp. 744-755
    • Gredell, J.1    Berger, A.2    Walton, S.3
  • 76
    • 0037470145 scopus 로고    scopus 로고
    • Baker, B.F. Efficient reduction of target rnas by small interfering rna and rnase h-dependent antisense agents. A comparative analysis
    • Vickers, T.A.; Koo, S.; Bennett, C.F.; Crooke, S.T.; Dean, N.M.; Baker, B.F. Efficient reduction of target rnas by small interfering rna and rnase h-dependent antisense agents. A comparative analysis. J. Biol. Chem. 2003, 278, 7108-7118.
    • (2003) J. Biol. Chem , vol.278 , pp. 7108-7118
    • Vickers, T.A.1    Koo, S.2    Bennett, C.F.3    Crooke, S.T.4    Dean, N.M.5
  • 77
    • 0038521255 scopus 로고    scopus 로고
    • The efficacy of small interfering rnas targeted to the type 1 insulin-like growth factor receptor (igf1r) is influenced by secondary structure in the igf1r transcript
    • Bohula, E.A.; Salisbury, A.J.; Sohail, M.; Playford, M.P.; Riedemann, J.; Southern, E.M.; Macaulay, V.M. The efficacy of small interfering rnas targeted to the type 1 insulin-like growth factor receptor (igf1r) is influenced by secondary structure in the igf1r transcript. J. Biol. Chem. 2003, 278, 15991-15997.
    • (2003) J. Biol. Chem , vol.278 , pp. 15991-15997
    • Bohula, E.A.1    Salisbury, A.J.2    Sohail, M.3    Playford, M.P.4    Riedemann, J.5    Southern, E.M.6    Macaulay, V.M.7
  • 79
    • 17444412299 scopus 로고    scopus 로고
    • Local rna target structure influences sirna efficacy: Systematic analysis of intentionally designed binding regions
    • Schubert, S.; Grünweller, A.; Erdmann, V.A.; Kurreck, J. Local rna target structure influences sirna efficacy: Systematic analysis of intentionally designed binding regions. J. Mol. Biol. 2005, 348, 883-893.
    • (2005) J. Mol. Biol , vol.348 , pp. 883-893
    • Schubert, S.1    Grünweller, A.2    Erdmann, V.A.3    Kurreck, J.4
  • 81
    • 1342306353 scopus 로고    scopus 로고
    • Effects on rnai of the tight structure, sequence and position of the targeted region
    • Yoshinari, K.; Miyagishi, M.; Taira, K. Effects on rnai of the tight structure, sequence and position of the targeted region. Nucleic Acids Res. 2004, 32, 691-699.
    • (2004) Nucleic Acids Res , vol.32 , pp. 691-699
    • Yoshinari, K.1    Miyagishi, M.2    Taira, K.3
  • 83
    • 78449299462 scopus 로고    scopus 로고
    • Staying on message: Design principles for controlling nonspecific responses to sirna
    • Samuel-Abraham, S.; Leonard, J.N. Staying on message: Design principles for controlling nonspecific responses to sirna. FEBS J. 2010, 277, 4828-4836.
    • (2010) FEBS J , vol.277 , pp. 4828-4836
    • Samuel-Abraham, S.1    Leonard, J.N.2
  • 84
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and avoiding sirna off-target effects for target identification and therapeutic application
    • Jackson, A. Recognizing and avoiding sirna off-target effects for target identification and therapeutic application. Nat. Rev. Drug Discov. 2010, 9, 57-67.
    • (2010) Nat. Rev. Drug Discov , vol.9 , pp. 57-67
    • Jackson, A.1
  • 85
    • 34548108038 scopus 로고    scopus 로고
    • 2'-o-methyl-modified rnas act as tlr7 antagonists
    • Robbins, M.; Judge, A.; Liang, L. 2'-o-methyl-modified rnas act as tlr7 antagonists. Mol. Ther. 2007, 15, 1663-1669.
    • (2007) Mol. Ther , vol.15 , pp. 1663-1669
    • Robbins, M.1    Judge, A.2    Liang, L.3
  • 86
    • 69249222518 scopus 로고    scopus 로고
    • 2'-5'-oligoadenylate synthetase is activated by a specific rna sequence motif
    • Kodym, R.; Kodym, E.; Story, M.D. 2'-5'-oligoadenylate synthetase is activated by a specific rna sequence motif. Biochem. Biophys. Res. Commun. 2009, 388, 317-322.
    • (2009) Biochem. Biophys. Res. Commun , vol.388 , pp. 317-322
    • Kodym, R.1    Kodym, E.2    Story, M.D.3
  • 87
    • 0026713151 scopus 로고
    • Interactions between double-stranded rna regulators and the protein kinase dai
    • Manche, L.; Green, S.R.; Schmedt, C.; Mathews, M.B. Interactions between double-stranded rna regulators and the protein kinase dai. Mol. Cell. Biol. 1992, 12, 5238-5248.
    • (1992) Mol. Cell. Biol , vol.12 , pp. 5238-5248
    • Manche, L.1    Green, S.R.2    Schmedt, C.3    Mathews, M.B.4
  • 88
    • 0029782652 scopus 로고    scopus 로고
    • Minor-groove recognition of double-stranded rna by the double-stranded rna-binding domain from the rna-activated protein kinase pkr
    • Bevilacqua, P.C.; Cech, T.R. Minor-groove recognition of double-stranded rna by the double-stranded rna-binding domain from the rna-activated protein kinase pkr. Biochemistry 1996, 35, 9983-9994.
    • (1996) Biochemistry , vol.35 , pp. 9983-9994
    • Bevilacqua, P.C.1    Cech, T.R.2
  • 90
    • 46949097299 scopus 로고    scopus 로고
    • Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-i and melanoma differentiation-associated gene 5
    • Kato, H.; Takeuchi, O.; Mikamo-Satoh, E.; Hirai, R.; Kawai, T.; Matsushita, K.; Hiiragi, A.; Dermody, T.S.; Fujita, T.; Akira, S. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-i and melanoma differentiation-associated gene 5. J. Exp. Med. 2008, 205, 1601-1610.
    • (2008) J. Exp. Med , vol.205 , pp. 1601-1610
    • Kato, H.1    Takeuchi, O.2    Mikamo-Satoh, E.3    Hirai, R.4    Kawai, T.5    Matsushita, K.6    Hiiragi, A.7    Dermody, T.S.8    Fujita, T.9    Akira, S.10
  • 91
    • 34548129595 scopus 로고    scopus 로고
    • The response of mammalian cells to double-stranded rna
    • Gantier, M.P.; Williams, B.R.G. The response of mammalian cells to double-stranded rna. Cytokine Growth Factor Rev. 2007, 18, 363-371.
    • (2007) Cytokine Growth Factor Rev , vol.18 , pp. 363-371
    • Gantier, M.P.1    Williams, B.R.G.2
  • 94
    • 84859361795 scopus 로고    scopus 로고
    • Toll-like receptor (tlr) 3 immune modulation by unformulated small interfering rna or DNA and the role of cd14 (in tlr-mediated effects)
    • Weber, C.; Müller, C.; Podszuweit, A.; Montino, C.; Vollmer, J.; Forsbach, A. Toll-like receptor (tlr) 3 immune modulation by unformulated small interfering rna or DNA and the role of cd14 (in tlr-mediated effects). Immunology 2012, 136, 64-77.
    • (2012) Immunology , vol.136 , pp. 64-77
    • Weber, C.1    Müller, C.2    Podszuweit, A.3    Montino, C.4    Vollmer, J.5    Forsbach, A.6
  • 95
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded rna and activation of nf-kappab by toll-like receptor 3
    • Alexopoulou, L.; Holt, A.C.; Medzhitov, R.; Flavell, R.A. Recognition of double-stranded rna and activation of nf-kappab by toll-like receptor 3. Nature 2001, 413, 732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 96
    • 2442705429 scopus 로고    scopus 로고
    • Small interfering rnas mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3
    • Kariko, K.; Bhuyan, P.; Capodici, J.; Weissman, D. Small interfering rnas mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3. J. Immunol. 2004, 172, 6545-6549.
    • (2004) J. Immunol , vol.172 , pp. 6545-6549
    • Kariko, K.1    Bhuyan, P.2    Capodici, J.3    Weissman, D.4
  • 98
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic sirna
    • Judge, A.D.; Sood, V.; Shaw, J.R.; Fang, D.; McClintock, K.; MacLachlan, I. Sequence-dependent stimulation of the mammalian innate immune response by synthetic sirna. Nat. Biotechnol. 2005, 23, 457-462.
    • (2005) Nat. Biotechnol , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    Maclachlan, I.6
  • 100
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of tlr7-mediated recognition of single-stranded rna
    • Diebold, S.S.; Kaisho, T.; Hemmi, H.; Akira, S.; Reis e Sousa, C. Innate antiviral responses by means of tlr7-mediated recognition of single-stranded rna. Science 2004, 303, 1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis e Sousa, C.5
  • 101
    • 33845579097 scopus 로고    scopus 로고
    • Nucleic acid agonists for toll-like receptor 7 are defined by the presence of uridine ribonucleotides
    • Diebold, S.S.; Massacrier, C.; Akira, S.; Paturel, C.; Morel, Y.; Reis e Sousa, C. Nucleic acid agonists for toll-like receptor 7 are defined by the presence of uridine ribonucleotides. Eur. J. Immunol. 2006, 36, 3256-3267.
    • (2006) Eur. J. Immunol , vol.36 , pp. 3256-3267
    • Diebold, S.S.1    Massacrier, C.2    Akira, S.3    Paturel, C.4    Morel, Y.5    Reis e Sousa, C.6
  • 106
    • 18044365415 scopus 로고    scopus 로고
    • Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded sirnas is sequence-dependent and requires endosomal localization
    • Sioud, M. Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded sirnas is sequence-dependent and requires endosomal localization. J. Mol. Biol. 2005, 348, 1079-1090.
    • (2005) J. Mol. Biol , vol.348 , pp. 1079-1090
    • Sioud, M.1
  • 110
    • 14344275144 scopus 로고    scopus 로고
    • Biological aspects of DNA/rna quadruplexes
    • Shafer, R.H.; Smirnov, I. Biological aspects of DNA/rna quadruplexes. Biopolymers 2000, 56, 209-227.
    • (2000) Biopolymers , vol.56 , pp. 209-227
    • Shafer, R.H.1    Smirnov, I.2
  • 112
    • 79959391612 scopus 로고    scopus 로고
    • The conformation of microrna seed regions in native micrornps is prearranged for presentation to mrna targets
    • Lambert, N.J.; Gu, S.G.; Zahler, A.M. The conformation of microrna seed regions in native micrornps is prearranged for presentation to mrna targets. Nucleic Acids Res. 2011, 39, 4827-4835.
    • (2011) Nucleic Acids Res , vol.39 , pp. 4827-4835
    • Lambert, N.J.1    Gu, S.G.2    Zahler, A.M.3
  • 113
    • 79959366354 scopus 로고    scopus 로고
    • Thermodynamic stability of small hairpin rnas highly influences the loading process of different mammalian argonautes
    • Gu, S.; Jin, L.; Zhang, F.; Huang, Y.; Grimm, D.; Rossi, J.J.; Kay, M.A. Thermodynamic stability of small hairpin rnas highly influences the loading process of different mammalian argonautes. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 9208-9213.
    • (2011) Proc. Natl. Acad. Sci. U. S. A , vol.108 , pp. 9208-9213
    • Gu, S.1    Jin, L.2    Zhang, F.3    Huang, Y.4    Grimm, D.5    Rossi, J.J.6    Kay, M.A.7
  • 114
    • 58249088751 scopus 로고    scopus 로고
    • Micrornas: Target recognition and regulatory functions
    • Bartel, D. Micrornas: Target recognition and regulatory functions. Cell 2009, 136, 215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.1
  • 117
    • 0036544755 scopus 로고    scopus 로고
    • Micro rnas are complementary to 3 ' utr sequence motifs that mediate negative post-transcriptional regulation
    • Lai, E.C. Micro rnas are complementary to 3 ' utr sequence motifs that mediate negative post-transcriptional regulation. Nat. Genet. 2002, 30, 363-364.
    • (2002) Nat. Genet , vol.30 , pp. 363-364
    • Lai, E.C.1
  • 119
    • 33748346026 scopus 로고    scopus 로고
    • Perfect seed pairing is not a generally reliable predictor for mirna-target interactions
    • Didiano, D.; Hobert, O. Perfect seed pairing is not a generally reliable predictor for mirna-target interactions. Nat. Struct. Mol. Biol. 2006, 13, 849-851.
    • (2006) Nat. Struct. Mol. Biol , vol.13 , pp. 849-851
    • Didiano, D.1    Hobert, O.2
  • 120
    • 1642374097 scopus 로고    scopus 로고
    • Specificity of microrna target selection in translational repression
    • Doench, J.G.; Sharp, P.A. Specificity of microrna target selection in translational repression. Genes Dev. 2004, 18, 504-511.
    • (2004) Genes Dev , vol.18 , pp. 504-511
    • Doench, J.G.1    Sharp, P.A.2
  • 121
    • 80053197539 scopus 로고    scopus 로고
    • Argonaute protein identity and pairing geometry determine cooperativity in mammalian rna silencing
    • Broderick, J.A.; Salomon, W.E.; Ryder, S.P.; Aronin, N.; Zamore, P.D. Argonaute protein identity and pairing geometry determine cooperativity in mammalian rna silencing. RNA 2011, 17, 1858-1869.
    • (2011) RNA , vol.17 , pp. 1858-1869
    • Broderick, J.A.1    Salomon, W.E.2    Ryder, S.P.3    Aronin, N.4    Zamore, P.D.5
  • 122
    • 78651293534 scopus 로고    scopus 로고
    • Mirbase: Integrating microrna annotation and deep-sequencing data
    • Kozomara, A.; Griffiths-Jones, S. Mirbase: Integrating microrna annotation and deep-sequencing data. Nucleic Acids Res. 2011, 39, D152-D157.
    • (2011) Nucleic Acids Res , vol.39
    • Kozomara, A.1    Griffiths-Jones, S.2
  • 124
    • 77949473897 scopus 로고    scopus 로고
    • Systematic analysis of off-target effects in an rnai screen reveals micrornas affecting sensitivity to trail-induced apoptosis
    • Sudbery, I.; Enright, A.J.; Fraser, A.G.; Dunham, I. Systematic analysis of off-target effects in an rnai screen reveals micrornas affecting sensitivity to trail-induced apoptosis. BMC Genomics 2010, 11, 175.
    • (2010) BMC Genomics , vol.11 , pp. 175
    • Sudbery, I.1    Enright, A.J.2    Fraser, A.G.3    Dunham, I.4
  • 126
    • 2442641279 scopus 로고    scopus 로고
    • Many commonly used sirnas risk off-target activity
    • Snove, O.; Holen, T. Many commonly used sirnas risk off-target activity. Biochem. Biophys. Res. Commun. 2004, 319, 256-263.
    • (2004) Biochem. Biophys. Res. Commun , vol.319 , pp. 256-263
    • Snove, O.1    Holen, T.2
  • 129
    • 33745612464 scopus 로고    scopus 로고
    • Widespread sirna "off-target" transcript silencing mediated by seed region sequence complementarity
    • Jackson, A.L.; Burchard, J.; Schelter, J.; Chau, B.N.; Cleary, M.; Lim, L.; Linsley, P.S. Widespread sirna "off-target" transcript silencing mediated by seed region sequence complementarity. RNA 2006,12, 1179-1187.
    • (2006) RNA , vol.12 , pp. 1179-1187
    • Jackson, A.L.1    Burchard, J.2    Schelter, J.3    Chau, B.N.4    Cleary, M.5    Lim, L.6    Linsley, P.S.7
  • 130
    • 0142173075 scopus 로고    scopus 로고
    • Small rnas with imperfect match to endogenous mrna repress translation. Implications for off-target activity of small inhibitory rna in mammalian cells
    • Saxena, S.; Jónsson, Z.O.; Dutta, A. Small rnas with imperfect match to endogenous mrna repress translation. Implications for off-target activity of small inhibitory rna in mammalian cells. J. Biol. Chem. 2003, 278, 44312-44319.
    • (2003) J. Biol. Chem , vol.278 , pp. 44312-44319
    • Saxena, S.1    Jónsson, Z.O.2    Dutta, A.3
  • 132
    • 33847245910 scopus 로고    scopus 로고
    • Comparison of sirna-induced off-target rna and protein effects
    • Aleman, L.M.; Doench, J.; Sharp, P.A. Comparison of sirna-induced off-target rna and protein effects. RNA 2007, 13, 385-395.
    • (2007) RNA , vol.13 , pp. 385-395
    • Aleman, L.M.1    Doench, J.2    Sharp, P.A.3
  • 133
    • 22144478256 scopus 로고    scopus 로고
    • Microrna-dependent localization of targeted mrnas to mammalian p-bodies
    • Liu, J.; Valencia-Sanchez, M.A.; Hannon, G.J.; Parker, R. Microrna-dependent localization of targeted mrnas to mammalian p-bodies. Nat. Cell Biol. 2005, 7, 719-723.
    • (2005) Nat. Cell Biol , vol.7 , pp. 719-723
    • Liu, J.1    Valencia-Sanchez, M.A.2    Hannon, G.J.3    Parker, R.4
  • 134
    • 15444379718 scopus 로고    scopus 로고
    • Processing bodies require rna for assembly and contain nontranslating mrnas
    • Teixeira, D.; Sheth, U.; Valencia-Sanchez, M.A.; Brengues, M.; Parker, R Processing bodies require rna for assembly and contain nontranslating mrnas. RNA 2005, 11, 371-382.
    • (2005) RNA , vol.11 , pp. 371-382
    • Teixeira, D.1    Sheth, U.2    Valencia-Sanchez, M.A.3    Brengues, M.4    Parker, R.5
  • 135
    • 34250653704 scopus 로고    scopus 로고
    • Micrornas silence gene expression by repressing protein expression and/or by promoting mrna decay
    • Behm-Ansmant, I.; Rehwinkel, J.; Izaurralde, E. Micrornas silence gene expression by repressing protein expression and/or by promoting mrna decay. Cold Spring Harb. Symp. Quant. Biol. 2006, 71, 523-530.
    • (2006) Cold Spring Harb. Symp. Quant. Biol , vol.71 , pp. 523-530
    • Behm-Ansmant, I.1    Rehwinkel, J.2    Izaurralde, E.3
  • 137
    • 0347623204 scopus 로고    scopus 로고
    • Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering rnas (sirnas)
    • Persengiev, S.P.; Zhu, X.; Green, M.R. Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering rnas (sirnas). RNA 2004, 10, 12-18.
    • (2004) RNA , vol.10 , pp. 12-18
    • Persengiev, S.P.1    Zhu, X.2    Green, M.R.3
  • 138
    • 79956196528 scopus 로고    scopus 로고
    • A simple bayesian estimate of direct rnai gene regulation events from differential gene expression profiles
    • Wilson, P.A.; Plucinski, M. A simple bayesian estimate of direct rnai gene regulation events from differential gene expression profiles. BMC Genomics 2011, 12, 250.
    • (2011) BMC Genomics , vol.12 , pp. 250
    • Wilson, P.A.1    Plucinski, M.2
  • 139
    • 3042654830 scopus 로고    scopus 로고
    • Protein expression profiling arrays: Tools for the multiplexed high-throughput analysis of proteins
    • Sydor, J.R; Nock, S. Protein expression profiling arrays: Tools for the multiplexed high-throughput analysis of proteins. Proteome Sci. 2003, 1, 3.
    • (2003) Proteome Sci , vol.1 , pp. 3
    • Sydor, J.R.1    Nock, S.2
  • 141
    • 75649121811 scopus 로고    scopus 로고
    • Profiling of mismatch discrimination in rnai enabled rational design of allele-specific sirnas
    • Huang, H.; Qiao, R.; Zhao, D.; Zhang, T.; Li, Y.; Yi, F.; Lai, F.; Hong, J.; Ding, X.; Yang, Z, et al. Profiling of mismatch discrimination in rnai enabled rational design of allele-specific sirnas. Nucleic Acids Res. 2009, 37, 7560-7569.
    • (2009) Nucleic Acids Res , vol.37 , pp. 7560-7569
    • Huang, H.1    Qiao, R.2    Zhao, D.3    Zhang, T.4    Li, Y.5    Yi, F.6    Lai, F.7    Hong, J.8    Ding, X.9    Yang, Z.10
  • 143
    • 58649113420 scopus 로고    scopus 로고
    • Enhancement of the seed-target recognition step in rna silencing by a piwi/mid domain protein
    • Parker, J.S.; Parizotto, E.A.; Wang, M.; Roe, S.M.; Barford, D. Enhancement of the seed-target recognition step in rna silencing by a piwi/mid domain protein. Mol. Cell 2009, 33, 204-214.
    • (2009) Mol. Cell , vol.33 , pp. 204-214
    • Parker, J.S.1    Parizotto, E.A.2    Wang, M.3    Roe, S.M.4    Barford, D.5
  • 145
    • 77954214431 scopus 로고    scopus 로고
    • Crystal structure and ligand binding of the mid domain of a eukaryotic argonaute protein
    • Boland, A.; Tritschler, F.; Heimst Auml Dt, S.; Izaurralde, E.; Weichenrieder, O. Crystal structure and ligand binding of the mid domain of a eukaryotic argonaute protein. EMBO Rep. 2010, 11, 522-527.
    • (2010) EMBO Rep , vol.11 , pp. 522-527
    • Boland, A.1    Tritschler, F.2    Heimst Auml, D.S.3    Izaurralde, E.4    Weichenrieder, O.5
  • 146
    • 2442679207 scopus 로고    scopus 로고
    • Structural basis for overhang-specific small interfering rna recognition by the paz domain
    • Ma, J.-B.; Ye, K.; Patel, D.J. Structural basis for overhang-specific small interfering rna recognition by the paz domain. Nature 2004, 429, 318-322.
    • (2004) Nature , vol.429 , pp. 318-322
    • Ma, J.-B.1    Ye, K.2    Patel, D.J.3
  • 150
    • 27944473306 scopus 로고    scopus 로고
    • Design of sirnas producing unstructured guide-rnas results in improved rna interference efficiency
    • Patzel, V.; Rutz, S.; Dietrich, I.; Köberle, C.; Scheffold, A.; Kaufmann, S.H.E. Design of sirnas producing unstructured guide-rnas results in improved rna interference efficiency. Nat. Biotechnol. 2005, 23, 1440-1444.
    • (2005) Nat. Biotechnol , vol.23 , pp. 1440-1444
    • Patzel, V.1    Rutz, S.2    Dietrich, I.3    Köberle, C.4    Scheffold, A.5    Kaufmann, S.H.E.6
  • 151
    • 33846634136 scopus 로고    scopus 로고
    • Selecting effective sirnas based on guide rna structure
    • Köberle, C.; Kaufmann, S.H.E.; Patzel, V. Selecting effective sirnas based on guide rna structure. Nat. Protoc. 2006, 1, 1832-1839.
    • (2006) Nat. Protoc , vol.1 , pp. 1832-1839
    • Köberle, C.1    Kaufmann, S.H.E.2    Patzel, V.3
  • 152
    • 33747777302 scopus 로고    scopus 로고
    • Gene silencing with sirna duplexes composed of target-mrna-complementary and partially palindromic or partially complementary single-stranded sirnas
    • Hossbach, M.; Gruber, J.; Osborn, M.; Weber, K.; Tuschl, T. Gene silencing with sirna duplexes composed of target-mrna-complementary and partially palindromic or partially complementary single-stranded sirnas. RNA Biol. 2006, 3, 82-89.
    • (2006) RNA Biol , vol.3 , pp. 82-89
    • Hossbach, M.1    Gruber, J.2    Osborn, M.3    Weber, K.4    Tuschl, T.5
  • 155
    • 84862317270 scopus 로고    scopus 로고
    • Rna interference trigger variants: Getting the most out of rna for rna interference-based therapeutics
    • Snead, N.M.; Rossi, J.J. Rna interference trigger variants: Getting the most out of rna for rna interference-based therapeutics. Nucleic Acid Ther. 2012, 22, 139-146.
    • (2012) Nucleic Acid Ther , vol.22 , pp. 139-146
    • Snead, N.M.1    Rossi, J.J.2
  • 156
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded antisense sirnas guide target rna cleavage in rnai
    • Martinez, J.; Patkaniowska, A.; Urlaub, H.; Lührmann, R.; Tuschl, T. Single-stranded antisense sirnas guide target rna cleavage in rnai. Cell 2002, 110, 563-574.
    • (2002) Cell , vol.110 , pp. 563-574
    • Martinez, J.1    Patkaniowska, A.2    Urlaub, H.3    Lührmann, R.4    Tuschl, T.5
  • 157
    • 0038074374 scopus 로고    scopus 로고
    • Similar behaviour of single-strand and double-strand sirnas suggests they act through a common rnai pathway
    • Holen, T.; Amarzguioui, M.; Babaie, E.; Prydz, H. Similar behaviour of single-strand and double-strand sirnas suggests they act through a common rnai pathway. Nucleic Acids Res. 2003, 31, 2401-2407.
    • (2003) Nucleic Acids Res , vol.31 , pp. 2401-2407
    • Holen, T.1    Amarzguioui, M.2    Babaie, E.3    Prydz, H.4
  • 160
    • 50649103008 scopus 로고    scopus 로고
    • Potent rnai by short rna triggers
    • Chu, C.-Y.; Rana, T.M. Potent rnai by short rna triggers. RNA 2008, 14, 1714-1719.
    • (2008) RNA , vol.14 , pp. 1714-1719
    • Chu, C.-Y.1    Rana, T.M.2
  • 161
    • 57449107290 scopus 로고    scopus 로고
    • Asymmetric rna duplexes mediate rna interference in mammalian cells
    • Sun, X.; Rogoff, H.A.; Li, C.J. Asymmetric rna duplexes mediate rna interference in mammalian cells. Nat. Biotechnol. 2008, 26, 1379-1382.
    • (2008) Nat. Biotechnol , vol.26 , pp. 1379-1382
    • Sun, X.1    Rogoff, H.A.2    Li, C.J.3
  • 162
    • 63949084982 scopus 로고    scopus 로고
    • Asymmetric shorter-duplex sirna structures trigger efficient gene silencing with reduced nonspecific effects
    • Chang, C.I.; Yoo, J.W.; Hong, S.W.; Lee, S.E.; Kang, H.S.; Sun, X.; Rogoff, H.A.; Ban, C.; Kim, S.; Li, C.J.; et al. Asymmetric shorter-duplex sirna structures trigger efficient gene silencing with reduced nonspecific effects. Mol. Ther. 2009, 17, 725-732.
    • (2009) Mol. Ther , vol.17 , pp. 725-732
    • Chang, C.I.1    Yoo, J.W.2    Hong, S.W.3    Lee, S.E.4    Kang, H.S.5    Sun, X.6    Rogoff, H.A.7    Ban, C.8    Kim, S.9    Li, C.J.10
  • 163
    • 1642491747 scopus 로고    scopus 로고
    • Enhancement of rnai activity by improved sirna duplexes
    • Hohjoh, H. Enhancement of rnai activity by improved sirna duplexes. FEBS Lett. 2004, 557, 193-198.
    • (2004) FEBS Lett , vol.557 , pp. 193-198
    • Hohjoh, H.1
  • 165
    • 80052393683 scopus 로고    scopus 로고
    • Modified sirna structure with a single nucleotide bulge overcomes conventional sirna-mediated off-target silencing
    • Dua, P.; Yoo, J.W.; Kim, S.; Lee, D.-K. Modified sirna structure with a single nucleotide bulge overcomes conventional sirna-mediated off-target silencing. Mol. Ther. 2011, 19, 1676-1687.
    • (2011) Mol. Ther , vol.19 , pp. 1676-1687
    • Dua, P.1    Yoo, J.W.2    Kim, S.3    Lee, D.-K.4
  • 168
    • 77649175477 scopus 로고    scopus 로고
    • Competition between sirna duplexes: Impact of rna-induced silencing complex loading efficiency and comparison between conventional-21 bp and dicer-substrate sirnas
    • Tanudji, M.; Machalek, D.; Arndt, G.M.; Rivory, L. Competition between sirna duplexes: Impact of rna-induced silencing complex loading efficiency and comparison between conventional-21 bp and dicer-substrate sirnas. Oligonucleotides 2010, 20, 27-32.
    • (2010) Oligonucleotides , vol.20 , pp. 27-32
    • Tanudji, M.1    Machalek, D.2    Arndt, G.M.3    Rivory, L.4
  • 170
    • 33845530239 scopus 로고    scopus 로고
    • Maldi-tof mass spectral analysis of sirna degradation in serum confirms an rnase a-like activity
    • Turner, J.J.; Jones, S.W.; Moschos, S.A.; Lindsay, M.A.; Gait, M.J. Maldi-tof mass spectral analysis of sirna degradation in serum confirms an rnase a-like activity. Mol. Biosyst. 2006, 3, 43-50.
    • (2006) Mol. Biosyst , vol.3 , pp. 43-50
    • Turner, J.J.1    Jones, S.W.2    Moschos, S.A.3    Lindsay, M.A.4    Gait, M.J.5
  • 177
    • 0041331496 scopus 로고    scopus 로고
    • Sirna function in rnai: A chemical modification analysis
    • Chiu, Y.-L.; Rana, T.M. Sirna function in rnai: A chemical modification analysis. RNA 2003, 9, 1034-1048.
    • (2003) RNA , vol.9 , pp. 1034-1048
    • Chiu, Y.-L.1    Rana, T.M.2
  • 179
    • 33751511117 scopus 로고    scopus 로고
    • Gene expression analysis in blood cells in response to unmodified and 2-modified sirnas reveals tlr-dependent and independent effects
    • Cekaite, L.; Furset, G.; Hovig, E.; Sioud, M. Gene expression analysis in blood cells in response to unmodified and 2-modified sirnas reveals tlr-dependent and independent effects. J. Mol. Biol. 2007, 365, 90-108.
    • (2007) J. Mol. Biol , vol.365 , pp. 90-108
    • Cekaite, L.1    Furset, G.2    Hovig, E.3    Sioud, M.4
  • 180
    • 65549109425 scopus 로고    scopus 로고
    • Sequences derived from self-rna containing certain natural modifications act as suppressors of rna-mediated inflammatory immune responses
    • Tluk, S.; Jurk, M.; Forsbach, A.; Weeratna, R.; Samulowitz, U.; Krieg, A.M.; Bauer, S.; Vollmer, J. Sequences derived from self-rna containing certain natural modifications act as suppressors of rna-mediated inflammatory immune responses. Int. Immunol. 2009, 21, 607-619.
    • (2009) Int. Immunol , vol.21 , pp. 607-619
    • Tluk, S.1    Jurk, M.2    Forsbach, A.3    Weeratna, R.4    Samulowitz, U.5    Krieg, A.M.6    Bauer, S.7    Vollmer, J.8
  • 182
    • 31044444460 scopus 로고    scopus 로고
    • Inhibition of rnase a family enzymes prevents degradation and loss of silencing activity of sirnas in serum
    • Haupenthal, J.; Baehr, C.; Kiermayer, S.; Zeuzem, S.; Piiper, A. Inhibition of rnase a family enzymes prevents degradation and loss of silencing activity of sirnas in serum. Biochem. Pharmacol. 2006, 71, 702-710.
    • (2006) Biochem. Pharmacol , vol.71 , pp. 702-710
    • Haupenthal, J.1    Baehr, C.2    Kiermayer, S.3    Zeuzem, S.4    Piiper, A.5
  • 183
    • 0037440005 scopus 로고    scopus 로고
    • Tolerance for mutations and chemical modifications in a sirna
    • Amarzguioui, M. Tolerance for mutations and chemical modifications in a sirna. Nucleic Acids Res. 2003, 31, 589-595.
    • (2003) Nucleic Acids Res , vol.31 , pp. 589-595
    • Amarzguioui, M.1
  • 185
    • 84875878783 scopus 로고    scopus 로고
    • Development of therapeutic-grade small interfering rnas by chemical engineering
    • Bramsen, J.B.; Kjems, J. Development of therapeutic-grade small interfering rnas by chemical engineering. Front. Genet. 2012, 3, 154-154.
    • (2012) Front. Genet , vol.3 , pp. 154
    • Bramsen, J.B.1    Kjems, J.2
  • 186
    • 79960363229 scopus 로고    scopus 로고
    • More effective nanomedicines through particle design
    • Wang, J.; Byrne, J.D.; Napier, M.E.; DeSimone, J.M. More effective nanomedicines through particle design. Small 2011, 7, 1919-1931.
    • (2011) Small , vol.7 , pp. 1919-1931
    • Wang, J.1    Byrne, J.D.2    Napier, M.E.3    Desimone, J.M.4
  • 187
    • 84858673601 scopus 로고    scopus 로고
    • Design of polymeric nanoparticles for biomedical delivery applications
    • Elsabahy, M.; Wooley, K.L. Design of polymeric nanoparticles for biomedical delivery applications. Chem. Soc. Rev. 2012, 41, 2545-2561.
    • (2012) Chem. Soc. Rev , vol.41 , pp. 2545-2561
    • Elsabahy, M.1    Wooley, K.L.2
  • 192
    • 70350292588 scopus 로고    scopus 로고
    • Liposomes and nanoparticles: Nanosized vehicles for drug delivery in cancer
    • Malam, Y.; Loizidou, M.; Seifalian, A.M. Liposomes and nanoparticles: Nanosized vehicles for drug delivery in cancer. Trends Pharmacol. Sci. 2009, 30, 592-599.
    • (2009) Trends Pharmacol. Sci , vol.30 , pp. 592-599
    • Malam, Y.1    Loizidou, M.2    Seifalian, A.M.3
  • 195
    • 51049108389 scopus 로고    scopus 로고
    • Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution
    • Dobrovolskaia, M.A.; Aggarwal, P.; Hall, J.B.; McNeil, S.E. Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution. Mol. Pharm. 2008, 5, 487-495.
    • (2008) Mol. Pharm , vol.5 , pp. 487-495
    • Dobrovolskaia, M.A.1    Aggarwal, P.2    Hall, J.B.3    McNeil, S.E.4
  • 196
    • 84860388978 scopus 로고    scopus 로고
    • Size-dependent cytotoxicity of amorphous silica nanoparticles in human hepatoma hepg2 cells
    • Li, Y.; Sun, L.; Jin, M.; Du, Z.; Liu, X.; Guo, C.; Li, Y.; Huang, P.; Sun, Z. Size-dependent cytotoxicity of amorphous silica nanoparticles in human hepatoma hepg2 cells. Toxicol. In Vitro 2011, 25, 1343-1352.
    • (2011) Toxicol. In Vitro , vol.25 , pp. 1343-1352
    • Li, Y.1    Sun, L.2    Jin, M.3    Du, Z.4    Liu, X.5    Guo, C.6    Li, Y.7    Huang, P.8    Sun, Z.9
  • 197
    • 34249780352 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticles for drug delivery and biosensing applications
    • Slowing, I.I.; Trewyn, B.G.; Giri, S.; Lin, V.S.Y. Mesoporous silica nanoparticles for drug delivery and biosensing applications. Adv. Funct. Mater. 2007, 17, 1225-1236.
    • (2007) Adv. Funct. Mater , vol.17 , pp. 1225-1236
    • Slowing, I.I.1    Trewyn, B.G.2    Giri, S.3    Lin, V.S.Y.4
  • 198
    • 84869443946 scopus 로고    scopus 로고
    • Biocompatibility of mesoporous silica nanoparticles
    • Asefa, T.; Tao, Z. Biocompatibility of mesoporous silica nanoparticles. Chem. Res. Toxicol. 2012,25, 2265-2284.
    • (2012) Chem. Res. Toxicol , vol.25 , pp. 2265-2284
    • Asefa, T.1    Tao, Z.2
  • 200
    • 79952035153 scopus 로고    scopus 로고
    • Magnetic nanoparticles as targeted delivery systems in oncology
    • Prijic, S.; Sersa, G. Magnetic nanoparticles as targeted delivery systems in oncology. Radiol. Oncol. 2011, 45, 1-16.
    • (2011) Radiol. Oncol , vol.45 , pp. 1-16
    • Prijic, S.1    Sersa, G.2
  • 201
    • 79951921750 scopus 로고    scopus 로고
    • Biodistribution and toxicity of engineered gold nanoparticles: A review of in vitro and in vivo studies
    • Khlebtsov, N.; Dykman, L. Biodistribution and toxicity of engineered gold nanoparticles: A review of in vitro and in vivo studies. Chem. Soc. Rev. 2011, 40, 1647-1671.
    • (2011) Chem. Soc. Rev , vol.40 , pp. 1647-1671
    • Khlebtsov, N.1    Dykman, L.2
  • 202
    • 79960132035 scopus 로고    scopus 로고
    • The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles
    • Cho, E.C.; Zhang, Q.; Xia, Y. The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles. Nat. Nanotechnol. 2011, 6, 385-391.
    • (2011) Nat. Nanotechnol , vol.6 , pp. 385-391
    • Cho, E.C.1    Zhang, Q.2    Xia, Y.3
  • 203
    • 84860875427 scopus 로고    scopus 로고
    • Cationic lipid-coated gold nanoparticles as efficient and non-cytotoxic intracellular sirna delivery vehicles
    • Kong, W.H.; Bae, K.H.; Jo, S.D.; Kim, J.S.; Park, T.G. Cationic lipid-coated gold nanoparticles as efficient and non-cytotoxic intracellular sirna delivery vehicles. Pharm. Res. 2012, 29, 362-374.
    • (2012) Pharm. Res , vol.29 , pp. 362-374
    • Kong, W.H.1    Bae, K.H.2    Jo, S.D.3    Kim, J.S.4    Park, T.G.5
  • 204
    • 84867642276 scopus 로고    scopus 로고
    • Rnai-based nanomedicines for targeted personalized therapy
    • Daka, A.; Peer, D. Rnai-based nanomedicines for targeted personalized therapy. Adv. Drug Deliv. Rev. 2012, 64, 1508-1521.
    • (2012) Adv. Drug Deliv. Rev , vol.64 , pp. 1508-1521
    • Daka, A.1    Peer, D.2
  • 205
    • 84855824016 scopus 로고    scopus 로고
    • Nanoparticles: A boon to drug delivery, therapeutics, diagnostics and imaging
    • Parveen, S.; Misra, R.; Sahoo, S.K. Nanoparticles: A boon to drug delivery, therapeutics, diagnostics and imaging. Nanomedicine 2012, 8, 147-166.
    • (2012) Nanomedicine , vol.8 , pp. 147-166
    • Parveen, S.1    Misra, R.2    Sahoo, S.K.3
  • 206
    • 84856389509 scopus 로고    scopus 로고
    • Rna-based therapeutics: Current progress and future prospects
    • Burnett, J.C.; Rossi, J.J. Rna-based therapeutics: Current progress and future prospects. Chem. Biol. 2012, 19, 60-71.
    • (2012) Chem. Biol , vol.19 , pp. 60-71
    • Burnett, J.C.1    Rossi, J.J.2
  • 208
    • 80051506742 scopus 로고    scopus 로고
    • Electrophysiological characterization of membrane disruption by nanoparticles
    • De Planque, M.R.R.; Aghdaei, S.; Roose, T.; Morgan, H. Electrophysiological characterization of membrane disruption by nanoparticles. ACS Nano 2011, 5, 3599-3606.
    • (2011) ACS Nano , vol.5 , pp. 3599-3606
    • de Planque, M.R.R.1    Aghdaei, S.2    Roose, T.3    Morgan, H.4
  • 209
    • 33644593889 scopus 로고    scopus 로고
    • Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery
    • Khalil, I.A.; Kogure, K.; Akita, H.; Harashima, H. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol. Rev. 2006, 58, 32-45.
    • (2006) Pharmacol. Rev , vol.58 , pp. 32-45
    • Khalil, I.A.1    Kogure, K.2    Akita, H.3    Harashima, H.4
  • 210
    • 84857777395 scopus 로고    scopus 로고
    • Designing nanoparticle translocation through membranes by computer simulations
    • Ding, H.M.; Tian, W.D.; Ma, Y.Q. Designing nanoparticle translocation through membranes by computer simulations. ACS Nano 2012, 6, 1230-1238.
    • (2012) ACS Nano , vol.6 , pp. 1230-1238
    • Ding, H.M.1    Tian, W.D.2    Ma, Y.Q.3
  • 211
    • 80052233389 scopus 로고    scopus 로고
    • Endosome maturation
    • Huotari, J.; Helenius, A. Endosome maturation. EMBO J. 2011, 30, 3481-3500.
    • (2011) EMBO J , vol.30 , pp. 3481-3500
    • Huotari, J.1    Helenius, A.2
  • 213
    • 63049113263 scopus 로고    scopus 로고
    • Defining macropinocytosis
    • Kerr, M.C.; Teasdale, R.D. Defining macropinocytosis. Traffic 2009, 10, 364-371.
    • (2009) Traffic , vol.10 , pp. 364-371
    • Kerr, M.C.1    Teasdale, R.D.2
  • 214
    • 34547114456 scopus 로고    scopus 로고
    • Pathways of clathrin-independent endocytosis
    • Mayor, S.; Pagano, R.E. Pathways of clathrin-independent endocytosis. Nat. Rev. Mol. Cell Biol. 2007, 8, 603-612.
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 603-612
    • Mayor, S.1    Pagano, R.E.2
  • 215
    • 23844462026 scopus 로고    scopus 로고
    • Role of clathrin-and caveolae-mediated endocytosis in gene transfer mediated by lipo-and polyplexes
    • Rejman, J.; Bragonzi, A.; Conese, M. Role of clathrin-and caveolae-mediated endocytosis in gene transfer mediated by lipo-and polyplexes. Mol. Ther. 2005, 12, 468-474.
    • (2005) Mol. Ther , vol.12 , pp. 468-474
    • Rejman, J.1    Bragonzi, A.2    Conese, M.3
  • 216
    • 84870383902 scopus 로고    scopus 로고
    • The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles
    • Frohlich, E. The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. Int. J. Nanomedicine 2012, 7, 5577-5591.
    • (2012) Int. J. Nanomedicine , vol.7 , pp. 5577-5591
    • Frohlich, E.1
  • 217
    • 4344697827 scopus 로고    scopus 로고
    • Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependent pathway impair the transfection efficiency of human hepatocarcinoma cells
    • Goncalves, C.; Mennesson, E.; Fuchs, R.; Gorvel, J.P.; Midoux, P.; Pichon, C. Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependent pathway impair the transfection efficiency of human hepatocarcinoma cells. Mol. Ther. 2004, 10, 373-385.
    • (2004) Mol. Ther , vol.10 , pp. 373-385
    • Goncalves, C.1    Mennesson, E.2    Fuchs, R.3    Gorvel, J.P.4    Midoux, P.5    Pichon, C.6
  • 219
    • 81855198887 scopus 로고    scopus 로고
    • Factors controlling nanoparticle pharmacokinetics: An integrated analysis and perspective
    • Moghimi, S.M.; Hunter, A.C.; Andresen, T.L. Factors controlling nanoparticle pharmacokinetics: An integrated analysis and perspective. Annu. Rev. Pharmacol. Toxicol. 2012, 52, 481-503.
    • (2012) Annu. Rev. Pharmacol. Toxicol , vol.52 , pp. 481-503
    • Moghimi, S.M.1    Hunter, A.C.2    Andresen, T.L.3
  • 220
    • 15044362503 scopus 로고    scopus 로고
    • Globular proteins as probes for testing glomerular permselectivity: Effects of molecular size, shape, charge, and deformability
    • Venturoli, D.; Rippe, B. Ficoll, and dextran VS. Globular proteins as probes for testing glomerular permselectivity: Effects of molecular size, shape, charge, and deformability. Am. J. Physiol. Renal Physiol. 2005, 288, F605-F613.
    • (2005) Am. J. Physiol. Renal Physiol , vol.288
    • Venturoli, D.1    Ficoll, R.P.2    Dextran, V.S.3
  • 221
    • 77955175216 scopus 로고    scopus 로고
    • Strategies in the design of nanoparticles for therapeutic applications
    • Petros, R.A.; DeSimone, J.M. Strategies in the design of nanoparticles for therapeutic applications. Nat. Rev. Drug Discov. 2010, 9, 615-627.
    • (2010) Nat. Rev. Drug Discov , vol.9 , pp. 615-627
    • Petros, R.A.1    Desimone, J.M.2
  • 222
    • 1642362625 scopus 로고    scopus 로고
    • Drug delivery systems: Entering the mainstream
    • Allen, T.M.; Cullis, P.R. Drug delivery systems: Entering the mainstream. Science 2004, 303, 1818-1822.
    • (2004) Science , vol.303 , pp. 1818-1822
    • Allen, T.M.1    Cullis, P.R.2
  • 223
    • 33646384586 scopus 로고    scopus 로고
    • Parameters influencing the stealthiness of colloidal drug delivery systems
    • Vonarbourg, A.; Passirani, C.; Saulnier, P.; Benoit, J.P. Parameters influencing the stealthiness of colloidal drug delivery systems. Biomaterials 2006, 27, 4356-4373.
    • (2006) Biomaterials , vol.27 , pp. 4356-4373
    • Vonarbourg, A.1    Passirani, C.2    Saulnier, P.3    Benoit, J.P.4
  • 224
    • 77956304534 scopus 로고    scopus 로고
    • Macrophages recognize size and shape of their targets
    • Doshi, N.; Mitragotri, S. Macrophages recognize size and shape of their targets. PLoS ONE 2010, 5, e10051.
    • (2010) PLoS ONE , vol.5
    • Doshi, N.1    Mitragotri, S.2
  • 225
    • 57749207052 scopus 로고    scopus 로고
    • Intravascular delivery of particulate systems: Does geometry really matter
    • Decuzzi, P.; Pasqualini, R.; Arap, W.; Ferrari, M. Intravascular delivery of particulate systems: Does geometry really matter? Pharm. Res. 2009, 26, 235-243.
    • (2009) Pharm. Res , vol.26 , pp. 235-243
    • Decuzzi, P.1    Pasqualini, R.2    Arap, W.3    Ferrari, M.4
  • 227
    • 77249104877 scopus 로고    scopus 로고
    • Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
    • He, C.; Hu, Y.; Yin, L.; Tang, C.; Yin, C. Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials 2010, 31, 3657-3666.
    • (2010) Biomaterials , vol.31 , pp. 3657-3666
    • He, C.1    Hu, Y.2    Yin, L.3    Tang, C.4    Yin, C.5
  • 231
    • 84858616151 scopus 로고    scopus 로고
    • Physico-chemical parameters that govern nanoparticles fate also dictate rules for their molecular evolution
    • Dufort, S.; Sancey, L.; Coll, J.L. Physico-chemical parameters that govern nanoparticles fate also dictate rules for their molecular evolution. Adv. Drug Deliv. Rev. 2012, 64, 179-189.
    • (2012) Adv. Drug Deliv. Rev , vol.64 , pp. 179-189
    • Dufort, S.1    Sancey, L.2    Coll, J.L.3
  • 232
    • 0031959490 scopus 로고    scopus 로고
    • Early phase tumor accumulation of macromolecules: A great difference in clearance rate between tumor and normal tissues
    • Noguchi, Y.; Wu, J.; Duncan, R.; Strohalm, J.; Ulbrich, K.; Akaike, T.; Maeda, H. Early phase tumor accumulation of macromolecules: A great difference in clearance rate between tumor and normal tissues. Jpn. J. Cancer Res. 1998, 89, 307-314.
    • (1998) Jpn. J. Cancer Res , vol.89 , pp. 307-314
    • Noguchi, Y.1    Wu, J.2    Duncan, R.3    Strohalm, J.4    Ulbrich, K.5    Akaike, T.6    Maeda, H.7
  • 233
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the epr effect in macromolecular therapeutics: A review
    • Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Tumor vascular permeability and the epr effect in macromolecular therapeutics: A review. J. Control. Release 2000, 65, 271-284.
    • (2000) J. Control. Release , vol.65 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3    Matsumura, Y.4    Hori, K.5
  • 234
    • 55849099605 scopus 로고    scopus 로고
    • Active targeting schemes for nanoparticle systems in cancer therapeutics
    • Byrne, J.D.; Betancourt, T.; Brannon-Peppas, L. Active targeting schemes for nanoparticle systems in cancer therapeutics. Adv. Drug Deliv. Rev. 2008, 60, 1615-1626.
    • (2008) Adv. Drug Deliv. Rev , vol.60 , pp. 1615-1626
    • Byrne, J.D.1    Betancourt, T.2    Brannon-Peppas, L.3
  • 235
    • 84869232766 scopus 로고    scopus 로고
    • Realizing the clinical potential of cancer nanotechnology by minimizing toxicologic and targeted delivery concerns
    • Singh, S.; Sharma, A.; Robertson, G.P. Realizing the clinical potential of cancer nanotechnology by minimizing toxicologic and targeted delivery concerns. Cancer Res. 2012, 72, 5663-5668.
    • (2012) Cancer Res , vol.72 , pp. 5663-5668
    • Singh, S.1    Sharma, A.2    Robertson, G.P.3
  • 236
    • 41649119539 scopus 로고    scopus 로고
    • Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery
    • Lo, A.; Lin, C.-T.; Wu, H.-C. Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery. Mol. Cancer Ther. 2008, 7, 579-589.
    • (2008) Mol. Cancer Ther , vol.7 , pp. 579-589
    • Lo, A.1    Lin, C.-T.2    Wu, H.-C.3
  • 237
    • 33847642135 scopus 로고    scopus 로고
    • Glycotargeting to improve cellular delivery efficiency of nucleic acids
    • Yan, H.B.; Tram, K. Glycotargeting to improve cellular delivery efficiency of nucleic acids. Glycoconj. J. 2007, 24, 107-123.
    • (2007) Glycoconj. J , vol.24 , pp. 107-123
    • Yan, H.B.1    Tram, K.2
  • 239
    • 39549117983 scopus 로고    scopus 로고
    • Delivery vehicles for small interfering rna in vivo
    • De Fougerolles, A.R. Delivery vehicles for small interfering rna in vivo. Hum. Gene Ther. 2008, 19, 125-132.
    • (2008) Hum. Gene Ther , vol.19 , pp. 125-132
    • de Fougerolles, A.R.1
  • 240
    • 80053536608 scopus 로고    scopus 로고
    • Uptake and intracellular fate of multifunctional nanoparticles: A comparison between lipoplexes and polyplexes via quantum dot mediated forster resonance energy transfer
    • Wu, Y.; Ho, Y.P.; Mao, Y.C.; Wang, X.M.; Yu, B.; Leong, K.W.; Lee, L.J. Uptake and intracellular fate of multifunctional nanoparticles: A comparison between lipoplexes and polyplexes via quantum dot mediated forster resonance energy transfer. Mol. Pharm. 2011, 8, 1662-1668.
    • (2011) Mol. Pharm , vol.8 , pp. 1662-1668
    • Wu, Y.1    Ho, Y.P.2    Mao, Y.C.3    Wang, X.M.4    Yu, B.5    Leong, K.W.6    Lee, L.J.7
  • 242
    • 44949169402 scopus 로고    scopus 로고
    • Cationic liposomal lipids: From gene carriers to cell signaling
    • Lonez, C.; Vandenbranden, M.; Ruysschaert, J.M. Cationic liposomal lipids: From gene carriers to cell signaling. Prog. Lipid Res. 2008, 47, 340-347.
    • (2008) Prog. Lipid Res , vol.47 , pp. 340-347
    • Lonez, C.1    Vandenbranden, M.2    Ruysschaert, J.M.3
  • 243
    • 84869169324 scopus 로고    scopus 로고
    • Safety profile of rnai nanomedicines
    • Barros, S.A.; Gollob, J.A. Safety profile of rnai nanomedicines. Adv. Drug Deliv. Rev. 2012, 64, 1730-1737.
    • (2012) Adv. Drug Deliv. Rev , vol.64 , pp. 1730-1737
    • Barros, S.A.1    Gollob, J.A.2
  • 244
    • 67249128859 scopus 로고    scopus 로고
    • The first targeted delivery of sirna in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: From concept to clinic
    • Davis, M.E. The first targeted delivery of sirna in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: From concept to clinic. Mol. Pharm. 2009, 6, 659-668.
    • (2009) Mol. Pharm , vol.6 , pp. 659-668
    • Davis, M.E.1
  • 245
    • 79952487130 scopus 로고    scopus 로고
    • Clinical developments in nanotechnology for cancer therapy
    • Heidel, J.D.; Davis, M.E. Clinical developments in nanotechnology for cancer therapy. Pharm. Res. 2011,28, 187-199.
    • (2011) Pharm. Res , vol.28 , pp. 187-199
    • Heidel, J.D.1    Davis, M.E.2
  • 247
    • 0037462997 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    • Panyam, J.; Labhasetwar, V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev. 2003, 55, 329-347.
    • (2003) Adv. Drug Deliv. Rev , vol.55 , pp. 329-347
    • Panyam, J.1    Labhasetwar, V.2
  • 248
    • 84860781764 scopus 로고    scopus 로고
    • Histone h3 tail peptides and poly(ethylenimine) have synergistic effects for gene delivery
    • Reilly, M.J.; Larsen, J.D.; Sullivan, M.O. Histone h3 tail peptides and poly(ethylenimine) have synergistic effects for gene delivery. Mol. Pharm. 2012, 9, 1031-1040.
    • (2012) Mol. Pharm , vol.9 , pp. 1031-1040
    • Reilly, M.J.1    Larsen, J.D.2    Sullivan, M.O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.