Unique gene-silencing and structural properties of 2′-fluoro-modified siRNAs

Angewandte Chemie - International Edition

Volumn 50, Issue 10, 2011, Pages 2284-2288

  Manoharan, Muthiah ^a   Akinc, Akin ^a   Pandey, Rajendra K ^a   Qin, June ^a   Hadwiger, Philipp ^a,d   John, Matthias ^a   Mills, Kathy ^a   Charisse, Klaus ^a   Maier, Martin A ^a   Nechev, Lubomir ^a   Greene, Emily M ^b   Pallan, Pradeep S ^c   Rozners, Eriks ^b   Rajeev, Kallanthottathil G ^a   Egli, Martin ^c  

^a ALNYLAM PHARMACEUTICALS   (United States)

^b BINGHAMTON UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Roche Kulmbach GmbH   (Germany)

Author keywords

Drug discovery; Nucleic acid modification; RNA interference; Thermodynamics; X ray crystallography

Indexed keywords

DRUG DISCOVERY; GENE SILENCING; NEGATIVE IMPACTS; NUCLEIC ACID MODIFICATION; RNA INTERFERENCE; SMALL INTERFERING RNA;

CRYSTAL STRUCTURE; MINERALOGY; NUCLEIC ACIDS; RNA; SELF ASSEMBLY; THERMODYNAMICS;

X RAY CRYSTALLOGRAPHY;

FLUORINE; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA;

ARTICLE; BINDING SITE; CHEMISTRY; CONFORMATION; GENE SILENCING; PROTEIN TERTIARY STRUCTURE; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FLUORINE; GENE SILENCING; NUCLEIC ACID CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RNA, SMALL INTERFERING; RNA-INDUCED SILENCING COMPLEX; THERMODYNAMICS;

EID: 79952066733     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201006519     Document Type: Article

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