3' UTR seed matches, but not overall identity, are associated with RNAi off-targets.

Nature methods

Volumn 3, Issue 3, 2006, Pages 199-204

  Birmingham, Amanda ^a   Anderson, Emily M ^a   Reynolds, Angela ^a   Ilsley Tyree, Diane ^a   Leake, Devin ^a   Fedorov, Yuriy ^a   Baskerville, Scott ^a   Maksimova, Elena ^a   Robinson, Kathryn ^a   Karpilow, Jon ^a   Marshall, William S ^a   Khvorova, Anastasia ^a  

^a Dharmacon Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; SILICON; SMALL INTERFERING RNA;

3' UNTRANSLATED REGION; ARTICLE; BASE MISPAIRING; BASE PAIRING; BIOLOGY; CELL LINE; CELL SURVIVAL; CHEMISTRY; DNA MICROARRAY; DRUG EFFECT; FACTUAL DATABASE; GENE EXPRESSION PROFILING; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; HELA CELL; HUMAN; MATHEMATICAL COMPUTING; METHODOLOGY; SENSITIVITY AND SPECIFICITY; SEQUENCE ALIGNMENT; SYNTHESIS;

3' UNTRANSLATED REGIONS; BASE PAIR MISMATCH; BASE PAIRING; CELL LINE; CELL SURVIVAL; COMPUTATIONAL BIOLOGY; DATABASES, FACTUAL; GENE EXPRESSION PROFILING; GENE SILENCING; HELA CELLS; HUMANS; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; RNA, SMALL INTERFERING; SENSITIVITY AND SPECIFICITY; SEQUENCE ALIGNMENT; SILICON; TRANSFECTION;

EID: 33646188259     PISSN: 15487091     EISSN: None     Source Type: Journal    
DOI: 10.1038/nmeth854     Document Type: Article

References (0)