MicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 71, Issue , 2006, Pages 523-530

  Behm Ansmant, I ^a   Rehwinkel, J ^a   Izaurralde, E ^a  

^a MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARGONAUTE1 PROTEIN, DROSOPHILA; CAPPED RNA; DROSOPHILA PROTEIN; MESSENGER RNA; MICRORNA; UNCLASSIFIED DRUG; ARGONAUTE 1 PROTEIN; GW182 PROTEIN; UBIQUITIN;

ANIMAL; BIOLOGICAL MODEL; DROSOPHILA; GENE SILENCING; GENETICS; METABOLISM; PROTEIN SYNTHESIS; REVIEW; RNA STABILITY; ADENYLATION; ARTICLE; BASE PAIRING; DEADENYLATION; GENE EXPRESSION; GENE REPRESSION; GENE TARGETING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RNA DEGRADATION; RNA TRANSLATION;

ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; GENE SILENCING; MICRORNAS; MODELS, BIOLOGICAL; PROTEIN BIOSYNTHESIS; RNA CAPS; RNA STABILITY; RNA, MESSENGER;

EID: 34250653704     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2006.71.013     Document Type: Conference Paper

References (39)

1. Allen E., Xie Z., Gustafson A.M., and Carrington J.C. 2005. microRNA-directed phasing during trans-acting siRNA biogenesis in plants. Cell 121: 207.
2. Bagga S., Bracht J., Hunter S., Massirer K., Holtz J., Eachus R., and Pasquinelli A.E. 2005. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 122: 553.
3. Bartel D.P. 2004. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116: 281.
4. Behm-Ansmant I., Rehwinkel J., Doerks T., Stark A., Bork P., and Izaurralde E. 2006. mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev. 20: 1885.
5. Bhattacharyya S.N., Habermacher R., Martine U., Closs E.I., and Filipowicz W. 2006. Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell 125: 1111.
6. Ding L., Spencer A., Morita K., and Han M. 2005. The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans. Mol. Cell 19: 437.
7. Eystathioy T., Chan E.K., Tenenbaum S.A., Keene J.D., Griffith K., and Fritzler M.J. 2002. A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. Mol. Biol. Cell 13: 1338.
8. Eystathioy T., Jakymiw A., Chan E.K., Seraphin B., Cougot N., and Fritzler M.J. 2003. The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW-bodies. RNA 9: 1171.
9. Filipowicz W. 2005. RNAi: The nuts and bolts of the RISC machine. Cell 122: 17.
10. Giraldez A.J., Mishima Y., Rihel J., Grocock R.J., Van Dongen S., Inoue K., Enright A.J., and Schier A.F. 2006. Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science 312: 75.
11. Guo H.S., Xie Q., Fei J.F., and Chua N.H. 2005. MicroRNA directs mRNA cleavage of the transcription factor NAC1 to downregulate auxin signals for Arabidopsis lateral root development. Plant Cell 17: 1376.
12. Humphreys D.T., Westman B.J., Martin D.I., and Preiss T. 2005. MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function. Proc. Natl. Acad. Sci. 102: 16961.
13. Jakymiw A., Lian S., Eystathioy T., Li S., Satoh M., Hamel J.C., Fritzler M.J., and Chan E.K. 2005. Disruption of GW bodies impairs mammalian RNA interference. Nat. Cell Biol. 7: 1167.
14. Jing Q., Huang S., Guth S., Zarubin T., Motoyama A., Chen J., Di Padova F., Lin S.C., Gram H., and Han J. 2005. Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell 120: 623.
15. Kim J., Krichevsky A., Grad Y., Hayes G.D., Kosik K.S., Church G.M., and Ruvkun G. 2004. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc. Natl. Acad. Sci. 101: 360.
16. Lee R.C., Feinbaum R.L., and Ambros V. 1993. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843.
17. Lim L.P., Lau N.C., Garrett-Engele P., Grimson A., Schelter J.M., Castle J., Bartel D.P., Linsley P.S., and Johnson J.M. 2005. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433: 769.
18. Lingel A. and Sattler M. 2005. Novel modes of protein-RNA recognition in the RNAi pathway. Curr. Opin. Struct. Biol. 15: 107.
19. Llave C., Xie Z., Kasschau K.D., and Carrington J.C. 2002. Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA. Science 297: 2053.
20. Liu J., Valencia-Sanchez M.A., Hannon G.J., and Parker R. 2005a. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat. Cell Biol. 7: 719.
21. Liu J., Rivas F.V., Wohlschlegel J., Yates J.R., Parker R., and Hannon G.J. 2005b. A role for the P-body component GW182 in microRNA function. Nat. Cell Biol. 7: 1261.
22. Mallory A.C., Reinhart B.J., Jones-Rhoades M.W., Tang G., Zamore P.D., Barton M.K., and Bartel D.P. 2004. MicroRNA control of PHABULOSA in leaf development: Importance of pairing to the microRNA 5′ region. EMBO J. 23: 3356.
23. Meister G., Landthaler M., Peters L., Chen P.Y., Urlaub H., Luhrmann R., and Tuschl T. 2005. Identification of novel Argonaute-associated proteins. Curr. Biol. 15: 2149.
24. Miyoshi K., Tsukumo H., Nagami T., Siomi H., and Siomi M.C. 2005. Slicer function of Drosophila Argonautes and its involvement in RISC formation. Genes Dev. 19: 2837.
25. Nelson P.T., Hatzigeorgiou A.G., and Mourelatos Z. 2004. miRNP:mRNA association in polyribosomes in a human neuronal cell line. RNA 10: 387.
26. Okamura K., Ishizuka A., Siomi H., and Siomi MC. 2004. Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev. 18: 1655.
27. Olsen P.H. and Ambros V. 1999. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev. Biol. 216: 671.
28. Petersen C.P., Bordeleau M.E., Pelletier J., and Sharp P.A. 2006. Short RNAs repress translation after initiation in mammalian cells. Mol. Cell 21: 533.
29. Pillai R.S., Bhattacharyya S.N., Artus C.G., Zoller T., Cougot N., Basyuk E., Bertrand E., and Filipowicz W. 2005. Inhibition of translational initiation by let-7 microRNA in human cells. Science 309: 1573.
30. Rand T.A., Ginalski K., Grishin N.V., and Wang X. 2004. Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc. Natl. Acad. Sci. 101: 14385.
31. Rehwinkel J., Behm-Ansmant I., Gatfield D., and Izaurralde E. 2005. A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. RNA 11: 1640.
32. Rehwinkel J., Natalin P., Stark A., Brennecke J., Cohen S.M., and Izaurralde E. 2006. Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila. Mol. Cell. Biol. 26: 2965.
33. Schwab R., Palatnik J.F., Riester M., Schommer C., Schmid M., and Weigel D. 2005. Specific effects of microRNAs on the plant transcriptome. Dev. Cell 8: 517.
34. Sen G.L. and Blau H.M. 2005. Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. Nat. Cell Biol. 7: 633.
35. Stark A., Brennecke J., Bushati N., Russell R.B., and Cohen S.M. 2005. Animal microRNAs confer robustness to gene expression and have a significant impact on 3′UTR evolution. Cell 123: 1133.
36. Temme C., Zaessinger S., Meyer S., Simonelig M., and Wahle E. 2004. A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila. EMBO J. 23: 2862.
37. Valencia-Sanchez M.A., Liu J., Hannon G.J., and Parker R. 2006. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20: 515.
38. Wightman B., Ha I., and Ruvkun G. 1993. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75: 855.
39. Wu L., Fan J., and Belasco J.G. 2006. MicroRNAs direct rapid deadenylation of mRNA. Proc. Natl. Acad. Sci. 103: 4034.