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Volumn 36, Issue 12, 2006, Pages 3256-3267

Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides

Author keywords

Dendritic cells; RNA; TLR7

Indexed keywords

MESSENGER RNA; RIBOSE; SINGLE STRANDED RNA; TOLL LIKE RECEPTOR 7; URACIL; URIDINE; VIRUS RNA;

EID: 33845579097     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636617     Document Type: Article
Times cited : (239)

References (48)
  • 1
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway, C. A. Jr, Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 1989. 54: 1-13.
    • (1989) Cold Spring Harb. Symp. Quant. Biol. , vol.54 , pp. 1-13
    • Janeway Jr., C.A.1
  • 2
    • 31344461659 scopus 로고    scopus 로고
    • Innate immune recognition of viral infection
    • Kawai T. and Akira, S., Innate immune recognition of viral infection. Nat. Immunol. 2006. 7: 131-137
    • (2006) Nat. Immunol. , vol.7 , pp. 131-137
    • Kawai, T.1    Akira, S.2
  • 3
    • 23844438864 scopus 로고    scopus 로고
    • Shared and unique functions of the DExD/H-box helicases RIG-1, MDA5, and LGP2 in antiviral innate immunity
    • Yoneyama, M., Kikuchi, M., Matsumoto, K., Imaizumi, T., Miyagishi, M., Taira, K., Foy, E. et al., Shared and unique functions of the DExD/H-box helicases RIG-1, MDA5, and LGP2 in antiviral innate immunity. J. Immunol. 2005. 175: 2851-2858.
    • (2005) J. Immunol. , vol.175 , pp. 2851-2858
    • Yoneyama, M.1    Kikuchi, M.2    Matsumoto, K.3    Imaizumi, T.4    Miyagishi, M.5    Taira, K.6    Foy, E.7
  • 4
    • 3242813113 scopus 로고    scopus 로고
    • The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    • Yoneyama, X, Kikuchi M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K. et al., The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 2004. 5: 730-737.
    • (2004) Nat. Immunol. , vol.5 , pp. 730-737
    • Yoneyama, X.1    Kikuchi, M.2    Natsukawa, T.3    Shinobu, N.4    Imaizumi, T.5    Miyagishi, M.6    Taira, K.7
  • 5
    • 29244471275 scopus 로고    scopus 로고
    • A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    • Ishii, K. J., Coban, C., Kato, H., Takahashi, K., Torii Y., Takeshita, F., Ludwig H. et al., A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat. Immunol. 2006. 7: 40-48.
    • (2006) Nat. Immunol. , vol.7 , pp. 40-48
    • Ishii, K.J.1    Coban, C.2    Kato, H.3    Takahashi, K.4    Torii, Y.5    Takeshita, F.6    Ludwig, H.7
  • 6
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • Stetson, D. B. and Medzhitov, R., Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 2006. 24: 93-103.
    • (2006) Immunity , vol.24 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 7
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou, L., Holt, A. C., Medzhitov, R. and Flavell, R. A., Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001. 413: 732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 8
    • 0036076593 scopus 로고    scopus 로고
    • Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling
    • Matsumoto, M., Kikkawa, S., Kohase, M., Miyake, K. and Seya, T., Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem. Biophys. Res. Commun. 2002. 293: 1364-1369.
    • (2002) Biochem. Biophys. Res. Commun. , vol.293 , pp. 1364-1369
    • Matsumoto, M.1    Kikkawa, S.2    Kohase, M.3    Miyake, K.4    Seya, T.5
  • 9
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells
    • Lund, J., Sato, A., Akira, S., Medzhitov, R. and Iwasaki, A., Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 2003. 198: 1-9.
    • (2003) J. Exp. Med. , vol.198 , pp. 1-9
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, R.4    Iwasaki, A.5
  • 10
    • 3142683548 scopus 로고    scopus 로고
    • TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
    • Krug, A., French, A. R., Barchet, W., Fischer, J. A., Dzioneir, A., Pingel, J. T., Orihuela, M. M. et al., TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 2004. 21: 107-119.
    • (2004) Immunity , vol.21 , pp. 107-119
    • Krug, A.1    French, A.R.2    Barchet, W.3    Fischer, J.A.4    Dzioneir, A.5    Pingel, J.T.6    Orihuela, M.M.7
  • 11
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S. and Reis e Sousa, C., Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004. 303: 1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis e Sousa, C.5
  • 13
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    • Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G. et al., Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004. 303: 1526-1529.
    • (2004) Science , vol.303 , pp. 1526-1529
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3    Ampenberger, F.4    Kirschning, C.5    Akira, S.6    Lipford, G.7
  • 14
    • 2342623292 scopus 로고    scopus 로고
    • TLR7: A new sensor of viral infection
    • Crozat, K. and Beutler, B., TLR7: A new sensor of viral infection. Proc. Natl. Acad. Sci. USA 2004.101: 6835-6836.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 6835-6836
    • Crozat, K.1    Beutler, B.2
  • 15
    • 27944459341 scopus 로고    scopus 로고
    • Activation of the mammalian immune system by siRNAs
    • Marques, J. T. and Williams, B. R., Activation of the mammalian immune system by siRNAs. Nat. Biotechnol. 2005. 23: 1399-1405.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1399-1405
    • Marques, J.T.1    Williams, B.R.2
  • 17
    • 3042548183 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
    • Boule, M. W., Broughton, C., Mackay, F., Akira, S., Marshak-Rothstein, A. and Rifkin, I. R., Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes, J. Exp. Med. 2004. 199: 1631-1640.
    • (2004) J. Exp. Med. , vol.199 , pp. 1631-1640
    • Boule, M.W.1    Broughton, C.2    Mackay, F.3    Akira, S.4    Marshak-Rothstein, A.5    Rifkin, I.R.6
  • 18
    • 18644383289 scopus 로고    scopus 로고
    • Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways
    • Yasuda, K., Yu, P., Kirschning, C. J., Schlatter, B., Schmitz, F., Heit, A., Bauer, S. et al., Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways. J. Immunol. 2005. 174: 6129-6136.
    • (2005) J. Immunol. , vol.174 , pp. 6129-6136
    • Yasuda, K.1    Yu, P.2    Kirschning, C.J.3    Schlatter, B.4    Schmitz, F.5    Heit, A.6    Bauer, S.7
  • 19
    • 29244450802 scopus 로고    scopus 로고
    • Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
    • Barton, G. M., Kagan, J. C. and Medzhitov, R., Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat. Immunol. 2006. 7: 49-56.
    • (2006) Nat. Immunol. , vol.7 , pp. 49-56
    • Barton, G.M.1    Kagan, J.C.2    Medzhitov, R.3
  • 20
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg, A. M., CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 2002. 20: 709-760.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 22
    • 1642268316 scopus 로고    scopus 로고
    • Cutting edge: Innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high-level IL-12 secretion by dendritic cells
    • Koski, G. K., Kariko, K., Xu, S., Weissman, D., Cohen, P. A. and Czerniecki, B. J., Cutting edge: innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high-level IL-12 secretion by dendritic cells. J. Immunol. 2004. 172: 3989-3993.
    • (2004) J. Immunol. , vol.172 , pp. 3989-3993
    • Koski, G.K.1    Kariko, K.2    Xu, S.3    Weissman, D.4    Cohen, P.A.5    Czerniecki, B.J.6
  • 23
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
    • Kariko, K., Buckstein, M., Ni, H. and Weissman D., Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 2005. 23: 165-175.
    • (2005) Immunity , vol.23 , pp. 165-175
    • Kariko, K.1    Buckstein, M.2    Ni, H.3    Weissman, D.4
  • 24
    • 20144389695 scopus 로고    scopus 로고
    • Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
    • Hornung, V., Guenthner-Biller, M., Bourquin, C., Ablasser, A., Schlee, M., Uematsu, S., Noronha, A. et al., Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat. Med. 2005. 11: 263-270.
    • (2005) Nat. Med. , vol.11 , pp. 263-270
    • Hornung, V.1    Guenthner-Biller, M.2    Bourquin, C.3    Ablasser, A.4    Schlee, M.5    Uematsu, S.6    Noronha, A.7
  • 25
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge, A. D., Sood, V., Shaw, J. R., Fang, D., McClintock K. and MacLachlan, I., Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 2005. 23: 457-462.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 26
    • 18044365415 scopus 로고    scopus 로고
    • Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded ARNAS is sequence-dependent and requires endosomal localization
    • Sioud, M., Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded ARNAS is sequence-dependent and requires endosomal localization. J. Mol. Biol. 2005. 348: 1079-1090.
    • (2005) J. Mol. Biol. , vol.348 , pp. 1079-1090
    • Sioud, M.1
  • 27
    • 0036534871 scopus 로고    scopus 로고
    • The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor
    • Gilliet, M., Boonstra, A., Paturel, C., Antonenko, S., Xu, X. L., Trinchieri G., O'Garra, A. and Liu, Y. J., The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 2002. 195: 953-958.
    • (2002) J. Exp. Med. , vol.195 , pp. 953-958
    • Gilliet, M.1    Boonstra, A.2    Paturel, C.3    Antonenko, S.4    Xu, X.L.5    Trinchieri, G.6    O'Garra, A.7    Liu, Y.J.8
  • 28
    • 0036008014 scopus 로고    scopus 로고
    • Small and-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T. et al., Small and-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 2002. 3: 196-200.
    • (2002) Nat. Immunol. , vol.3 , pp. 196-200
    • Hemmi, H.1    Kaisho, T.2    Takeuchi, O.3    Sato, S.4    Sanjo, H.5    Hoshino, K.6    Horiuchi, T.7
  • 29
    • 0038651180 scopus 로고    scopus 로고
    • Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7
    • Lee, J., Chuang, T. H., Redecke, V., She, L., Pitha, P. M., Carson, D. A., Raz, E. and Cottam, H. B., Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc. Natl. Acad. Sci. USA 2003. 100: 6646-6651.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 6646-6651
    • Lee, J.1    Chuang, T.H.2    Redecke, V.3    She, L.4    Pitha, P.M.5    Carson, D.A.6    Raz, E.7    Cottam, H.B.8
  • 30
    • 0242391997 scopus 로고    scopus 로고
    • The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily
    • Heil, F., Ahmad-Nejad, P., Hemmi, H., Hochrein, H., Ampenberger, F., Gellert, T., Dietrich, H. et al., The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur. J. Immunol. 2003. 33: 2987-2997.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 2987-2997
    • Heil, F.1    Ahmad-Nejad, P.2    Hemmi, H.3    Hochrein, H.4    Ampenberger, F.5    Gellert, T.6    Dietrich, H.7
  • 33
    • 0003458038 scopus 로고
    • Principles of nucleic acid structure
    • Springer-Verlag, New York
    • Saenger, W., Principles of nucleic acid structure.Springer-Verlag, New York 1984
    • (1984)
    • Saenger, W.1
  • 34
    • 32944454941 scopus 로고    scopus 로고
    • Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
    • Judge, A. D., Bola, G., Lee, A. C. and MacLachlan, I., Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol. Ther. 2006.13: 494-505.
    • (2006) Mol. Ther. , vol.13 , pp. 494-505
    • Judge, A.D.1    Bola, G.2    Lee, A.C.3    MacLachlan, I.4
  • 36
    • 17844380477 scopus 로고    scopus 로고
    • Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    • Honda, K., Ohba, Y., Yanai, H., Negishi, H., Mizutani, T., Takaoka, A., Taya, C. and Taniguchi, T., Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 2005. 434: 1035-1040.
    • (2005) Nature , vol.434 , pp. 1035-1040
    • Honda, K.1    Ohba, Y.2    Yanai, H.3    Negishi, H.4    Mizutani, T.5    Takaoka, A.6    Taya, C.7    Taniguchi, T.8
  • 37
    • 33746884630 scopus 로고    scopus 로고
    • Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
    • Guiducci, C., Ott, G., Chan, J. H., Damon, L, Calacoan, C., Matray, T., Lee, K. D. et al., Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J. Exp. Med. 2006. 203: 1999-2008.
    • (2006) J. Exp. Med. , vol.203 , pp. 1999-2008
    • Guiducci, C.1    Ott, G.2    Chan, J.H.3    Damon, L.4    Calacoan, C.5    Matray, T.6    Lee, K.D.7
  • 41
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • Barrat, F. J., Meeker, T., Gregorio, J., Chan, J. H., Uematsu, S., Akira, S., Chang, B. et al., Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J. Exp. Med. 2005. 202: 1131-1139.
    • (2005) J. Exp. Med. , vol.202 , pp. 1131-1139
    • Barrat, F.J.1    Meeker, T.2    Gregorio, J.3    Chan, J.H.4    Uematsu, S.5    Akira, S.6    Chang, B.7
  • 42
    • 33645741218 scopus 로고    scopus 로고
    • U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells via TLR7
    • Savarese, E., Chae, O. W., Trowitzsch, S., Weber, G., Kastner, B., Akira, S., Wagner, H. et al., U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells via TLR7. Blood 2006. 107. 3229-3234.
    • (2006) Blood , vol.107 , pp. 3229-3234
    • Savarese, E.1    Chae, O.W.2    Trowitzsch, S.3    Weber, G.4    Kastner, B.5    Akira, S.6    Wagner, H.7
  • 43
    • 0037094095 scopus 로고    scopus 로고
    • Priming Th1 immunity to viral core particles is facilitated by trace amounts of RNA bound to its arginine-rich domain
    • Riedl, P., Stober, D., Oelminger, C., Melber, K., Reimann, J. and Schirmbeck, R., Priming Th1 immunity to viral core particles is facilitated by trace amounts of RNA bound to its arginine-rich domain. J. Immunol. 2002. 168: 4951-4959.
    • (2002) J. Immunol. , vol.168 , pp. 4951-4959
    • Riedl, P.1    Stober, D.2    Oelminger, C.3    Melber, K.4    Reimann, J.5    Schirmbeck, R.6
  • 47
  • 48
    • 0037443644 scopus 로고    scopus 로고
    • The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
    • Hemmi H., Kaisho, T., Takeda, K. and Akira, S., The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J. Immunol. 2003. 170: 3059-3064.
    • (2003) J. Immunol. , vol.170 , pp. 3059-3064
    • Hemmi, H.1    Kaisho, T.2    Takeda, K.3    Akira, S.4


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