Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 32, 2007, Pages 12982-12987

  Rozema, David B ^a   Lewis, David L ^a   Wakefield, Darren H ^a   Wong, So C ^a   Klein, Jason J ^a   Roesch, Paula L ^a   Bertin, Stephanie L ^a   Reppen, Tom W ^a   Chu, Qili ^a   Blokhin, Andrei V ^a   Hagstrom, James E ^a   Wolff, Jon A ^b  

^a Mirus Bio Corporation   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Endosomolytic polymers; Nonviral siRNA delivery; pH labile bonds; siRNA polymer conjugates

Indexed keywords

APOLIPOPROTEIN B; CHOLESTEROL; CYTOKINE; DYNAMIC POLYCONJUGATE; LIVER ENZYME; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; POLYMER; SMALL INTERFERING RNA; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENDOSOME; GENE DELIVERY SYSTEM; IN VIVO STUDY; KNOCKOUT GENE; KNOCKOUT MOUSE; LIVER CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RNA INTERFERENCE; ANIMAL; C57BL MOUSE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; GENETICS; METABOLISM;

MUS;

ANIMALS; APOLIPOPROTEINS B; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; ENDOSOMES; HEPATOCYTES; MICE; MICE, INBRED C57BL; PHENOTYPE; POLYMERS; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 34548735210     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0703778104     Document Type: Article

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