Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis

Journal of Biological Chemistry

Volumn 278, Issue 9, 2003, Pages 7108-7118

  Vickers, Timothy A ^a   Koo, Seongjoon ^b   Bennett, C Frank ^b   Crooke, Stanley T ^b   Dean, Nicholas M ^b   Baker, Brenda F ^b  

^a ISIS PHARMACEUTICALS   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; GENES; HYDROLYSIS; RNA;

ANTISENSE MECHANISM;

BIOCHEMISTRY;

OLIGONUCLEOTIDE; RIBONUCLEASE; SMALL INTERFERING RNA; SMALL NUCLEAR RNA; UNCLASSIFIED DRUG; ANTISENSE OLIGONUCLEOTIDE; INTERCELLULAR ADHESION MOLECULE 1; LUCIFERASE; MESSENGER RNA; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, HUMAN; RIBONUCLEASE H; RNA; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BASE PAIRING; ENZYME PHOSPHORYLATION; GENE FUNCTION; GENE SILENCING; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYDROLYSIS; NUCLEIC ACID PROBE; NUCLEOTIDE SEQUENCE; OLIGONUCLEOTIDE PROBE; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; RNA ANALYSIS; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL STRAIN COS1; CONFORMATION; DOSE RESPONSE; FLOW CYTOMETRY; GENETICS; INTRON; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; TIME;

ANIMALS; BASE SEQUENCE; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTRONS; LUCIFERASES; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN STRUCTURE, TERTIARY; PTEN PHOSPHOHYDROLASE; RIBONUCLEASE H, CALF THYMUS; RNA; RNA, MESSENGER; RNA, SMALL INTERFERING; TIME FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0037470145     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M210326200     Document Type: Article

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