Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2

Silence

Volumn 2, Issue 1, 2011, Pages

  Schultz, Nikolaus ^a   Marenstein, Dina R ^a   De Angelis, Dino A ^a   Wang, Wei Qing ^a   Nelander, Sven ^a,b   Jacobsen, Anders ^a   Marks, Debora S ^c   Massagué, Joan ^a   Sander, Chris ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; MICRORNA; MICRORNA 20A; MICRORNA 34A; MICRORNA 373; SMAD2 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CDKN1A GENE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GENE; GENE IDENTIFICATION; GENE SEQUENCE; GENE TARGETING; GENE TRANSLOCATION; GENETIC ANALYSIS; GENETIC REGULATION; GENETIC SCREENING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; KERATINOCYTE; NUCLEAR LOCALIZATION SIGNAL; OPEN READING FRAME; PAI 1 GENE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RNA INTERFERENCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SMAD7 GENE; TGFBR1 GENE; TGFBR2 GENE;

EID: 80052890070     PISSN: None     EISSN: 1758907X     Source Type: Journal    
DOI: 10.1186/1758-907X-2-3     Document Type: Article

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