Sirna off-target effects can be reduced at concentrations that match their individual potency

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Caffrey, Daniel R ^a,e   Zhao, Juan ^a   Song, Zhili ^a   Schaffer, Michael E ^a,b   Haney, Steven A ^a   Subramanian, Romesh R ^a   Seymour, Albert B ^a,c   Hughes, Jason D ^a,d  

^a PFIZER INC   (United States)

^b CENTOCOR INC   (United States)

^c Research and Development   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; HEXOKINASE; HEXOKINASE ISOENZYME; MESSENGER RNA; SMALL INTERFERING RNA; STAT3 PROTEIN; UNCLASSIFIED DRUG; CASPASE 3; CASPASE 7;

3' UNTRANSLATED REGION; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; IMMUNE RESPONSE; PROMOTER REGION; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; BASE SEQUENCE; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION PROFILING; HEXOKINASE; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; STAT3 TRANSCRIPTION FACTOR;

EID: 79959931148     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021503     Document Type: Article

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