Early phase tumor accumulation of Macromolecules: A great difference in clearance rate between tumor and normal tissues

Japanese Journal of Cancer Research

Volumn 89, Issue 3, 1998, Pages 307-314

  Noguchi, Youichiro ^a   Wu, Jun ^a   Duncan, Ruth ^b   Strohalm, Jiří ^c   Ulbrich, Karel ^c   Akaike, Takaaki ^a   Maeda, Hiroshi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

Author keywords

EPR effect; Polymer drugs; Tissue clearance; Tumor targeting accumulation; Tumor vascular permeability

Indexed keywords

COPOLYMER; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER; RADIOACTIVE IODINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; KIDNEY; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; SARCOMA 180; URINARY EXCRETION;

EID: 0031959490     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1998.tb00563.x     Document Type: Article

References (37)

1. Konno, T., Maeda, H., Iwai, K., Tashiro, S., Maki, S., Morinaga, T., Mochinaga, M., Hiraoka, T. and Yokoyama, I. Effect of arterial administration of high molecular weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report. Eur. J. Cancer Clin. Oncol., 19, 1053-1065 (1983).
2. Iwai, K., Maeda, H. and Konno, T. Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image. Cancer Res., 44, 2115-2121 (1984).
3. Konno, T., Maeda. H., Iwai. K., Maki, S., Tashiro, S., Uchida, M. and Miyauchi, Y. Selective targeting of anticancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium. Cancer, 54, 2367-2374 (1983).
4. Iwai, K., Maeda, H., Konno, T., Matsumura, Y., Yamashita, R., Yamasaki, K., Hirayama, S. and Miyauchi, Y. Tumor targeting by arterial administration of lipids: rabbit model with VX2 carcinoma in the liver. Anticancer Res., 7, 321-328 (1987).
5. Seymour, L. W., Ulbrich, K., Steyger, P. S., Brereton, M., Subr, V., Strohalm, J. and Duncan R. Tumour tropism and anticancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16 F10 melanoma. Br. J. Cancer, 70, 636-641 (1994).
6. Sinn, H., Shrenk, H. H., Fredrich, E. A., Schilling, U. and Maier-Borst, W. A. A, Design of compounds having an increased tumour uptake: using serum albumin as carrier. Part 1. Nucl. Med Biol., 17, 819-827 (1990).
7. Wu, N. Z., Da, D., Rudoll, T. L., Needham, D., Whorton, A. R. and Dewhirst, M. W. Increased microvascular permeability contributes to preferential accumulation of stealth liposomes in tumor tissue. Cancer Res., 53, 3765-3770 (1993).
8. Yuan, P., Dellian, M., Fukumura, D., Leunig, M., Berk, D. A., Torchilin, V. P. and Jain, R. K. Vascular permeability in a human tumour xenograft: molecular size dependence and cutoff size. Cancer Res., 55, 3752-3756 (1995).
9. Matsumura, Y. and Maeda, H. A new concept for macromolecular therapeutics in cancer therapy: mechanism of tumoritropic accumulation of proteins and the antitumor agents SMANCS. Cancer Res., 46: 6387-6392 (1986).
10. Maeda, H. and Matsumura, Y. Tumoritropic and lymphotropic principles of macromolecular drugs. Crit. Rev. Ther. Drug Carrier Syst., 6, 193-210 (1989).
11. Maeda, H. SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy. Adv. Drug Delivery Rev., 6, 181-202 (1991).
12. Seymour, L. W., Miyamoto, Y., Maeda, H., Brereton, M., Strohalm, J., Ulbrich, K. and Duncan, R. Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier. Eur. J. Cancer, 31A, 766-770 (1995).
13. Li, C. J., Miyamoto, Y., Kojima, Y. and Maeda, H. Augmentation of tumour delivery of macromolecular drugs with reduced bone marrow delivery by elevating blood pressure. Br. J. Cancer, 67, 975-980 (1993).
14. 3]bradykinin in ascitic fluid from a patient with gastric cancer. J. Biol. Chem., 263, 16051-16054 (1988).
15. Matsumura, Y., Kimura, M., Yamamoto, T. and Maeda, H. Involvement of the kinin-generating cascade in enhanced vascular permeability in tumor tissue. Jpn. J. Cancer Res., 79, 1327-1334 (1988).
16. Maeda, H., Noguchi, Y., Sato, K. and Akaike, T. Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both nitric oxide scavenger and nitric oxide synthase inhibitor. Jpn. J. Cancer Res., 85, 331-334 (1994).
17. Doi, K., Akaike, T., Horie, H., Noguchi, Y., Fujii, S., Beppu, T., Ogawa, M. and Maeda, H. Excessive production of nitric oxide in rat solid tumor and its implications in rapid tumor growth. Cancer, 77, 1598-1604 (1996).
18. Senger, D. R., Galli, S. J., Dvorak, A. M., Perruzi, C. A., Harvey, V. S. and Dvorak, H. F. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science, 219, 983-985 (1983).
19. Leung, D. W., Cachianes, G., Kuang, W. J., Goeddel D. V. and Ferrara, N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science, 246, 1306-1309 (1989).
20. Keck. P. J., Hauser, S. D., Krivi, G., Sanzo, K., Warren, T., Feder, J. and Connolly, D. T. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science, 246, 1309-1312 (1989).
21. Wu, J., Akaike, T. and Maeda, H. Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and an nitric oxide scavenger. Cancer Res., 58, 159-165 (1998)
22. Seymour, L. W., Duncan, R., Strohalm, J. and Kopecek, J. Effect of molecular weight of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal and intravenous administration to rats. J. Biomed. Mater. Rea., 21, 1341-1358 (1987).
23. Vasey, P. A., Duncan, R., Twelves, C., Kaye, S. B., Strolin-Benedetti, M. and Cassidy, J. Clinical and pharmacokinetic phase I study of PKI (HPMA co-polymer doxorubicin). Ann. Oncol., 7, 97 (1996).
24. Cassidy, J., Duncan, R., Morrison, G. J., Strohalm, J., Plocova, D., Kopecek, J. and Kaye, S. B. Activity of N-(2-hydroxypropyl)methacrylamide copolymers containing daunomycin against a rat tumour model. Biochem. Pharmacol.,. 38, 857-879 (1989).
25. Duncan, R., Kopecek, J., Rejmanova, P. and Lloyd, J. B. Targeting of N-(2-hydroxypropyl)methacrylamide copolymers to liver by incorporation of galactose residues. Biochim. Biophys. Acta, 755, 518-521 (1983).
26. Cartlidge, S. A., Duncan, R., Lloyd, J. B., Kopeckova-Rejmanova, P. and Kopecek, J. Soluble, crosslinked N-(2-hydroxypropyl)methacrylamide copolymers as potential drug curriers. 3. Targeting by incorporation of galactosamine residues. Effect of route of administration. J. Controlled Rel., 4, 265 278 (1987).
27. Maeda, H., Seymour, L. W. and Miyamoto, Y. Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo. Bioconjugate Chem., 3, 351-362 (1992).
28. Duncan, R., Dimitrijevic, S. and Evagorou, E. G. The role of polymer conjugates in the diagnosis and treatment of cancer. S.T.P. Pharma. Sci., 6, 237-263 (1996).
29. Kimoto, A., Kono, T., Kawaguchi, T., Miyauchi, Y. and Maeda, H. Antitumor effect of SMANCS on rat mammary tumor induced by 7,12-dimethylbenz[a]anthracene. Cancer Res., 52, 1013-1017 (1992).
30. Murakami, Y., Tabata, Y. and Ikuda, Y. Effect of the molecular weight of water-soluble polymers on accumulation at a inflammatory site following intravenous injection. Drug Delivery, 3, 231-238 (1996).
31. Maeda, H., Oda, T., Matsumura, Y. and Kimura, M. Improvement of pharmacological properties of protein-drugs by tailoring with synthetic polymers. J. Bioact. Compat. Polym., 3, 27-43 (1988).
32. Kimura, N. T., Taniguchi, S., Aoki, K. and Baba, T. Selective localization and growth of Bifidobacterium bifidum in mouse tumors following intravenous administration. Cancer Res., 40, 2061-2068 (1980).
33. Duncan, R., Rejmanova, P., Kopecek, J. and Lloyd, J. B. Pinocytic uptake and intracellular degradation of N-(2-hydroxypropyl)methacrylamide copolymers. A potential drug delivery system. Biochim. Biophys. Acta, 678, 143-150 (1981).
34. Skinner, S. A., Tutton, P. J. M. and O'Brien, P. E. Microvascular architecture of experimental colon tumors in the rats. Cancer Res., 50, 2411-2417 (1990).
35. Suzuki, M., Takahashi, T. and Sato, T. Medial regression and its functional significance in tumor-supplying host arteries: a morphometric study of hepatic arteries in human liver with hepatocellular carcinoma. Cancer, 59, 444-450 (1987).
36. Ettinghausen, S. E., Puri, R. J. and Rosenberg, S. A. Increased vascular permeability in organs mediated by the systemic administration of lymphokine-activated killer cells and recombinant interleukin-2 in mice. J. Natl. Cancer Inst., 80, 177-187 (1988).
37. Kimura, M., Konno, T., Oda, T., Maeda, H. and Miyauchi, Y. Intracavitary treatment of malignant ascitic carcinomatosis with oily anticancer agents in rats. Anticancer Res., 13, 1287-1292 (1993).