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Volumn 3, Issue AUG, 2012, Pages

Development of therapeutic-grade small interfering rnas by chemical engineering

Author keywords

Chemical modification; Immunogenicity; LNA; Off target effect; OMe; RNAi; siRNA; siRNA therapeutic

Indexed keywords


EID: 84875878783     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2012.00154     Document Type: Review
Times cited : (82)

References (254)
  • 1
    • 37049000624 scopus 로고    scopus 로고
    • Dumbbell-shaped nanocircular RNAs for RNA interference
    • Abe, N., Abe, H., and Ito, Y. (2007). Dumbbell-shaped nanocircular RNAs for RNA interference. J. Am. Chem. Soc. 129, 15108-1510
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 15108-21510
    • Abe, N.1    Abe, H.2    Ito, Y.3
  • 4
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou, L., Holt, A. C., Medzhitov, R., and Flavell, R. A. (2001). Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413, 732-73
    • (2001) Nature , vol.413 , pp. 732-773
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 6
    • 0037440005 scopus 로고    scopus 로고
    • Tolerance for mutations and chemical modifications in a siRNA
    • Amarzguioui, M., Holen, T., Babaie, E., and Prydz, H. (2003). Tolerance for mutations and chemical modifications in a siRNA. Nucleic Acids Res. 31,589-59
    • (2003) Nucleic Acids Res , vol.31 , pp. 589-659
    • Amarzguioui, M.1    Holen, T.2    Babaie, E.3    Prydz, H.4
  • 8
    • 1642273831 scopus 로고    scopus 로고
    • An algorithm for selection of functional siRNA sequences
    • Amarzguioui, M., and Prydz, H. (2004). An algorithm for selection of functional siRNA sequences. Biochem. Biophys. Res. Commun. 316, 1050-105
    • (2004) Biochem. Biophys. Res. Commun. , vol.316 , pp. 1050-1105
    • Amarzguioui, M.1    Prydz, H.2
  • 9
    • 47249127194 scopus 로고    scopus 로고
    • Small interfering RNAs induce macrophage migration inhibitory factor production and proliferation in breast cancer cells via a double-stranded RNA-dependent protein kinase-dependent mechanism
    • Armstrong, M. E., Gantier, M., Li, L., Chung, W Y, McCann, A., Baugh, J. A., and Donnelly, S. C. (2008). Small interfering RNAs induce macrophage migration inhibitory factor production and proliferation in breast cancer cells via a double-stranded RNA-dependent protein kinase-dependent mechanism. J. Immunol. 180, 7125-713
    • (2008) J. Immunol. , vol.180 , pp. 7125-7713
    • Armstrong, M.E.1    Gantier, M.2    Li, L.3    Chung, W.Y.4    McCann, A.5    Baugh, J.A.6    Donnelly, S.C.7
  • 11
    • 77956901498 scopus 로고    scopus 로고
    • The promise of microRNA replacement therapy
    • Bader, A. G., Brown, D., and Winkler, M. (2010). The promise of microRNA replacement therapy. Cancer Res. 70, 7027-703
    • (2010) Cancer Res , vol.70 , pp. 7027-7703
    • Bader, A.G.1    Brown, D.2    Winkler, M.3
  • 13
    • 34447306000 scopus 로고    scopus 로고
    • Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing
    • Bartlett, D. W., and Davis, M. E. (2007). Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing. Biotechnol. Bioeng. 97, 909-92
    • (2007) Biotechnol. Bioeng. , vol.97 , pp. 909-992
    • Bartlett, D.W.1    Davis, M.E.2
  • 14
    • 33645500266 scopus 로고    scopus 로고
    • Progress towards in vivo use of siRNAs
    • Behlke, M. A. (2006). Progress towards in vivo use of siRNAs. Mol. Ther. 13, 644-67
    • (2006) Mol. Ther. , vol.13 , pp. 644-667
    • Behlke, M.A.1
  • 15
    • 57349134691 scopus 로고    scopus 로고
    • Chemical modification of siRNAs for in vivo use
    • Behlke, M. A. (2008). Chemical modification of siRNAs for in vivo use. Oligonucleotides 18, 305-31
    • (2008) Oligonucleotides , vol.18 , pp. 305-331
    • Behlke, M.A.1
  • 16
    • 78650188526 scopus 로고    scopus 로고
    • Small interfering RNAs induce target-independent inhibition of tumor growth and vasculature remodeling in a mouse model of hepatocellular carcinoma
    • Berge, M., Bonnin, P., Sulpice, E., Vilar, J., Allanic, D., Silvestre, J. S., Levy, B. I., Tucker, G. C., Tobelem, G., and Merkulova-Rainon, T. (2010). Small interfering RNAs induce target-independent inhibition of tumor growth and vasculature remodeling in a mouse model of hepatocellular carcinoma. Am. J. Pathol. 177, 3192-320
    • (2010) Am. J. Pathol. , vol.177 , pp. 3192-3320
    • Berge, M.1    Bonnin, P.2    Sulpice, E.3    Vilar, J.4    Allanic, D.5    Silvestre, J.S.6    Levy, B.I.7    Tucker, G.C.8    Tobelem, G.9    Merkulova-Rainon, T.10
  • 17
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein, E., Caudy, A. A., Hammond, S. M., and Hannon, G. J. (2001). Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363-36
    • (2001) Nature , vol.409 , pp. 363-436
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 19
    • 80054791942 scopus 로고    scopus 로고
    • High-dose siRNAs upregulate mouse Eri-1 at both transcription and posttranscription levels
    • doi:10.1371/journal.pone.0026466
    • Bian, Y., Zhou, W., Zhao, Y., Li, X., Geng, W., Hao, R., Yang, Q., and Huang, W. (2011). High-dose siRNAs upregulate mouse Eri-1 at both transcription and posttranscription levels. PLoS ONE 6, e26466. doi:10.1371/journal.pone.0026466
    • (2011) PLoS ONE , vol.6
    • Bian, Y.1    Zhou, W.2    Zhao, Y.3    Li, X.4    Geng, W.5    Hao, R.6    Yang, Q.7    Huang, W.8
  • 21
    • 34547748373 scopus 로고    scopus 로고
    • Fully 2'-deoxy-2'-fluoro substituted nucleic acids induce RNA interference in mammalian cell culture
    • Blidner, R. A., Hammer, R. P., Lopez, M. J., Robinson, S. O., and Monroe, W. T. (2007). Fully 2'-deoxy-2'-fluoro substituted nucleic acids induce RNA interference in mammalian cell culture. Chem. Biol. Drug Des. 70, 113-12
    • (2007) Chem. Biol. Drug Des. , vol.70 , pp. 113-212
    • Blidner, R.A.1    Hammer, R.P.2    Lopez, M.J.3    Robinson, S.O.4    Monroe, W.T.5
  • 27
    • 84856389509 scopus 로고    scopus 로고
    • RNA-based therapeutics: current progress and future prospects
    • Burnett, J. C., and Rossi, J. J. (2012). RNA-based therapeutics: current progress and future prospects. Chem. Biol. 19, 60-7
    • (2012) Chem. Biol. , vol.19 , pp. 60-67
    • Burnett, J.C.1    Rossi, J.J.2
  • 28
    • 80052627990 scopus 로고    scopus 로고
    • Current progress of siRNA/shRNA therapeutics in clinical trials
    • Burnett, J. C., Rossi, J. J., and Tiemann, K. (2011). Current progress of siRNA/shRNA therapeutics in clinical trials. Biotechnol. J. 6, 1130-114
    • (2011) Biotechnol. J. , vol.6 , pp. 1130-2114
    • Burnett, J.C.1    Rossi, J.J.2    Tiemann, K.3
  • 29
    • 0036839458 scopus 로고    scopus 로고
    • Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference
    • Capodici, J., Kariko, K., and Weissman, D. (2002). Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference. J. Immunol. 169,5196-520
    • (2002) J. Immunol. , vol.169 , pp. 5196-5520
    • Capodici, J.1    Kariko, K.2    Weissman, D.3
  • 30
    • 0034445697 scopus 로고    scopus 로고
    • Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
    • Cario, E., and Podolsky, D. K. (2000). Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect. Immun. 68, 7010-701
    • (2000) Infect. Immun. , vol.68 , pp. 7010-7701
    • Cario, E.1    Podolsky, D.K.2
  • 32
    • 33751511117 scopus 로고    scopus 로고
    • Gene expression analysis in blood cells in response to unmodified and 2'-modified siRNAs reveals TLR-dependent and independent effects
    • Cekaite, L., Furset, G., Hovig, E., and Sioud, M. (2007). Gene expression analysis in blood cells in response to unmodified and 2'-modified siRNAs reveals TLR-dependent and independent effects. J. Mol. Biol. 365, 90-10
    • (2007) J. Mol. Biol. , vol.365 , pp. 10-90
    • Cekaite, L.1    Furset, G.2    Hovig, E.3    Sioud, M.4
  • 33
    • 60849136323 scopus 로고    scopus 로고
    • A structural interpretation of the effect of GC-content on efficiency of RNA interference
    • doi:10.1186/1471-2105-10-S1-S33
    • Chan, C. Y., Carmack, C. S., Long, D. D., Maliyekkel, A., Shao, Y., Roninson, I. B., and Ding, Y (2009). A structural interpretation of the effect of GC-content on efficiency of RNA interference. BMC Bioinformatics 10(Suppl.1),S33.doi:10.1186/1471-2105-10-S1-S33
    • (2009) BMC Bioinformatics , vol.10 , Issue.SUPPL.1
    • Chan, C.Y.1    Carmack, C.S.2    Long, D.D.3    Maliyekkel, A.4    Shao, Y.5    Roninson, I.B.6    Ding, Y.7
  • 35
    • 38649099969 scopus 로고    scopus 로고
    • Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity
    • Chen, P. Y., Weinmann, L., Gaidatzis, D., Pei, Y., Zavolan, M., Tuschl, T., and Meister, G. (2008). Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity. RNA 14, 263-27
    • (2008) RNA , vol.14 , pp. 263-327
    • Chen, P.Y.1    Weinmann, L.2    Gaidatzis, D.3    Pei, Y.4    Zavolan, M.5    Tuschl, T.6    Meister, G.7
  • 36
    • 0036752785 scopus 로고    scopus 로고
    • RNAi in human cells: basic structural and functional features of small interfering RNA
    • Chiu, Y. L., and Rana, T. M. (2002). RNAi in human cells: basic structural and functional features of small interfering RNA. Mol. Cell 10, 549-56
    • (2002) Mol. Cell , vol.10 , pp. 549-556
    • Chiu, Y.L.1    Rana, T.M.2
  • 37
    • 0041331496 scopus 로고    scopus 로고
    • siRNA function in RNAi: a chemical modification analysis
    • Chiu, Y. L., and Rana, T. M. (2003). siRNA function in RNAi: a chemical modification analysis. RNA 9, 1034-104
    • (2003) RNA , vol.9 , pp. 1034-1104
    • Chiu, Y.L.1    Rana, T.M.2
  • 39
    • 33644620908 scopus 로고    scopus 로고
    • Chemical modification of siRNAs to improve serum stability without loss of efficacy
    • Choung, S., Kim, Y. J., Kim, S., Park, H. O., and Choi, Y. C. (2006). Chemical modification of siRNAs to improve serum stability without loss of efficacy. Biochem. Biophys. Res. Commun. 342, 919-92
    • (2006) Biochem. Biophys. Res. Commun. , vol.342 , pp. 919-992
    • Choung, S.1    Kim, Y.J.2    Kim, S.3    Park, H.O.4    Choi, Y.C.5
  • 40
    • 50649103008 scopus 로고    scopus 로고
    • Potent RNAi by short RNA triggers
    • Chu, C. Y., and Rana, T. M. (2008). Potent RNAi by short RNA triggers. RNA 14, 1714-171
    • (2008) RNA , vol.14 , pp. 1714-2171
    • Chu, C.Y.1    Rana, T.M.2
  • 45
    • 33644860608 scopus 로고    scopus 로고
    • Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2' - O-alkyl modifications
    • Dande, P., Prakash, T. P., Sioufi, N., Gaus, H., Jarres, R., Berdeja, A., Swayze, E. E., Griffey, R. H., and Bhat, B. (2006). Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2' - O-alkyl modifications. J. Med. Chem. 49, 1624-163
    • (2006) J. Med. Chem. , vol.49 , pp. 1624-2163
    • Dande, P.1    Prakash, T.P.2    Sioufi, N.3    Gaus, H.4    Jarres, R.5    Berdeja, A.6    Swayze, E.E.7    Griffey, R.H.8    Bhat, B.9
  • 46
    • 79954580272 scopus 로고    scopus 로고
    • Current prospects for RNA interference-based therapies
    • Davidson, B. L., and McCray, P. B. Jr. (2011). Current prospects for RNA interference-based therapies. Nat Rev. Genet. 12, 329-34
    • (2011) Nat Rev. Genet. , vol.12 , pp. 329-334
    • Davidson, B.L.1    McCray Jr., P.B.2
  • 50
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold, S. S., Kaisho, T., Hemmi, H., Akira,S.,andReise Sousa, C. (2004). Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529-153
    • (2004) Science , vol.303 , pp. 1529-2153
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    andReise Sousa, C.5
  • 51
    • 33845579097 scopus 로고    scopus 로고
    • Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides
    • Diebold, S. S., Massacrier, C., Akira, S., Paturel, C., Morel, Y., and Reis e Sousa, C. (2006). Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides. Eur. J. Immunol. 36, 3256-326
    • (2006) Eur. J. Immunol. , vol.36 , pp. 3256-3326
    • Diebold, S.S.1    Massacrier, C.2    Akira, S.3    Paturel, C.4    Morel, Y.5    Reis e Sousa, C.6
  • 53
    • 1642374097 scopus 로고    scopus 로고
    • Specificity of microRNA target selection in translational repression
    • Doench, J. G., and Sharp, P. A. (2004). Specificity of microRNA target selection in translational repression. GenesDev. 18,504-51
    • (2004) GenesDev , vol.18 , pp. 504-551
    • Doench, J.G.1    Sharp, P.A.2
  • 54
    • 33645533269 scopus 로고    scopus 로고
    • Improvements in siRNA properties mediated by 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA)
    • Dowler, T., Bergeron, D., Tedeschi, A. L., Paquet, L., Ferrari, N., and Damha, M. J. (2006). Improvements in siRNA properties mediated by 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA). Nucleic Acids Res. 34, 1669-167
    • (2006) Nucleic Acids Res , vol.34 , pp. 1669-2167
    • Dowler, T.1    Bergeron, D.2    Tedeschi, A.L.3    Paquet, L.4    Ferrari, N.5    Damha, M.J.6
  • 55
    • 15044358407 scopus 로고    scopus 로고
    • A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites
    • Du, Q., Thonberg, H., Wang, J., Wahlestedt, C., and Liang, Z. (2005). A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites. Nucleic Acids Res. 33, 1671-167
    • (2005) Nucleic Acids Res , vol.33 , pp. 1671-2167
    • Du, Q.1    Thonberg, H.2    Wang, J.3    Wahlestedt, C.4    Liang, Z.5
  • 56
    • 80052393683 scopus 로고    scopus 로고
    • Modified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing
    • Dua, P., Yoo, J. W., Kim, S., and Lee, D. K. (2011). Modified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing. Mol. Ther. 19, 1676-168
    • (2011) Mol. Ther. , vol.19 , pp. 1676-2168
    • Dua, P.1    Yoo, J.W.2    Kim, S.3    Lee, D.K.4
  • 57
    • 79952116683 scopus 로고    scopus 로고
    • Informatics approach to the rational design of siRNA libraries
    • Ebalunode, J. O., Jagun, C., and Zheng, W (2011). Informatics approach to the rational design of siRNA libraries. Methods Mol. Biol. 672, 341-35
    • (2011) Methods Mol. Biol. , vol.672 , pp. 341-435
    • Ebalunode, J.O.1    Jagun, C.2    Zheng, W.3
  • 58
    • 48549105152 scopus 로고    scopus 로고
    • Modifications in small interfering RNA that separate immunostimulation from RNA interference
    • Eberle, F., Giessler, K., Deck, C., Heeg, K., Peter, M., Richert, C., and Dalpke, A. H. (2008). Modifications in small interfering RNA that separate immunostimulation from RNA interference. J. Immunol. 180, 3229-323
    • (2008) J. Immunol. , vol.180 , pp. 3229-3323
    • Eberle, F.1    Giessler, K.2    Deck, C.3    Heeg, K.4    Peter, M.5    Richert, C.6    Dalpke, A.H.7
  • 59
    • 0036760718 scopus 로고    scopus 로고
    • Developments in RNA chemistry, a personal view
    • Eckstein, F. (2002). Developments in RNA chemistry, a personal view. Biochimie 84, 841-84
    • (2002) Biochimie , vol.84 , pp. 841-884
    • Eckstein, F.1
  • 60
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschl, T. (2001a). Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-49
    • (2001) Nature , vol.411 , pp. 494-549
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 61
    • 0035803583 scopus 로고    scopus 로고
    • Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
    • Elbashir, S. M., Martinez, J., Patkaniowska, A., Lendeckel, W., and Tuschl, T. (2001b). Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 20, 6877-688
    • (2001) EMBO J , vol.20 , pp. 6877-7688
    • Elbashir, S.M.1    Martinez, J.2    Patkaniowska, A.3    Lendeckel, W.4    Tuschl, T.5
  • 65
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., and Mello, C. C. (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-81
    • (1998) Nature , vol.391 , pp. 806-881
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 70
    • 0030727765 scopus 로고    scopus 로고
    • The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes
    • Freier,S.M.,andAltmann,K.H. (1997). The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes. Nucleic Acids Res. 25, 4429-444
    • (1997) Nucleic Acids Res , vol.25 , pp. 4429-4444
    • Freier, S.M.1    andAltmann, K.H.2
  • 72
    • 42149167357 scopus 로고    scopus 로고
    • TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages
    • Gantier, M. P., Tong, S., Behlke, M. A., Xu, D., Phipps, S., Foster, P. S., and Williams, B. R. (2008). TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages. J. Immunol. 180,2117-212
    • (2008) J. Immunol. , vol.180 , pp. 2117-2212
    • Gantier, M.P.1    Tong, S.2    Behlke, M.A.3    Xu, D.4    Phipps, S.5    Foster, P.S.6    Williams, B.R.7
  • 73
    • 67649865399 scopus 로고    scopus 로고
    • The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice
    • Gao, S., Dagnaes-Hansen, F., Nielsen, E. J., Wengel, J., Besenbacher, F., Howard, K. A., and Kjems, J. (2009). The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice. Mol. Ther. 17, 1225-123
    • (2009) Mol. Ther. , vol.17 , pp. 1225-2123
    • Gao, S.1    Dagnaes-Hansen, F.2    Nielsen, E.J.3    Wengel, J.4    Besenbacher, F.5    Howard, K.A.6    Kjems, J.7
  • 74
    • 75649128759 scopus 로고    scopus 로고
    • Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs
    • Ge, Q., Dallas, A., Ilves, H., Shorenstein, J., Behlke, M. A., and Johnston, B. H. (2009a). Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs. RNA 16, 118-13
    • (2009) RNA , vol.16 , pp. 118-213
    • Ge, Q.1    Dallas, A.2    Ilves, H.3    Shorenstein, J.4    Behlke, M.A.5    Johnston, B.H.6
  • 75
    • 75649143739 scopus 로고    scopus 로고
    • Minimal-length short hairpin RNAs: the relationship of structure and RNAi activity
    • Ge, Q., Ilves, H., Dallas, A., Kumar, P., Shorenstein, J., Kazakov, S. A., and Johnston, B. H. (2009b). Minimal-length short hairpin RNAs: the relationship of structure and RNAi activity. RNA 16, 106-11
    • (2009) RNA , vol.16 , pp. 106-111
    • Ge, Q.1    Ilves, H.2    Dallas, A.3    Kumar, P.4    Shorenstein, J.5    Kazakov, S.A.6    Johnston, B.H.7
  • 76
    • 67650556402 scopus 로고    scopus 로고
    • Comparing 2-nt 3' overhangs against blunt-ended siR-NAs: a systems biology based study
    • doi:10.1186/1471-2164-10-S1-S17
    • Ghosh, P., Dullea, R., Fischer, J. E., Turi, T. G., Sarver, R. W., Zhang, C., Basu, K., Das, S. K., and Poland, B. W. (2009). Comparing 2-nt 3' overhangs against blunt-ended siR-NAs: a systems biology based study. BMC Genomics 10(Suppl. 1), S17. doi:10.1186/1471-2164-10-S1-S17
    • (2009) BMC Genomics , vol.10 , Issue.SUPPL. 1
    • Ghosh, P.1    Dullea, R.2    Fischer, J.E.3    Turi, T.G.4    Sarver, R.W.5    Zhang, C.6    Basu, K.7    Das, S.K.8    Poland, B.W.9
  • 77
    • 66249133061 scopus 로고    scopus 로고
    • Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration
    • Glud, S. Z., Bramsen, J. B., Dagnaes-Hansen, F., Wengel, J., Howard, K. A., Nyengaard, J. R., and Kjems, J. (2009). Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration. Oligonucleotides 19, 163-16
    • (2009) Oligonucleotides , vol.19 , pp. 163-216
    • Glud, S.Z.1    Bramsen, J.B.2    Dagnaes-Hansen, F.3    Wengel, J.4    Howard, K.A.5    Nyengaard, J.R.6    Kjems, J.7
  • 81
    • 0038578021 scopus 로고    scopus 로고
    • Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA
    • Grunweller, A., Wyszko, E., Bieber, B., Jahnel, R., Erdmann, V. A., and Kurreck, J. (2003). Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res. 31, 3185-319
    • (2003) Nucleic Acids Res , vol.31 , pp. 3185-3319
    • Grunweller, A.1    Wyszko, E.2    Bieber, B.3    Jahnel, R.4    Erdmann, V.A.5    Kurreck, J.6
  • 82
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian microRNAs predominantly act to decrease target mRNA levels
    • Guo, H., Ingolia, N. T., Weissman, J. S., and Bartel, D. P. (2010). Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466, 835-84
    • (2010) Nature , vol.466 , pp. 835-884
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3    Bartel, D.P.4
  • 83
    • 77956519356 scopus 로고    scopus 로고
    • Alocked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo
    • doi:10.1371/journal.pone.0010682
    • Gupta, N., Fisker, N., Asselin, M. C., Lindholm, M., Rosenbohm, C., Orum, H., Elmen, J., Seidah, N. G., and Straarup, E. M. (2010). Alocked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo. PLoS ONE 5, e10682. doi:10.1371/journal.pone.0010682
    • (2010) PLoS ONE , vol.5
    • Gupta, N.1    Fisker, N.2    Asselin, M.C.3    Lindholm, M.4    Rosenbohm, C.5    Orum, H.6    Elmen, J.7    Seidah, N.G.8    Straarup, E.M.9
  • 84
    • 11344257391 scopus 로고    scopus 로고
    • RNA interference using boranophosphate siRNAs: structure-activity relationships
    • Hall, A. H., Wan, J., Shaughnessy, E. E., Ramsay Shaw, B., and Alexander, K. A. (2004). RNA interference using boranophosphate siRNAs: structure-activity relationships. Nucleic Acids Res. 32, 5991-600
    • (2004) Nucleic Acids Res , vol.32 , pp. 5991-6600
    • Hall, A.H.1    Wan, J.2    Shaughnessy, E.E.3    Ramsay Shaw, B.4    Alexander, K.A.5
  • 86
    • 0036811055 scopus 로고    scopus 로고
    • Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3'-ends of siRNAs
    • Hamada, M., Ohtsuka, T., Kawaida, R., Koizumi, M., Morita, K., Furukawa, H., Imanishi, T., Miyagishi, M., and Taira, K. (2002). Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3'-ends of siRNAs. Anti-sense Nucleic Acid Drug Dev. 12, 301-30
    • (2002) Anti-sense Nucleic Acid Drug Dev , vol.12 , pp. 301-330
    • Hamada, M.1    Ohtsuka, T.2    Kawaida, R.3    Koizumi, M.4    Morita, K.5    Furukawa, H.6    Imanishi, T.7    Miyagishi, M.8    Taira, K.9
  • 87
    • 77953543643 scopus 로고    scopus 로고
    • Alternating 2'- O-ribosemethylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist
    • Hamm, S., Latz, E., Hangel, D., Muller, T., Yu, P., Golenbock, D., Sparwasser, T., Wagner, H., and Bauer, S. (2009). Alternating 2'- O-ribosemethylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist. Immunobiology 215, 559-56
    • (2009) Immunobiology , vol.215 , pp. 559-656
    • Hamm, S.1    Latz, E.2    Hangel, D.3    Muller, T.4    Yu, P.5    Golenbock, D.6    Sparwasser, T.7    Wagner, H.8    Bauer, S.9
  • 88
    • 0035839109 scopus 로고    scopus 로고
    • Argonaute2,alinkbetween genetic and biochemical analyses of RNAi
    • Hammond, S. M., Boettcher, S., Caudy, A. A.,Kobayashi, R., andHannon, G. J. (2001).Argonaute2,alinkbetween genetic and biochemical analyses of RNAi. Science 293, 1146-115
    • (2001) Science , vol.293 , pp. 1146-2115
    • Hammond, S.M.1    Boettcher, S.2    Caudy, A.A.3    Kobayashi, R.4    Hannon, G.J.5
  • 89
    • 82955201589 scopus 로고    scopus 로고
    • Involvement of activation of PKR in HBx-siRNA-mediated innate immune effects on HBV inhibition
    • doi:10.1371/journal.pone.0027931
    • Han, Q., Zhang, C., Zhang, J., and Tian, Z. (2011). Involvement of activation of PKR in HBx-siRNA-mediated innate immune effects on HBV inhibition. PLoS ONE 6, e27931. doi:10.1371/journal.pone.0027931
    • (2011) PLoS ONE , vol.6
    • Han, Q.1    Zhang, C.2    Zhang, J.3    Tian, Z.4
  • 90
    • 24344500241 scopus 로고    scopus 로고
    • Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing
    • Harborth, J., Elbashir, S. M., Vandenburgh, K., Manninga, H., Scaringe, S. A., Weber, K., and Tuschl, T. (2003). Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense Nucleic Acid Drug Dev. 13, 83-10
    • (2003) Antisense Nucleic Acid Drug Dev , vol.13 , pp. 10-83
    • Harborth, J.1    Elbashir, S.M.2    Vandenburgh, K.3    Manninga, H.4    Scaringe, S.A.5    Weber, K.6    Tuschl, T.7
  • 91
    • 31044444460 scopus 로고    scopus 로고
    • Inhibition of RNAse A family enzymes prevents degradation and loss of silencing activity of siRNAs in serum
    • Haupenthal, J., Baehr, C., Kiermayer, S., Zeuzem, S., and Piiper, A. (2006). Inhibition of RNAse A family enzymes prevents degradation and loss of silencing activity of siRNAs in serum. Biochem. Pharmacol. 71,702-71
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 702-771
    • Haupenthal, J.1    Baehr, C.2    Kiermayer, S.3    Zeuzem, S.4    Piiper, A.5
  • 92
    • 34248593248 scopus 로고    scopus 로고
    • RNAse A-like enzymes in serum inhibit the anti-neoplastic activity of siRNA targeting polo-like kinase 1
    • Haupenthal, J., Baehr, C., Zeuzem, S., and Piiper, A. (2007). RNAse A-like enzymes in serum inhibit the anti-neoplastic activity of siRNA targeting polo-like kinase 1. Int. J. Cancer 121,206-21
    • (2007) Int. J. Cancer , vol.121 , pp. 206-221
    • Haupenthal, J.1    Baehr, C.2    Zeuzem, S.3    Piiper, A.4
  • 95
    • 84888001876 scopus 로고    scopus 로고
    • FDA approves fomivirsen, famciclovir, and Thalidomide. Food and Drug Administration. BETA. Higuchi, Y., Kawakami, S., and Hashida, M. (2010). Strategies for in vivo delivery of siRNAs: recent progress
    • Highleyman, L. (1998). FDA approves fomivirsen, famciclovir, and Thalidomide. Food and Drug Administration. BETA. Higuchi, Y., Kawakami, S., and Hashida, M. (2010). Strategies for in vivo delivery of siRNAs: recent progress. BioDrugs 24, 195-20
    • (1998) BioDrugs , vol.24 , pp. 195-220
    • Highleyman, L.1
  • 96
    • 35549005821 scopus 로고    scopus 로고
    • Chemical modification resolves the asymmetry of siRNA strand degradation in human blood serum
    • Hoerter, J. A., and Walter, N. G. (2007). Chemical modification resolves the asymmetry of siRNA strand degradation in human blood serum. RNA 13, 1887-189
    • (2007) RNA , vol.13 , pp. 1887-2189
    • Hoerter, J.A.1    Walter, N.G.2
  • 97
  • 98
    • 1642491747 scopus 로고    scopus 로고
    • Enhancement of RNAi activity by improved siRNA duplexes
    • Hohjoh, H. (2004). Enhancement of RNAi activity by improved siRNA duplexes. FEBS Lett. 557,193-19
    • (2004) FEBS Lett , vol.557 , pp. 193-219
    • Hohjoh, H.1
  • 99
    • 0038074374 scopus 로고    scopus 로고
    • Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway
    • Holen, T., Amarzguioui, M., Babaie, E., and Prydz, H. (2003). Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway. Nucleic Acids Res. 31,2401-240
    • (2003) Nucleic Acids Res , vol.31 , pp. 2401-3240
    • Holen, T.1    Amarzguioui, M.2    Babaie, E.3    Prydz, H.4
  • 101
    • 25844450312 scopus 로고    scopus 로고
    • High doses of siRNAs induce eri-1 andadar-1 gene expression and reduce the efficiency of RNA interference in the mouse
    • Hong, J., Qian, Z., Shen, S., Min, T., Tan, C., Xu, J., Zhao, Y., and Huang, W. (2005). High doses of siRNAs induce eri-1 andadar-1 gene expression and reduce the efficiency of RNA interference in the mouse. Biochem. J. 390,675-67
    • (2005) Biochem. J. , vol.390 , pp. 675-767
    • Hong, J.1    Qian, Z.2    Shen, S.3    Min, T.4    Tan, C.5    Xu, J.6    Zhao, Y.7    Huang, W.8
  • 104
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdorfer, B., Giese, T., Endres, S., and Hartmann, G. (2002). Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivityto CpG oligodeoxynucleotides. J. Immunol. 168,4531-453
    • (2002) J. Immunol. , vol.168 , pp. 4531-5453
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 105
    • 20444410838 scopus 로고    scopus 로고
    • RNA interference induced by siRNAs modified with 4'-fhioribonucleosides in cultured mammalian cells
    • Hoshika, S., Minakawa, N., Kamiya, H., Harashima, H., and Matsuda, A. (2005). RNA interference induced by siRNAs modified with 4'-fhioribonucleosides in cultured mammalian cells. FEBS Lett. 579, 3115-311
    • (2005) FEBS Lett , vol.579 , pp. 3115-3311
    • Hoshika, S.1    Minakawa, N.2    Kamiya, H.3    Harashima, H.4    Matsuda, A.5
  • 106
    • 36849060537 scopus 로고    scopus 로고
    • Study of modification pattern-RNAi activity relationships by using siRNAs modified with 4'-thioribonucleosides
    • Hoshika, S., Minakawa, N., Shionoya, A., Imada, K., Ogawa, N., and Matsuda, A. (2007). Study of modification pattern-RNAi activity relationships by using siRNAs modified with 4'-thioribonucleosides. Chem-biochem 8, 2133-213
    • (2007) Chem-biochem , vol.8 , pp. 2133-2213
    • Hoshika, S.1    Minakawa, N.2    Shionoya, A.3    Imada, K.4    Ogawa, N.5    Matsuda, A.6
  • 108
    • 0037144546 scopus 로고    scopus 로고
    • A microRNA in a multiple-turnover RNAi enzyme complex
    • Hutvagner, G., and Zamore, P. D. (2002). A microRNA in a multiple-turnover RNAi enzyme complex. Science 297,2056-206
    • (2002) Science , vol.297 , pp. 2056-2206
    • Hutvagner, G.1    Zamore, P.D.2
  • 110
    • 84856522997 scopus 로고    scopus 로고
    • Atelocollagen-mediated systemic delivery prevents immunostimulatory adverse effects of siRNA in mammals
    • Inaba, S., Nagahara, S., Makita, N., Tarumi, Y., Ishimoto, T., Matsuo, S., Kadomatsu, K., and Takei, Y. (2012). Atelocollagen-mediated systemic delivery prevents immunostimulatory adverse effects of siRNA in mammals. Mol. Ther. 20, 356-36
    • (2012) Mol. Ther. , vol.20 , pp. 356-436
    • Inaba, S.1    Nagahara, S.2    Makita, N.3    Tarumi, Y.4    Ishimoto, T.5    Matsuo, S.6    Kadomatsu, K.7    Takei, Y.8
  • 111
    • 36949011397 scopus 로고    scopus 로고
    • Solid-phase synthesis of modified RNAs containing amide-linked oligoribonucleosides at their 3'-end and their application to siRNA
    • Iwase, R., Toyama, T., and Nishimori, K. (2007). Solid-phase synthesis of modified RNAs containing amide-linked oligoribonucleosides at their 3'-end and their application to siRNA. Nucleosides Nucleotides Nucleic Acids 26, 1451-145
    • (2007) Nucleosides Nucleotides Nucleic Acids , vol.26 , pp. 1451-2145
    • Iwase, R.1    Toyama, T.2    Nishimori, K.3
  • 114
    • 33745612464 scopus 로고    scopus 로고
    • Widespread siRNA off-target transcript silencing mediated by seed region sequence complementarity
    • Jackson, A. L., Burchard, J., Schelter, J., Chau, B. N., Cleary, M., Lim, L., and Linsley, P. S. (2006b). Widespread siRNA " off-target" transcript silencing mediated by seed region sequence complementarity. RNA 12, 1179-118
    • (2006) RNA , vol.12 , pp. 1179-2118
    • Jackson, A.L.1    Burchard, J.2    Schelter, J.3    Chau, B.N.4    Cleary, M.5    Lim, L.6    Linsley, P.S.7
  • 116
    • 32944454941 scopus 로고    scopus 로고
    • Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
    • Judge, A. D., Bola, G., Lee, A. C., and MacLachlan, I. (2006). Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol. Ther. 13, 494-50
    • (2006) Mol. Ther. , vol.13 , pp. 494-550
    • Judge, A.D.1    Bola, G.2    Lee, A.C.3    MacLachlan, I.4
  • 117
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge, A. D., Sood, V., Shaw, J. R., Fang, D., McClintock, K., and MacLachlan, I. (2005). Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 23, 457-46
    • (2005) Nat. Biotechnol. , vol.23 , pp. 457-546
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 119
    • 0037154176 scopus 로고    scopus 로고
    • mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
    • Kang, D. C., Gopalkrishnan, R. V., Wu, Q., Jankowsky E., Pyle, A. M., and Fisher, P. B. (2002). mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. Proc. Natl. Acad. Sci. U.S.A. 99, 637-64
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 637-664
    • Kang, D.C.1    Gopalkrishnan, R.V.2    Wu, Q.3    Jankowsky, E.4    Pyle, A.M.5    Fisher, P.B.6
  • 121
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA
    • Kariko, K., Buckstein, M., Ni, H., and Weissman,D. (2005). Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23, 165-17
    • (2005) Immunity , vol.23 , pp. 165-217
    • Kariko, K.1    Buckstein, M.2    Ni, H.3    Weissman, D.4
  • 122
    • 1342346710 scopus 로고    scopus 로고
    • A conserved siRNA-degrading RNase negatively regulates RNA interference in C.elegans
    • Kennedy, S., Wang, D., and Ruvkun, G. (2004). A conserved siRNA-degrading RNase negatively regulates RNA interference in C.elegans. Nature 427, 645-649.
    • (2004) Nature , vol.427 , pp. 645-649
    • Kennedy, S.1    Wang, D.2    Ruvkun, G.3
  • 123
    • 67149115119 scopus 로고    scopus 로고
    • Transfection of small RNAs globally perturbs gene regu lation by endogenous microRNAs
    • Khan, A. A., Betel, D., Miller, M. L., Sander, C., Leslie, C. S., and Marks, D. S. (2009). Transfection of small RNAs globally perturbs gene regu lation by endogenous microRNAs. Nat. Biotechnol. 27, 549-55
    • (2009) Nat. Biotechnol. , vol.27 , pp. 549-555
    • Khan, A.A.1    Betel, D.2    Miller, M.L.3    Sander, C.4    Leslie, C.S.5    Marks, D.S.6
  • 124
    • 0142165224 scopus 로고    scopus 로고
    • Functional siRNAs and miRNAs exhibit strand bias
    • Khvorova, A., Reynolds, A., and Jayasena, S. D. (2003). Functional siRNAs and miRNAs exhibit strand bias. Cell 115,209-21
    • (2003) Cell , vol.115 , pp. 209-221
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 127
    • 67649236703 scopus 로고    scopus 로고
    • Approximate Bayesian feature selection on a large meta-dataset offers novel insights on factors that effect siRNA potency
    • Klingelhoefer, J. W., Moutsianas, L., and Holmes, C. (2009). Approximate Bayesian feature selection on a large meta-dataset offers novel insights on factors that effect siRNA potency. Bioinformatics 25, 1594-160
    • (2009) Bioinformatics , vol.25 , pp. 1594-2160
    • Klingelhoefer, J.W.1    Moutsianas, L.2    Holmes, C.3
  • 128
    • 16844381590 scopus 로고    scopus 로고
    • Toll-like receptor mRNA expression patterns in human dendritic cells and monocytes
    • Kokkinopoulos, I., Jordan, W J., and Ritter, M. A. (2005). Toll-like receptor mRNA expression patterns in human dendritic cells and monocytes. Mol. Immunol. 42, 957-96
    • (2005) Mol. Immunol. , vol.42 , pp. 957-996
    • Kokkinopoulos, I.1    Jordan, W.J.2    Ritter, M.A.3
  • 130
    • 29844452007 scopus 로고    scopus 로고
    • Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity
    • Kraynack, B. A., and Baker, B. F. (2006). Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity. RNA 12,163-17
    • (2006) RNA , vol.12 , pp. 163-217
    • Kraynack, B.A.1    Baker, B.F.2
  • 131
    • 79957928508 scopus 로고    scopus 로고
    • Is RNAI dead Mol
    • Krieg, A. M. (2011). Is RNAI dead Mol. Ther. 19,1001-100
    • (2011) Ther , vol.19 , pp. 1001-1100
    • Krieg, A.M.1
  • 132
    • 0037733977 scopus 로고    scopus 로고
    • Antisense technologies Improvement through novel chemical modifications
    • Kurreck, J. (2003). Antisense technologies. Improvement through novel chemical modifications. Eur. J. Biochem. 270,1628-164
    • (2003) Eur. J. Biochem. , vol.270 , pp. 1628-2164
    • Kurreck, J.1
  • 133
    • 33846906687 scopus 로고    scopus 로고
    • More complete gene silencing by fewer siRNAs: transparent optimized design and biophysical signature
    • Ladunga, I. (2007). More complete gene silencing by fewer siRNAs: transparent optimized design and biophysical signature. Nucleic Acids Res. 35, 433-44
    • (2007) Nucleic Acids Res , vol.35 , pp. 433-444
    • Ladunga, I.1
  • 134
    • 67651112027 scopus 로고    scopus 로고
    • UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability
    • Langkjær, N., Pasternak, A., and Wengel, J. (2009). UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability. Bioorg. Med. Chem. 17, 5420-542
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 5420-5542
    • Langkjær, N.1    Pasternak, A.2    Wengel, J.3
  • 135
    • 77957820261 scopus 로고    scopus 로고
    • RNAi and small interfering RNAs in human disease therapeutic applications
    • Lares, M. R., Rossi, J. J., and Ouellet, D. L. (2010). RNAi and small interfering RNAs in human disease therapeutic applications. Trends Biotechnol. 28, 570-57
    • (2010) Trends Biotechnol , vol.28 , pp. 570-657
    • Lares, M.R.1    Rossi, J.J.2    Ouellet, D.L.3
  • 139
    • 78649466225 scopus 로고    scopus 로고
    • Drug giants turn their backs on RNA interference
    • Ledford, H. (2010). Drug giants turn their backs on RNA interference. Nature 468,48
    • (2010) Nature , vol.468 , pp. 48
    • Ledford, H.1
  • 140
    • 33846781627 scopus 로고    scopus 로고
    • Contributions of 3'-overhang to the dissociation of small interfering RNAs from the PAZ domain: molecular dynamics simulation study
    • Lee, H. S., Lee, S. N., Joo, C. H., Lee, H., Yoon, S. Y., Kim, Y. K., and Choe, H. (2007). Contributions of 3'-overhang to the dissociation of small interfering RNAs from the PAZ domain: molecular dynamics simulation study. J. Mol. Graph. Model. 25, 784-79
    • (2007) J. Mol. Graph. Model. , vol.25 , pp. 784-879
    • Lee, H.S.1    Lee, S.N.2    Joo, C.H.3    Lee, H.4    Yoon, S.Y.5    Kim, Y.K.6    Choe, H.7
  • 141
    • 33645763485 scopus 로고    scopus 로고
    • Cleavage of the siRNA passenger strand during RISC assembly in human cells
    • Leuschner, P. J., Ameres, S. L., Kueng, S., and Martinez, J. (2006). Cleavage of the siRNA passenger strand during RISC assembly in human cells. EMBORep. 7,314-32
    • (2006) EMBORep , vol.7 , pp. 314-332
    • Leuschner, P.J.1    Ameres, S.L.2    Kueng, S.3    Martinez, J.4
  • 142
    • 36948998836 scopus 로고    scopus 로고
    • Nucleoside and oligonucleoside boranophosphates: chemistry and properties
    • Li, P., Sergueeva, Z. A., Dobrikov, M., and Shaw, B. R. (2007). Nucleoside and oligonucleoside boranophosphates: chemistry and properties. Chem. Rev. 107,4746-479
    • (2007) Chem. Rev. , vol.107 , pp. 4746-5479
    • Li, P.1    Sergueeva, Z.A.2    Dobrikov, M.3    Shaw, B.R.4
  • 143
    • 14844303872 scopus 로고    scopus 로고
    • The effects of thiophosphate substitutions on native siRNA gene silencing
    • Li, Z. Y., Mao, H., Kallick, D. A., and Gorenstein, D. G. (2005). The effects of thiophosphate substitutions on native siRNA gene silencing. Biochem. Biophys. Res. Commun. 329,1026-103
    • (2005) Biochem. Biophys. Res. Commun. , vol.329 , pp. 1026-1103
    • Li, Z.Y.1    Mao, H.2    Kallick, D.A.3    Gorenstein, D.G.4
  • 149
    • 2442679207 scopus 로고    scopus 로고
    • Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain
    • Ma, J. B., Ye, K., and Patel, D. J. (2004). Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature 429, 318-32
    • (2004) Nature , vol.429 , pp. 318-332
    • Ma, J.B.1    Ye, K.2    Patel, D.J.3
  • 150
    • 79251611629 scopus 로고    scopus 로고
    • Structural and binding study of modified siRNAs with the Argonaute 2 PAZ domain by NMR spectroscopy
    • Maiti, M., Nauwelaerts, K., Lescrinier, E., and Herdewijn, P. (2011). Structural and binding study of modified siRNAs with the Argonaute 2 PAZ domain by NMR spectroscopy. Chemistry (Easton) 17, 1519-152
    • (2011) Chemistry (Easton) , vol.17 , pp. 1519-2152
    • Maiti, M.1    Nauwelaerts, K.2    Lescrinier, E.3    Herdewijn, P.4
  • 151
    • 0026713151 scopus 로고
    • Interactions between double-stranded RNA regulators and the protein kinase DAI
    • Manche, L., Green, S. R., Schmedt, C., and Mathews, M. B. (1992). Interactions between double-stranded RNA regulators and the protein kinase DAI. Mol. Cell. Biol. 12, 5238-524
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5238-5524
    • Manche, L.1    Green, S.R.2    Schmedt, C.3    Mathews, M.B.4
  • 152
    • 29144431656 scopus 로고    scopus 로고
    • A human, ATP-independent RISC assembly machine fueled by pre-miRNA
    • Maniataki, E., and Mourelatos, Z. (2005). A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev. 19, 2979-299
    • (2005) Genes Dev , vol.19 , pp. 2979-3299
    • Maniataki, E.1    Mourelatos, Z.2
  • 155
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded anti-sense siRNAs guide target RNA cleavage in RNAi
    • Martinez, J., Patkaniowska, A., Urlaub, H., Luhrmann, R., and Tuschl, T. (2002). Single-stranded anti-sense siRNAs guide target RNA cleavage in RNAi. Cell 110, 563-57
    • (2002) Cell , vol.110 , pp. 563-657
    • Martinez, J.1    Patkaniowska, A.2    Urlaub, H.3    Luhrmann, R.4    Tuschl, T.5
  • 156
    • 2442495329 scopus 로고    scopus 로고
    • RISC is a 5; phosphomonoester-producing RNA endonuclease
    • Martinez, J., and Tuschl, T. (2004). RISC is a 5; phosphomonoester-producing RNA endonuclease. Genes Dev. 18,975-98
    • (2004) Genes Dev , vol.18 , pp. 975-998
    • Martinez, J.1    Tuschl, T.2
  • 157
    • 27744590896 scopus 로고    scopus 로고
    • Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
    • Matranga, C., Tomari, Y., Shin, C., Bartel, D. P., and Zamore, P. D. (2005). Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell 123, 607-62
    • (2005) Cell , vol.123 , pp. 607-662
    • Matranga, C.1    Tomari, Y.2    Shin, C.3    Bartel, D.P.4    Zamore, P.D.5
  • 158
    • 77952515974 scopus 로고    scopus 로고
    • The road to therapeutic RNA interference (RNAi): Tackling the 800 pound siRNA delivery gorilla
    • Meade, B. R., and Dowdy, S. E (2009). The road to therapeutic RNA interference (RNAi): Tackling the 800 pound siRNA delivery gorilla. Discov. Med. 8, 253-25
    • (2009) Discov. Med. , vol.8 , pp. 253-325
    • Meade, B.R.1    Dowdy, S.E.2
  • 161
    • 61849179561 scopus 로고    scopus 로고
    • In vivo SPECT and realtime gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure
    • Merkel, O. M., Librizzi, D., Pfestroff, A., Schurrat, T., Behe, M., and Kissel, T. (2009). In vivo SPECT and realtime gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure. Bioconjug. Chem. 20, 174-18
    • (2009) Bioconjug. Chem. , vol.20 , pp. 174-218
    • Merkel, O.M.1    Librizzi, D.2    Pfestroff, A.3    Schurrat, T.4    Behe, M.5    Kissel, T.6
  • 162
    • 0018801485 scopus 로고
    • Structural requirements of double-stranded RNA for the activation of 2' 5'-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells
    • Minks, M. A., West, D. K., Benvin, S., and Baglioni, C. (1979). Structural requirements of double-stranded RNA for the activation of 2',5'-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells. J. Biol. Chem. 254, 10180-1018
    • (1979) J. Biol. Chem. , vol.254 , pp. 10180-11018
    • Minks, M.A.1    West, D.K.2    Benvin, S.3    Baglioni, C.4
  • 164
    • 34147180058 scopus 로고    scopus 로고
    • Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo
    • Mook, O. R., Baas, F., De Wissel, M. B., and Fluiter, K. (2007). Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo. Mol. Cancer Ther. 6, 833-84
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 833-884
    • Mook, O.R.1    Baas, F.2    De Wissel, M.B.3    Fluiter, K.4
  • 168
    • 25144524025 scopus 로고    scopus 로고
    • Silencing gene expression with dicer-generated siRNA pools
    • Myers, J. W., and Ferrell, J. E. (2005). Silencing gene expression with dicer-generated siRNA pools. Methods Mol. Biol. 309,93-19
    • (2005) Methods Mol. Biol. , vol.309 , pp. 19-93
    • Myers, J.W.1    Ferrell, J.E.2
  • 169
    • 44149112583 scopus 로고    scopus 로고
    • Nucleoside modifica tions modulate activation of the protein kinase PKR in an RNA structure-specific manner
    • Nallagatla, S. R., and Bevilacqua, P. C. (2008). Nucleoside modifica tions modulate activation of the protein kinase PKR in an RNA structure-specific manner. RNA 14, 1201-121
    • (2008) RNA , vol.14 , pp. 1201-2121
    • Nallagatla, S.R.1    Bevilacqua, P.C.2
  • 170
    • 0032530310 scopus 로고    scopus 로고
    • Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation
    • Nanduri, S., Carpick, B. W., Yang, Y., Williams, B. R., and Qin, J. (1998). Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation. EMBO J. 17,5458-546
    • (1998) EMBO J , vol.17 , pp. 5458-5546
    • Nanduri, S.1    Carpick, B.W.2    Yang, Y.3    Williams, B.R.4    Qin, J.5
  • 172
    • 41149179660 scopus 로고    scopus 로고
    • Efficient in vivo delivery of siRNA to the liver by conjugation of alphatocopherol
    • Nishina, K.,Unno,T.,Uno,Y.,Kubodera, T., Kanouchi, T., Mizusawa, H., and Yokota, T. (2008). Efficient in vivo delivery of siRNA to the liver by conjugation of alphatocopherol. Mol. Ther. 16,734-74
    • (2008) Mol. Ther. , vol.16 , pp. 734-774
    • Nishina, K.1    Unno, T.2    Uno, Y.3    Kubodera, T.4    Kanouchi, T.5    Mizusawa, H.6    Yokota, T.7
  • 173
    • 0035798415 scopus 로고    scopus 로고
    • ATP requirements and small interfering RNA structure in the RNA interference pathway
    • Nykanen, A., Haley, B., and Zamore, P. D. (2001). ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell 107,309-32
    • (2001) Cell , vol.107 , pp. 309-332
    • Nykanen, A.1    Haley, B.2    Zamore, P.D.3
  • 174
  • 175
    • 38049058354 scopus 로고    scopus 로고
    • Synthesis of 2'-O-modified adenosine building blocks and application for RNA interference
    • Odadzic, D., Bramsen, J. B., Smicius, R., Bus, C., Kjems, J., and Engels, J. W. (2008). Synthesis of 2'-O-modified adenosine building blocks and application for RNA interference. Bioorg. Med. Chem. 16,518-52
    • (2008) Bioorg. Med. Chem. , vol.16 , pp. 518-552
    • Odadzic, D.1    Bramsen, J.B.2    Smicius, R.3    Bus, C.4    Kjems, J.5    Engels, J.W.6
  • 176
    • 15444376018 scopus 로고    scopus 로고
    • Stability of 3' double nucleotide overhangs that model the 3' ends of siRNA
    • O'Toole, A. S., Miller, S., and Serra, M. J. (2005). Stability of 3' double nucleotide overhangs that model the 3' ends of siRNA. RNA 11, 512-51
    • (2005) RNA , vol.11 , pp. 512-551
    • O'Toole, A.S.1    Miller, S.2    Serra, M.J.3
  • 177
    • 0033634682 scopus 로고    scopus 로고
    • Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference
    • Parrish, S., Fleenor, J., Xu, S., Mello, C., and Fire, A. (2000). Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference. Mol. Cell 6, 1077-108
    • (2000) Mol. Cell , vol.6 , pp. 1077-1108
    • Parrish, S.1    Fleenor, J.2    Xu, S.3    Mello, C.4    Fire, A.5
  • 178
    • 80052748882 scopus 로고    scopus 로고
    • Chemical modification of siRNA bases to probe and enhance RNA interference
    • Peacock, H., Kannan, A., Beal, P. A., and Burrows, C. J. (2011). Chemical modification of siRNA bases to probe and enhance RNA interference. J. Org. Chem. 76, 7295-730
    • (2011) J. Org. Chem. , vol.76 , pp. 7295-7730
    • Peacock, H.1    Kannan, A.2    Beal, P.A.3    Burrows, C.J.4
  • 179
    • 0037310844 scopus 로고    scopus 로고
    • LNA: a versatile tool for therapeutics andgenomics
    • Petersen, M., and Wengel, J. (2003). LNA: a versatile tool for therapeutics andgenomics. TrendsBiotechnol. 21, 74-8
    • (2003) TrendsBiotechnol , vol.21 , pp. 74-78
    • Petersen, M.1    Wengel, J.2
  • 180
    • 79953020954 scopus 로고    scopus 로고
    • Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects
    • Petri, S., Dueck, A., Lehmann, G., Putz, N., Rudel, S., Kremmer, E., and Meister, G. (2011). Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects. RNA 17, 737-74
    • (2011) RNA , vol.17 , pp. 737-774
    • Petri, S.1    Dueck, A.2    Lehmann, G.3    Putz, N.4    Rudel, S.5    Kremmer, E.6    Meister, G.7
  • 183
    • 34249720999 scopus 로고    scopus 로고
    • Antisense - down, but not out
    • Potera, C. (2007). Antisense - down, but not out. Nat. Biotechnol. 25, 497-49
    • (2007) Nat. Biotechnol. , vol.25 , pp. 497-549
    • Potera, C.1
  • 184
    • 0038401429 scopus 로고    scopus 로고
    • Anti-sense oligonuclotides with oxetane-constrained cytidine enhance heteroduplex stability, and elicit satisfactory RNase H response as well as showing improved resistance to both exo and endonucleases
    • Pradeepkumar, P. I., Amirkhanov, N. V., and Chattopadhyaya, J. (2003). Anti-sense oligonuclotides with oxetane-constrained cytidine enhance heteroduplex stability, and elicit satisfactory RNase H response as well as showing improved resistance to both exo and endonucleases. Org. Biomol. Chem. 1,81-9
    • (2003) Org. Biomol. Chem. , vol.1 , pp. 81-89
    • Pradeepkumar, P.I.1    Amirkhanov, N.V.2    Chattopadhyaya, J.3
  • 187
    • 33750201146 scopus 로고    scopus 로고
    • Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification
    • Puthenveetil, S., Whitby, L., Ren, J., Kelnar, K., Krebs, J. F., and Beal, P. A. (2006). Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification. Nucleic Acids Res. 34, 4900-491
    • (2006) Nucleic Acids Res , vol.34 , pp. 4900-5491
    • Puthenveetil, S.1    Whitby, L.2    Ren, J.3    Kelnar, K.4    Krebs, J.F.5    Beal, P.A.6
  • 189
  • 196
    • 84856402483 scopus 로고    scopus 로고
    • A status update of modified oligonucleotides for chemotherapeutics applications
    • Chapter 4 Unit 4
    • Sanghvi, Y S. (2011). A status update of modified oligonucleotides for chemotherapeutics applications. Curr. Protoc. Nucleic Acid Chem. Chapter 4, Unit 4 1, 1-2
    • (2011) Curr. Protoc. Nucleic Acid Chem. , vol.1 , pp. 1-2
    • Sanghvi, Y.S.1
  • 197
    • 79957959362 scopus 로고    scopus 로고
    • RNAi momentum fizzles as pharma shifts priorities
    • Schmidt, C. (2011). RNAi momentum fizzles as pharma shifts priorities. Nat. Biotechnol. 29, 93-9
    • (2011) Nat. Biotechnol. , vol.29 , pp. 93-99
    • Schmidt, C.1
  • 198
    • 10744225153 scopus 로고    scopus 로고
    • Asymmetry in the assembly of the RNAi enzyme complex
    • Schwarz, D. S., Hutvagner, G., Du, T., Xu, Z., Aronin, N., and Zamore, P. D. (2003). Asymmetry in the assembly of the RNAi enzyme complex. Cell 115, 199-20
    • (2003) Cell , vol.115 , pp. 199-220
    • Schwarz, D.S.1    Hutvagner, G.2    Du, T.3    Xu, Z.4    Aronin, N.5    Zamore, P.D.6
  • 199
    • 84861539981 scopus 로고    scopus 로고
    • In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important
    • Schyth, B. D., Bramsen, J. B., Pakula, M. M., Larashati, S., Kjems, J., Wengel, J., and Lorenzen, N. (2012). In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important. Nucleic Acids Res. 40,4653-466
    • (2012) Nucleic Acids Res , vol.40 , pp. 4653-5466
    • Schyth, B.D.1    Bramsen, J.B.2    Pakula, M.M.3    Larashati, S.4    Kjems, J.5    Wengel, J.6    Lorenzen, N.7
  • 200
    • 33748701701 scopus 로고    scopus 로고
    • Computational models with thermodynamic and composition features improve siRNA design
    • doi:10.1186/1471-2105-7-65
    • Shabalina, S. A., Spiridonov, A. N., and Ogurtsov, A. Y. (2006). Computational models with thermodynamic and composition features improve siRNA design. BMC Bioinformatics 7,65. doi:10.1186/1471-2105-7-65
    • (2006) BMC Bioinformatics , vol.7 , pp. 65
    • Shabalina, S.A.1    Spiridonov, A.N.2    Ogurtsov, A.Y.3
  • 201
    • 0242317681 scopus 로고    scopus 로고
    • Biochemical properties of phosphonoacetate and thiophosphonoacetate oligodeoxyribonucleotides
    • Sheehan, D., Lunstad, B., Yamada, C. M., Stell, B. G., Caruthers, M. H., and Dellinger, D. J. (2003). Biochemical properties of phosphonoacetate and thiophosphonoacetate oligodeoxyribonucleotides. Nucleic AcidsRes. 31,4109-411
    • (2003) Nucleic AcidsRes , vol.31 , pp. 4109-4411
    • Sheehan, D.1    Lunstad, B.2    Yamada, C.M.3    Stell, B.G.4    Caruthers, M.H.5    Dellinger, D.J.6
  • 202
    • 35648934491 scopus 로고    scopus 로고
    • Immunostimulatory properties and antiviral activity of modified HBV-specific siR-NAs
    • Shin, D., Kim, S. I., Park, M., and Kim, M. (2007). Immunostimulatory properties and antiviral activity of modified HBV-specific siR-NAs. Biochem. Biophys. Res. Commun. 364, 436-44
    • (2007) Biochem. Biophys. Res. Commun. , vol.364 , pp. 436-444
    • Shin, D.1    Kim, S.I.2    Park, M.3    Kim, M.4
  • 203
    • 77249096959 scopus 로고    scopus 로고
    • Exploring chemical modifications for siRNA therapeutics: a structural and functional outlook
    • Shukla, S., Sumaria, C. S., and Pradeep-kumar, P. I. (2010). Exploring chemical modifications for siRNA therapeutics: a structural and functional outlook. ChemMedChem 5, 328-34
    • (2010) ChemMedChem , vol.5 , pp. 328-334
    • Shukla, S.1    Sumaria, C.S.2    Pradeep-kumar, P.I.3
  • 205
    • 18044365415 scopus 로고    scopus 로고
    • Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization
    • Sioud, M. (2005). Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. J. Mol. Biol. 348, 1079-109
    • (2005) J. Mol. Biol. , vol.348 , pp. 1079-1109
    • Sioud, M.1
  • 206
    • 33646544416 scopus 로고    scopus 로고
    • Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2'-hydroxyl uridines in immune responses
    • Sioud, M. (2006). Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2'-hydroxyl uridines in immune responses. Eur. J. Immunol. 36, 1222-123
    • (2006) Eur. J. Immunol. , vol.36 , pp. 1222-2123
    • Sioud, M.1
  • 207
    • 64549134275 scopus 로고    scopus 로고
    • Deciphering the code of innate immunity recognition of siRNAs
    • Sioud, M. (2009). Deciphering the code of innate immunity recognition of siRNAs. Methods Mol. Biol. 487, 41-5
    • (2009) Methods Mol. Biol. , vol.487 , pp. 41-45
    • Sioud, M.1
  • 208
    • 34447507937 scopus 로고    scopus 로고
    • Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA
    • Sipa, K., Sochacka, E., Kazmierczak-Baranska, J., Maszewska, M., Janicka, M., Nowak, G., and Nawrot, B. (2007). Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA. RNA 13, 1301-131
    • (2007) RNA , vol.13 , pp. 1301-2131
    • Sipa, K.1    Sochacka, E.2    Kazmierczak-Baranska, J.3    Maszewska, M.4    Janicka, M.5    Nowak, G.6    Nawrot, B.7
  • 211
    • 0031671323 scopus 로고    scopus 로고
    • Human extracellular ribonucleases: multiplicity, molecular diversity and catalytic properties of the major RNase types
    • Sorrentino, S. (1998). Human extracellular ribonucleases: multiplicity, molecular diversity and catalytic properties of the major RNase types. Cell. Mol. Life Sci. 54, 785-79
    • (1998) Cell. Mol. Life Sci. , vol.54 , pp. 785-879
    • Sorrentino, S.1
  • 213
    • 34447129727 scopus 로고    scopus 로고
    • Five-and six-membered conformationally locked 2',4'-carbocyclic ribothymidines: synthesis, structure, and biochemical studies
    • Srivastava, P., Barman, J., Pathmasiri, W., Plashkevych, O., Wenska, M., and Chattopadhyaya, J. (2007). Five-and six-membered conformationally locked 2',4'-carbocyclic ribothymidines: synthesis, structure, and biochemical studies. J. Am. Chem. Soc. 129,8362-837
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 8362-8837
    • Srivastava, P.1    Barman, J.2    Pathmasiri, W.3    Plashkevych, O.4    Wenska, M.5    Chattopadhyaya, J.6
  • 214
    • 0028001098 scopus 로고
    • Problems in interpretation of data derived from in vitro and in vivo use of antisense oligodeoxynucleotides
    • Stein, C. A., and Krieg, A. M. (1994). Problems in interpretation of data derived from in vitro and in vivo use of antisense oligodeoxynucleotides. Antisense Res. Dev. 4, 67-6
    • (1994) Antisense Res. Dev. , vol.4 , pp. 67-76
    • Stein, C.A.1    Krieg, A.M.2
  • 216
    • 57449107290 scopus 로고    scopus 로고
    • Asymmetric RNA duplexes mediate RNA interference in mammalian cells
    • Sun, X., Rogoff, H. A., and Li, C. J. (2008). Asymmetric RNA duplexes mediate RNA interference in mammalian cells. Nat. Biotechnol. 26, 1379-138
    • (2008) Nat. Biotechnol. , vol.26 , pp. 1379-2138
    • Sun, X.1    Rogoff, H.A.2    Li, C.J.3
  • 219
    • 62549113972 scopus 로고    scopus 로고
    • Synthesis and characterization of 2'-modified-4'-thioRNA: a comprehensive comparison of nuclease stability
    • Takahashi, M., Minakawa, N., and Matsuda, A. (2009). Synthesis and characterization of 2'-modified-4'-thioRNA: a comprehensive comparison of nuclease stability. Nucleic AcidsRes. 37, 1353-136
    • (2009) Nucleic AcidsRes , vol.37 , pp. 1353-2136
    • Takahashi, M.1    Minakawa, N.2    Matsuda, A.3
  • 220
    • 84863194833 scopus 로고    scopus 로고
    • Intra-cellular stability of 2'-OMe-4'-thioribonucleoside modified siRNA leads to long-term RNAi effect
    • Takahashi, M., Nagai, C., Hatakeyama, H., Minakawa, N., Harashima, H., and Matsuda, A. (2012). Intra-cellular stability of 2'-OMe-4'-thioribonucleoside modified siRNA leads to long-term RNAi effect. Nucleic Acids Res. 40, 5787-579
    • (2012) Nucleic Acids Res , vol.40 , pp. 5787-6579
    • Takahashi, M.1    Nagai, C.2    Hatakeyama, H.3    Minakawa, N.4    Harashima, H.5    Matsuda, A.6
  • 222
    • 77649175477 scopus 로고    scopus 로고
    • Competition between siRNA duplexes: impact of RISC loading efficiency and comparison between conventional-21 bp and dicer-substrate siRNAs
    • Tanudji, M., Machalek, D., Arndt, G. M., and Rivory, L. (2009). Competition between siRNA duplexes: impact of RISC loading efficiency and comparison between conventional-21 bp and dicer-substrate siRNAs. Oligonucleotides 20, 27-3
    • (2009) Oligonucleotides , vol.20 , pp. 27-33
    • Tanudji, M.1    Machalek, D.2    Arndt, G.M.3    Rivory, L.4
  • 224
    • 84555178927 scopus 로고    scopus 로고
    • Synthesis and biological activity of phosphonoacetate- and thiophosphonoacetatemo dified 2'-O-methyloligoribonucleotides
    • Threlfall, R. N., Torres, A. G., Krivenko, A., Gait, M. J., and Caruthers, M. H. (2012). Synthesis and biological activity of phosphonoacetate- and thiophosphonoacetatemo dified 2'-O-methyloligoribonucleotides. Org. Biomol. Chem. 10, 746-75
    • (2012) Org. Biomol. Chem. , vol.10 , pp. 746-775
    • Threlfall, R.N.1    Torres, A.G.2    Krivenko, A.3    Gait, M.J.4    Caruthers, M.H.5
  • 225
    • 65549109425 scopus 로고    scopus 로고
    • Sequences derived from self-RNA containing certain natural modifications act as suppressors of RNA-mediated inflammatory immune responses
    • Tluk, S., Jurk, M., Forsbach, A., Weeratna, R., Samulowitz, U., Krieg, A. M., Bauer, S., and Vollmer, J. (2009). Sequences derived from self-RNA containing certain natural modifications act as suppressors of RNA-mediated inflammatory immune responses. Int. Immunol. 21, 607-61
    • (2009) Int. Immunol. , vol.21 , pp. 607-661
    • Tluk, S.1    Jurk, M.2    Forsbach, A.3    Weeratna, R.4    Samulowitz, U.5    Krieg, A.M.6    Bauer, S.7    Vollmer, J.8
  • 226
    • 14644393684 scopus 로고    scopus 로고
    • Perspective: machines for RNAi
    • Tomari, Y., and Zamore, P. D. (2005). Perspective: machines for RNAi. Genes Dev. 19,517-52
    • (2005) Genes Dev , vol.19 , pp. 517-552
    • Tomari, Y.1    Zamore, P.D.2
  • 227
    • 0036794062 scopus 로고    scopus 로고
    • Stability of endogenous and added RNA in blood specimens, serum, and plasma
    • Tsui, N. B., Ng, E. K., and Lo, Y M. (2002). Stability of endogenous and added RNA in blood specimens, serum, and plasma. Clin. Chem. 48, 1647-165
    • (2002) Clin. Chem. , vol.48 , pp. 1647-2165
    • Tsui, N.B.1    Ng, E.K.2    Lo, Y.M.3
  • 228
    • 33845530239 scopus 로고    scopus 로고
    • MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNAse A-like activity
    • Turner, J. J., Jones, S. W., Moschos, S. A., Lindsay, M. A., and Gait, M. J. (2007). MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNAse A-like activity. Mol. Biosyst. 3, 43-5
    • (2007) Mol. Biosyst. , vol.3 , pp. 43-45
    • Turner, J.J.1    Jones, S.W.2    Moschos, S.A.3    Lindsay, M.A.4    Gait, M.J.5
  • 230
    • 42449091989 scopus 로고    scopus 로고
    • Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect
    • Ui-Tei, K., Naito, Y., Zenno, S., Nishi, K., Yamato, K., Takahashi, F., Juni, A., and Saigo, K. (2008). Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect. Nucleic Acids Res. 36,2136-215
    • (2008) Nucleic Acids Res , vol.36 , pp. 2136-2215
    • Ui-Tei, K.1    Naito, Y.2    Zenno, S.3    Nishi, K.4    Yamato, K.5    Takahashi, F.6    Juni, A.7    Saigo, K.8
  • 231
    • 0014486604 scopus 로고
    • On the mechanism of ribonuclease action
    • Usher, D. A. (1969). On the mechanism of ribonuclease action. Proc. Natl. Acad. Sci. U.S.A. 62, 661-66
    • (1969) Proc. Natl. Acad. Sci. U.S.A. , vol.62 , pp. 661-666
    • Usher, D.A.1
  • 234
    • 33845663097 scopus 로고    scopus 로고
    • An accurate and interpretable model for siRNA efficacy prediction
    • doi:10.1186/1471-2105-7-520
    • Vert, J. P., Foveau, N., Lajaunie, C., and Vandenbrouck, Y. (2006). An accurate and interpretable model for siRNA efficacy prediction. BMC Bioinformatics 7, 520. doi:10.1186/1471-2105-7-520
    • (2006) BMC Bioinformatics , vol.7 , pp. 520
    • Vert, J.P.1    Foveau, N.2    Lajaunie, C.3    Vandenbrouck, Y.4
  • 235
    • 36148972467 scopus 로고    scopus 로고
    • Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells
    • Vickers, T. A., Lima, W. F., Nichols, J. G., and Crooke, S. T. (2007). Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells. Nucleic AcidsRes. 35,6598-661
    • (2007) Nucleic AcidsRes , vol.35 , pp. 6598-6661
    • Vickers, T.A.1    Lima, W.F.2    Nichols, J.G.3    Crooke, S.T.4
  • 237
    • 78649681328 scopus 로고    scopus 로고
    • Predicting siRNA potency with random forests and support vector machines
    • doi:10.1186/1471-2164-11-S3-S2
    • Wang, L., Huang, C., and Yang, J. Y. (2010). Predicting siRNA potency with random forests and support vector machines. BMC Genomics 11(SUPPL 3), S2. doi:10.1186/1471-2164-11-S3-S2
    • (2010) BMC Genomics , vol.11 , Issue.SUPPL. 3
    • Wang, L.1    Huang, C.2    Yang, J.Y.3
  • 239
    • 70349961432 scopus 로고    scopus 로고
    • Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes
    • Wang, Y., Juranek, S., Li, H., Sheng, G., Wardle, G. S., Tuschl, T., and Patel, D. J. (2009b). Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature 461, 754-76
    • (2009) Nature , vol.461 , pp. 754-776
    • Wang, Y.1    Juranek, S.2    Li, H.3    Sheng, G.4    Wardle, G.S.5    Tuschl, T.6    Patel, D.J.7
  • 240
    • 56249145105 scopus 로고    scopus 로고
    • Structure of the guide-strand-containing argonaute silencing complex
    • Wang, Y., Sheng, G., Juranek, S., Tuschl, T., and Patel, D. J. (2008). Structure of the guide-strand-containing argonaute silencing complex. Nature 456,209-21
    • (2008) Nature , vol.456 , pp. 209-221
    • Wang, Y.1    Sheng, G.2    Juranek, S.3    Tuschl, T.4    Patel, D.J.5
  • 242
    • 84859361795 scopus 로고    scopus 로고
    • Toll-like receptor (TLR) 3 immune modulation by unformulated small interfering RNA or DNA and the role of CD 14 (in TLR-mediated effects)
    • Weber, C., Muller, C., Podszuweit, A., Montino, C., Vollmer, J., and Forsbach, A. (2012). Toll-like receptor (TLR) 3 immune modulation by unformulated small interfering RNA or DNA and the role of CD 14 (in TLR-mediated effects). Immunology 136, 64-7
    • (2012) Immunology , vol.136 , pp. 64-67
    • Weber, C.1    Muller, C.2    Podszuweit, A.3    Montino, C.4    Vollmer, J.5    Forsbach, A.6
  • 243
    • 65549130010 scopus 로고    scopus 로고
    • Both strands of siRNA have potential to guide posttranscriptional gene silencing in mammalian cells
    • doi:10.1371/journal.pone.0005382
    • Wei, J. X., Yang, J., Sun, J. F., Jia, L. T., Zhang, Y., Zhang, H. Z., Li, X., Meng, Y. L., Yao, L. B., and Yang, A. G. (2009). Both strands of siRNA have potential to guide posttranscriptional gene silencing in mammalian cells. PLoS ONE 4, e5382. doi:10.1371/journal.pone.0005382
    • (2009) PLoS ONE , vol.4
    • Wei, J.X.1    Yang, J.2    Sun, J.F.3    Jia, L.T.4    Zhang, Y.5    Zhang, H.Z.6    Li, X.7    Meng, Y.L.8    Yao, L.B.9    Yang, A.G.10
  • 245
    • 33751430435 scopus 로고    scopus 로고
    • Building oligonucleotide therapeutics using non-natural chemistries
    • Wilson, C., and Keefe, A. D. (2006). Building oligonucleotide therapeutics using non-natural chemistries. Curr. Opin. Chem. Biol. 10, 607-61
    • (2006) Curr. Opin. Chem. Biol. , vol.10 , pp. 607-661
    • Wilson, C.1    Keefe, A.D.2
  • 246
    • 33645119514 scopus 로고    scopus 로고
    • MicroRNAs direct rapid deadenylation of mRNA
    • Wu, L., Fan, J., and Belasco, J. G. (2006). MicroRNAs direct rapid deadenylation of mRNA. Proc. Natl. Acad. Sci. U.S.A. 103, 4034-403
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 4034-4403
    • Wu, L.1    Fan, J.2    Belasco, J.G.3
  • 251
    • 0041582974 scopus 로고
    • Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
    • Zamecnik, P. C., and Stephenson, M. L. (1978). Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl. Acad. Sci. U.S.A. 75, 280-28
    • (1978) Proc. Natl. Acad. Sci. U.S.A. , vol.75 , pp. 280-328
    • Zamecnik, P.C.1    Stephenson, M.L.2
  • 252
    • 33645698822 scopus 로고    scopus 로고
    • siRNA binding proteins of microglial cells: PKR is an unanticipated ligand
    • Zhang, Z., Weinschenk, T., Guo, K., and Schluesener, H. J. (2006). siRNA binding proteins of microglial cells: PKR is an unanticipated ligand. J. Cell Biochem. 97, 1217-122
    • (2006) J. Cell Biochem. , vol.97 , pp. 1217-2122
    • Zhang, Z.1    Weinschenk, T.2    Guo, K.3    Schluesener, H.J.4


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