Design of a genome-wide siRNA library using an artificial neural network

Nature Biotechnology

Volumn 23, Issue 8, 2005, Pages 995-1001

  Huesken, Dieter ^a   Lange, Joerg ^a   Mickanin, Craig ^b   Weiler, Jan ^a   Asselbergs, Fred ^a   Warner, Justin ^b   Meloon, Brian ^c,d   Engel, Sharon ^c   Rosenberg, Avi ^c   Cohen, Dalia ^b   Labow, Mark ^b   Reinhardt, Mischa ^a   Natt, François ^a   Hall, Jonathan ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c Compugen USA Inc ^*  (Israel)

^d Campbell and Company Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALGORITHMS; BIOTECHNOLOGY; NEURAL NETWORKS; PROTEINS; RNA;

GENE SYSTEMS; HYPOXIA TRANSCRIPTION; KNOCK-DOWN EXPRIMENTS; STUTTGART NEURAL NETWORK SIMULATORS;

GENES;

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; MESSENGER RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ALGORITHM; ARTICLE; ARTIFICIAL NEURAL NETWORK; FLUORESCENCE; GENE LIBRARY; GENE TARGETING; GENOME; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYPOXIA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REPORTER GENE;

ALGORITHMS; BASE SEQUENCE; COMPUTER SIMULATION; COMPUTER-AIDED DESIGN; GENE LIBRARY; GENE SILENCING; MODELS, GENETIC; MODELS, STATISTICAL; MOLECULAR SEQUENCE DATA; NERVE NET; RNA, SMALL INTERFERING; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, RNA;

EID: 23444437819     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt1118     Document Type: Article

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