Fully 2′-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA

Journal of Medicinal Chemistry

Volumn 48, Issue 4, 2005, Pages 901-904

  Allerson, Charles R ^a   Sioufi, Namir ^a   Jarres, Russell ^a   Prakash, Thazha P ^a   Naik, Nishant ^a   Berdeja, Andres ^a   Wanders, Lisa ^a   Griffey, Richard H ^a   Swayze, Eric E ^a   Bhat, Balkrishen ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' FLUORO OLIGONUCLEOTIDE; 2' O METHYL OLIGONUCLEOTIDE; DOUBLE STRANDED OLIGONUCLEOTIDE; MESSENGER RNA; OLIGONUCLEOTIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 1,2 DIELAIDOYLPHOSPHATIDYLETHANOLAMINE; 1,2-DIELAIDOYLPHOSPHATIDYLETHANOLAMINE; DRUG CARRIER; PHOSPHATASE; PHOSPHATIDYLETHANOLAMINE; PTEN PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG DESIGN; DRUG POTENCY; HUMAN; HUMAN CELL; MOLECULAR STABILITY; MOUSE; NONHUMAN; PLASMA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY; ANIMAL; BIOSYNTHESIS; CHEMISTRY; COMPARATIVE STUDY; DRUG STABILITY; GENETIC TRANSFECTION; GENETICS; HELA CELL; SYNTHESIS;

ANIMALS; DRUG CARRIERS; DRUG STABILITY; HELA CELLS; HUMANS; MICE; OLIGONUCLEOTIDES; PHOSPHATIDYLETHANOLAMINES; PHOSPHORIC MONOESTER HYDROLASES; PTEN PHOSPHOHYDROLASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

EID: 13944261143     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049167j     Document Type: Article

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