Experimental validation of the importance of seed complement frequency to siRNA specificity

RNA

Volumn 14, Issue 5, 2008, Pages 853-861

  Anderson, Emily M ^a   Birmingham, Amanda ^a   Baskerville, Scott ^a   Reynolds, Angela ^a   Maksimova, Elena ^a   Leake, Devin ^a   Fedorov, Yuriy ^a   Karpilow, Jon ^a   Khvorova, Anastasia ^a,b  

^a Thermo Fisher Scientific   (United States)

^b Advirna LLC   (United States)

Author keywords

MicroRNAs (miRNAs); RNA induced silencing complex (RISC); RNA interference (RNAi); Seed complement frequencies (SCFs); Small interfering RNAs (siRNA)

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE (NADP); NUCLEOTIDE; SMALL INTERFERING RNA; TRANSCRIPTOME; MESSENGER RNA; RNA INDUCED SILENCING COMPLEX;

ARTICLE; CONTROLLED STUDY; GENE CONTROL; GENE FREQUENCY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; RNA SEQUENCE; UNTRANSLATED REGION; VALIDATION STUDY; 3' UNTRANSLATED REGION; BIOLOGICAL MODEL; CHEMISTRY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETIC COMPLEMENTATION; GENETICS; HELA CELL; INTERNET; METABOLISM; RNA INTERFERENCE;

3' UNTRANSLATED REGIONS; BASE SEQUENCE; GENE EXPRESSION PROFILING; GENETIC COMPLEMENTATION TEST; HELA CELLS; HUMANS; INTERNET; MODELS, GENETIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; RNA-INDUCED SILENCING COMPLEX; TRANSFECTION;

EID: 42449152837     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.704708     Document Type: Article

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