Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependent pathway impair the transfection efficiency of human hepatocarcinoma cells

Molecular Therapy

Volumn 10, Issue 2, 2004, Pages 373-385

  GonçalvesGon, Christine ^a   Mennesson, Eric ^a   Fuchs, Renate ^b   Gorvel, Jean Pierre ^c   Midoux, Patrick ^a   Pichon, Chantal ^a  

^a CENTRE DE BIOPHYSIQUE MOLÉCULAIRE   (France)

^b Department of Pathophysiology ^*  (Austria)

^c CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

5 (N,N DIMETHYL)AMILORIDE; CELL MARKER; CHLORPROMAZINE; CLATHRIN; FLUORESCEIN; HISTIDINE; LUCIFERASE; PHORBOL MYRISTATE; PLASMID DNA; POLYLYSINE; TRANSFERRIN RECEPTOR;

ARTICLE; CANCER CELL CULTURE; CELL ORGANELLE; CELL STIMULATION; CELL STRAIN HEPG2; CELL TRANSPORT; CHEMICAL MODIFICATION; COMPLEX FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOSOME; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC CODE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LIVER CELL CARCINOMA; NONHUMAN; PH; PINOCYTOSIS; PLASMID;

BIOLOGICAL TRANSPORT; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CHLORPROMAZINE; CLATHRIN; ENDOSOMES; FLUORESCEIN; HUMANS; HYDROGEN-ION CONCENTRATION; LIVER NEOPLASMS; LUCIFERASES; NOCODAZOLE; PINOCYTOSIS; PLASMIDS; POLYLYSINE; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION;

EID: 4344697827     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.05.023     Document Type: Article

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