Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

Nature

Volumn 441, Issue 7092, 2006, Pages 537-541

  Grimm, Dirk ^a   Streetz, Konrad L ^a,d   Jopling, Catherine L ^a   Storm, Theresa A ^a   Pandey, Kusum ^a   Davis, Corrine R ^b   Marion, Patricia ^c   Salazar, Felix ^c   Kay, Mark A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c Hepadnavirus Testing Inc   (United States)

^d UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CELLS; DISEASES; DNA; VIRUSES;

HEPATITIS B VIRUS; INTRAVENOUS INFUSION; LIVER-DERIVED MICRORNAS; NUCLEAR KARYOPHERIN;

RNA;

EXPORTIN 5; KARYOPHERIN; MICRORNA; PARVOVIRUS VECTOR; SHORT HAIRPIN RNA; RNA; XPO5 PROTEIN, MOUSE;

CAUSE OF DEATH; GENE EXPRESSION; GENOMICS; HEPATITIS; MORBIDITY; RNA; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUSE OF DEATH; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; FATALITY; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSFECTION; HEPATITIS B; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER INJURY; LOW DRUG DOSE; MORBIDITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA PROCESSING; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; CONFORMATION; DRUG EFFECT; GENETICS; HEPATITIS B VIRUS; INJURY; LIVER; LIVER REGENERATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; RNA INTERFERENCE; SURVIVAL; TRANSGENIC MOUSE;

ADENO-ASSOCIATED VIRUS; ANIMALIA; HEPATITIS B VIRUS;

ANIMALS; HEPATITIS B VIRUS; HUMANS; KARYOPHERINS; LIVER; LIVER REGENERATION; MICE; MICE, TRANSGENIC; MICRORNAS; NUCLEIC ACID CONFORMATION; RNA; RNA INTERFERENCE; SURVIVAL ANALYSIS;

EID: 33745299723     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04791     Document Type: Article

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