Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

RNA

Volumn 12, Issue 7, 2006, Pages 1179-1187

  Jackson, Aimee L ^a   Burchard, Julja ^a   Schelter, Janell ^a   Chau, B Nelson ^a   Cleary, Michele ^a   Lim, Lee ^a   Linsley, Peter S ^a  

^a ROSETTA INPHARMATICS   (United States)

Author keywords

miRNA; Off target; RNAi; Seed region; shRNA; siRNA

Indexed keywords

MICRORNA; SMALL INTERFERING RNA;

3' UNTRANSLATED REGION; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RNA SEQUENCE;

3' UNTRANSLATED REGIONS; BASE SEQUENCE; GENE SILENCING; HELA CELLS; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, SMALL INTERFERING; SEQUENCE ALIGNMENT; TRANSCRIPTION, GENETIC;

EID: 33745612464     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.25706     Document Type: Article

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