Rational design of cationic lipids for siRNA delivery

Nature Biotechnology

Volumn 28, Issue 2, 2010, Pages 172-176

  Semple, Sean C ^a   Akinc, Akin ^b   Chen, Jianxin ^a,e   Sandhu, Ammen P ^a   Mui, Barbara L ^a,e   Cho, Connie K ^a   Sah, Dinah W Y ^b   Stebbing, Derrick ^a   Crosley, Erin J ^a   Yaworski, Ed ^a   Hafez, Ismail M ^c   Dorkin, J Robert ^b   Qin, June ^b   Lam, Kieu ^a   Rajeev, Kallanthottathil G ^b   Wong, Kim F ^c   Jeffs, Lloyd B ^a   Nechev, Lubomir ^b   Eisenhardt, Merete L ^a   Jayaraman, Muthusamy ^b   Kazem, Mikameh ^c   Maier, Martin A ^b   Srinivasulu, Masuna ^d   Weinstein, Michael J ^b   Chen, Qingmin ^b   Alvarez, Rene ^b   Barros, Scott A ^b   De, Soma ^b   Klimuk, Sandra K ^a   Borland, Todd ^b   Kosovrasti, Verbena ^b   Cantley, William L ^b   Tam, Ying K ^a,e   Manoharan, Muthiah ^b   Ciufolini, Marco A ^d   Tracy, Mark A ^b   De Fougerolles, Antonin ^b   MacLachlan, Ian ^a   Cullis, Pieter R ^c   Madden, Thomas D ^a,e   Hope, Michael J ^a,e   more..

^a Tekmira Pharmaceuticals Corporation   (Canada)

^b ALNYLAM PHARMACEUTICALS   (United States)

^c Department of Biochemistry and Molecular Biology ^*

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e Alcana Technologies   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATIONIC LIPIDS; DELIVERY CAPACITY; HEPATIC GENES; IN-VIVO; LIPID PARTICLES; MECHANISM OF ACTION; NON-HUMAN PRIMATE; RATIONAL DESIGN; SIRNA DELIVERY; SMALL INTERFERING RNA (SIRNA);

GENETIC ENGINEERING; MACHINE DESIGN; MAMMALS; NUCLEIC ACIDS; RNA;

LIPIDS;

1,2 DILINOLEYLOXY 3 DIMETHYLAMINOPROPANE; APOLIPOPROTEIN B; BLOOD CLOTTING FACTOR 7; DISTEAROYLPHOSPHATIDYLCHOLINE; DLIN K DMA; DLIN KC2 DMA; DLIN KC3 DMA; DLIN KC4 DMA; DLINDAP; LIPID NANOPARTICLE; MACROGOL; NANOPARTICLE; PHOSPHATIDYLCHOLINE; PREALBUMIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; DRUG SYNTHESIS; DRUG TISSUE LEVEL; GENE SILENCING; LIPID BILAYER; MONKEY; NONHUMAN; PRIORITY JOURNAL; RODENT; STRUCTURE ACTIVITY RELATION;

CATIONS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DESIGN; LIPIDS; RNA, SMALL INTERFERING; TRANSFECTION;

PRIMATES; RODENTIA;

EID: 76349111051     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.1602     Document Type: Article

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