2′-O-methyl-modified RNAs act as TLR7 antagonists

Molecular Therapy

Volumn 15, Issue 9, 2007, Pages 1663-1669

  Robbins, Marjorie ^a   Judge, Adam ^a   Liang, Lisa ^a   McClintock, Kevin ^a   Yaworski, Ed ^a   MacLachlan, Ian ^a  

^a Protiva Biotherapeutics   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIINFLAMMATORY AGENT; IMMUNOMODULATING AGENT; INTERLEUKIN 6; LOXORIBINE; RNA; SINGLE STRANDED RNA; SINGLE STRANDED RNA AGONIST; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 7 ANTAGONIST; UNCLASSIFIED DRUG; CYTOKINE; DRUG DERIVATIVE; GUANOSINE; IMMUNOSUPPRESSIVE AGENT; TOLL LIKE RECEPTOR 7;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; INFLAMMATION; MOUSE; NONHUMAN; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; RNA INTERFERENCE; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENETICS; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; MONONUCLEAR CELL;

MURINAE; MUS;

ANIMALS; CELLS, CULTURED; CYTOKINES; FEMALE; GUANOSINE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAVENOUS; INTERFERON-ALPHA; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; RNA, SMALL INTERFERING; TOLL-LIKE RECEPTOR 7;

EID: 34548108038     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/sj.mt.6300240     Document Type: Article

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