A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells

Nature Biotechnology

Volumn 24, Issue 5, 2006, Pages 559-565

  Marques, Joao Trindade ^a   Devosse, Thalie ^a   Wang, Die ^a   Zamanian Daryoush, Maryam ^a   Serbinowski, Paul ^a   Hartmann, Rune ^b   Fujita, Takashi ^c   Behlke, Mark A ^d   Williams, Bryan R G ^a,e  

^a LERNER RESEARCH INSTITUTE   (United States)

^b AARHUS UNIVERSITY   (Denmark)

^c KYOTO UNIVERSITY   (Japan)

^d INTEGRATED DNA TECHNOLOGIES   (United States)

^e MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENETIC ENGINEERING; INTERFERONS; MOLECULAR STRUCTURE; SIGNAL INTERFERENCE; TUMORS;

INTERFERON SYSTEMS; MAMMALIAN CELLS; SIGNALING PATHWAYS; SIRNA-BASED TREATMENTS;

RNA;

DOUBLE STRANDED RNA; INTERFERON; INTERFERON REGULATORY FACTOR 3; MICRORNA; NUCLEOTIDE; RNA HELICASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR;

3' UNTRANSLATED REGION; ARTICLE; CANCER; CONTROLLED STUDY; EMBRYO; GENE REPRESSION; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; MAMMAL CELL; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; RNA STRUCTURE; RNA SYNTHESIS; SIGNAL TRANSDUCTION; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALS; CELL LINE; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION REGULATION; GENETIC TECHNIQUES; HUMANS; INTERFERON REGULATORY FACTOR-3; LIPID METABOLISM; MODELS, GENETIC; NEOPLASMS; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING;

MAMMALIA;

EID: 33646561864     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1205     Document Type: Article

References (28)

1. Marques, J.T. & Williams, B.R. Activation of the mammalian immune system by siRNAs. Nat. Biotechnol. 23, 1399-1405 (2005).
2. Sledz, C.A., Holko, M., de Veer, M.J., Silverman, R.H. & Williams, B.R. Activation of the interferon system by short-interfering RNAs. Nat. Cell Biol. 5, 834-839 (2003).
3. Kim, D.H. et al. Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat. Biotechnol. 22, 321-325 (2004).
4. Kariko, K., Bhuyan, P., Capodici, J. & Weissman, D. Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3. J. Immunol. 172, 6545-6549 (2004).
5. Persengiev, S.P., Zhu, X. & Green, M.R. Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). RNA 10, 12-18 (2004).
6. Kim, D.H. et al. Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat. Biotechnol. 23, 222-226 (2005).
7. Peters, K.L., Smith, H.L., Stark, G.R. & Sen, G.C. IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA. Proc. Natl. Acad. Sci. USA 99, 6322-6327 (2002).
8. Hornung, V. et al. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat. Med. 11, 263-270 (2005).
9. Judge, A.D. et al. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 23, 457-462 (2005).
10. Ishii, K.J. et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat. Immunol. 7, 40-48 (2006).
11. Stetson, D.B. & Medzhitov, R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24, 93-103 (2006).
12. Yoneyama, M. et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. immunol. 5, 730-737 (2004).
13. Kato, H. et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity 23, 19-28 (2005).
14. Tanner, N.K. & Linder, P. DExD/H box RNA helicases: from generic motors to specific dissociation functions. Mol. Cell 8, 251-262 (2001).
15. Czauderna, F. et al. Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells. Nucleic Acids Res. 31, 2705-2716 (2003).
16. Siolas, D. et al. Synthetic shRNAs as potent RNAi triggers. Nat. Biotechnol. 23, 227-231 (2005).
17. Rose, S.D. et al. Functional polarity is introduced by Dicer processing of short substrate RNAs. Nucleic Acids Res. 33, 4140-4156 (2005).
18. Cullen, B.R. Transcription and processing of human microRNA precursors. Mol. Cell 16, 861-865 (2004).
19. Marques, J.T. et al. Down-regulation of p53 by double-stranded RNA modulates the antiviral response. J. Virol. 79, 11105-11114 (2005).
20. Ambros, V. The functions of animal microRNAs. Nature 431, 350-355 (2004).
21. Elbashir, S.M., Lendeckel, W. & Tuschl, T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15, 188-200 (2001).
22. Elbashir, S.M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498 (2001).
23. Caplen, N.J., Parrish, S., Imani, F., Fire, A. & Morgan, R.A. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc. Natl. Acad. Sci. USA 98, 9742-9747 (2001).
24. Manche, L., Green, S.R., Schmedt, C. & Mathews, M.B. Interactions between double-stranded RNA regulators and the protein kinase DAI. Mol. Cell. Biol. 12, 5238-5248 (1992).
25. Levy, D.E. & Marie, I.J. RIGging an antiviral defense - it's in the CARDs. Nat. Immunol. 5, 699-701 (2004).
26. Zhang, W. et al. Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene. Nat. Med. 11, 56-62 (2005).
27. Palliser, D. et al. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature 439, 89-94 (2006).
28. Carpick, B.W. et al. Characterization of the solution complex between the interferon-induced, double-stranded RNA-activated protein kinase and HIV-I trans-activating region RNA. J. Biol. Chem. 272, 9510-9516 (1997).