Immunostimulatory potential of silencing RNAs can be mediated by a non-uridine-rich toll-like receptor 7 motif

Nucleic Acid Therapeutics

Volumn 21, Issue 3, 2011, Pages 201-214

  Jurk, Marion ^a   Chikh, Ghania ^b   Schulte, Bettina ^a   Kritzler, Andrea ^a   Richardt Pargmann, Denise ^a   Lampron, Catherine ^b   Luu, Rachel ^b   Krieg, Arthur M ^a   Vicari, Alain P ^c   Vollmer, Jörg ^a  

^a PFIZER INC   (United States)

^b Pfizer Vaccines Research Ottawa   (Canada)

^c MERCK SERONO S A   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; DOUBLE STRANDED RNA; OLIGORIBONUCLEOTIDE; PHOSPHODIESTERASE; PHOSPHOROTHIOIC ACID; SINGLE STRANDED RNA; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 7; URIDINE;

ANIMAL EXPERIMENT; ARTICLE; CYTOKINE PRODUCTION; GENE SILENCING; IMMUNE RESPONSE; IMMUNOSTIMULATION; IN VIVO STUDY; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; SEQUENCE ANALYSIS;

AMINO ACID MOTIFS; ANIMALS; BLOOD BUFFY COAT; CYTOKINES; GENE SILENCING; HUMANS; IMMUNIZATION; MICE; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; OLIGORIBONUCLEOTIDES; PHOSPHOROTHIOATE OLIGONUCLEOTIDES; RNA, SMALL INTERFERING; TOLL-LIKE RECEPTOR 7; URIDINE;

MUS;

EID: 80052181600     PISSN: 21593337     EISSN: None     Source Type: Journal    
DOI: 10.1089/nat.2011.0298     Document Type: Article

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