Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation

EMBO Journal

Volumn 17, Issue 18, 1998, Pages 5458-5465

  Nanduri, Sambasivarao ^a   Carpick, Bruce W ^a   Yang, Yanwu ^a   Williams, Bryan R G ^a   Qin, Jun ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

dsRNA binding domain; NMR; PKR; Solution structure

Indexed keywords

DOUBLE STRANDED RNA; INTERFERON; PROTEIN KINASE;

ARTICLE; BINDING SITE; ENZYME ACTIVATION; ENZYME STRUCTURE; HOMEOSTASIS; HUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN RNA BINDING; RNA BINDING; VIRUS INFECTION;

AMINO ACID SEQUENCE; BINDING SITES; EIF-2 KINASE; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, SECONDARY; RNA, DOUBLE-STRANDED; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0032530310     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.18.5458     Document Type: Article

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