Improving RNA interference in mammalian cells by 4′-thio-modified small interfering RNA (siRNA): Effect on siRNA activity and nuclease stability when used in combination with 2′-O-alkyl modifications

Journal of Medicinal Chemistry

Volumn 49, Issue 5, 2006, Pages 1624-1634

  Dande, Prasad ^a   Prakash, Thazha P ^a   Sioufi, Namir ^a   Gaus, Hans ^a   Jarres, Russell ^a   Berdeja, Andreas ^a   Swayze, Eric E ^a   Griffey, Richard H ^a   Bhat, Balkrishen ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GROUP; COMPLEMENTARY RNA; DOUBLE STRANDED RNA; NUCLEASE; RIBONUCLEOSIDE DERIVATIVE; SMALL INTERFERING RNA; SULFOXIDE; THIOL DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; CHIRALITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MAMMAL CELL; QUANTUM YIELD; RNA INTERFERENCE; RNA STABILITY; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY;

ANIMALS; DRUG STABILITY; HEATING; HELA CELLS; HUMANS; MICE; ORGANOPHOSPHORUS COMPOUNDS; PLASMA; PTEN PHOSPHOHYDROLASE; RIBONUCLEASES; RIBOSE; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFOXIDES; THIONUCLEOSIDES;

EID: 33644860608     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050822c     Document Type: Article

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