Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

Nucleic Acids Research

Volumn 31, Issue 11, 2003, Pages 2705-2716

  Czauderna, Frank ^b   Fechtner, Melanie ^b   Dames, Sibylle ^b   Aygün, Hüseyin ^a   Klippel, Anke ^b   Pronk, Gijsbertus J ^b   Giese, Klaus ^b   Kaufmann, Jörg ^b  

^a BioSpring GmbH   (Germany)

^b Atugen AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DOUBLE STRANDED RNA; NUCLEASE; NUCLEOTIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ONCOPROTEIN; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; PTEN PROTEIN, HUMAN; RIBONUCLEASE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DNA MODIFICATION; DROSOPHILA; GENE ACTIVITY; GENE SILENCING; GENE STRUCTURE; GENETIC STABILITY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MAMMAL CELL; PRIORITY JOURNAL; RNA SYNTHESIS; TERMINAL SEQUENCE; BIOSYNTHESIS; CHEMISTRY; GENETIC TRANSFECTION; GENETICS; HELA CELL; METABOLISM; METHYLATION; RNA INTERFERENCE; RNA STABILITY;

MAMMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ENDORIBONUCLEASES; HELA CELLS; HUMANS; METHYLATION; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RNA INTERFERENCE; RNA STABILITY; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

EID: 0038606999     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg393     Document Type: Article

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