Intracellular stability of 2′-OMe-4′-thioribonucleoside modified siRNA leads to long-term RNAi effect

Nucleic Acids Research

Volumn 40, Issue 12, 2012, Pages 5787-5793

  Takahashi, Mayumi ^a   Nagai, Chisato ^a   Hatakeyama, Hiroto ^a   Minakawa, Noriaki ^b   Harashima, Hideyoshi ^a   Matsuda, Akira ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2' O METHYL 4' THIORNA; LUCIFERASE; NUCLEASE; RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RESEARCH; ENZYME ASSAY; ENZYME DEGRADATION; GENE SEQUENCE; GENE SILENCING; HELA CELL; HUMAN; IC 50; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA HYBRIDIZATION; RNA INTERFERENCE; THERMOSTABILITY;

GENES, REPORTER; HELA CELLS; HUMANS; LUCIFERASES, FIREFLY; RIBONUCLEASES; RIBONUCLEOSIDES; RNA INTERFERENCE; RNA STABILITY; RNA, SMALL INTERFERING; THIONUCLEOSIDES;

EID: 84863194833     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks204     Document Type: Article

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