Chemical modification resolves the asymmetry of siRNA strand degradation in human blood serum

RNA

Volumn 13, Issue 11, 2007, Pages 1887-1893

  Hoerter, John A H ^a   Walter, Nils G ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

2 O methyl modification; Melting temperature; Off target toxicity; siRNA therapeutics

Indexed keywords

SMALL INTERFERING RNA;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DEPHOSPHORYLATION; HALF LIFE TIME; HUMAN; KINETICS; PRIORITY JOURNAL; RNA CLEAVAGE; RNA DEGRADATION; RNA SEQUENCE; SERUM; THERMODYNAMICS;

BASE PAIRING; BASE SEQUENCE; HUMANS; METHYLATION; MOLECULAR SEQUENCE DATA; RNA STABILITY; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING; THERMODYNAMICS;

EID: 35549005821     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.602307     Document Type: Article

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