Fully 2′-deoxy-2′-fluoro substituted nucleic acids induce RNA interference in mammalian cell culture

Chemical Biology and Drug Design

Volumn 70, Issue 2, 2007, Pages 113-122

  Blidner, Richard A ^a   Hammer, Robert P ^a   Lopez, Mandi J ^a   Robinson, Sandra O ^a   Monroe, W Todd ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

2 fluoro modification; Antisense; Green fluorescent protein expression; Nuclease resistance; RNAi; Small interfering RNA

Indexed keywords

COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; NUCLEIC ACID; NUCLEOSIDE TRIPHOSPHATE; RIBONUCLEASE; RNA; SMALL INTERFERING FLUORONUCLEIC ACID; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; DEOXYRIBONUCLEOTIDE; FLUORINATED HYDROCARBON;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; FLUORINATION; GENE SILENCING; IN VITRO STUDY; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SOLID; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; HAMSTER;

MAMMALIA;

ANIMALS; CELLS, CULTURED; CRICETINAE; DEOXYRIBONUCLEOTIDES; GREEN FLUORESCENT PROTEINS; HYDROCARBONS, FLUORINATED; RNA; RNA INTERFERENCE;

EID: 34547748373     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2007.00542.x     Document Type: Article

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