Positional effect of chemical modifications on short interference RNA activity in mammalian cells

Journal of Medicinal Chemistry

Volumn 48, Issue 13, 2005, Pages 4247-4253

  Prakash, Thazha P ^a   Allerson, Charles R ^a   Dande, Prasad ^a   Vickers, Timothy A ^a   Sioufi, Namir ^a   Jarres, Russell ^a   Baker, Brenda F ^a   Swayze, Eric E ^a   Griffey, Richard H ^a   Bhat, Balkrishen ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' F 2' DEOXY NUCLEOSIDE; 2' O METHYL NUCLEOSIDE; [2' O(2 METHOXYETHYL)]NUCLEOSIDE; COMPLEMENTARY RNA; NUCLEOSIDE DERIVATIVE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RIBONUCLEOTIDE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; MAMMAL CELL; POSITION EFFECT; PROTEIN EXPRESSION; RNA INTERFERENCE; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; BASE SEQUENCE; CELL LINE; GERM-LINE MUTATION; HELA CELLS; HUMANS; MAMMALS; PHOSPHORIC MONOESTER HYDROLASES; PTEN PHOSPHOHYDROLASE; RNA INTERFERENCE; RNA, ANTISENSE; RNA, NEOPLASM; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEINS;

EID: 21244497878     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050044o     Document Type: Article

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