Antisense oligonuclotides with oxetene-constrained cytidine enhance heteroduplex stability, and elicit satisfactory RNase H response as well as showing improved resistance to both exo and endonucleases

Organic and Biomolecular Chemistry

Volumn 1, Issue 1, 2003, Pages 81-92

  Pradeepkumar, Pushpangadan I ^a   Amirkhanov, Nariman V ^a   Chattopadhyaya, Jyoti ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHEMICAL BONDS; CHEMICAL MODIFICATION; COMPLEXATION; DEGRADATION; DISSOCIATION; ENZYME KINETICS; HYDROLYSIS; MELTING; STOICHIOMETRY; SUBSTRATES; TEMPERATURE;

CYTIDINE; ENDONUCLEASE; EXONUCLEASE; HETERODUPLEX STABILITY; MICHAELIS-MENTEN KINETIC ANALYSIS; OLIGONUCLOTIDE; OXETANE;

ENZYME INHIBITION;

EID: 0038401429     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b210163g     Document Type: Article

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