Synthesis of 2′-O-modified adenosine building blocks and application for RNA interference

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 1, 2008, Pages 518-529

  Odadzic, Dalibor ^a   Bramsen, Jesper B ^b   Smicius, Romualdas ^a   Bus, Claus ^b   Kjems, Jørgen ^b   Engels, Joachim W ^a  

^a GOETHE UNIVERSITY   (Germany)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

2 O Modified building blocks; eGFP knock down; Nuclease resistence; RNAi

Indexed keywords

2 O AMINOETHYLADENOSINE; 2' O GUANIDINOETHYLADENOSINE; ADENOSINE; ANTISENSE OLIGONUCLEOTIDE; ETHYLAMINE; GUANIDINE DERIVATIVE; NUCLEASE; OLIGONUCLEOTIDE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; DRUG DERIVATIVE;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; GENE FUNCTION; GENE SILENCING; HUMAN; HUMAN CELL; KNOCKOUT GENE; RNA INTERFERENCE; RNA METABOLISM; RNA STABILITY; CHEMISTRY; SYNTHESIS;

ADENOSINE; RNA INTERFERENCE; RNA STABILITY; RNA, SMALL INTERFERING;

EID: 38049058354     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.09.019     Document Type: Article

References (21)

1. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., and Tuschl T. Nature 411 (2001) 494-498
2. Mello C.C., and Conte Jr. D. Nature 431 (2004) 338-342
3. Zamore P.D., Tuschl T., Sharp P.A., and Bartel D.P. Cell 101 (2000) 25-33
4. Stevenson M. N. Engl. J. Med. 351 (2004) 1772-1777
5. Elbashir S.M., Martinez J., et al. EMBO J. 20 (2001) 6877-6888
6. Chiu Y.L., and Rana T.M. RNA 9 (2003) 1034-1048
7. Saneyoshi H., Seio K., and Sekine M. J. Org. Chem. 70 (2005) 4284-4299
8. Zhang H.Y., Du Q., Wahlestedt C., and Liang Z. Curr. Top. Med. Chem. 6 (2006) 893-900
9. Manoharan M. Curr. Opin. Chem. Biol. 8 (2004) 570-579
10. Allerson C.R., Sioufi N., Jarres R., Prakash T.P., Naik N., Berdeja A., Wanders L., Griffey R.H., Swayze E.E., and Bhat B. J. Med. Chem. 48 (2005) 901-904
11. Griffey R.H., Monia P.B., Cummins L.L., Freier S., Greig M.J., Guinosso C.J., Lesnik E., Manalili S.M., Mohan V., Owens S., Ross B.R., Sasmor H., Wancewicz E., Weiler K., Wheeler P.D., and Cook P.D. J. Med. Chem. 39 (1996) 5100-5109
12. Prakash T.P., Puschl A., Lesnik E., Mohan V., Tereshko V., Egli M., and Manoharan M.. Org. Lett. 6 (2004) 1971-1974
13. Odadzic, D.; Engels J.W. Nucleosides Nucleotides & Nucleic Acids, 2007, (in print).
14. Jin S., Miduturu C.V., McKinney D.C., and Silverman S.K. J. Org. Chem. 70 (2005) 4284-4299
15. Feichtinger K., Sings H.L., Baker T.J., Matthews K., and Goodman M.T. J. Org. Chem. 63 (1998) 8432-8439
16. Kumar V., Gopalakrishnan V., and Ganesh K.N. NCL Commun. (1991) 4939
17. Howard K.A., Rahbek U.L., Liu X., Damgaard C.K., Glud S.Z., Andersen M.O., Hovgaard M.B., Schmitz A., Nyengaard J.R., Besenbacher F., and Kjems J. Mol. Ther. 14 (2006) 476
18. Bramsen, J.B.; Damgaard, C.K.; Lauersen, M.B.; Willsen, S.L.; Wengel, J.; Kjems, J.: Submitted (2007).
19. Wincott F.E., and Usman N. Methods Mol. Biol. 74 (2000) 59
20. Schweitzer M., and Engels J.W. In: Schlinqensiepen R., and Bryscch K.-H. (Eds). Antisense: From Technology to Therapy Vol. 6 (1997), Blackwell Science, Cambridge, MA 78-103
21. Marky L.A., and Breslauer K.J. Biopolymers 26 (1987) 1601